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The map label for this gene is tynA [H]

Identifier: 238894478

GI number: 238894478

Start: 2371922

End: 2374189

Strand: Reverse

Name: tynA [H]

Synonym: KP1_2469

Alternate gene names: 238894478

Gene position: 2374189-2371922 (Counterclockwise)

Preceding gene: 238894479

Following gene: 238894474

Centisome position: 45.24

GC content: 57.28

Gene sequence:

>2268_bases
ATGGCAAATGGCTTGAAATTTTCTCCTCGTAAAACCGCGCTGGCGCTGGCCGTGGCGGTGGTTTGCGCCTGGCAATCACC
GGTCTTCGCTCACGGTAGCGAAGCCCACATGGTACCGCTGGATAAAACGCTGCAGGAATTCGGCGCCGATGTGCAGTGGG
ATGACTACGCGCAAATGTTCACCCTGATAAAAGACGGCGCTTACGTCAAAGTAAAGCCCGGCGCCAAAACGGCGATCGTC
AACGGTAAATCCCTTGACCTACCGGTGCCTGTGGTAATGAAGGAAGGTAAAGCCTGGGTTTCCGATACCTTTATCAACGA
TGTCTTCCAGTCCGGTCTCGATCAGACCTTCCAGGTGGAAAAGCGCCCGCACCCGTTAAACTCGCTCTCGGCGGCGGAAA
TCAGTGAAGCGGTGACCATTGTCAAAGCCGCGCCGGAGTTTCAGCCGAATACCCGCTTTACTGAGATTTCCTTACACGAG
CCGGACAAGGCGGCGGTATGGGCCTTTGCCCTGCAGGGAACGCCGGTCGATGCTCCCCGCACTGCCGATGTGGTGATGCT
CGATGGCAAACACGTCATTGAAGCCGTGGTCGATCTGCAAAACAAAAAAATCCTCTCCTGGACGCCGATCAAAGGCGCCC
ACGGGATGGTGCTGCTCGATGATTTTGTCAGCGTGCAGAACATCATCAATGCCAGCAGCGAATTCGCTGAGGTGCTGAAA
AAGCACGGTATTACCGATCCTGGCAAAGTGGTCACCACCCCGCTCACCGTTGGCTTTTTTGATGGCAAAGATGGCCTGCA
GCAGGATGCGCGTCTGCTGAAGGTGGTCAGTTATCTGGATACCGGCGACGGCAACTACTGGGCGCACCCGATTGAAAACC
TGGTGGCGGTGGTCGACCTTGAAGCGAAGAAAATCATCAAAATCGAAGAAGGTCCGGTGATCCCGGTCCCAATGGAGCCC
CGTCCTTATGATGGTCGCGACCGCAACGCCCCGGCGGTGAAACCGCTGGAGATAACCGAACCGGAAGGCAAAAACTACAC
CATTACCGGCGATACCATTCACTGGCAGAACTGGGATTTCCACCTGCGTCTTAACTCGCGCGTCGGACCAATTCTGTCAA
CGGTGACCTACAACGATAACGGCACAAAACGCCAGGTGATGTATGAAGGTTCCCTCGGCGGGATGATCGTCCCCTACGGC
GACCCGGACGTCGGCTGGTATTTCAAAGCCTACCTCGACTCCGGCGATTACGGCATGGGCACCCTGACGTCGCCAATTGT
TCGCGGTAAAGATGCGCCGTCAAATGCGGTACTGCTGGACGAAACTATCGCCGATTACACCGGCAAACCAACCACTATTC
CAGGCGCGGTGGCCATATTCGAACGCTATGCCGGGCCTGAGTATAAGCACCTGGAAATGGGCAAACCCAACGTCAGCACC
GAACGCCGGGAGCTGGTGGTGCGCTGGATCAGCACCGTCGGCAACTACGACTATATCTTTGACTGGGTGTTCCATGACAA
CGGCACCATCGGTATCGACGCTGGCGCCACCGGCATTGAAGCGGTGAAAGGCGTGCTGGCGAAGACCATGCATGACCCCA
GCGCCAAAGAGGATACCCGCTACGGAACGCTGATCGACCATAATATTGTCGGCACCACTCACCAGCACATCTATAACTTC
CGCCTCGACCTCGATGTGGACGGCGAGAACAACACCCTGGTGGCGATGGACCCGGAAGTGAAGCCCAACACCGCCGGCGG
CCCGCGCACCAGTACTATGCAGGTGAATCAGTACACGATTGACAGCGAGCAAAAAGCGGCGCAGAAATTCGACCCGGGCA
CTATCCGCCTGCTGAGCAACACCAGCAAAGAGAACCGCATGGGCAACCCGGTCTCATACCAGATTATCCCTTACGCCGGC
GGCACGCACCCGGCGGCGACCGGTGCCAAATTCGCCCCGGACGAGTGGATATATCATCGCCTGAGCTTTATGGATAAACA
GCTGTGGGTGACGCGCTACCACCCGACAGAGCGATATCCGGAAGGGAAATACCCGAACCGTTCCGCCCACGATACCGGCC
TGGGCCAGTACGCGAAGGATGATGAGTCGCTGACTAACCACGATGACGTCGTGTGGATCACCACCGGCACCACCCACGTG
GCGCGCGCCGAAGAGTGGCCGATCATGCCGACCGAGTGGGCGCACGCGCTGCTCAAGCCGTGGAACTTCTTTGACGAAAC
CCCTACTCTGGGCGAAAAGAAAAAGTAA

Upstream 100 bases:

>100_bases
AAGCAAACAAACGCCCCGGCACCGCTGGCTGGTAGCTTAAGGATGACAAAGCCGACATTCGCAGCGGCAAGAGACAACAC
AACAATAAGATGAGGTCACA

Downstream 100 bases:

>100_bases
TCTTAACCGGCGGTGAAATCCAGCAGGATCTTACCGCCTCTTCCCGGCTGGCCGGCGGCGGCAATCGCCGCCCGCCAGTC
GTTCAACGCTATACGCTGGG

Product: tyramine oxidase

Products: NA

Alternate protein names: Copper amine oxidase; Monamine oxidase; Tyramine oxidase [H]

Number of amino acids: Translated: 755; Mature: 754

Protein sequence:

>755_residues
MANGLKFSPRKTALALAVAVVCAWQSPVFAHGSEAHMVPLDKTLQEFGADVQWDDYAQMFTLIKDGAYVKVKPGAKTAIV
NGKSLDLPVPVVMKEGKAWVSDTFINDVFQSGLDQTFQVEKRPHPLNSLSAAEISEAVTIVKAAPEFQPNTRFTEISLHE
PDKAAVWAFALQGTPVDAPRTADVVMLDGKHVIEAVVDLQNKKILSWTPIKGAHGMVLLDDFVSVQNIINASSEFAEVLK
KHGITDPGKVVTTPLTVGFFDGKDGLQQDARLLKVVSYLDTGDGNYWAHPIENLVAVVDLEAKKIIKIEEGPVIPVPMEP
RPYDGRDRNAPAVKPLEITEPEGKNYTITGDTIHWQNWDFHLRLNSRVGPILSTVTYNDNGTKRQVMYEGSLGGMIVPYG
DPDVGWYFKAYLDSGDYGMGTLTSPIVRGKDAPSNAVLLDETIADYTGKPTTIPGAVAIFERYAGPEYKHLEMGKPNVST
ERRELVVRWISTVGNYDYIFDWVFHDNGTIGIDAGATGIEAVKGVLAKTMHDPSAKEDTRYGTLIDHNIVGTTHQHIYNF
RLDLDVDGENNTLVAMDPEVKPNTAGGPRTSTMQVNQYTIDSEQKAAQKFDPGTIRLLSNTSKENRMGNPVSYQIIPYAG
GTHPAATGAKFAPDEWIYHRLSFMDKQLWVTRYHPTERYPEGKYPNRSAHDTGLGQYAKDDESLTNHDDVVWITTGTTHV
ARAEEWPIMPTEWAHALLKPWNFFDETPTLGEKKK

Sequences:

>Translated_755_residues
MANGLKFSPRKTALALAVAVVCAWQSPVFAHGSEAHMVPLDKTLQEFGADVQWDDYAQMFTLIKDGAYVKVKPGAKTAIV
NGKSLDLPVPVVMKEGKAWVSDTFINDVFQSGLDQTFQVEKRPHPLNSLSAAEISEAVTIVKAAPEFQPNTRFTEISLHE
PDKAAVWAFALQGTPVDAPRTADVVMLDGKHVIEAVVDLQNKKILSWTPIKGAHGMVLLDDFVSVQNIINASSEFAEVLK
KHGITDPGKVVTTPLTVGFFDGKDGLQQDARLLKVVSYLDTGDGNYWAHPIENLVAVVDLEAKKIIKIEEGPVIPVPMEP
RPYDGRDRNAPAVKPLEITEPEGKNYTITGDTIHWQNWDFHLRLNSRVGPILSTVTYNDNGTKRQVMYEGSLGGMIVPYG
DPDVGWYFKAYLDSGDYGMGTLTSPIVRGKDAPSNAVLLDETIADYTGKPTTIPGAVAIFERYAGPEYKHLEMGKPNVST
ERRELVVRWISTVGNYDYIFDWVFHDNGTIGIDAGATGIEAVKGVLAKTMHDPSAKEDTRYGTLIDHNIVGTTHQHIYNF
RLDLDVDGENNTLVAMDPEVKPNTAGGPRTSTMQVNQYTIDSEQKAAQKFDPGTIRLLSNTSKENRMGNPVSYQIIPYAG
GTHPAATGAKFAPDEWIYHRLSFMDKQLWVTRYHPTERYPEGKYPNRSAHDTGLGQYAKDDESLTNHDDVVWITTGTTHV
ARAEEWPIMPTEWAHALLKPWNFFDETPTLGEKKK
>Mature_754_residues
ANGLKFSPRKTALALAVAVVCAWQSPVFAHGSEAHMVPLDKTLQEFGADVQWDDYAQMFTLIKDGAYVKVKPGAKTAIVN
GKSLDLPVPVVMKEGKAWVSDTFINDVFQSGLDQTFQVEKRPHPLNSLSAAEISEAVTIVKAAPEFQPNTRFTEISLHEP
DKAAVWAFALQGTPVDAPRTADVVMLDGKHVIEAVVDLQNKKILSWTPIKGAHGMVLLDDFVSVQNIINASSEFAEVLKK
HGITDPGKVVTTPLTVGFFDGKDGLQQDARLLKVVSYLDTGDGNYWAHPIENLVAVVDLEAKKIIKIEEGPVIPVPMEPR
PYDGRDRNAPAVKPLEITEPEGKNYTITGDTIHWQNWDFHLRLNSRVGPILSTVTYNDNGTKRQVMYEGSLGGMIVPYGD
PDVGWYFKAYLDSGDYGMGTLTSPIVRGKDAPSNAVLLDETIADYTGKPTTIPGAVAIFERYAGPEYKHLEMGKPNVSTE
RRELVVRWISTVGNYDYIFDWVFHDNGTIGIDAGATGIEAVKGVLAKTMHDPSAKEDTRYGTLIDHNIVGTTHQHIYNFR
LDLDVDGENNTLVAMDPEVKPNTAGGPRTSTMQVNQYTIDSEQKAAQKFDPGTIRLLSNTSKENRMGNPVSYQIIPYAGG
THPAATGAKFAPDEWIYHRLSFMDKQLWVTRYHPTERYPEGKYPNRSAHDTGLGQYAKDDESLTNHDDVVWITTGTTHVA
RAEEWPIMPTEWAHALLKPWNFFDETPTLGEKKK

Specific function: Active on tyramine, tryptamine, beta-phenethylamine and dopamine [H]

COG id: COG3733

COG function: function code Q; Cu2+-containing amine oxidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the copper/topaquinone oxidase family [H]

Homologues:

Organism=Homo sapiens, GI73486661, Length=434, Percent_Identity=27.6497695852535, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI60498984, Length=448, Percent_Identity=28.125, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI60498982, Length=446, Percent_Identity=27.1300448430493, Blast_Score=133, Evalue=8e-31,
Organism=Homo sapiens, GI4502119, Length=423, Percent_Identity=27.8959810874704, Blast_Score=132, Evalue=2e-30,
Organism=Escherichia coli, GI1787651, Length=749, Percent_Identity=84.7797062750334, Blast_Score=1338, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000269
- InterPro:   IPR012854
- InterPro:   IPR015798
- InterPro:   IPR016182
- InterPro:   IPR015800
- InterPro:   IPR015801
- InterPro:   IPR015802 [H]

Pfam domain/function: PF01179 Cu_amine_oxid; PF07833 Cu_amine_oxidN1; PF02727 Cu_amine_oxidN2; PF02728 Cu_amine_oxidN3 [H]

EC number: =1.4.3.21 [H]

Molecular weight: Translated: 83572; Mature: 83441

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS01164 COPPER_AMINE_OXID_1 ; PS01165 COPPER_AMINE_OXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANGLKFSPRKTALALAVAVVCAWQSPVFAHGSEAHMVPLDKTLQEFGADVQWDDYAQMF
CCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCEEECHHHHHHHHCCCCCCHHHHHHH
TLIKDGAYVKVKPGAKTAIVNGKSLDLPVPVVMKEGKAWVSDTFINDVFQSGLDQTFQVE
HHHCCCCEEEECCCCCEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEC
KRPHPLNSLSAAEISEAVTIVKAAPEFQPNTRFTEISLHEPDKAAVWAFALQGTPVDAPR
CCCCCCCCCCHHHHHHHEEEEEECCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCC
TADVVMLDGKHVIEAVVDLQNKKILSWTPIKGAHGMVLLDDFVSVQNIINASSEFAEVLK
CCCEEEECCHHHHHHHHHHCCCEEEEECCCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHH
KHGITDPGKVVTTPLTVGFFDGKDGLQQDARLLKVVSYLDTGDGNYWAHPIENLVAVVDL
HCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEECCCHHCEEEEEEE
EAKKIIKIEEGPVIPVPMEPRPYDGRDRNAPAVKPLEITEPEGKNYTITGDTIHWQNWDF
CCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCEEEECCCEE
HLRLNSRVGPILSTVTYNDNGTKRQVMYEGSLGGMIVPYGDPDVGWYFKAYLDSGDYGMG
EEEECCCCCCEEEEEEECCCCCEEEEEEECCCCCEEEECCCCCCCEEEEEEECCCCCCCC
TLTSPIVRGKDAPSNAVLLDETIADYTGKPTTIPGAVAIFERYAGPEYKHLEMGKPNVST
CCCCHHHCCCCCCCCEEEEECHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCH
ERRELVVRWISTVGNYDYIFDWVFHDNGTIGIDAGATGIEAVKGVLAKTMHDPSAKEDTR
HHHHHHHHHHHHHCCCCEEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCC
YGTLIDHNIVGTTHQHIYNFRLDLDVDGENNTLVAMDPEVKPNTAGGPRTSTMQVNQYTI
CCEEEECCCCCCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEEEEEEC
DSEQKAAQKFDPGTIRLLSNTSKENRMGNPVSYQIIPYAGGTHPAATGAKFAPDEWIYHR
CCHHHHHHHCCCCEEEEEECCCCHHCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHH
LSFMDKQLWVTRYHPTERYPEGKYPNRSAHDTGLGQYAKDDESLTNHDDVVWITTGTTHV
HHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEE
ARAEEWPIMPTEWAHALLKPWNFFDETPTLGEKKK
ECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ANGLKFSPRKTALALAVAVVCAWQSPVFAHGSEAHMVPLDKTLQEFGADVQWDDYAQMF
CCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCEEECHHHHHHHHCCCCCCHHHHHHH
TLIKDGAYVKVKPGAKTAIVNGKSLDLPVPVVMKEGKAWVSDTFINDVFQSGLDQTFQVE
HHHCCCCEEEECCCCCEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEC
KRPHPLNSLSAAEISEAVTIVKAAPEFQPNTRFTEISLHEPDKAAVWAFALQGTPVDAPR
CCCCCCCCCCHHHHHHHEEEEEECCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCC
TADVVMLDGKHVIEAVVDLQNKKILSWTPIKGAHGMVLLDDFVSVQNIINASSEFAEVLK
CCCEEEECCHHHHHHHHHHCCCEEEEECCCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHH
KHGITDPGKVVTTPLTVGFFDGKDGLQQDARLLKVVSYLDTGDGNYWAHPIENLVAVVDL
HCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEECCCHHCEEEEEEE
EAKKIIKIEEGPVIPVPMEPRPYDGRDRNAPAVKPLEITEPEGKNYTITGDTIHWQNWDF
CCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCEEEECCCEE
HLRLNSRVGPILSTVTYNDNGTKRQVMYEGSLGGMIVPYGDPDVGWYFKAYLDSGDYGMG
EEEECCCCCCEEEEEEECCCCCEEEEEEECCCCCEEEECCCCCCCEEEEEEECCCCCCCC
TLTSPIVRGKDAPSNAVLLDETIADYTGKPTTIPGAVAIFERYAGPEYKHLEMGKPNVST
CCCCHHHCCCCCCCCEEEEECHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCH
ERRELVVRWISTVGNYDYIFDWVFHDNGTIGIDAGATGIEAVKGVLAKTMHDPSAKEDTR
HHHHHHHHHHHHHCCCCEEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCC
YGTLIDHNIVGTTHQHIYNFRLDLDVDGENNTLVAMDPEVKPNTAGGPRTSTMQVNQYTI
CCEEEECCCCCCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEEEEEEC
DSEQKAAQKFDPGTIRLLSNTSKENRMGNPVSYQIIPYAGGTHPAATGAKFAPDEWIYHR
CCHHHHHHHCCCCEEEEEECCCCHHCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHH
LSFMDKQLWVTRYHPTERYPEGKYPNRSAHDTGLGQYAKDDESLTNHDDVVWITTGTTHV
HHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEE
ARAEEWPIMPTEWAHALLKPWNFFDETPTLGEKKK
ECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1556068 [H]