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The map label for this gene is ddc [H]

Identifier: 238894837

GI number: 238894837

Start: 2720141

End: 2721622

Strand: Direct

Name: ddc [H]

Synonym: KP1_2853

Alternate gene names: 238894837

Gene position: 2720141-2721622 (Clockwise)

Preceding gene: 238894836

Following gene: 238894838

Centisome position: 51.83

GC content: 61.67

Gene sequence:

>1482_bases
GTGACCGCCATGTCCACATTGAATCCGATTCTTGCTGGTTCAGCGCAGAGCGTTGAAGCCTATCAGCAGGTTATCGAGCA
GACCAGCCAGGCCGTTGTGCAGTGGCTGAAGCAACCTGAGATGTATCAGGGGAAAAGCGTTGACGAGCTGCGTGAGCGTA
TCTCCCTAGAATTTAACGAACAGGGTTTGGGTAACCAGGCGGCGATTGATCGTGCGATCGAGTACTTCCTGAAAGACAGC
CTGTCGGTGCATCACCCGCAGTGCGTGGCGCACCTGCACTGCCCGAGCCTGGTGATTAGCCAGGCGGCGGAAGTGCTGAT
TAACGCCACCAACCAGAGCATGGACTCCTGGGATCAGAGCCCGTCGGCAACCATTATCGAGATGAAGCTGATCGAATGGC
TGCGCGCCCGGGTCGGTTTTCCGGCGGGCGACGCCGGCGTCTTCACCAGCGGCGGCACCCAGAGCAACCTGATGGGCCTG
ATGCTGGCGCGCGACGCCTTCTTCGCCCGTCAGGGCCACTCCATCCAGCAGGATGGGCTGCCGGGGGATATCCGCAAGTA
CAAAGTCTTGTGCTCGGAAAACGCCCACTTCTCGGTGCAGAAGAACATGGCGCTGATGGGCCTCGGCTACCGCTCGGTAA
CGCTGGTGAAAACCGACGAATTCGCGCGGATGGACGTGTCCGACCTGCAGGCGAAGATTGCGCAAGCGCAGGCTAACGGC
GAGCAGATCATGGCGATCGTCGCCACCGCCGGCACCACCGACGCAGGCGCTATCGACCCGCTGCGCGACATCGCCGGTAT
CGCTGCGGAACATCAGATCTGGCTGCACGTTGACGCAGCCTGGGGCGGCGCCCTGCTGCTGTCTGAGCAGTATCGCGACT
ACCTTGACGGTCTGGAGCTGGTGGATTCCGTTACCCTGGACTTCCATAAGCAGTTCTTCCAGACCATCAGCTGCGGCGCA
TTCCTGCTGAAGGACGCGCGCCATTACGAGCTGATGCGTTATCAGGCGGCCTATCTGAACTCCGAGTTCGATGAAGAACA
CGGCGTACCGAACCTGGTGTCTAAGTCGCTGCAGACCACCCGTCGCTTCGATGCGCTGAAGCTGTGGATGGGTCTGGAAG
CGCTGGGCCAGAAACAGTATGCGGCGATCATCGATCACGGCGTCACGATGGCGAAAAACGTGGCGGAGTACGTGAAGTCG
CAGCCGACGCTGGAGCTGGTGATGCAGCCGCAGCTGGCGAGCGTGCTGTTCCGTTCCCGTCCGGCGCAGATGGCCGGGAG
CGACGCGGCGGCTATCGCGCTGCTCAACCAGCGCGTCGGCGACGCCCTGCTGGCCTCCGGCCGCGCTAACGTCGGCGTAA
CCGAGCACAACGGCGTTACCTGCCTGAAGCTGACTCTGCTGAACCCGGTGGTGACGCTGGATGACGTGAAGGTTCTGCTG
AACCTGGTGGAGCGCACCGCTCAGGAGCTGCTGGCGCAATAA

Upstream 100 bases:

>100_bases
GCCGTCCCTGCTGATCAGCGACGCGGAGCTGGACGTGTTCCTCGACAAATTTGAACAGGCCCTGCTGGCCGCCGGCGTAA
AACCGGTCTGAGTGGAGTAA

Downstream 100 bases:

>100_bases
CCTGCCTTAGCGAGGCGGCGCCTGCCGCCCCGCTGTCAGCCTTGCCTGCAATAAGCCGATAATGTCCTTATCGGCTTTTT
TTATTTCTTTCCGCACCGCT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MTAMSTLNPILAGSAQSVEAYQQVIEQTSQAVVQWLKQPEMYQGKSVDELRERISLEFNEQGLGNQAAIDRAIEYFLKDS
LSVHHPQCVAHLHCPSLVISQAAEVLINATNQSMDSWDQSPSATIIEMKLIEWLRARVGFPAGDAGVFTSGGTQSNLMGL
MLARDAFFARQGHSIQQDGLPGDIRKYKVLCSENAHFSVQKNMALMGLGYRSVTLVKTDEFARMDVSDLQAKIAQAQANG
EQIMAIVATAGTTDAGAIDPLRDIAGIAAEHQIWLHVDAAWGGALLLSEQYRDYLDGLELVDSVTLDFHKQFFQTISCGA
FLLKDARHYELMRYQAAYLNSEFDEEHGVPNLVSKSLQTTRRFDALKLWMGLEALGQKQYAAIIDHGVTMAKNVAEYVKS
QPTLELVMQPQLASVLFRSRPAQMAGSDAAAIALLNQRVGDALLASGRANVGVTEHNGVTCLKLTLLNPVVTLDDVKVLL
NLVERTAQELLAQ

Sequences:

>Translated_493_residues
MTAMSTLNPILAGSAQSVEAYQQVIEQTSQAVVQWLKQPEMYQGKSVDELRERISLEFNEQGLGNQAAIDRAIEYFLKDS
LSVHHPQCVAHLHCPSLVISQAAEVLINATNQSMDSWDQSPSATIIEMKLIEWLRARVGFPAGDAGVFTSGGTQSNLMGL
MLARDAFFARQGHSIQQDGLPGDIRKYKVLCSENAHFSVQKNMALMGLGYRSVTLVKTDEFARMDVSDLQAKIAQAQANG
EQIMAIVATAGTTDAGAIDPLRDIAGIAAEHQIWLHVDAAWGGALLLSEQYRDYLDGLELVDSVTLDFHKQFFQTISCGA
FLLKDARHYELMRYQAAYLNSEFDEEHGVPNLVSKSLQTTRRFDALKLWMGLEALGQKQYAAIIDHGVTMAKNVAEYVKS
QPTLELVMQPQLASVLFRSRPAQMAGSDAAAIALLNQRVGDALLASGRANVGVTEHNGVTCLKLTLLNPVVTLDDVKVLL
NLVERTAQELLAQ
>Mature_492_residues
TAMSTLNPILAGSAQSVEAYQQVIEQTSQAVVQWLKQPEMYQGKSVDELRERISLEFNEQGLGNQAAIDRAIEYFLKDSL
SVHHPQCVAHLHCPSLVISQAAEVLINATNQSMDSWDQSPSATIIEMKLIEWLRARVGFPAGDAGVFTSGGTQSNLMGLM
LARDAFFARQGHSIQQDGLPGDIRKYKVLCSENAHFSVQKNMALMGLGYRSVTLVKTDEFARMDVSDLQAKIAQAQANGE
QIMAIVATAGTTDAGAIDPLRDIAGIAAEHQIWLHVDAAWGGALLLSEQYRDYLDGLELVDSVTLDFHKQFFQTISCGAF
LLKDARHYELMRYQAAYLNSEFDEEHGVPNLVSKSLQTTRRFDALKLWMGLEALGQKQYAAIIDHGVTMAKNVAEYVKSQ
PTLELVMQPQLASVLFRSRPAQMAGSDAAAIALLNQRVGDALLASGRANVGVTEHNGVTCLKLTLLNPVVTLDDVKVLLN
LVERTAQELLAQ

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI194294551, Length=504, Percent_Identity=31.3492063492063, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI197383062, Length=498, Percent_Identity=26.1044176706827, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI197276620, Length=427, Percent_Identity=28.8056206088993, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4503875, Length=427, Percent_Identity=28.8056206088993, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI58331246, Length=424, Percent_Identity=28.3018867924528, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI92110055, Length=422, Percent_Identity=26.7772511848341, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI4503281, Length=368, Percent_Identity=26.3586956521739, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI132814448, Length=368, Percent_Identity=26.3586956521739, Blast_Score=122, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI71993062, Length=437, Percent_Identity=26.0869565217391, Blast_Score=166, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17555682, Length=429, Percent_Identity=26.3403263403263, Blast_Score=165, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71993058, Length=342, Percent_Identity=28.9473684210526, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17534819, Length=426, Percent_Identity=25.1173708920188, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17534817, Length=426, Percent_Identity=25.1173708920188, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71981211, Length=457, Percent_Identity=21.6630196936543, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71981217, Length=466, Percent_Identity=21.244635193133, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17551992, Length=458, Percent_Identity=21.8340611353712, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI133931025, Length=317, Percent_Identity=22.397476340694, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136594, Length=400, Percent_Identity=30, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21356415, Length=351, Percent_Identity=31.9088319088319, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24657193, Length=387, Percent_Identity=27.6485788113695, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24657185, Length=387, Percent_Identity=27.6485788113695, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24657188, Length=387, Percent_Identity=27.6485788113695, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24652373, Length=402, Percent_Identity=27.1144278606965, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585139, Length=371, Percent_Identity=26.9541778975741, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221476190, Length=371, Percent_Identity=26.9541778975741, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585143, Length=371, Percent_Identity=26.9541778975741, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585135, Length=329, Percent_Identity=26.1398176291793, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17136190, Length=317, Percent_Identity=26.1829652996845, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24586044, Length=397, Percent_Identity=23.6775818639798, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28573972, Length=429, Percent_Identity=26.1072261072261, Blast_Score=100, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 54045; Mature: 53914

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAMSTLNPILAGSAQSVEAYQQVIEQTSQAVVQWLKQPEMYQGKSVDELRERISLEFNE
CCCHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCC
QGLGNQAAIDRAIEYFLKDSLSVHHPQCVAHLHCPSLVISQAAEVLINATNQSMDSWDQS
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHCCCC
PSATIIEMKLIEWLRARVGFPAGDAGVFTSGGTQSNLMGLMLARDAFFARQGHSIQQDGL
CCCEEHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
PGDIRKYKVLCSENAHFSVQKNMALMGLGYRSVTLVKTDEFARMDVSDLQAKIAQAQANG
CCHHHHHEEEECCCCCEEEECCEEEEECCCCEEEEEECCCHHHCCHHHHHHHHHHHHCCC
EQIMAIVATAGTTDAGAIDPLRDIAGIAAEHQIWLHVDAAWGGALLLSEQYRDYLDGLEL
CEEEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
VDSVTLDFHKQFFQTISCGAFLLKDARHYELMRYQAAYLNSEFDEEHGVPNLVSKSLQTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHH
RRFDALKLWMGLEALGQKQYAAIIDHGVTMAKNVAEYVKSQPTLELVMQPQLASVLFRSR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHCC
PAQMAGSDAAAIALLNQRVGDALLASGRANVGVTEHNGVTCLKLTLLNPVVTLDDVKVLL
CHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEEEEHHCCCCCHHHHHHHH
NLVERTAQELLAQ
HHHHHHHHHHHCC
>Mature Secondary Structure 
TAMSTLNPILAGSAQSVEAYQQVIEQTSQAVVQWLKQPEMYQGKSVDELRERISLEFNE
CCHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCC
QGLGNQAAIDRAIEYFLKDSLSVHHPQCVAHLHCPSLVISQAAEVLINATNQSMDSWDQS
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHCCCC
PSATIIEMKLIEWLRARVGFPAGDAGVFTSGGTQSNLMGLMLARDAFFARQGHSIQQDGL
CCCEEHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
PGDIRKYKVLCSENAHFSVQKNMALMGLGYRSVTLVKTDEFARMDVSDLQAKIAQAQANG
CCHHHHHEEEECCCCCEEEECCEEEEECCCCEEEEEECCCHHHCCHHHHHHHHHHHHCCC
EQIMAIVATAGTTDAGAIDPLRDIAGIAAEHQIWLHVDAAWGGALLLSEQYRDYLDGLEL
CEEEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
VDSVTLDFHKQFFQTISCGAFLLKDARHYELMRYQAAYLNSEFDEEHGVPNLVSKSLQTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHH
RRFDALKLWMGLEALGQKQYAAIIDHGVTMAKNVAEYVKSQPTLELVMQPQLASVLFRSR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHCC
PAQMAGSDAAAIALLNQRVGDALLASGRANVGVTEHNGVTCLKLTLLNPVVTLDDVKVLL
CHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEEEEHHCCCCCHHHHHHHH
NLVERTAQELLAQ
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]