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The map label for this gene is marR [H]

Identifier: 238894655

GI number: 238894655

Start: 2545976

End: 2546410

Strand: Reverse

Name: marR [H]

Synonym: KP1_2659

Alternate gene names: 238894655

Gene position: 2546410-2545976 (Counterclockwise)

Preceding gene: 238894658

Following gene: 238894654

Centisome position: 48.52

GC content: 55.17

Gene sequence:

>435_bases
ATGAAAAGTACCAGCGACCTGTTTAATGAAATGATCCCGCTGGGCCGCTTGATCCAGATGGTTAACCAGAAAAAAGATCG
CCTGCTCAATGACTACCTCTCACCTATGGATATTACCGCGACCCAGTTTCGCGTGCTCTGCTCCATTCGTTGCGAAGTAT
GTATTACCCCCGTTGAGCTGAAAACCGTGCTTTCCGTCGACCCGGGCGCGATGACGCGCATGCTCGACCGCCTGGCGTGC
AAAGGCTGGATTGAACGGTTACCCAACCCCGCTGACAAGCGCGGCGTGCTGGTGCAGTTGACGCCGGACGGCGCAGCCCT
TTGCGAGCAGTGTCATCAGGTTGTGGGTCAGAAGTTACACCAGGAGTTAACGAAAAATCTGTCGGCGGACGAAGTCGCCA
TGCTTGAGCAACTGCTCAAGAAGGTCCTGCCGTAA

Upstream 100 bases:

>100_bases
CATTTTAGCAAATCGTGGCATCGGCCAATTCATAATGTTGACTTATGATTGCCTGGGCAATAGTATCACTTGCAACTAAT
TACTTGCCTGGGCAACCATT

Downstream 100 bases:

>100_bases
AAATAAGAAGAGGTAAGATGATGTCCAGACGTAATAATGACGCCATCACTATCCATAGTATTTTGTCGTGGATCGAGGAT
AACCTGGAATCGCCCCTGTC

Product: DNA-binding transcriptional repressor MarR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MKSTSDLFNEMIPLGRLIQMVNQKKDRLLNDYLSPMDITATQFRVLCSIRCEVCITPVELKTVLSVDPGAMTRMLDRLAC
KGWIERLPNPADKRGVLVQLTPDGAALCEQCHQVVGQKLHQELTKNLSADEVAMLEQLLKKVLP

Sequences:

>Translated_144_residues
MKSTSDLFNEMIPLGRLIQMVNQKKDRLLNDYLSPMDITATQFRVLCSIRCEVCITPVELKTVLSVDPGAMTRMLDRLAC
KGWIERLPNPADKRGVLVQLTPDGAALCEQCHQVVGQKLHQELTKNLSADEVAMLEQLLKKVLP
>Mature_144_residues
MKSTSDLFNEMIPLGRLIQMVNQKKDRLLNDYLSPMDITATQFRVLCSIRCEVCITPVELKTVLSVDPGAMTRMLDRLAC
KGWIERLPNPADKRGVLVQLTPDGAALCEQCHQVVGQKLHQELTKNLSADEVAMLEQLLKKVLP

Specific function: Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site [H]

COG id: COG1846

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH marR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081927, Length=144, Percent_Identity=84.0277777777778, Blast_Score=253, Evalue=3e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000835
- InterPro:   IPR023187
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR [H]

EC number: NA

Molecular weight: Translated: 16174; Mature: 16174

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS01117 HTH_MARR_1 ; PS50995 HTH_MARR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
9.0 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
9.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTSDLFNEMIPLGRLIQMVNQKKDRLLNDYLSPMDITATQFRVLCSIRCEVCITPVEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHH
KTVLSVDPGAMTRMLDRLACKGWIERLPNPADKRGVLVQLTPDGAALCEQCHQVVGQKLH
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
QELTKNLSADEVAMLEQLLKKVLP
HHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSTSDLFNEMIPLGRLIQMVNQKKDRLLNDYLSPMDITATQFRVLCSIRCEVCITPVEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHH
KTVLSVDPGAMTRMLDRLACKGWIERLPNPADKRGVLVQLTPDGAALCEQCHQVVGQKLH
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
QELTKNLSADEVAMLEQLLKKVLP
HHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383113; 9097039; 9278503; 8282690; 7768850; 10760140 [H]