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The map label for this gene is dcuS [H]

Identifier: 238894570

GI number: 238894570

Start: 2468923

End: 2470611

Strand: Reverse

Name: dcuS [H]

Synonym: KP1_2568

Alternate gene names: 238894570

Gene position: 2470611-2468923 (Counterclockwise)

Preceding gene: 238894575

Following gene: 238894569

Centisome position: 47.07

GC content: 59.27

Gene sequence:

>1689_bases
TTGATTACACGGCTTTATGTATGCCGCGCTATCGGCGATAATAATCTTTCACTGAATCTACCCGGGGTCGTCATGAAGGC
TTCAGAGCACCCGCCTCGCGTTCGCCAACGCGCCTTACCGTTAAAGCTGAGCACCGCCGTGTCCTTGATGATCGGCAGCG
TCATCGGCGCCGTGCTGCTGCTGGTGTATGCCTTGTGGTATATGCAGATCAGCAACGCCACCCGCGACGGTCTGAAAGAA
ACCGCGCTGGCGGTGGCGCGCACCATGGCCGATATGCCGCAGGTGAAGCGCGGACTGGAGGCGCCCCCGCAGCAGCAGAT
CATTCAGCCGCTGGCGCAGGCCATTACCCGCCGCAACGACCTGTTGTACGCTATCGTCACCGATATGCAGGGTATTCGCT
ATTCGCATCCGGACAGCTCAATCATCGGCAAACCGTTCATCGGCCACGATATTCAGCCGACGCTGCAGGGGAAAGAGAAT
GTCGCCATCAACCACGGGGTGCTGGCCCCGGCGCTACGGGTGTTTACGCCGGTGTTCAACGAACGGCATCAGCAAATCGG
CGTGGTGGTGGTCGGCATTTCACTGAGTAAAGTGGACGAACAGATCGCCAACAGCCGTTGGGACGTGCTGCTGACCATCC
TGTTCAGCGCGCTGGTCTGCGCGCTGGGCACCTGGAGCCTGGTTCGCGGCCTGAAGCGCGTACTGCTGGGGCTGGAGCCG
CACGAAATATCCACCCAGTTTCAGCAGCGTCAGGCCATGCTTCACGCCCTCAAGGAGGGGGTGGTGGCGGTCGATGCCCA
TGGCGAGGTAAATCTCATCAACCCCGCGGCGGAAGAGATCCTCTTTTCCGGCCCGGATAAGACTCTCGTTCACAGCCCCC
TGCTCGACGATCTGCAGACCGTACTGCAGAGCGGCGAGCCAATGTACGACCGCGAACTGGGGTGCAATGGTCTGCTGCTG
ATCGGCAATACAGTGCCCATTCGCAGCCAGGGTGCGGTGGTCGGCGCCATCTGTACCTTCCGCGATAAAACTGAGGTCAG
CCAATTGCTGCAGCGACTGGACGGCATGATGAGCTATGTGGATGCCCTGCGCACCACCTCCCATGAGTTTATGAATAAAT
TGCACGTGATCCTCGGTCTGCTGAATATGAAAAGCTACGGCAAACTCGAGGAATACGTGCTGCAGACCGCCCACCGCTAC
CAGGCGGACATCGGCGACATTCAGCACCGCATTAAATCCCCGGTGGTGGCCGGCTTCCTGATAAGTAAAATTCAGCGCGC
CACAGAGTGCGGCTTTACCCTGACGCTGGCGGAGGAGAGCCTGGTGCCGGATTGTCCAAACGAGAAACAGGTCACGGTGC
TGGTGACGGTGCTGGGCAACCTTATTGAGAACGCGCTGGACGCCATGTGCGGCCAGGCGGAGGGTGAGATCGGCCTGCTG
CTGCACTACCAGGACGGCTGGCTAAGCGGTGAAGTGAGCGACGATGGGCCGGGGATCCCGGAGAACAACATCGACGCTAT
CTTTAACAAAGGCTTCTCCACCAAAGGCGAGAATCGCGGCGTCGGGCTGTTTCTTGCTAACCAGCAGTTGCGCGAGCTCG
GCGGCACCCTCGCCGTCGAATCGGAACCCGGCGTATTTACCCAATTTTTTGTTCATCTCCCCTGGGATAGTAAAAGGAAA
CCTGCGTGA

Upstream 100 bases:

>100_bases
AGAGAAGCCAGTTCCATAGTGTCTCCCTTAAGCCTGTGGCGAAAAGCCGCAGTGTACCGCGCGCAGGAGGAGTCTGCCGT
AGCAAAAGCGGCCTTTTGCT

Downstream 100 bases:

>100_bases
TAAATGTTTTAATTGTTGACGATGATGCCATGGTGGCCGAACTGAATCGCCTGTACGTGGCAAGGGTTCCCGGCTTTCGT
TGCAGCGGGAGCGCTTCGAC

Product: sensory histidine kinase DcuS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MITRLYVCRAIGDNNLSLNLPGVVMKASEHPPRVRQRALPLKLSTAVSLMIGSVIGAVLLLVYALWYMQISNATRDGLKE
TALAVARTMADMPQVKRGLEAPPQQQIIQPLAQAITRRNDLLYAIVTDMQGIRYSHPDSSIIGKPFIGHDIQPTLQGKEN
VAINHGVLAPALRVFTPVFNERHQQIGVVVVGISLSKVDEQIANSRWDVLLTILFSALVCALGTWSLVRGLKRVLLGLEP
HEISTQFQQRQAMLHALKEGVVAVDAHGEVNLINPAAEEILFSGPDKTLVHSPLLDDLQTVLQSGEPMYDRELGCNGLLL
IGNTVPIRSQGAVVGAICTFRDKTEVSQLLQRLDGMMSYVDALRTTSHEFMNKLHVILGLLNMKSYGKLEEYVLQTAHRY
QADIGDIQHRIKSPVVAGFLISKIQRATECGFTLTLAEESLVPDCPNEKQVTVLVTVLGNLIENALDAMCGQAEGEIGLL
LHYQDGWLSGEVSDDGPGIPENNIDAIFNKGFSTKGENRGVGLFLANQQLRELGGTLAVESEPGVFTQFFVHLPWDSKRK
PA

Sequences:

>Translated_562_residues
MITRLYVCRAIGDNNLSLNLPGVVMKASEHPPRVRQRALPLKLSTAVSLMIGSVIGAVLLLVYALWYMQISNATRDGLKE
TALAVARTMADMPQVKRGLEAPPQQQIIQPLAQAITRRNDLLYAIVTDMQGIRYSHPDSSIIGKPFIGHDIQPTLQGKEN
VAINHGVLAPALRVFTPVFNERHQQIGVVVVGISLSKVDEQIANSRWDVLLTILFSALVCALGTWSLVRGLKRVLLGLEP
HEISTQFQQRQAMLHALKEGVVAVDAHGEVNLINPAAEEILFSGPDKTLVHSPLLDDLQTVLQSGEPMYDRELGCNGLLL
IGNTVPIRSQGAVVGAICTFRDKTEVSQLLQRLDGMMSYVDALRTTSHEFMNKLHVILGLLNMKSYGKLEEYVLQTAHRY
QADIGDIQHRIKSPVVAGFLISKIQRATECGFTLTLAEESLVPDCPNEKQVTVLVTVLGNLIENALDAMCGQAEGEIGLL
LHYQDGWLSGEVSDDGPGIPENNIDAIFNKGFSTKGENRGVGLFLANQQLRELGGTLAVESEPGVFTQFFVHLPWDSKRK
PA
>Mature_562_residues
MITRLYVCRAIGDNNLSLNLPGVVMKASEHPPRVRQRALPLKLSTAVSLMIGSVIGAVLLLVYALWYMQISNATRDGLKE
TALAVARTMADMPQVKRGLEAPPQQQIIQPLAQAITRRNDLLYAIVTDMQGIRYSHPDSSIIGKPFIGHDIQPTLQGKEN
VAINHGVLAPALRVFTPVFNERHQQIGVVVVGISLSKVDEQIANSRWDVLLTILFSALVCALGTWSLVRGLKRVLLGLEP
HEISTQFQQRQAMLHALKEGVVAVDAHGEVNLINPAAEEILFSGPDKTLVHSPLLDDLQTVLQSGEPMYDRELGCNGLLL
IGNTVPIRSQGAVVGAICTFRDKTEVSQLLQRLDGMMSYVDALRTTSHEFMNKLHVILGLLNMKSYGKLEEYVLQTAHRY
QADIGDIQHRIKSPVVAGFLISKIQRATECGFTLTLAEESLVPDCPNEKQVTVLVTVLGNLIENALDAMCGQAEGEIGLL
LHYQDGWLSGEVSDDGPGIPENNIDAIFNKGFSTKGENRGVGLFLANQQLRELGGTLAVESEPGVFTQFFVHLPWDSKRK
PA

Specific function: Member of the two-component regulatory system dcuR/dcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-di

COG id: COG3290

COG function: function code T; Signal transduction histidine kinase regulating citrate/malate metabolism

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790567, Length=530, Percent_Identity=57.7358490566038, Blast_Score=621, Evalue=1e-179,
Organism=Escherichia coli, GI1786837, Length=540, Percent_Identity=29.8148148148148, Blast_Score=210, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR016120
- InterPro:   IPR005467
- InterPro:   IPR016121 [H]

Pfam domain/function: PF02518 HATPase_c; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61582; Mature: 61582

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITRLYVCRAIGDNNLSLNLPGVVMKASEHPPRVRQRALPLKLSTAVSLMIGSVIGAVLL
CCCCEEEEEEECCCCEEEECCCEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LVYALWYMQISNATRDGLKETALAVARTMADMPQVKRGLEAPPQQQIIQPLAQAITRRND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
LLYAIVTDMQGIRYSHPDSSIIGKPFIGHDIQPTLQGKENVAINHGVLAPALRVFTPVFN
EEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHH
ERHQQIGVVVVGISLSKVDEQIANSRWDVLLTILFSALVCALGTWSLVRGLKRVLLGLEP
HHHHEECEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HEISTQFQQRQAMLHALKEGVVAVDAHGEVNLINPAAEEILFSGPDKTLVHSPLLDDLQT
HHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECHHHHHHEECCCCCHHHHCHHHHHHHH
VLQSGEPMYDRELGCNGLLLIGNTVPIRSQGAVVGAICTFRDKTEVSQLLQRLDGMMSYV
HHHCCCCCCHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
DALRTTSHEFMNKLHVILGLLNMKSYGKLEEYVLQTAHRYQADIGDIQHRIKSPVVAGFL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ISKIQRATECGFTLTLAEESLVPDCPNEKQVTVLVTVLGNLIENALDAMCGQAEGEIGLL
HHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LHYQDGWLSGEVSDDGPGIPENNIDAIFNKGFSTKGENRGVGLFLANQQLRELGGTLAVE
EEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEEECCHHHHHCCCEEEEC
SEPGVFTQFFVHLPWDSKRKPA
CCCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MITRLYVCRAIGDNNLSLNLPGVVMKASEHPPRVRQRALPLKLSTAVSLMIGSVIGAVLL
CCCCEEEEEEECCCCEEEECCCEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LVYALWYMQISNATRDGLKETALAVARTMADMPQVKRGLEAPPQQQIIQPLAQAITRRND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
LLYAIVTDMQGIRYSHPDSSIIGKPFIGHDIQPTLQGKENVAINHGVLAPALRVFTPVFN
EEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHH
ERHQQIGVVVVGISLSKVDEQIANSRWDVLLTILFSALVCALGTWSLVRGLKRVLLGLEP
HHHHEECEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HEISTQFQQRQAMLHALKEGVVAVDAHGEVNLINPAAEEILFSGPDKTLVHSPLLDDLQT
HHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECHHHHHHEECCCCCHHHHCHHHHHHHH
VLQSGEPMYDRELGCNGLLLIGNTVPIRSQGAVVGAICTFRDKTEVSQLLQRLDGMMSYV
HHHCCCCCCHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
DALRTTSHEFMNKLHVILGLLNMKSYGKLEEYVLQTAHRYQADIGDIQHRIKSPVVAGFL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ISKIQRATECGFTLTLAEESLVPDCPNEKQVTVLVTVLGNLIENALDAMCGQAEGEIGLL
HHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LHYQDGWLSGEVSDDGPGIPENNIDAIFNKGFSTKGENRGVGLFLANQQLRELGGTLAVE
EEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEEECCHHHHHCCCEEEEC
SEPGVFTQFFVHLPWDSKRKPA
CCCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]