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The map label for this gene is trpC [H]

Identifier: 238894317

GI number: 238894317

Start: 2206745

End: 2208103

Strand: Reverse

Name: trpC [H]

Synonym: KP1_2296

Alternate gene names: 238894317

Gene position: 2208103-2206745 (Counterclockwise)

Preceding gene: 238894318

Following gene: 238894316

Centisome position: 42.07

GC content: 61.74

Gene sequence:

>1359_bases
ATGCAAACCGTTTTAGCAAAAATCGTTGCCGACAAAGCGATTTGGGTGGAAGCCCGCAAACAACAACAACCGTTAGCCAG
TTTTCAAAATGAGATCGTTCCGACGCAGCGCAATTTCTATGACGCGCTGGCCGGCACCCGCACCGCGTTTATTCTCGAGT
GCAAGAAGGCCTCACCGTCGAAGGGGTTGATTCGCGAGGATTTCGATCCGGCAGCGATCGCCAGCATCTACAAGCACTAC
GCCTCGGCGATCTCGGTGCTGTGTGATGAGAAATATTTCCAGGGCAGCTTCGATTTCCTGCCGATCGTCAGCCAGGTCGC
GCCGCAGCCGATCCTGTGTAAGGACTTCACCATCGACCCTTACCAGATCTACCTGGCGCGCTACTATCAGGCCGACGCCT
GTCTGCTGATGCTCTCGGTGCTCGACGATGAACAGTATCGTCAGCTCTCGGCGGTGGCTCACAGCCTGAATATGGGCGTG
CTGACCGAAGTCAGCAATGAAGAGGAACTGGAGCGCGCCATCGCCCTGAAGGCGAAGGTGGTGGGCATTAACAACCGCGA
CCTGCGCGATATGTCGATTGACCTTAACCGCACCCGTCAGCTGGCGGCGCGTCTCGGCCCGGATGTCACGGTGATCAGCG
AATCCGGCATCCATACCTATGCCGAAGTGCGCGAGCTGAGCCACTTCGCCAACGGCTTCCTGATCGGCTCCGCCCTGATG
GAGCAGGCGGATCTGGAAGCGGCGGTTAAACGCGTGCTGCTCGGCGAGAACAAAGTGTGCGGCCTGACGCGCCCGCAGGA
TGCCCAGGTGGCCTGGGAGTCCGGCGCCATTTACGGTGGGCTGATCTTCGTCCCGACCTCGCCGCGAGCGGTGAATGACG
CCCAGGCCAAAGCGGTGATCGCCGCTGCGCCGCTGCAGTACGTCGGCGTCTTCCGCAATGCGCCGCTGGAGGAGGTGGTC
GCCCGCGCGCAGGCTCTGGGGCTGGCCGCCGTGCAGCTGCACGGTGATGAAGACCAGGCCTATATCGACGCGCTGCGCGA
CGCCCTCGCGGACAACGTCCGCATCTGGAAAGCGCTGAGCGTCGGCGAAACCTTCCCGGCCCGTACGCTCCGCCATGTCG
ACAAGTACCTGCTCGACAACGGCCAGGGCGGCAGCGGCCAGCGCTTTGACTGGAGCCTGCTGCAGGGCCAGGATCTGCGC
AACGTCATGCTGGCGGGCGGCCTCGGCGCCGATAACTGTGTGGAAGCGGCCAAAAGCGGCTGTGCCGGACTCGATTTCAA
TTCAGGCGTAGAGTCGCAACCCGGGATTAAAGACGCCAGCAAGCTGGCCTCGGTATTCCAGACGCTGCGCGCATATTAA

Upstream 100 bases:

>100_bases
GCATGAAGATCTGAAAGCTAACGCTCAGCAGGTACTGGATGTGCTGCACAGCGGCGCGGCCTATGACAGAGTGACCGCCT
TAGCGGCAAGAGGGTAAAGA

Downstream 100 bases:

>100_bases
GGAGCAATAATGAGCACTTTACTGAACCCCTACTTCGGCGAATTCGGCGGCATGTATGTGCCGCAGATCCTGATGCCCGC
CCTGCGCCAGCTGGAAGAAG

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIVPTQRNFYDALAGTRTAFILECKKASPSKGLIREDFDPAAIASIYKHY
ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNMGV
LTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVRELSHFANGFLIGSALM
EQADLEAAVKRVLLGENKVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVIAAAPLQYVGVFRNAPLEEVV
ARAQALGLAAVQLHGDEDQAYIDALRDALADNVRIWKALSVGETFPARTLRHVDKYLLDNGQGGSGQRFDWSLLQGQDLR
NVMLAGGLGADNCVEAAKSGCAGLDFNSGVESQPGIKDASKLASVFQTLRAY

Sequences:

>Translated_452_residues
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIVPTQRNFYDALAGTRTAFILECKKASPSKGLIREDFDPAAIASIYKHY
ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNMGV
LTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVRELSHFANGFLIGSALM
EQADLEAAVKRVLLGENKVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVIAAAPLQYVGVFRNAPLEEVV
ARAQALGLAAVQLHGDEDQAYIDALRDALADNVRIWKALSVGETFPARTLRHVDKYLLDNGQGGSGQRFDWSLLQGQDLR
NVMLAGGLGADNCVEAAKSGCAGLDFNSGVESQPGIKDASKLASVFQTLRAY
>Mature_452_residues
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIVPTQRNFYDALAGTRTAFILECKKASPSKGLIREDFDPAAIASIYKHY
ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNMGV
LTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVRELSHFANGFLIGSALM
EQADLEAAVKRVLLGENKVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVIAAAPLQYVGVFRNAPLEEVV
ARAQALGLAAVQLHGDEDQAYIDALRDALADNVRIWKALSVGETFPARTLRHVDKYLLDNGQGGSGQRFDWSLLQGQDLR
NVMLAGGLGADNCVEAAKSGCAGLDFNSGVESQPGIKDASKLASVFQTLRAY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=452, Percent_Identity=82.5221238938053, Blast_Score=768, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322638, Length=270, Percent_Identity=34.4444444444444, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320210, Length=211, Percent_Identity=31.2796208530806, Blast_Score=85, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 49301; Mature: 49301

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIVPTQRNFYDALAGTRTAFILECKKASPS
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCCCC
KGLIREDFDPAAIASIYKHYASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCH
YQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNMGVLTEVSNEEELERAIALKAKV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHEE
VGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVRELSHFANGFLIGSALM
EECCCCCCCCEEECHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCHHHHHHHHH
EQADLEAAVKRVLLGENKVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVI
HHHHHHHHHHHHHHCCCCEECCCCCCCCCEEECCCCEEEEEEEEECCCCCCCCHHHHHHH
AAAPLQYVGVFRNAPLEEVVARAQALGLAAVQLHGDEDQAYIDALRDALADNVRIWKALS
HHHHHHHHHHHCCCCHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHCCHHEEEECC
VGETFPARTLRHVDKYLLDNGQGGSGQRFDWSLLQGQDLRNVMLAGGLGADNCVEAAKSG
CCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHCCCCHHHHHHCCCCCCHHHHHHHHCC
CAGLDFNSGVESQPGIKDASKLASVFQTLRAY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIVPTQRNFYDALAGTRTAFILECKKASPS
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCCCC
KGLIREDFDPAAIASIYKHYASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCH
YQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNMGVLTEVSNEEELERAIALKAKV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHEE
VGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVRELSHFANGFLIGSALM
EECCCCCCCCEEECHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCHHHHHHHHH
EQADLEAAVKRVLLGENKVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVI
HHHHHHHHHHHHHHCCCCEECCCCCCCCCEEECCCCEEEEEEEEECCCCCCCCHHHHHHH
AAAPLQYVGVFRNAPLEEVVARAQALGLAAVQLHGDEDQAYIDALRDALADNVRIWKALS
HHHHHHHHHHHCCCCHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHCCHHEEEECC
VGETFPARTLRHVDKYLLDNGQGGSGQRFDWSLLQGQDLRNVMLAGGLGADNCVEAAKSG
CCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHCCCCHHHHHHCCCCCCHHHHHHHHCC
CAGLDFNSGVESQPGIKDASKLASVFQTLRAY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]