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The map label for this gene is yicM [H]

Identifier: 238894699

GI number: 238894699

Start: 2582637

End: 2583881

Strand: Direct

Name: yicM [H]

Synonym: KP1_2705

Alternate gene names: 238894699

Gene position: 2582637-2583881 (Clockwise)

Preceding gene: 238894697

Following gene: 238894702

Centisome position: 49.21

GC content: 64.82

Gene sequence:

>1245_bases
TTGTATATGAGTTCCTGCATAGCTGCTGACGCGAGCCTGTCATCCGCCAAACCTGCCTGGCGCGCCGTCTATGCCCTGGC
CCTCGGGGTGTTCGGCCTGATCGTGGCCGAGTTTCTGCCCGCCAGCCTGTTAACGCCGATGGCCAGCAGCCTCGGCGTCA
GTGAAGGGATGGCCGGACAGGCGGTCACCGCGACGGCGCTGGTGGCGTTAGTTACCGGCCTGCTGATCGCCACCGCCACC
CGCAATATCGATCGCCGCTGGGTGCTGATGTTCTTTTCCATACTGCAGATAGTCTCCAGCCTGATGGTCGCGTTTGCCGA
TTCGCTGGCGTTTCTCCTGCTGGGCCGTCTGCTGTTGGGGATCGCCATCGGCGGCTTCTGGGCGATGTCCACCGCCACGG
CGATGCGTCTGGTGCCGGCGGCCCATGTGCCAAAGGCGCTGGCGATCATCTTTTCCGCGGTGTCTGTCGCCACGGTGGTG
GCCGCGCCGCTCGGCAGCTACCTCGGGGAGCTGATCGGCTGGCGCAACGTGTTTATTCTCTGTGCGATACCCAGCCTGCT
GGCGCTGCTCTGGCAGCTGTGGGTGCTGCCCTCCATGCGCCCGGAGAGCGTCGGGACCTTCTCCACGCTGTTCAGGGTGC
TGCGCCGTCCCGGTATGCTGGGCGGCATGCTGGCGACGATCCTGATTTTCAGCGGCCATTTCGCCTTCTTTACCTACCTG
CGGCCGTTCCTTGAGACCGTCGCACAGGCCAGTATCGAAGGGGTTTCGCTGATATTGCTCGGCTTCGGTGTCGCTAACTT
TATCGGCACTTCGGTGGCGAGCTATCTGCTGAGCCGTAGCCTGCGCCTGACCCTGGCGCTGGTGCCGTTGATGATGAGCG
TTCTGGCGCTGCTGATGGTGACGTTTGGCCATCTGACCGTGCTGGCCGGGCTGCTGGTCGCCCTGTGGGGATTTGCCTTC
GGCCTGGTGCCGGTGGCCTGGTCCACCTGGCTTGCCACCACCGTGCCGGATGAAGCAGAAAGCGCGGGCGGTCTGCTGGT
CGCCTCTATTCAGCTGGCCATCAGCGCCGGGGCCGCCGGCGGCGGGGCGGTGTTTGATTTGCACGGCGCCAGCGGCGTCT
TCACCGGCAGCGGTCTGCTGCTGTTGAGCGCGATGGTGATTGTCTTCGCCGCCGTACGGGTGAAACCGGTCGCCCGCGCC
GACCAGCCGGTGACGGGCCGCTTATCCCGCGAGATCGATAACTAA

Upstream 100 bases:

>100_bases
TGGTAATTCCGGACGAATAATCAATAACTGAAGAGTATGCATCATATATCGTCCGAAAGTAAGGCCCTAAGATGACCAGG
ATGTTAATAAACCTGGAGAG

Downstream 100 bases:

>100_bases
ATTGGCCGACAGGCTGCGGGAGCAGCACAGCGCAATATGCTGCTCTGCGGCCTGTTTTTCCGCCTCCGACTGCACGGTAT
CCCGGTGGTCGACGGTTCCC

Product: putative inner membrane transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MYMSSCIAADASLSSAKPAWRAVYALALGVFGLIVAEFLPASLLTPMASSLGVSEGMAGQAVTATALVALVTGLLIATAT
RNIDRRWVLMFFSILQIVSSLMVAFADSLAFLLLGRLLLGIAIGGFWAMSTATAMRLVPAAHVPKALAIIFSAVSVATVV
AAPLGSYLGELIGWRNVFILCAIPSLLALLWQLWVLPSMRPESVGTFSTLFRVLRRPGMLGGMLATILIFSGHFAFFTYL
RPFLETVAQASIEGVSLILLGFGVANFIGTSVASYLLSRSLRLTLALVPLMMSVLALLMVTFGHLTVLAGLLVALWGFAF
GLVPVAWSTWLATTVPDEAESAGGLLVASIQLAISAGAAGGGAVFDLHGASGVFTGSGLLLLSAMVIVFAAVRVKPVARA
DQPVTGRLSREIDN

Sequences:

>Translated_414_residues
MYMSSCIAADASLSSAKPAWRAVYALALGVFGLIVAEFLPASLLTPMASSLGVSEGMAGQAVTATALVALVTGLLIATAT
RNIDRRWVLMFFSILQIVSSLMVAFADSLAFLLLGRLLLGIAIGGFWAMSTATAMRLVPAAHVPKALAIIFSAVSVATVV
AAPLGSYLGELIGWRNVFILCAIPSLLALLWQLWVLPSMRPESVGTFSTLFRVLRRPGMLGGMLATILIFSGHFAFFTYL
RPFLETVAQASIEGVSLILLGFGVANFIGTSVASYLLSRSLRLTLALVPLMMSVLALLMVTFGHLTVLAGLLVALWGFAF
GLVPVAWSTWLATTVPDEAESAGGLLVASIQLAISAGAAGGGAVFDLHGASGVFTGSGLLLLSAMVIVFAAVRVKPVARA
DQPVTGRLSREIDN
>Mature_414_residues
MYMSSCIAADASLSSAKPAWRAVYALALGVFGLIVAEFLPASLLTPMASSLGVSEGMAGQAVTATALVALVTGLLIATAT
RNIDRRWVLMFFSILQIVSSLMVAFADSLAFLLLGRLLLGIAIGGFWAMSTATAMRLVPAAHVPKALAIIFSAVSVATVV
AAPLGSYLGELIGWRNVFILCAIPSLLALLWQLWVLPSMRPESVGTFSTLFRVLRRPGMLGGMLATILIFSGHFAFFTYL
RPFLETVAQASIEGVSLILLGFGVANFIGTSVASYLLSRSLRLTLALVPLMMSVLALLMVTFGHLTVLAGLLVALWGFAF
GLVPVAWSTWLATTVPDEAESAGGLLVASIQLAISAGAAGGGAVFDLHGASGVFTGSGLLLLSAMVIVFAAVRVKPVARA
DQPVTGRLSREIDN

Specific function: Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine. Involved in the resistance to 6-mercaptopurine [H]

COG id: COG2814

COG function: function code G; Arabinose efflux permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily [H]

Homologues:

Organism=Escherichia coli, GI145693198, Length=394, Percent_Identity=47.9695431472081, Blast_Score=353, Evalue=8e-99,
Organism=Escherichia coli, GI1786595, Length=282, Percent_Identity=28.7234042553192, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1787808, Length=234, Percent_Identity=29.0598290598291, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1787947, Length=310, Percent_Identity=29.0322580645161, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43248; Mature: 43248

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYMSSCIAADASLSSAKPAWRAVYALALGVFGLIVAEFLPASLLTPMASSLGVSEGMAGQ
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
AVTATALVALVTGLLIATATRNIDRRWVLMFFSILQIVSSLMVAFADSLAFLLLGRLLLG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAIGGFWAMSTATAMRLVPAAHVPKALAIIFSAVSVATVVAAPLGSYLGELIGWRNVFIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CAIPSLLALLWQLWVLPSMRPESVGTFSTLFRVLRRPGMLGGMLATILIFSGHFAFFTYL
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RPFLETVAQASIEGVSLILLGFGVANFIGTSVASYLLSRSLRLTLALVPLMMSVLALLMV
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFGHLTVLAGLLVALWGFAFGLVPVAWSTWLATTVPDEAESAGGLLVASIQLAISAGAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEHHHHHHHHCCCCCC
GGAVFDLHGASGVFTGSGLLLLSAMVIVFAAVRVKPVARADQPVTGRLSREIDN
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MYMSSCIAADASLSSAKPAWRAVYALALGVFGLIVAEFLPASLLTPMASSLGVSEGMAGQ
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
AVTATALVALVTGLLIATATRNIDRRWVLMFFSILQIVSSLMVAFADSLAFLLLGRLLLG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAIGGFWAMSTATAMRLVPAAHVPKALAIIFSAVSVATVVAAPLGSYLGELIGWRNVFIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CAIPSLLALLWQLWVLPSMRPESVGTFSTLFRVLRRPGMLGGMLATILIFSGHFAFFTYL
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RPFLETVAQASIEGVSLILLGFGVANFIGTSVASYLLSRSLRLTLALVPLMMSVLALLMV
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFGHLTVLAGLLVALWGFAFGLVPVAWSTWLATTVPDEAESAGGLLVASIQLAISAGAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEHHHHHHHHCCCCCC
GGAVFDLHGASGVFTGSGLLLLSAMVIVFAAVRVKPVARADQPVTGRLSREIDN
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA