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The map label for this gene is manA [H]

Identifier: 238894530

GI number: 238894530

Start: 2426715

End: 2427911

Strand: Reverse

Name: manA [H]

Synonym: KP1_2524

Alternate gene names: 238894530

Gene position: 2427911-2426715 (Counterclockwise)

Preceding gene: 238894533

Following gene: 238894529

Centisome position: 46.26

GC content: 61.49

Gene sequence:

>1197_bases
TTGAAACAGGGATTGAGAATGCAAAAGCTGATTAACGCCGTGCAGAACTATGCATGGGGAAGCCACACCGCCTTAACCGA
ACTCTATGGCATCGCCAACCCGGACAATCTGCCGATGGCAGAGCTGTGGATGGGGGCGCATCCGAAGAGCAGTTCGCAGA
TCCTGGCGGCCGACGGCCAGCCGCGTTCGCTGCGCGAGGTGATTGACGCGGATAAAGCCGCTCTGCTCGGCGACAAGGTT
GCCGCCCGCTTTGGTGAACTGCCGTTCCTGTTTAAGGTACTGTGCGCCGCTCAGCCGCTCTCAATTCAGGTGCATCCCAA
CAAGCAGGCCTCGGAAGAAGGTTTCGCCCGCGAGAACGCCGCCGGTATCCCGCTCTCCGCCGCCGAGCGTAACTACAAAG
ATCCGAACCACAAACCGGAGCTGGTTTTTGCCCTGACGCCGTTCCTGGCGATGAATGCATTTCGCGAGTTCAGCGAGATT
GTCACCCTGCTGCAGCCGGTGGCTAGCGCGCATCCGGCAATCGGCGCCTTCCTGCAGCAGCCGGACGCGACTCACCTGAG
CCAGCTGTTTGCCAGCCTGCTAAATATGCAGGGTGAGGAAAAGGCCAAGGCGCTGCAGGTGCTGCGCGACGTACTGGCCC
GTGAACAAGGCGAACCGTGGCAGACAATCCGCCTGATCGCGGAATTCTATCCGGACGACAGCGGCCTCTTCTCCCCGCTG
CTGCTGAACGTAGTGAAGCTGAACCCAGGCGAAGCGATGTTCCTGTTTGCTGAAACGCCGCACGCCTATCTGCAGGGGGT
GGCGCTGGAGGTGATGGCCAACTCGGATAACGTACTGCGCGCCGGCCTGACGCCGAAATACATTGATATTCCTGAGCTGG
TTGCTAACGTCAAGTTCGAGGCTAAACCGGCGGGTGAGCTGTTGACCCAGCCGCAGCGTCACGGCGCGGAACTCGACTTC
CCGATCCCGGTGGAAGATTTTGCCTTCTCCCTGCATGACCTCTCCGCCGAGGCCAGCGATCTGGCCCAGGCAAGCGCGGC
GATCGTGTTCTGCGTCGACGGCGAAGCCGTACTGCGCAAAGGCGACCAGAGCCTGACCCTCAAGCCGGGCGAGTCGGCCT
TCGTGGCCGCCAGTGAATCGCCGGTGCAGGTCAGCGGCCGCGGCCGCGTGGCGCGCGTTTTCAATAAGCTCCAGTAA

Upstream 100 bases:

>100_bases
CACAATTTTTTAACAAAAACTGAGACAAGGACGACTTTTTCTTTCAGCAGTTGCTTCTCCACCGTTTGCTGGTTTAATAG
GGCGATAAAATTTACTTTGT

Downstream 100 bases:

>100_bases
GCGACTGCCCCTTCAGGTCGCGCTTACTGTTGGTGATAACTCAGCCAGGCGGTCTCTCCGCCTGGCTTCATTTATGGATA
AATGCTATGAAAAAATCGCT

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKQGLRMQKLINAVQNYAWGSHTALTELYGIANPDNLPMAELWMGAHPKSSSQILAADGQPRSLREVIDADKAALLGDKV
AARFGELPFLFKVLCAAQPLSIQVHPNKQASEEGFARENAAGIPLSAAERNYKDPNHKPELVFALTPFLAMNAFREFSEI
VTLLQPVASAHPAIGAFLQQPDATHLSQLFASLLNMQGEEKAKALQVLRDVLAREQGEPWQTIRLIAEFYPDDSGLFSPL
LLNVVKLNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPAGELLTQPQRHGAELDF
PIPVEDFAFSLHDLSAEASDLAQASAAIVFCVDGEAVLRKGDQSLTLKPGESAFVAASESPVQVSGRGRVARVFNKLQ

Sequences:

>Translated_398_residues
MKQGLRMQKLINAVQNYAWGSHTALTELYGIANPDNLPMAELWMGAHPKSSSQILAADGQPRSLREVIDADKAALLGDKV
AARFGELPFLFKVLCAAQPLSIQVHPNKQASEEGFARENAAGIPLSAAERNYKDPNHKPELVFALTPFLAMNAFREFSEI
VTLLQPVASAHPAIGAFLQQPDATHLSQLFASLLNMQGEEKAKALQVLRDVLAREQGEPWQTIRLIAEFYPDDSGLFSPL
LLNVVKLNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPAGELLTQPQRHGAELDF
PIPVEDFAFSLHDLSAEASDLAQASAAIVFCVDGEAVLRKGDQSLTLKPGESAFVAASESPVQVSGRGRVARVFNKLQ
>Mature_398_residues
MKQGLRMQKLINAVQNYAWGSHTALTELYGIANPDNLPMAELWMGAHPKSSSQILAADGQPRSLREVIDADKAALLGDKV
AARFGELPFLFKVLCAAQPLSIQVHPNKQASEEGFARENAAGIPLSAAERNYKDPNHKPELVFALTPFLAMNAFREFSEI
VTLLQPVASAHPAIGAFLQQPDATHLSQLFASLLNMQGEEKAKALQVLRDVLAREQGEPWQTIRLIAEFYPDDSGLFSPL
LLNVVKLNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPAGELLTQPQRHGAELDF
PIPVEDFAFSLHDLSAEASDLAQASAAIVFCVDGEAVLRKGDQSLTLKPGESAFVAASESPVQVSGRGRVARVFNKLQ

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=411, Percent_Identity=35.7664233576642, Blast_Score=199, Evalue=6e-51,
Organism=Escherichia coli, GI1787899, Length=391, Percent_Identity=80.306905370844, Blast_Score=651, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71997620, Length=400, Percent_Identity=33.5, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17557650, Length=398, Percent_Identity=27.6381909547739, Blast_Score=127, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6320839, Length=419, Percent_Identity=31.2649164677804, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI21356061, Length=396, Percent_Identity=30.3030303030303, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 43238; Mature: 43238

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00965 PMI_I_1 ; PS00966 PMI_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQGLRMQKLINAVQNYAWGSHTALTELYGIANPDNLPMAELWMGAHPKSSSQILAADGQ
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEEECCC
PRSLREVIDADKAALLGDKVAARFGELPFLFKVLCAAQPLSIQVHPNKQASEEGFARENA
CHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCCCCCHHCCCCCCC
AGIPLSAAERNYKDPNHKPELVFALTPFLAMNAFREFSEIVTLLQPVASAHPAIGAFLQQ
CCCCCHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
PDATHLSQLFASLLNMQGEEKAKALQVLRDVLAREQGEPWQTIRLIAEFYPDDSGLFSPL
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHH
LLNVVKLNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFE
HHHHHEECCCCEEEEEECCCHHHHCCEEEEEEECCCCEEECCCCCCCCCHHHHHHCCCCC
AKPAGELLTQPQRHGAELDFPIPVEDFAFSLHDLSAEASDLAQASAAIVFCVDGEAVLRK
CCCCHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCEEEEEEECCHHHHHC
GDQSLTLKPGESAFVAASESPVQVSGRGRVARVFNKLQ
CCCCEEECCCCCEEEEECCCCEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MKQGLRMQKLINAVQNYAWGSHTALTELYGIANPDNLPMAELWMGAHPKSSSQILAADGQ
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEEECCC
PRSLREVIDADKAALLGDKVAARFGELPFLFKVLCAAQPLSIQVHPNKQASEEGFARENA
CHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCCCCCHHCCCCCCC
AGIPLSAAERNYKDPNHKPELVFALTPFLAMNAFREFSEIVTLLQPVASAHPAIGAFLQQ
CCCCCHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
PDATHLSQLFASLLNMQGEEKAKALQVLRDVLAREQGEPWQTIRLIAEFYPDDSGLFSPL
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHH
LLNVVKLNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFE
HHHHHEECCCCEEEEEECCCHHHHCCEEEEEEECCCCEEECCCCCCCCCHHHHHHCCCCC
AKPAGELLTQPQRHGAELDFPIPVEDFAFSLHDLSAEASDLAQASAAIVFCVDGEAVLRK
CCCCHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCEEEEEEECCHHHHHC
GDQSLTLKPGESAFVAASESPVQVSGRGRVARVFNKLQ
CCCCEEECCCCCEEEEECCCCEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6397402; 9097039; 9278503 [H]