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The map label for this gene is smvA [H]

Identifier: 238894920

GI number: 238894920

Start: 2805754

End: 2807253

Strand: Reverse

Name: smvA [H]

Synonym: KP1_2943

Alternate gene names: 238894920

Gene position: 2807253-2805754 (Counterclockwise)

Preceding gene: 238894927

Following gene: 238894918

Centisome position: 53.49

GC content: 64.6

Gene sequence:

>1500_bases
ATGTCACGGCAATGGATGACGCTGATGGCGATTTTGCTGGTTTATATTCCGGTGGCGATTGACGCTACGGTGTTGCATGT
GGCCGCGCCGACCCTCAGCGTGGCGCTGGGTAGCAGCGGCAATGAGCTGTTGTGGATCATTGATATCTACTCATTAGTGA
TGGCCGGCATGGTGCTGCCGATGGGCGCCCTTGGCGATAAGATCGGCTTTAAGCGCCTGCTGCTGCTCGGCAGCGCCATT
TTTGGCATCGCCTCGCTGTGCGCCGCGCTGTCGCCGACGGCCATGACGCTGATTGCCTCACGCGCTTTGCTGGCGGTGGG
GGCGGCGATGATCGTCCCGGCGACGCTGGCCGGGATCCGCAGCACCTTTGCCGAGGCCAGCCAGCGCAATATGGCGCTGG
GGCTGTGGGCAGCGGTCGGCTCCGGCGGCGCAGCCTTCGGCCCGCTGGTGGGCGGTATCCTGCTGGAGCATTTCTACTGG
GGGTCGGTGTTCCTGATCAATGTGCCGATCGTGCTGGTGGTTATCGCGATTAACGCGAAAGTGGTGCCGCGCCAGCCCGC
GCGCCGCGAACAGCCGCTCAATCTACTGCAGGCGCTCGTTTTGATTGCCGCGATCCTGATGCTGGTGTTTAGCGCGAAAT
CGGCGCTGAAGGGCCAGCTGGCGCTGTGGCTCACCGCGCTGGTGGCGCTCGGCGGGGCGGCGATGTTAACCTGGTTTATC
CGCAAGCAGCTGTCGGCGGCCCGCCCGATGGTGGATATGCGCCTGTTCACCCATCGCATTATCTTAAGCGGGGTGATGAT
GGCGATGACGGCCCTGATTACCCTGGTCGGTTTTGAGCTACTGATGGCCCAGGAGCTGCAGTTTGTGCACCAGAAAACGC
CGTTCGAGGCGGGGATATTTATGCTGCCGGTAATGGTGGCCAGCGGCTTCAGCGGCCCGATTGCCGGCCTGCTGGTGTCG
CGGCTTGGGCTGCGCGAGGTGGCGACCGGCGGGATGCTGCTCAGCGCCTTCAGCTTTCTCGGCCTGGCGTTGACCGATTT
CAGTACCCAGCAGTGGCTGGCATGGGGGCTGATGACGCTGCTGGGCTTTAGCGTGGCCAGCGCGCTGCTGGCCTCCAGTT
CCGCGATTATGGCGGCAGCGCCGAAGGAGAAAGCGGCGGCCGCCGGGGCGATTGAAACCATGGCCTATGAGCTGGGCGCC
GGTCTCGGCATAGCGCTGTTCGGCCTCATCCTGACCCGCAGCTACAGCGCCTCTATTGCGCTGCCGTCTGGCCTGAGTGG
CGCCATGGCGCAGCAGGCGGCGTCATCGATTGGCGAGGCGGTGAGTCTGTCCCAGGCGCTGCCCGCCGGGGTGGCGCAGG
CGCTGATGGCGGCGGCGAAGACGGCTTTTATTCAGGCTCATAGCCTGGTGCTGGCGACGGCGGGTGTATTGCTTCTGCTG
CTGGCCGCTGGGATCTGGCGCAGCCTCGCCACCGTGGCGAAACCGCAGTCGGCGCTATAG

Upstream 100 bases:

>100_bases
TGGCCGAGTGTAACAAAAAGTTGGACATGTGTTCAACAATCCGGCAGGATCGCCATCCTGGACGTGTGTCCAATATTCAA
TATTGATTGAGGTACAAGCT

Downstream 100 bases:

>100_bases
CTGCAGCGACAGATCCATCGCCGCGCGCCGTAGCGGGGCGAGAGCCTTCTCTTTTAACGCCGCGGCGCTGACCGTCGCGG
CAGGTACCCCGACATTCAGG

Product: energy-dependent efflux protein for methyl viologen resistance

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MSRQWMTLMAILLVYIPVAIDATVLHVAAPTLSVALGSSGNELLWIIDIYSLVMAGMVLPMGALGDKIGFKRLLLLGSAI
FGIASLCAALSPTAMTLIASRALLAVGAAMIVPATLAGIRSTFAEASQRNMALGLWAAVGSGGAAFGPLVGGILLEHFYW
GSVFLINVPIVLVVIAINAKVVPRQPARREQPLNLLQALVLIAAILMLVFSAKSALKGQLALWLTALVALGGAAMLTWFI
RKQLSAARPMVDMRLFTHRIILSGVMMAMTALITLVGFELLMAQELQFVHQKTPFEAGIFMLPVMVASGFSGPIAGLLVS
RLGLREVATGGMLLSAFSFLGLALTDFSTQQWLAWGLMTLLGFSVASALLASSSAIMAAAPKEKAAAAGAIETMAYELGA
GLGIALFGLILTRSYSASIALPSGLSGAMAQQAASSIGEAVSLSQALPAGVAQALMAAAKTAFIQAHSLVLATAGVLLLL
LAAGIWRSLATVAKPQSAL

Sequences:

>Translated_499_residues
MSRQWMTLMAILLVYIPVAIDATVLHVAAPTLSVALGSSGNELLWIIDIYSLVMAGMVLPMGALGDKIGFKRLLLLGSAI
FGIASLCAALSPTAMTLIASRALLAVGAAMIVPATLAGIRSTFAEASQRNMALGLWAAVGSGGAAFGPLVGGILLEHFYW
GSVFLINVPIVLVVIAINAKVVPRQPARREQPLNLLQALVLIAAILMLVFSAKSALKGQLALWLTALVALGGAAMLTWFI
RKQLSAARPMVDMRLFTHRIILSGVMMAMTALITLVGFELLMAQELQFVHQKTPFEAGIFMLPVMVASGFSGPIAGLLVS
RLGLREVATGGMLLSAFSFLGLALTDFSTQQWLAWGLMTLLGFSVASALLASSSAIMAAAPKEKAAAAGAIETMAYELGA
GLGIALFGLILTRSYSASIALPSGLSGAMAQQAASSIGEAVSLSQALPAGVAQALMAAAKTAFIQAHSLVLATAGVLLLL
LAAGIWRSLATVAKPQSAL
>Mature_498_residues
SRQWMTLMAILLVYIPVAIDATVLHVAAPTLSVALGSSGNELLWIIDIYSLVMAGMVLPMGALGDKIGFKRLLLLGSAIF
GIASLCAALSPTAMTLIASRALLAVGAAMIVPATLAGIRSTFAEASQRNMALGLWAAVGSGGAAFGPLVGGILLEHFYWG
SVFLINVPIVLVVIAINAKVVPRQPARREQPLNLLQALVLIAAILMLVFSAKSALKGQLALWLTALVALGGAAMLTWFIR
KQLSAARPMVDMRLFTHRIILSGVMMAMTALITLVGFELLMAQELQFVHQKTPFEAGIFMLPVMVASGFSGPIAGLLVSR
LGLREVATGGMLLSAFSFLGLALTDFSTQQWLAWGLMTLLGFSVASALLASSSAIMAAAPKEKAAAAGAIETMAYELGAG
LGIALFGLILTRSYSASIALPSGLSGAMAQQAASSIGEAVSLSQALPAGVAQALMAAAKTAFIQAHSLVLATAGVLLLLL
AAGIWRSLATVAKPQSAL

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=490, Percent_Identity=25.1020408163265, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790195, Length=410, Percent_Identity=26.0975609756098, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788710, Length=414, Percent_Identity=25.3623188405797, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87081983, Length=404, Percent_Identity=25.7425742574257, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788392, Length=416, Percent_Identity=24.7596153846154, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51619; Mature: 51488

Theoretical pI: Translated: 10.57; Mature: 10.57

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQWMTLMAILLVYIPVAIDATVLHVAAPTLSVALGSSGNELLWIIDIYSLVMAGMVLP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEHHHHHHHHHHHHHHHC
MGALGDKIGFKRLLLLGSAIFGIASLCAALSPTAMTLIASRALLAVGAAMIVPATLAGIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STFAEASQRNMALGLWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVIAINAK
HHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCE
VVPRQPARREQPLNLLQALVLIAAILMLVFSAKSALKGQLALWLTALVALGGAAMLTWFI
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
RKQLSAARPMVDMRLFTHRIILSGVMMAMTALITLVGFELLMAQELQFVHQKTPFEAGIF
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
MLPVMVASGFSGPIAGLLVSRLGLREVATGGMLLSAFSFLGLALTDFSTQQWLAWGLMTL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LGFSVASALLASSSAIMAAAPKEKAAAAGAIETMAYELGAGLGIALFGLILTRSYSASIA
HHHHHHHHHHHCCCHHEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEE
LPSGLSGAMAQQAASSIGEAVSLSQALPAGVAQALMAAAKTAFIQAHSLVLATAGVLLLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAGIWRSLATVAKPQSAL
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SRQWMTLMAILLVYIPVAIDATVLHVAAPTLSVALGSSGNELLWIIDIYSLVMAGMVLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEHHHHHHHHHHHHHHHC
MGALGDKIGFKRLLLLGSAIFGIASLCAALSPTAMTLIASRALLAVGAAMIVPATLAGIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STFAEASQRNMALGLWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVIAINAK
HHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCE
VVPRQPARREQPLNLLQALVLIAAILMLVFSAKSALKGQLALWLTALVALGGAAMLTWFI
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
RKQLSAARPMVDMRLFTHRIILSGVMMAMTALITLVGFELLMAQELQFVHQKTPFEAGIF
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
MLPVMVASGFSGPIAGLLVSRLGLREVATGGMLLSAFSFLGLALTDFSTQQWLAWGLMTL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LGFSVASALLASSSAIMAAAPKEKAAAAGAIETMAYELGAGLGIALFGLILTRSYSASIA
HHHHHHHHHHHCCCHHEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEE
LPSGLSGAMAQQAASSIGEAVSLSQALPAGVAQALMAAAKTAFIQAHSLVLATAGVLLLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAGIWRSLATVAKPQSAL
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7926834; 11677609 [H]