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The map label for this gene is pdxA [H]

Identifier: 238894665

GI number: 238894665

Start: 2555519

End: 2556505

Strand: Direct

Name: pdxA [H]

Synonym: KP1_2670

Alternate gene names: 238894665

Gene position: 2555519-2556505 (Clockwise)

Preceding gene: 238894664

Following gene: 238894666

Centisome position: 48.69

GC content: 61.8

Gene sequence:

>987_bases
GTGTCTAAGATGATTGCAGTGACAATGGGCGACCCGGCAGGGATTGGTCCGGAGATTATTATCAAATCCCTCGCCGAGGG
GGCGCTGAGCGGCGCGCCGGTGGTGGTGGTGGGCTGCGCGCAGACGCTGCGGCGGATCCTGGCGCTAAATATCACACCGC
GGGCGGAGCTGCGCATTATTGACCATCCCGCCGAGGCGAGTTTTTCCCCAGCGACTATCAACGTCATTGATGAACCACTC
AGCGACCCGCAGGGGCTGCGCCCTGGCGAAGTCCAGGCCCAGGCAGGGGATCTCGCGTTTCGCTGCATCAGGCGGGCGAC
CGCGCTGGCGCTGGAGGGCGCGGTCGCGGCCATCGCTACCGCGCCGCTGAATAAAGAGGCGCTGCATCTCGCCGGGCACG
CTTATCCCGGCCATACCGAACTGCTGGCCCACCTGACGCAGACTACCGATTACGCCATGGTGCTCTATACCGAGAAGCTT
AAGGTTATCCATATCACTACCCATATTTCCTTGCGCCAGTTCCTCGATACCCTCAACCAGCCGCGGATTGAGACGGTGAT
TGGCGTGGCGGATCGCTTTCTGCGCCGCGTCGGCTATCCACGTCCGCGCATCGCGGTCGCCGGCGTTAACCCGCACGCCG
GGGAGAACGGCCTGTTTGGCGATGAAGAGATCCGTATCGTCGCCCCGGCGGTCGCCGCCATGCGGGCGAAGGGAGTGGAG
GTGACCGGCCCCTGTCCGCCGGACACGGTGTTTATGCAGTGTCACGAAGGCATGTACGACATGGTGGTGGCGATGTATCA
CGACCAGGGGCATATTCCGCTGAAGCTGCTGGGATTCTATGACGGGGTGAATATTACCGCCGGGCTGCCGTTTATCCGTA
CCTCCGCGGATCATGGCACTGCGTTTGATATTGCCTGGACAGGTAAAGCGAAGTCTGAGAGCATGGCAACCTCCATTGAG
CTCGCCATGCACATCGCGCAGGAATAA

Upstream 100 bases:

>100_bases
CTCGGCGGCCGCTGGTCGCGGCCGGTGATGACCAAAGCCGGAGGATTCGGCACCGACACCACGCTGTTACATGTTGTGAA
TTTTATTGAGGAGAAACTGA

Downstream 100 bases:

>100_bases
CATGAAGGGATATAACCGGTTAGAGCAGATTATGGACTTCCTGAAAAGCCATAATCTGGTGACAGTCGACCAGCTGGTGG
CGGCGACCAACGCCTCGCCG

Product: 4-hydroxythreonine-4-phosphate dehydrogenase 2

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase 2 [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSKMIAVTMGDPAGIGPEIIIKSLAEGALSGAPVVVVGCAQTLRRILALNITPRAELRIIDHPAEASFSPATINVIDEPL
SDPQGLRPGEVQAQAGDLAFRCIRRATALALEGAVAAIATAPLNKEALHLAGHAYPGHTELLAHLTQTTDYAMVLYTEKL
KVIHITTHISLRQFLDTLNQPRIETVIGVADRFLRRVGYPRPRIAVAGVNPHAGENGLFGDEEIRIVAPAVAAMRAKGVE
VTGPCPPDTVFMQCHEGMYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAFDIAWTGKAKSESMATSIE
LAMHIAQE

Sequences:

>Translated_328_residues
MSKMIAVTMGDPAGIGPEIIIKSLAEGALSGAPVVVVGCAQTLRRILALNITPRAELRIIDHPAEASFSPATINVIDEPL
SDPQGLRPGEVQAQAGDLAFRCIRRATALALEGAVAAIATAPLNKEALHLAGHAYPGHTELLAHLTQTTDYAMVLYTEKL
KVIHITTHISLRQFLDTLNQPRIETVIGVADRFLRRVGYPRPRIAVAGVNPHAGENGLFGDEEIRIVAPAVAAMRAKGVE
VTGPCPPDTVFMQCHEGMYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAFDIAWTGKAKSESMATSIE
LAMHIAQE
>Mature_327_residues
SKMIAVTMGDPAGIGPEIIIKSLAEGALSGAPVVVVGCAQTLRRILALNITPRAELRIIDHPAEASFSPATINVIDEPLS
DPQGLRPGEVQAQAGDLAFRCIRRATALALEGAVAAIATAPLNKEALHLAGHAYPGHTELLAHLTQTTDYAMVLYTEKLK
VIHITTHISLRQFLDTLNQPRIETVIGVADRFLRRVGYPRPRIAVAGVNPHAGENGLFGDEEIRIVAPAVAAMRAKGVEV
TGPCPPDTVFMQCHEGMYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAFDIAWTGKAKSESMATSIEL
AMHIAQE

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=330, Percent_Identity=37.8787878787879, Blast_Score=192, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35112; Mature: 34981

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKMIAVTMGDPAGIGPEIIIKSLAEGALSGAPVVVVGCAQTLRRILALNITPRAELRII
CCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHEECCCCCCEEEEE
DHPAEASFSPATINVIDEPLSDPQGLRPGEVQAQAGDLAFRCIRRATALALEGAVAAIAT
ECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
APLNKEALHLAGHAYPGHTELLAHLTQTTDYAMVLYTEKLKVIHITTHISLRQFLDTLNQ
CCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCEEEEEEEEHHHHHHHHHHHCC
PRIETVIGVADRFLRRVGYPRPRIAVAGVNPHAGENGLFGDEEIRIVAPAVAAMRAKGVE
CHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHCCEE
VTGPCPPDTVFMQCHEGMYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGT
EECCCCCCHHHHHHHCCHHHEEEEEEECCCCCCEEEEEEECCCEEEECCCEEEECCCCCC
AFDIAWTGKAKSESMATSIELAMHIAQE
EEEEEECCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKMIAVTMGDPAGIGPEIIIKSLAEGALSGAPVVVVGCAQTLRRILALNITPRAELRII
CCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHEECCCCCCEEEEE
DHPAEASFSPATINVIDEPLSDPQGLRPGEVQAQAGDLAFRCIRRATALALEGAVAAIAT
ECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
APLNKEALHLAGHAYPGHTELLAHLTQTTDYAMVLYTEKLKVIHITTHISLRQFLDTLNQ
CCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCEEEEEEEEHHHHHHHHHHHCC
PRIETVIGVADRFLRRVGYPRPRIAVAGVNPHAGENGLFGDEEIRIVAPAVAAMRAKGVE
CHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHCCEE
VTGPCPPDTVFMQCHEGMYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGT
EECCCCCCHHHHHHHCCHHHEEEEEEECCCCCCEEEEEEECCCEEEECCCEEEECCCCCC
AFDIAWTGKAKSESMATSIELAMHIAQE
EEEEEECCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]