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The map label for this gene is trpE [H]

Identifier: 238894319

GI number: 238894319

Start: 2209702

End: 2211264

Strand: Reverse

Name: trpE [H]

Synonym: KP1_2298

Alternate gene names: 238894319

Gene position: 2211264-2209702 (Counterclockwise)

Preceding gene: 238894322

Following gene: 238894318

Centisome position: 42.13

GC content: 62.44

Gene sequence:

>1563_bases
ATGCAAACATCCAAACCGGCACTCGAGCTTCTCACCAGCGACGCCATCTACCGGGAGAACCCGACGGCGTTATTCCACCA
ACTGTGCGGCGCCCGTCCGGCGACGCTGCTGCTGGAATCCGCTGACATCGACAGCAAAGATGACTTAAAAAGCCTACTGC
TGGTCGATAGCGCGCTGCGCATTACGGCCCTTGGTGACACTGTCACTATTCAGGCCCTCTCCGCCAACGGCGCGGCGCTG
CTGGAACTACTGGACGGCGCGCTGCCCTCCGGGATCAACAATCAGCGCCAGCCCAACGGCCGCATCCTGACCTTCCCGGC
CGTCAGCGCCCTGCTCGATGAAGACGCCCGTCTCTGCTCACTGTCGGTGTTTGACGCCTTCCGTCTCCTGCAGGAGCTGG
TGAGCGTTCCGGACAACGAGCGCGAAGCGATGTTCTTCGGCGGCCTGTTCGCCTATGACCTGGTGGCCGGTTTTGAAGAT
CTTCCCCAGTTGCAAAGCGACACCACCTGCCCGGACTACTGCTTCTATCTGGCGGAAACCCTGCTGGTCATCGACCATCA
GACCAAGCATACCCGCATTCAGGCCAGCCTGTTCACCCCGCTGGAGAGTGAAAAACAGCGCCTGGAGCAGCGCCTGAGCC
AGCTGCGTCAGCAGCTGAACGAGCCGCCGGCGCCGCTACCGGTTACCACCGTGGCCGAAATGCGCTGCGACGTTGACCAG
AGCGATGAAGAGTACGGCGCGGTGGTGCGCAAAATGCAGCGCGCGATCCGCGCCGGGGAAATCTTCCAGGTGGTTCCTTC
CCGCCGCTTCTCGCTGCCCTGCCCATCGCCGCTGGCCGCTTATGATGTGCTGAAGAAGAGCAACCCCAGCCCGTACATGT
TCTTTATGCAGGACAATGATTTCACCCTGTTCGGCGCCTCGCCGGAAAGCTCGCTGAAGTATGATGCCGTCAGCCGTCAG
ATTGAGATCTACCCCATCGCCGGCACCCGGCCACGCGGCCGCCGCGCCGACGGCTCGCTGGATCGCGACCTCGACAGCCG
CATCGAGCTGGAAATGCGCACCGATCATAAAGAGCTTTCCGAACACCTGATGCTGGTGGACCTGGCGCGTAATGACCTGG
CGCGCATCTGCACCCCGGGCAGCCGCTATGTCGCTGATTTAACCAAGGTTGACCGCTACTCCTTCGTGATGCATCTGGTC
TCCCGTGTAGTAGGCGAATTGCGTCAGGATCTCGACGTCCTCCACGCCTATCGCGCCTGCATGAATATGGGCACCCTCAG
CGGCGCGCCGAAGGTCCGCGCCATGCAGCTGATTGCCGCCGCCGAAGGTAAACGCCGCGGCAGCTACGGCGGCGCGGTGG
GCTATTTCACCGCCCACGGCGACCTCGACACCTGCATCGTCATCCGTTCCGCCTACGTGCAGGAAGGTATCGCTACCGTC
CAGGCCGGAGCCGGCATTGTGCTCGACTCGGTTCCCCAGTCGGAAGCGGATGAGACCCGAAATAAAGCCCGCGCGGTGCT
GCGCGCCATTGCCCAGGCCCATCACGCGAAGGAGATTTTCTGA

Upstream 100 bases:

>100_bases
GGCGGCGTGATCGCGTTTTGCATTCAGCATACAGATACCCGGCCCGCCAATGAGCGGGCTTTTTATTGGACAAAAATAAT
ACGAACAGGCGAGAACAATA

Downstream 100 bases:

>100_bases
TGGCTGACATTCTGCTGCTCGATAATATCGATTCCTTTACCTATAACCTGGCAGACCAGCTGCGCGCCAACGGCCATAAC
GTAGTGATTTATCGCAACTC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MQTSKPALELLTSDAIYRENPTALFHQLCGARPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIQALSANGAAL
LELLDGALPSGINNQRQPNGRILTFPAVSALLDEDARLCSLSVFDAFRLLQELVSVPDNEREAMFFGGLFAYDLVAGFED
LPQLQSDTTCPDYCFYLAETLLVIDHQTKHTRIQASLFTPLESEKQRLEQRLSQLRQQLNEPPAPLPVTTVAEMRCDVDQ
SDEEYGAVVRKMQRAIRAGEIFQVVPSRRFSLPCPSPLAAYDVLKKSNPSPYMFFMQDNDFTLFGASPESSLKYDAVSRQ
IEIYPIAGTRPRGRRADGSLDRDLDSRIELEMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSFVMHLV
SRVVGELRQDLDVLHAYRACMNMGTLSGAPKVRAMQLIAAAEGKRRGSYGGAVGYFTAHGDLDTCIVIRSAYVQEGIATV
QAGAGIVLDSVPQSEADETRNKARAVLRAIAQAHHAKEIF

Sequences:

>Translated_520_residues
MQTSKPALELLTSDAIYRENPTALFHQLCGARPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIQALSANGAAL
LELLDGALPSGINNQRQPNGRILTFPAVSALLDEDARLCSLSVFDAFRLLQELVSVPDNEREAMFFGGLFAYDLVAGFED
LPQLQSDTTCPDYCFYLAETLLVIDHQTKHTRIQASLFTPLESEKQRLEQRLSQLRQQLNEPPAPLPVTTVAEMRCDVDQ
SDEEYGAVVRKMQRAIRAGEIFQVVPSRRFSLPCPSPLAAYDVLKKSNPSPYMFFMQDNDFTLFGASPESSLKYDAVSRQ
IEIYPIAGTRPRGRRADGSLDRDLDSRIELEMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSFVMHLV
SRVVGELRQDLDVLHAYRACMNMGTLSGAPKVRAMQLIAAAEGKRRGSYGGAVGYFTAHGDLDTCIVIRSAYVQEGIATV
QAGAGIVLDSVPQSEADETRNKARAVLRAIAQAHHAKEIF
>Mature_520_residues
MQTSKPALELLTSDAIYRENPTALFHQLCGARPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIQALSANGAAL
LELLDGALPSGINNQRQPNGRILTFPAVSALLDEDARLCSLSVFDAFRLLQELVSVPDNEREAMFFGGLFAYDLVAGFED
LPQLQSDTTCPDYCFYLAETLLVIDHQTKHTRIQASLFTPLESEKQRLEQRLSQLRQQLNEPPAPLPVTTVAEMRCDVDQ
SDEEYGAVVRKMQRAIRAGEIFQVVPSRRFSLPCPSPLAAYDVLKKSNPSPYMFFMQDNDFTLFGASPESSLKYDAVSRQ
IEIYPIAGTRPRGRRADGSLDRDLDSRIELEMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSFVMHLV
SRVVGELRQDLDVLHAYRACMNMGTLSGAPKVRAMQLIAAAEGKRRGSYGGAVGYFTAHGDLDTCIVIRSAYVQEGIATV
QAGAGIVLDSVPQSEADETRNKARAVLRAIAQAHHAKEIF

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=520, Percent_Identity=85.3846153846154, Blast_Score=895, Evalue=0.0,
Organism=Escherichia coli, GI1788114, Length=425, Percent_Identity=29.4117647058824, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87082077, Length=303, Percent_Identity=27.3927392739274, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1786809, Length=231, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=377, Percent_Identity=37.1352785145889, Blast_Score=218, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6324361, Length=420, Percent_Identity=26.6666666666667, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57439; Mature: 57439

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTSKPALELLTSDAIYRENPTALFHQLCGARPATLLLESADIDSKDDLKSLLLVDSALR
CCCCCHHHHHHHCCCHHCCCHHHHHHHHHCCCCHHEEEECCCCCCHHHHHHHHHHHHHHE
ITALGDTVTIQALSANGAALLELLDGALPSGINNQRQPNGRILTFPAVSALLDEDARLCS
EEEECCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCHHHHH
LSVFDAFRLLQELVSVPDNEREAMFFGGLFAYDLVAGFEDLPQLQSDTTCPDYCFYLAET
HHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LLVIDHQTKHTRIQASLFTPLESEKQRLEQRLSQLRQQLNEPPAPLPVTTVAEMRCDVDQ
HHHHCCCCCHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
SDEEYGAVVRKMQRAIRAGEIFQVVPSRRFSLPCPSPLAAYDVLKKSNPSPYMFFMQDND
CCHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCC
FTLFGASPESSLKYDAVSRQIEIYPIAGTRPRGRRADGSLDRDLDSRIELEMRTDHKELS
EEEEECCCCCCCCHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCHHEEEEECCCHHHHH
EHLMLVDLARNDLARICTPGSRYVADLTKVDRYSFVMHLVSRVVGELRQDLDVLHAYRAC
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNMGTLSGAPKVRAMQLIAAAEGKRRGSYGGAVGYFTAHGDLDTCIVIRSAYVQEGIATV
HHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
QAGAGIVLDSVPQSEADETRNKARAVLRAIAQAHHAKEIF
HCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTSKPALELLTSDAIYRENPTALFHQLCGARPATLLLESADIDSKDDLKSLLLVDSALR
CCCCCHHHHHHHCCCHHCCCHHHHHHHHHCCCCHHEEEECCCCCCHHHHHHHHHHHHHHE
ITALGDTVTIQALSANGAALLELLDGALPSGINNQRQPNGRILTFPAVSALLDEDARLCS
EEEECCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCHHHHH
LSVFDAFRLLQELVSVPDNEREAMFFGGLFAYDLVAGFEDLPQLQSDTTCPDYCFYLAET
HHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LLVIDHQTKHTRIQASLFTPLESEKQRLEQRLSQLRQQLNEPPAPLPVTTVAEMRCDVDQ
HHHHCCCCCHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
SDEEYGAVVRKMQRAIRAGEIFQVVPSRRFSLPCPSPLAAYDVLKKSNPSPYMFFMQDND
CCHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCC
FTLFGASPESSLKYDAVSRQIEIYPIAGTRPRGRRADGSLDRDLDSRIELEMRTDHKELS
EEEEECCCCCCCCHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCHHEEEEECCCHHHHH
EHLMLVDLARNDLARICTPGSRYVADLTKVDRYSFVMHLVSRVVGELRQDLDVLHAYRAC
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNMGTLSGAPKVRAMQLIAAAEGKRRGSYGGAVGYFTAHGDLDTCIVIRSAYVQEGIATV
HHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
QAGAGIVLDSVPQSEADETRNKARAVLRAIAQAHHAKEIF
HCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7038627; 7021857; 9097039; 9278503; 351195; 4598537 [H]