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The map label for this gene is ttcA [H]

Identifier: 238894461

GI number: 238894461

Start: 2353959

End: 2354894

Strand: Reverse

Name: ttcA [H]

Synonym: KP1_2451

Alternate gene names: 238894461

Gene position: 2354894-2353959 (Counterclockwise)

Preceding gene: 238894462

Following gene: 238894458

Centisome position: 44.87

GC content: 55.77

Gene sequence:

>936_bases
ATGCTGCAAAACCAAGAAATCAGTAAAAAAGAAAAGTACAACATCGATAAGCTGCAGAAACGTCTGCGCCGCAACGTCGG
TGAGGCGATTGCCGACTTCAATATGATTGAAGAGGGCGACCGCATTATGGTTTGTCTTTCAGGCGGCAAGGACAGCTATA
CCATGCTGGAGATCCTGCGCAATCTGCAGAAAAGCGCGCCCATCTCCTTCTCGCTGGTGGCGGTGAACCTCGATCAGAAG
CAGCCAGGGTTCCCGGAGCATATTCTGCCGGCGTATCTGGAGCAGCTGGGGGTTGAATACAAGATTGTCGAAGAGAACAC
CTACGGCATCGTCAAAGAGAAGATCCCGGAAGGAAAAACCACCTGCTCGCTGTGCTCTCGCCTGCGTCGCGGCATCCTCT
ATCGTACCGCCACCGAGCTTGGGGCGACCAAGATCGCCCTCGGCCATCATCGCGACGATATCCTGCAGACGCTGTTTTTG
AATATGTTCTACGGCGGCAAAATGAAAGGGATGCCGCCGAAGCTGATGAGCGACGACGGCAAACACATCGTCATCCGCCC
GCTGGCCTACTGCCGGGAAAAGGACATCGAGCGCTTCTCCCAGGCCAAAGGCTTCCCGATTATTCCGTGCAACCTGTGCG
GTTCGCAGCCAAACCTGCAGCGCCAGGTGATCGCCGATATGCTCCGCGACTGGGACAAGCGTTATCCTGGGCGCATTGAA
ACCATGTTCAGCGCGATGCAGAACGTGGTGCCTTCGCACCTGAGCGACGTCAATCTGTTTGATTTTAAAGGCATCACCCA
CGGCTCAGAGGTGGTGGATGGTGGCGATCTGGCGTTTGACCGGGAAGATATTCCCCTGCAGCCCGCCGGCTGGCAGCCGG
AAGAAGAAGACGCCCGTCTCGATGAGCTGCGTCTGAACGTAGTGGAAGTGAAATAA

Upstream 100 bases:

>100_bases
GTCAAACCTCAATAATTGCTACGCGCCAGCGCCACGTTGTTCAGCGGCTGGCAGAATGCGTGCTCTTCTGATGCCACACT
ATGAATTGAGCCACTATTAC

Downstream 100 bases:

>100_bases
CCCTCACGCGTCTCAGGCAGCCGCCTGAGACGCACTCTCCTGCCCTTACTTCAGCAGTCGTACGCGGCAGGATTTACCTT
TGATCTTGCCATTTTGTAAC

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MLQNQEISKKEKYNIDKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQKSAPISFSLVAVNLDQK
QPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFL
NMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIERFSQAKGFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIE
TMFSAMQNVVPSHLSDVNLFDFKGITHGSEVVDGGDLAFDREDIPLQPAGWQPEEEDARLDELRLNVVEVK

Sequences:

>Translated_311_residues
MLQNQEISKKEKYNIDKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQKSAPISFSLVAVNLDQK
QPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFL
NMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIERFSQAKGFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIE
TMFSAMQNVVPSHLSDVNLFDFKGITHGSEVVDGGDLAFDREDIPLQPAGWQPEEEDARLDELRLNVVEVK
>Mature_311_residues
MLQNQEISKKEKYNIDKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQKSAPISFSLVAVNLDQK
QPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFL
NMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIERFSQAKGFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIE
TMFSAMQNVVPSHLSDVNLFDFKGITHGSEVVDGGDLAFDREDIPLQPAGWQPEEEDARLDELRLNVVEVK

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=311, Percent_Identity=91.9614147909968, Blast_Score=605, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI193211090, Length=250, Percent_Identity=30.4, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17540090, Length=235, Percent_Identity=26.8085106382979, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24651972, Length=234, Percent_Identity=26.4957264957265, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 35386; Mature: 35386

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQNQEISKKEKYNIDKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILR
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHH
NLQKSAPISFSLVAVNLDQKQPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKT
HHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCH
TCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDG
HHHHHHHHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCC
KHIVIRPLAYCREKDIERFSQAKGFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIE
CEEEECCHHHHHHHHHHHHHHCCCCCEEEHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
TMFSAMQNVVPSHLSDVNLFDFKGITHGSEVVDGGDLAFDREDIPLQPAGWQPEEEDARL
HHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHH
DELRLNVVEVK
HHHEEEEEECC
>Mature Secondary Structure
MLQNQEISKKEKYNIDKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILR
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHH
NLQKSAPISFSLVAVNLDQKQPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKT
HHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCH
TCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDG
HHHHHHHHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCC
KHIVIRPLAYCREKDIERFSQAKGFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIE
CEEEECCHHHHHHHHHHHHHHCCCCCEEEHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
TMFSAMQNVVPSHLSDVNLFDFKGITHGSEVVDGGDLAFDREDIPLQPAGWQPEEEDARL
HHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHH
DELRLNVVEVK
HHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA