Click here to switch to the map view.

The map label for this gene is pgtA [H]

Identifier: 238894756

GI number: 238894756

Start: 2636530

End: 2637780

Strand: Reverse

Name: pgtA [H]

Synonym: KP1_2764

Alternate gene names: 238894756

Gene position: 2637780-2636530 (Counterclockwise)

Preceding gene: 238894757

Following gene: 238894755

Centisome position: 50.26

GC content: 55.24

Gene sequence:

>1251_bases
ATGTTGAGTAATAACTGTTCGATTCTGCTGATTGACGATGATGCCGATGTGCTGGATGCCTATACGCAGCTGCTTGAGCA
AGCGGGGTATCATGTCAGTGCCTGTAATAATCCGTTTGATGCGCGGGAGCAGGTGCCGAAGGACTGGCCCGGCATCGTTT
TAAGCGATGTCTGCATGCCCGGCTGCTCCGGTATCGATTTAATGACGTTGTTTCATCAGGATGACGATCTGCTGCCGATT
CTGCTTATCACCGGTCACGGCGATGTGCCGATGGCGGTGGAGGCGGTGAAAAAAGGGGCCTGGGATTTCCTGCAAAAGCC
GATCGATCCGGGCAAACTGCTCACGCTGGTGGACGCCGCGCTGCGTCAGAGGCAATCGGTTATCGCCCGTCGCCAGTATT
GTCAGCAAAAATTACAGGTTGAGCTTATTGGCCGCAGCCAATGGACGGTTCGGTATCGCCAGCGCCTTCAGCAGCTGGCA
GAAACGGATATTGCGGTATGGCTTTACGGCGAGCCGGGAACCGGCCGCATGACCGGCGCGCGTTACCTGCACCAGTTAGG
ACGGCACGCTGAAGGTCCGTTTATCGCCTGCGAGCTGACTCCGGCTAACGCCCATACGCTTAATGAACTGATCGCCCAGG
CCCAGGGCGGAACGCTGGTCTTAAGTCACCCCGAGCATCTGACTCACGAGCAACAGCATCAGCTGGTACAGCTGCAGAGT
CATGAGAAGCGGCCTTTTCGCCTGATTGGTATCGGTAGCGCTTCGCTGGTGGAGTTGGCCGCCAGCAGCCAGATAGTGGC
GGAACTCTATTACTGCTTTGCGATGACGCAAATTGGCTGCCAGCCTCTGTCAAAGCGACCTGATGATATCGAGCCGCTGT
TTCATCACTATTTGCAAAAAACCTGTCAACGGCTGAATCATCCCGTCCCGGAGGTGGATGCTGGTCTGTTGAAGGGGATG
ATGCGCCGGGTGTGGCCAAATAACGTTCGCGAACTGGCGAACGCCGCCGAGCTGTTTGCAGTGGGGGTATTACCACTTGC
AGAAACGGTTAATCCGCTGATGCACATCGGCGAGCCGACGCCGCTGGATCAGCGGGTTGAGGACGTCGAACGGCAGATCA
TCACCGAAGCGCTGAATATCCACCAGGGACGTATTAATGAGGTGGCGGAGTATCTGCTGATACCGCGTAAAAAACTTTAT
CTCAGAATGAAGAAGTATGGTCTGAATAAAGAGCACTACAAAGGGGTTTAG

Upstream 100 bases:

>100_bases
GTTTCGCTGATGACGCAAATGGAAGGGGCGTTGCGCCTGGCGTCGACGTTTACACGCAGTGCCTGCGTGGTGCTGGAATT
CAATTTGACGGATGTAAAAG

Downstream 100 bases:

>100_bases
GGCATCTTGTCAGACGATGGTTGAAAATTATGAGGACAGATACAGATTATAAATGCCTTCAAGTCAGCAGAGGCGATTTA
TGTTATTGTGACTGCTTAAA

Product: phosphoglycerate transport system activator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MLSNNCSILLIDDDADVLDAYTQLLEQAGYHVSACNNPFDAREQVPKDWPGIVLSDVCMPGCSGIDLMTLFHQDDDLLPI
LLITGHGDVPMAVEAVKKGAWDFLQKPIDPGKLLTLVDAALRQRQSVIARRQYCQQKLQVELIGRSQWTVRYRQRLQQLA
ETDIAVWLYGEPGTGRMTGARYLHQLGRHAEGPFIACELTPANAHTLNELIAQAQGGTLVLSHPEHLTHEQQHQLVQLQS
HEKRPFRLIGIGSASLVELAASSQIVAELYYCFAMTQIGCQPLSKRPDDIEPLFHHYLQKTCQRLNHPVPEVDAGLLKGM
MRRVWPNNVRELANAAELFAVGVLPLAETVNPLMHIGEPTPLDQRVEDVERQIITEALNIHQGRINEVAEYLLIPRKKLY
LRMKKYGLNKEHYKGV

Sequences:

>Translated_416_residues
MLSNNCSILLIDDDADVLDAYTQLLEQAGYHVSACNNPFDAREQVPKDWPGIVLSDVCMPGCSGIDLMTLFHQDDDLLPI
LLITGHGDVPMAVEAVKKGAWDFLQKPIDPGKLLTLVDAALRQRQSVIARRQYCQQKLQVELIGRSQWTVRYRQRLQQLA
ETDIAVWLYGEPGTGRMTGARYLHQLGRHAEGPFIACELTPANAHTLNELIAQAQGGTLVLSHPEHLTHEQQHQLVQLQS
HEKRPFRLIGIGSASLVELAASSQIVAELYYCFAMTQIGCQPLSKRPDDIEPLFHHYLQKTCQRLNHPVPEVDAGLLKGM
MRRVWPNNVRELANAAELFAVGVLPLAETVNPLMHIGEPTPLDQRVEDVERQIITEALNIHQGRINEVAEYLLIPRKKLY
LRMKKYGLNKEHYKGV
>Mature_416_residues
MLSNNCSILLIDDDADVLDAYTQLLEQAGYHVSACNNPFDAREQVPKDWPGIVLSDVCMPGCSGIDLMTLFHQDDDLLPI
LLITGHGDVPMAVEAVKKGAWDFLQKPIDPGKLLTLVDAALRQRQSVIARRQYCQQKLQVELIGRSQWTVRYRQRLQQLA
ETDIAVWLYGEPGTGRMTGARYLHQLGRHAEGPFIACELTPANAHTLNELIAQAQGGTLVLSHPEHLTHEQQHQLVQLQS
HEKRPFRLIGIGSASLVELAASSQIVAELYYCFAMTQIGCQPLSKRPDDIEPLFHHYLQKTCQRLNHPVPEVDAGLLKGM
MRRVWPNNVRELANAAELFAVGVLPLAETVNPLMHIGEPTPLDQRVEDVERQIITEALNIHQGRINEVAEYLLIPRKKLY
LRMKKYGLNKEHYKGV

Specific function: Member of the two-component regulatory system pgtB/pgtA that regulates the inducible phosphoglycerate transport system. When activated by pgtB it acts in conjunction with sigma-54 as a transcriptional activator [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=26.5486725663717, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=28.0898876404494, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=24.8394004282655, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788905, Length=442, Percent_Identity=24.6606334841629, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=25.2336448598131, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87082117, Length=227, Percent_Identity=27.3127753303965, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081858, Length=297, Percent_Identity=26.5993265993266, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787583, Length=294, Percent_Identity=24.4897959183673, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=27.1186440677966, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786784, Length=141, Percent_Identity=28.3687943262411, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 46835; Mature: 46835

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSNNCSILLIDDDADVLDAYTQLLEQAGYHVSACNNPFDAREQVPKDWPGIVLSDVCMP
CCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHCCCCCCCCHHHHHHHCC
GCSGIDLMTLFHQDDDLLPILLITGHGDVPMAVEAVKKGAWDFLQKPIDPGKLLTLVDAA
CCCCCHHHEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LRQRQSVIARRQYCQQKLQVELIGRSQWTVRYRQRLQQLAETDIAVWLYGEPGTGRMTGA
HHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHH
RYLHQLGRHAEGPFIACELTPANAHTLNELIAQAQGGTLVLSHPEHLTHEQQHQLVQLQS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCHHHCHHHHHHHHHHHH
HEKRPFRLIGIGSASLVELAASSQIVAELYYCFAMTQIGCQPLSKRPDDIEPLFHHYLQK
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
TCQRLNHPVPEVDAGLLKGMMRRVWPNNVRELANAAELFAVGVLPLAETVNPLMHIGEPT
HHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PLDQRVEDVERQIITEALNIHQGRINEVAEYLLIPRKKLYLRMKKYGLNKEHYKGV
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHCCCC
>Mature Secondary Structure
MLSNNCSILLIDDDADVLDAYTQLLEQAGYHVSACNNPFDAREQVPKDWPGIVLSDVCMP
CCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHCCCCCCCCHHHHHHHCC
GCSGIDLMTLFHQDDDLLPILLITGHGDVPMAVEAVKKGAWDFLQKPIDPGKLLTLVDAA
CCCCCHHHEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LRQRQSVIARRQYCQQKLQVELIGRSQWTVRYRQRLQQLAETDIAVWLYGEPGTGRMTGA
HHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHH
RYLHQLGRHAEGPFIACELTPANAHTLNELIAQAQGGTLVLSHPEHLTHEQQHQLVQLQS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCHHHCHHHHHHHHHHHH
HEKRPFRLIGIGSASLVELAASSQIVAELYYCFAMTQIGCQPLSKRPDDIEPLFHHYLQK
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
TCQRLNHPVPEVDAGLLKGMMRRVWPNNVRELANAAELFAVGVLPLAETVNPLMHIGEPT
HHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PLDQRVEDVERQIITEALNIHQGRINEVAEYLLIPRKKLYLRMKKYGLNKEHYKGV
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3023201; 11677609; 2842311 [H]