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The map label for this gene is paaX [H]

Identifier: 238894492

GI number: 238894492

Start: 2386636

End: 2387562

Strand: Direct

Name: paaX [H]

Synonym: KP1_2483

Alternate gene names: 238894492

Gene position: 2386636-2387562 (Clockwise)

Preceding gene: 238894491

Following gene: 238894493

Centisome position: 45.47

GC content: 60.41

Gene sequence:

>927_bases
ATGAGTAAACTCGACGCCTTTATTCAACAAGCGGTGACGGCGATGCCCATCAGCGGCACGTCATTAATTGCCTCGCTGTA
TGGCGACGCTTTATTACAACGCGGTGGGGAAGTGTGGCTGGGCAGCGTCGCGGCGCTGCTGGAAGGATTAGGCTTCGGCG
AGCGCTTCGTACGCACCGCGCTGTTTCGCCTCAATAAAGAAGAGTGGCTTGATGTTGTCCGCATCGGCCGGCGCAGCTTC
TATCGCCTGAGTGATAAAGGGCTGCGCCTGACCCGGCGCGCGGAGCATAAAATTTATCGCGCCAGTGCCCCGGAATGGGA
CGGTACCTGGCTGCTGCTGCTTTCGGAAGGCCTGGAGAAAAATGTGCTCGCCGACGTTAAAAAGCAGCTGCTGTGGCAGG
GGTTTGGCGCGCTGGCGCCGAGCCTGCTGGCCTCGCCGTCGCAAAAGCTGACCGATGTCCAGTCTCTGCTCCACGAAGCG
GGCGTCGCCGAAAACGTCATCTGTTTTGAAGCCCATTCGCCGCTGGCGCTCTCCAGGGCGGCCCTGCGCAGCCGGGTGGA
GGAGTGCTGGCATCTCACCGAACAAAATGAGATGTACGAGGCGTTTATCGCCTTGTTCCGACCTCTACTGCCGCTGCTGC
GCGATTGCGACCCGTCAGAGTTGACGCCGGATCGCTGTTTCCAGATCCAACTGCTCCTTATCCATTTCTATCGCCGGGTG
GTGCTCAAAGACCCGCTGCTGCCGGAAGAGCTCCTGCCGGCGCATTGGGCAGGGCAAACCGCCCGCCAGCTGTGTATCAA
TATTTATCAACGCGTGAGTCCCGGCGCGCTGGCGTTTGTCAGCGAGAAAGGTGAGAGCTCGGTGGGCGAGCTCCCGGTGC
CGGGTCCGCTCTATTATCAGCGCTTTGGCGGTTTGCCGGGCGCATAA

Upstream 100 bases:

>100_bases
GCTGCGCGGCAGGCACCCGGCTGAAGCGTTTGCGCCGTCAGCCGGGGAGTTTCCTGTGCTATGATTCATAAAGGAAAAAT
ATAACAACAGAATGAATCAG

Downstream 100 bases:

>100_bases
GGAGGTTGCATGCCGATATATCAGATTGATGGGCTGACGCCGGTGGTGCCGGAGGAGAGTTACGTTCACCCGACCGCGGT
GTTGATTGGCGACGTGATCC

Product: transcriptional repressor for phenylacetic acid degradation

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSKLDAFIQQAVTAMPISGTSLIASLYGDALLQRGGEVWLGSVAALLEGLGFGERFVRTALFRLNKEEWLDVVRIGRRSF
YRLSDKGLRLTRRAEHKIYRASAPEWDGTWLLLLSEGLEKNVLADVKKQLLWQGFGALAPSLLASPSQKLTDVQSLLHEA
GVAENVICFEAHSPLALSRAALRSRVEECWHLTEQNEMYEAFIALFRPLLPLLRDCDPSELTPDRCFQIQLLLIHFYRRV
VLKDPLLPEELLPAHWAGQTARQLCINIYQRVSPGALAFVSEKGESSVGELPVPGPLYYQRFGGLPGA

Sequences:

>Translated_308_residues
MSKLDAFIQQAVTAMPISGTSLIASLYGDALLQRGGEVWLGSVAALLEGLGFGERFVRTALFRLNKEEWLDVVRIGRRSF
YRLSDKGLRLTRRAEHKIYRASAPEWDGTWLLLLSEGLEKNVLADVKKQLLWQGFGALAPSLLASPSQKLTDVQSLLHEA
GVAENVICFEAHSPLALSRAALRSRVEECWHLTEQNEMYEAFIALFRPLLPLLRDCDPSELTPDRCFQIQLLLIHFYRRV
VLKDPLLPEELLPAHWAGQTARQLCINIYQRVSPGALAFVSEKGESSVGELPVPGPLYYQRFGGLPGA
>Mature_307_residues
SKLDAFIQQAVTAMPISGTSLIASLYGDALLQRGGEVWLGSVAALLEGLGFGERFVRTALFRLNKEEWLDVVRIGRRSFY
RLSDKGLRLTRRAEHKIYRASAPEWDGTWLLLLSEGLEKNVLADVKKQLLWQGFGALAPSLLASPSQKLTDVQSLLHEAG
VAENVICFEAHSPLALSRAALRSRVEECWHLTEQNEMYEAFIALFRPLLPLLRDCDPSELTPDRCFQIQLLLIHFYRRVV
LKDPLLPEELLPAHWAGQTARQLCINIYQRVSPGALAFVSEKGESSVGELPVPGPLYYQRFGGLPGA

Specific function: Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'- WWTRTGATTCGYGWT-3'. Binding of paaX is specifically inhibited by phenylacetyl-coenzyme A [H]

COG id: COG3327

COG function: function code K; Phenylacetic acid-responsive transcriptional repressor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787666, Length=305, Percent_Identity=83.2786885245902, Blast_Score=521, Evalue=1e-149,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012906
- InterPro:   IPR013225
- InterPro:   IPR011965 [H]

Pfam domain/function: PF07848 PaaX; PF08223 PaaX_C [H]

EC number: NA

Molecular weight: Translated: 34423; Mature: 34292

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLDAFIQQAVTAMPISGTSLIASLYGDALLQRGGEVWLGSVAALLEGLGFGERFVRTA
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHH
LFRLNKEEWLDVVRIGRRSFYRLSDKGLRLTRRAEHKIYRASAPEWDGTWLLLLSEGLEK
HHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHH
NVLADVKKQLLWQGFGALAPSLLASPSQKLTDVQSLLHEAGVAENVICFEAHSPLALSRA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHH
ALRSRVEECWHLTEQNEMYEAFIALFRPLLPLLRDCDPSELTPDRCFQIQLLLIHFYRRV
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
VLKDPLLPEELLPAHWAGQTARQLCINIYQRVSPGALAFVSEKGESSVGELPVPGPLYYQ
HHCCCCCCHHHCCHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHH
RFGGLPGA
HHCCCCCC
>Mature Secondary Structure 
SKLDAFIQQAVTAMPISGTSLIASLYGDALLQRGGEVWLGSVAALLEGLGFGERFVRTA
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHH
LFRLNKEEWLDVVRIGRRSFYRLSDKGLRLTRRAEHKIYRASAPEWDGTWLLLLSEGLEK
HHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHH
NVLADVKKQLLWQGFGALAPSLLASPSQKLTDVQSLLHEAGVAENVICFEAHSPLALSRA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHH
ALRSRVEECWHLTEQNEMYEAFIALFRPLLPLLRDCDPSELTPDRCFQIQLLLIHFYRRV
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
VLKDPLLPEELLPAHWAGQTARQLCINIYQRVSPGALAFVSEKGESSVGELPVPGPLYYQ
HHCCCCCCHHHCCHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHH
RFGGLPGA
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]