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The map label for this gene is fabD [H]

Identifier: 238894575

GI number: 238894575

Start: 2475129

End: 2476031

Strand: Reverse

Name: fabD [H]

Synonym: KP1_2573

Alternate gene names: 238894575

Gene position: 2476031-2475129 (Counterclockwise)

Preceding gene: 238894576

Following gene: 238894570

Centisome position: 47.18

GC content: 67.11

Gene sequence:

>903_bases
ATGAAGATTTTATTTACCTTTCCCGGTCAGGGCGGCCAGCGTCCCGGCATGCTGGCGATGATCCCCGATCGCGAGGCAAT
CCTCACCCAGGCGCGCGCCGTGCTGGGGGATGAAGTCGATACCCTCGATAGCGCCGATGCGCTACAACACACCCGTGCGG
TCCAGCTCTGTCTGCTGATCGCCGGTGTCGCCTGGGCGCGCGAGCTACAGCGTCAGGGCGTGGATCCGCAGATGGTCAGC
GGCCTCTCTATCGGCGCGTTTCCGGCCGCGGTGATTGCCGGCGCGCTCGATTTCGCCAGCGCGTTGCGGCTGGTGGCCCT
GCGCGGGGACTTAATGGAACAGGCGTATCCTGAAGGTTACGGACTGACGGCGATTATGGGCCTGACCCGCCCGCGGGTTG
AGGCGCTGATGCAGGGCCACGAGGTTTATCTCGCCAACCTGAACGCCGAAACGCAGTTCGTGATTGCGGGCCGTGATGAG
GCAATGGCCGAGGTGGCGCAGCTGGCGCTGCGGGCTGGCGCCAGTAAAGCCCAGCGGCTGGCGGTCAGCGTCCCGTCGCA
CTGCGCGCTGCTGGATAAACCCGCCGCTGAGCTGGCGAAAGCTTTTGCCGGCGCCAGCTTAAGGCGCCCACGGTGCGCCT
ATTTAAGCGGCTCGACGGCGCGCGTGCTGTGGGATCCGCAGCGGATCGCCGACGATCTGGCGATGAACATGGCGCGCCCG
GTCCACTGGCAGGAGGCGATGGTCGCCGCCGATGAGCGCGATGCGCGCTTAGCCATTGAGATGCCCCCCGGGGGGGTGCT
CACCTGCCTGACCCGCCAGGCGGGCTGGCGCGGGGAGACCATTGCGCTGGAGCGCAGCGGCCTGGACGTCGCCCGCCATC
TGGCGCAGCGGCTTAGCGATTAA

Upstream 100 bases:

>100_bases
GCGCCTTCGCCCTTAATGAATGGCTGCGCGACGGGCGCGCGCTGCTGAAAACGTCCCGCGGCGCGCGCTTAACCGCGACG
CCGTGGCACAGGGAGGAATA

Downstream 100 bases:

>100_bases
TACTGCGGGCGTACATCCGTCCTTCCGCTGCCAGCGCCAGCAGGTCGGCATCGCGTTCGCGATGGTGCGAATAGACGATA
GAGATCAGCTGGCGCATCTG

Product: acyl carrier protein S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKILFTFPGQGGQRPGMLAMIPDREAILTQARAVLGDEVDTLDSADALQHTRAVQLCLLIAGVAWARELQRQGVDPQMVS
GLSIGAFPAAVIAGALDFASALRLVALRGDLMEQAYPEGYGLTAIMGLTRPRVEALMQGHEVYLANLNAETQFVIAGRDE
AMAEVAQLALRAGASKAQRLAVSVPSHCALLDKPAAELAKAFAGASLRRPRCAYLSGSTARVLWDPQRIADDLAMNMARP
VHWQEAMVAADERDARLAIEMPPGGVLTCLTRQAGWRGETIALERSGLDVARHLAQRLSD

Sequences:

>Translated_300_residues
MKILFTFPGQGGQRPGMLAMIPDREAILTQARAVLGDEVDTLDSADALQHTRAVQLCLLIAGVAWARELQRQGVDPQMVS
GLSIGAFPAAVIAGALDFASALRLVALRGDLMEQAYPEGYGLTAIMGLTRPRVEALMQGHEVYLANLNAETQFVIAGRDE
AMAEVAQLALRAGASKAQRLAVSVPSHCALLDKPAAELAKAFAGASLRRPRCAYLSGSTARVLWDPQRIADDLAMNMARP
VHWQEAMVAADERDARLAIEMPPGGVLTCLTRQAGWRGETIALERSGLDVARHLAQRLSD
>Mature_300_residues
MKILFTFPGQGGQRPGMLAMIPDREAILTQARAVLGDEVDTLDSADALQHTRAVQLCLLIAGVAWARELQRQGVDPQMVS
GLSIGAFPAAVIAGALDFASALRLVALRGDLMEQAYPEGYGLTAIMGLTRPRVEALMQGHEVYLANLNAETQFVIAGRDE
AMAEVAQLALRAGASKAQRLAVSVPSHCALLDKPAAELAKAFAGASLRRPRCAYLSGSTARVLWDPQRIADDLAMNMARP
VHWQEAMVAADERDARLAIEMPPGGVLTCLTRQAGWRGETIALERSGLDVARHLAQRLSD

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=276, Percent_Identity=26.0869565217391, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1787334, Length=282, Percent_Identity=36.8794326241135, Blast_Score=137, Evalue=7e-34,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 32170; Mature: 32170

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILFTFPGQGGQRPGMLAMIPDREAILTQARAVLGDEVDTLDSADALQHTRAVQLCLLI
CEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHH
AGVAWARELQRQGVDPQMVSGLSIGAFPAAVIAGALDFASALRLVALRGDLMEQAYPEGY
HHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GLTAIMGLTRPRVEALMQGHEVYLANLNAETQFVIAGRDEAMAEVAQLALRAGASKAQRL
CHHHHHHCCCHHHHHHHCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHE
AVSVPSHCALLDKPAAELAKAFAGASLRRPRCAYLSGSTARVLWDPQRIADDLAMNMARP
EEECCCHHHHHCCCHHHHHHHHHCCCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHCCC
VHWQEAMVAADERDARLAIEMPPGGVLTCLTRQAGWRGETIALERSGLDVARHLAQRLSD
CCHHHHHHHCCCCCCEEEEECCCCCEEEEEHHCCCCCCCEEEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKILFTFPGQGGQRPGMLAMIPDREAILTQARAVLGDEVDTLDSADALQHTRAVQLCLLI
CEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHH
AGVAWARELQRQGVDPQMVSGLSIGAFPAAVIAGALDFASALRLVALRGDLMEQAYPEGY
HHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GLTAIMGLTRPRVEALMQGHEVYLANLNAETQFVIAGRDEAMAEVAQLALRAGASKAQRL
CHHHHHHCCCHHHHHHHCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHE
AVSVPSHCALLDKPAAELAKAFAGASLRRPRCAYLSGSTARVLWDPQRIADDLAMNMARP
EEECCCHHHHHCCCHHHHHHHHHCCCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHCCC
VHWQEAMVAADERDARLAIEMPPGGVLTCLTRQAGWRGETIALERSGLDVARHLAQRLSD
CCHHHHHHHCCCCCCEEEEECCCCCEEEEEHHCCCCCCCEEEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]