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The map label for this gene is ttuC [H]

Identifier: 238894313

GI number: 238894313

Start: 2202166

End: 2203254

Strand: Direct

Name: ttuC [H]

Synonym: KP1_2292

Alternate gene names: 238894313

Gene position: 2202166-2203254 (Clockwise)

Preceding gene: 238894312

Following gene: 238894314

Centisome position: 41.96

GC content: 55.74

Gene sequence:

>1089_bases
ATGCGTCACTACAAAATTGCTGCCATCCCTGCGGACGGTATCGGACCGGAAGTCATTTCGGCAGGTATTGAAGTCTTGCA
CGCGCTGACGCGCCACGATCCGCAACTGAAATTTGATATAGAGACCTTTGACTGGGGGTCAGACTATTACAAAAAACATG
GCGTGATGATGCCGGAAGAAGGGCTGAACATGCTGAAAGCATTTGATGCCATTTACTTCGGCGCGGTGGGGGCCCCGGAT
GTCCCTGACCACATCACACTCTGGGGCCTGCGGCTGCCTATTTGCCAGGGCTTTGACCAGTACGCCAATGTGCGACCCAC
CAAAATTCTGCCGGGCGTCACTTCACCGCTGCGCAACCGCGGGCCTGGCGATCTTGACTGGGTCATCGTGCGCGAAAACT
CCGAAGGTGAATATTCTGGTAACGGCGGCCGTACCCACCGTGGTTTACCTGAAGAAGTCGGTACCGAAGTGGCAATCTTT
ACCCGTGTTGGGGTGACACGCATTATGCGCTATGCCTTCAGACTGGCACAGTCTCGTCCACGTAAACTGCTGACCGTGGT
GACCAAATCCAACGCCCAGCGCCATGGTATGGTGATGTGGGATGAGATTGCCGCTGAAGTGGCGCAGGAATTCCCGGATG
TGCAGTGGGACAAAATGTTGGTCGATGCCATGACGCACCGTATGACGTTGCATCCCCAGACCCTGGATACCATCGTTGCC
ACCAATCTGCACGCCGATATCCTTTCCGATCTGGCTGGCGCGCTGGCGGGTAGTCTGGGCGTAGCGCCGACCGCGAATAT
TGATCCTGAACGCCGCTTCCCTTCCATGTTCGAACCGATCCATGGTTCCGCATTCGATATCACCGGCAAAGGGATTGCGA
ACCCCATTGCCACTTTCTGGACCGCGGTACAGATGCTTGAACATCTGGGCGAACGCCATGCCGCTGCGCTGATTATGGAA
AGCATTGAGTATGTGTGTGAAAAAGGCATTCTGACGCCAGATGTCGGTGGCTCAGCCAATACCGCGGAGGTGACACGCGC
CGTGGTGCACTACATTGACGCTAAAGCTGACATTGCCGAGACCGCATAA

Upstream 100 bases:

>100_bases
CGCTCTCGGCCCTCGTGGTCATGATTCTTTCTGCCAGAGCGAACAAATCGCCGACGGCAGAGCTTCCACATCCTCATACT
CATTAACTGGAGAAGTAACG

Downstream 100 bases:

>100_bases
CCATGAATAACGAACAGGCTGCAGAGATCCTGCAGGATATCTTTCAACATGCGGTCAACAGTGCCCGCGCCGGGCCGGTG
ACCCTGGCTAACCTGCCGGA

Product: putative tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MRHYKIAAIPADGIGPEVISAGIEVLHALTRHDPQLKFDIETFDWGSDYYKKHGVMMPEEGLNMLKAFDAIYFGAVGAPD
VPDHITLWGLRLPICQGFDQYANVRPTKILPGVTSPLRNRGPGDLDWVIVRENSEGEYSGNGGRTHRGLPEEVGTEVAIF
TRVGVTRIMRYAFRLAQSRPRKLLTVVTKSNAQRHGMVMWDEIAAEVAQEFPDVQWDKMLVDAMTHRMTLHPQTLDTIVA
TNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPIATFWTAVQMLEHLGERHAAALIME
SIEYVCEKGILTPDVGGSANTAEVTRAVVHYIDAKADIAETA

Sequences:

>Translated_362_residues
MRHYKIAAIPADGIGPEVISAGIEVLHALTRHDPQLKFDIETFDWGSDYYKKHGVMMPEEGLNMLKAFDAIYFGAVGAPD
VPDHITLWGLRLPICQGFDQYANVRPTKILPGVTSPLRNRGPGDLDWVIVRENSEGEYSGNGGRTHRGLPEEVGTEVAIF
TRVGVTRIMRYAFRLAQSRPRKLLTVVTKSNAQRHGMVMWDEIAAEVAQEFPDVQWDKMLVDAMTHRMTLHPQTLDTIVA
TNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPIATFWTAVQMLEHLGERHAAALIME
SIEYVCEKGILTPDVGGSANTAEVTRAVVHYIDAKADIAETA
>Mature_362_residues
MRHYKIAAIPADGIGPEVISAGIEVLHALTRHDPQLKFDIETFDWGSDYYKKHGVMMPEEGLNMLKAFDAIYFGAVGAPD
VPDHITLWGLRLPICQGFDQYANVRPTKILPGVTSPLRNRGPGDLDWVIVRENSEGEYSGNGGRTHRGLPEEVGTEVAIF
TRVGVTRIMRYAFRLAQSRPRKLLTVVTKSNAQRHGMVMWDEIAAEVAQEFPDVQWDKMLVDAMTHRMTLHPQTLDTIVA
TNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPIATFWTAVQMLEHLGERHAAALIME
SIEYVCEKGILTPDVGGSANTAEVTRAVVHYIDAKADIAETA

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=348, Percent_Identity=30.7471264367816, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4758582, Length=358, Percent_Identity=29.8882681564246, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI28178821, Length=355, Percent_Identity=27.887323943662, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI28178816, Length=349, Percent_Identity=28.6532951289398, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI28178838, Length=327, Percent_Identity=30.2752293577982, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI28178819, Length=203, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788101, Length=360, Percent_Identity=50.5555555555556, Blast_Score=351, Evalue=4e-98,
Organism=Escherichia coli, GI87081683, Length=363, Percent_Identity=33.6088154269972, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI1787381, Length=373, Percent_Identity=26.0053619302949, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI25144293, Length=357, Percent_Identity=29.1316526610644, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI71986051, Length=346, Percent_Identity=29.7687861271676, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17505779, Length=364, Percent_Identity=28.8461538461538, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17550882, Length=353, Percent_Identity=30.028328611898, Blast_Score=131, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6322097, Length=369, Percent_Identity=37.6693766937669, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6324709, Length=354, Percent_Identity=31.9209039548023, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319830, Length=366, Percent_Identity=30.8743169398907, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324291, Length=355, Percent_Identity=30.4225352112676, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24643268, Length=350, Percent_Identity=31.7142857142857, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24643270, Length=350, Percent_Identity=31.7142857142857, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24661184, Length=354, Percent_Identity=29.3785310734463, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI281362242, Length=343, Percent_Identity=30.6122448979592, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24648872, Length=343, Percent_Identity=30.6122448979592, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI161078639, Length=260, Percent_Identity=29.6153846153846, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161078635, Length=362, Percent_Identity=25.6906077348066, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161078633, Length=260, Percent_Identity=29.6153846153846, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24650122, Length=260, Percent_Identity=29.6153846153846, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161078637, Length=362, Percent_Identity=25.6906077348066, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI20130355, Length=350, Percent_Identity=27.7142857142857, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 39744; Mature: 39744

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHYKIAAIPADGIGPEVISAGIEVLHALTRHDPQLKFDIETFDWGSDYYKKHGVMMPEE
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHCCCCCCHH
GLNMLKAFDAIYFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGVTSPLRNR
HHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHCC
GPGDLDWVIVRENSEGEYSGNGGRTHRGLPEEVGTEVAIFTRVGVTRIMRYAFRLAQSRP
CCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHCCCEEEHHHHHHHHHHHHHHHHHHCCC
RKLLTVVTKSNAQRHGMVMWDEIAAEVAQEFPDVQWDKMLVDAMTHRMTLHPQTLDTIVA
HHEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
TNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPIATFW
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHCCCCCCEEEECCCCHHHHHHHHH
TAVQMLEHLGERHAAALIMESIEYVCEKGILTPDVGGSANTAEVTRAVVHYIDAKADIAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHC
TA
CC
>Mature Secondary Structure
MRHYKIAAIPADGIGPEVISAGIEVLHALTRHDPQLKFDIETFDWGSDYYKKHGVMMPEE
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHCCCCCCHH
GLNMLKAFDAIYFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGVTSPLRNR
HHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHCC
GPGDLDWVIVRENSEGEYSGNGGRTHRGLPEEVGTEVAIFTRVGVTRIMRYAFRLAQSRP
CCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHCCCEEEHHHHHHHHHHHHHHHHHHCCC
RKLLTVVTKSNAQRHGMVMWDEIAAEVAQEFPDVQWDKMLVDAMTHRMTLHPQTLDTIVA
HHEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
TNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPIATFW
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHCCCCCCEEEECCCCHHHHHHHHH
TAVQMLEHLGERHAAALIMESIEYVCEKGILTPDVGGSANTAEVTRAVVHYIDAKADIAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHC
TA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]