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The map label for this gene is cynR [H]

Identifier: 238894702

GI number: 238894702

Start: 2586007

End: 2586930

Strand: Direct

Name: cynR [H]

Synonym: KP1_2708

Alternate gene names: 238894702

Gene position: 2586007-2586930 (Clockwise)

Preceding gene: 238894699

Following gene: 238894704

Centisome position: 49.27

GC content: 64.72

Gene sequence:

>924_bases
ATGAGTCCATTTTCCCGTTTCGCGCACTATTTCATCGCCGTGGCCCGCTGCGGCAGTCTGCGCCGGGCCGCCGAGCAGCT
GCATATCTCCGCCTCGGCAATTAACCGCCAGATCCTGCAGGCCGAGGAGGCCTTCGGTACCCCGCTGTTCGAGCGCCTGC
CGGAGGGACTGCGGATGACCACCGCCGGTGAACTGCTGTATGACAATCTGCTGCGCTGGCAGAAGGAATTTCGTCAGACC
CGACAGAAATTTGATGAGCTGCAGGGGATGAAGCGCGGGAGCGTTAGCGTTGGCATGGTGCAGGCGCTGGCGGAAGGGGG
CTTCGCCGCCGCGCTGGCGGAGATCATCGCCAGCTGGCCGTGGCTGGAGCTGGATCTGCAGGTGGCTGACAGCCACACCG
TCAGCCAGAAAGTGCGTCAGGCGGACCTGGACGTCGGCCTGATCCTCGATCCGCAGGGGCAGGCTGGACTCAGCGTGCTG
GCCTTTGCCGAACTGGAGGTGGGGATTGTGATGCGTCCGGACCATCCCCTGGCGGGGGCGAAGGCGCTGTCTTTGGGCGA
GCTCAGCCTGGAGCGGCATATCGTGCCCGGCGCGCCGCTGATCGTCCATGAGCGGGTGGCGCTCCTCTATCGCCACCATG
ACTTTGCGCCGGAGAATACCATCAGCTGCAATGATATCCGGCTTATCAAGTCGTTGGTGCTGCGCGGCAGCGGCGTGACA
CTCCTTAGCCTGCTCGACGTGCTGGACGAGGTCCAGCGTGGACAGCTGGCCTTTGTCCCGCTGCGCAGTACGCTGCTGCG
ACCGCTGACCCTGGCGCTGTGTACTGCACCCTCGCGTCAGCTTTCGCGGCCCGCGCAAATGGCCATTCAGACGCTGAGTG
CGGTGATCGAATCCATGGCGACGGTCAGCCCAGCGGCCCGCTGA

Upstream 100 bases:

>100_bases
GATTGTTTTATTGTTGTGAGATTATTGTTGTCATATTAGGGTGTTCACATCCATCACCATTAATTCACTCTGCTGTTGCA
AAAAAGAGTACAGGGGCGCC

Downstream 100 bases:

>100_bases
GGATGGTGTCGCACATGCCGTTGATAATGCGCTCCCCGGTCTCCTCGCGCAGCTCCTGGTACCAGGCTTCGGTGAGCTGC
ATATCCTTCCCGTGGGTAAT

Product: putative LysR family regulatory protein

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSPFSRFAHYFIAVARCGSLRRAAEQLHISASAINRQILQAEEAFGTPLFERLPEGLRMTTAGELLYDNLLRWQKEFRQT
RQKFDELQGMKRGSVSVGMVQALAEGGFAAALAEIIASWPWLELDLQVADSHTVSQKVRQADLDVGLILDPQGQAGLSVL
AFAELEVGIVMRPDHPLAGAKALSLGELSLERHIVPGAPLIVHERVALLYRHHDFAPENTISCNDIRLIKSLVLRGSGVT
LLSLLDVLDEVQRGQLAFVPLRSTLLRPLTLALCTAPSRQLSRPAQMAIQTLSAVIESMATVSPAAR

Sequences:

>Translated_307_residues
MSPFSRFAHYFIAVARCGSLRRAAEQLHISASAINRQILQAEEAFGTPLFERLPEGLRMTTAGELLYDNLLRWQKEFRQT
RQKFDELQGMKRGSVSVGMVQALAEGGFAAALAEIIASWPWLELDLQVADSHTVSQKVRQADLDVGLILDPQGQAGLSVL
AFAELEVGIVMRPDHPLAGAKALSLGELSLERHIVPGAPLIVHERVALLYRHHDFAPENTISCNDIRLIKSLVLRGSGVT
LLSLLDVLDEVQRGQLAFVPLRSTLLRPLTLALCTAPSRQLSRPAQMAIQTLSAVIESMATVSPAAR
>Mature_306_residues
SPFSRFAHYFIAVARCGSLRRAAEQLHISASAINRQILQAEEAFGTPLFERLPEGLRMTTAGELLYDNLLRWQKEFRQTR
QKFDELQGMKRGSVSVGMVQALAEGGFAAALAEIIASWPWLELDLQVADSHTVSQKVRQADLDVGLILDPQGQAGLSVLA
FAELEVGIVMRPDHPLAGAKALSLGELSLERHIVPGAPLIVHERVALLYRHHDFAPENTISCNDIRLIKSLVLRGSGVTL
LSLLDVLDEVQRGQLAFVPLRSTLLRPLTLALCTAPSRQLSRPAQMAIQTLSAVIESMATVSPAAR

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=239, Percent_Identity=28.4518828451883, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1787601, Length=289, Percent_Identity=23.1833910034602, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789204, Length=293, Percent_Identity=23.2081911262799, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790399, Length=257, Percent_Identity=24.5136186770428, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788887, Length=259, Percent_Identity=24.7104247104247, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081904, Length=177, Percent_Identity=29.9435028248588, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790262, Length=179, Percent_Identity=27.9329608938547, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788481, Length=256, Percent_Identity=26.5625, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33609; Mature: 33478

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPFSRFAHYFIAVARCGSLRRAAEQLHISASAINRQILQAEEAFGTPLFERLPEGLRMT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEH
TAGELLYDNLLRWQKEFRQTRQKFDELQGMKRGSVSVGMVQALAEGGFAAALAEIIASWP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCC
WLELDLQVADSHTVSQKVRQADLDVGLILDPQGQAGLSVLAFAELEVGIVMRPDHPLAGA
CEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEEEEEEEECCCCCCCCC
KALSLGELSLERHIVPGAPLIVHERVALLYRHHDFAPENTISCNDIRLIKSLVLRGSGVT
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHH
LLSLLDVLDEVQRGQLAFVPLRSTLLRPLTLALCTAPSRQLSRPAQMAIQTLSAVIESMA
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHH
TVSPAAR
HCCCCCC
>Mature Secondary Structure 
SPFSRFAHYFIAVARCGSLRRAAEQLHISASAINRQILQAEEAFGTPLFERLPEGLRMT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEH
TAGELLYDNLLRWQKEFRQTRQKFDELQGMKRGSVSVGMVQALAEGGFAAALAEIIASWP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCC
WLELDLQVADSHTVSQKVRQADLDVGLILDPQGQAGLSVLAFAELEVGIVMRPDHPLAGA
CEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEEEEEEEECCCCCCCCC
KALSLGELSLERHIVPGAPLIVHERVALLYRHHDFAPENTISCNDIRLIKSLVLRGSGVT
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHH
LLSLLDVLDEVQRGQLAFVPLRSTLLRPLTLALCTAPSRQLSRPAQMAIQTLSAVIESMA
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHH
TVSPAAR
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]