Click here to switch to the map view.

The map label for this gene is csgA [H]

Identifier: 238894307

GI number: 238894307

Start: 2197147

End: 2197929

Strand: Reverse

Name: csgA [H]

Synonym: KP1_2285

Alternate gene names: 238894307

Gene position: 2197929-2197147 (Counterclockwise)

Preceding gene: 238894309

Following gene: 238894306

Centisome position: 41.88

GC content: 62.58

Gene sequence:

>783_bases
GTGCACTGGCGGCGTCTTCCGCCCGATCTCGGGCCTGATTATAGTGAAGACCTCCTTTCTGCAGCGAGAGACATCATGAA
ATCCGATCAGCACAACACTATCCTCATCGTCGGCGCCTCGCGCGGCCTTGGCCATGCTATGGCGGCGACGTTCCTGCAGC
ACGGCTGGGAGGTCATCGGCACCGTGCGCGATTTATCATCCCACACGCCGCTCCACGACCTGGCCAAGACGCATCCCCTG
CGGCTACGCCTGGCGACGCTCGACATTCGCGATGAAGCCCAACTGGCCGCTCTGCAGGCGACGCTTCCCCCGGCAAGCCT
CGATATGCTGTTTGTCAACGCCGGTACCACCAATCGTGACCCATCGCAGATCATTGGCGACGTCTCCACCGAGGAGTTTT
ACCAGGTGATGCTCACCAATGCCCTGGCGCCGATGCGGGTTATCGAGCGCCTGCAGCAGGCAGTTAAACCGCAGGGGCTG
CTCGGCGTGATGTCCTCTGGCCAGGGGAGCCTGACCAATAACCTTACCGGCCAGCGGGAACTCTACCGCGGGAGTAAAGC
TGCGCTGAATATGTTTATGCGCAGCTTTGCCGCTCGCCCCACCTCGGCCTCCCATCCGCTGGTGGTGATGGCCCCGGGAT
GGATCCGCACCGAGCTCGGCGGGGCAGATGCCCCGCTGACCATCGAAGAGACGATCCCACGCCTGGTGAACGTCCTGCTC
GACAAACGGCAACGTCCGGGACTGGAGTATCTCGATTACCAGGGCCGTACCGTGCCCTGGTGA

Upstream 100 bases:

>100_bases
GGTACTGACCGGCAGCGGATCGAGGGCCGCCAGCAAATTAAAATCGGGATCGTTCATTATCGCTCCAGTCGCCAGACAGG
GCGTTTGCTGCAAGATATGA

Downstream 100 bases:

>100_bases
TCCGTGCCGGAACAACCATCATATGGCCGCCCGGAAGTTAACCCCGCCCGGCGCGGCTTGCTACCGACCTTATTCTGCAG
CACATTCCCTATATTTCCGC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MHWRRLPPDLGPDYSEDLLSAARDIMKSDQHNTILIVGASRGLGHAMAATFLQHGWEVIGTVRDLSSHTPLHDLAKTHPL
RLRLATLDIRDEAQLAALQATLPPASLDMLFVNAGTTNRDPSQIIGDVSTEEFYQVMLTNALAPMRVIERLQQAVKPQGL
LGVMSSGQGSLTNNLTGQRELYRGSKAALNMFMRSFAARPTSASHPLVVMAPGWIRTELGGADAPLTIEETIPRLVNVLL
DKRQRPGLEYLDYQGRTVPW

Sequences:

>Translated_260_residues
MHWRRLPPDLGPDYSEDLLSAARDIMKSDQHNTILIVGASRGLGHAMAATFLQHGWEVIGTVRDLSSHTPLHDLAKTHPL
RLRLATLDIRDEAQLAALQATLPPASLDMLFVNAGTTNRDPSQIIGDVSTEEFYQVMLTNALAPMRVIERLQQAVKPQGL
LGVMSSGQGSLTNNLTGQRELYRGSKAALNMFMRSFAARPTSASHPLVVMAPGWIRTELGGADAPLTIEETIPRLVNVLL
DKRQRPGLEYLDYQGRTVPW
>Mature_260_residues
MHWRRLPPDLGPDYSEDLLSAARDIMKSDQHNTILIVGASRGLGHAMAATFLQHGWEVIGTVRDLSSHTPLHDLAKTHPL
RLRLATLDIRDEAQLAALQATLPPASLDMLFVNAGTTNRDPSQIIGDVSTEEFYQVMLTNALAPMRVIERLQQAVKPQGL
LGVMSSGQGSLTNNLTGQRELYRGSKAALNMFMRSFAARPTSASHPLVVMAPGWIRTELGGADAPLTIEETIPRLVNVLL
DKRQRPGLEYLDYQGRTVPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Caenorhabditis elegans, GI17558994, Length=225, Percent_Identity=31.5555555555556, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193207563, Length=238, Percent_Identity=28.1512605042017, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17558992, Length=223, Percent_Identity=27.3542600896861, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17558990, Length=223, Percent_Identity=27.8026905829596, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559962, Length=231, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559964, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640547, Length=251, Percent_Identity=29.4820717131474, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28645; Mature: 28645

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHWRRLPPDLGPDYSEDLLSAARDIMKSDQHNTILIVGASRGLGHAMAATFLQHGWEVIG
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
TVRDLSSHTPLHDLAKTHPLRLRLATLDIRDEAQLAALQATLPPASLDMLFVNAGTTNRD
HHHHHHCCCCHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCC
PSQIIGDVSTEEFYQVMLTNALAPMRVIERLQQAVKPQGLLGVMSSGQGSLTNNLTGQRE
HHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHH
LYRGSKAALNMFMRSFAARPTSASHPLVVMAPGWIRTELGGADAPLTIEETIPRLVNVLL
HHCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEHHCCCCCCCEEHHHHHHHHHHHHH
DKRQRPGLEYLDYQGRTVPW
HHCCCCCCCEECCCCCCCCC
>Mature Secondary Structure
MHWRRLPPDLGPDYSEDLLSAARDIMKSDQHNTILIVGASRGLGHAMAATFLQHGWEVIG
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
TVRDLSSHTPLHDLAKTHPLRLRLATLDIRDEAQLAALQATLPPASLDMLFVNAGTTNRD
HHHHHHCCCCHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCC
PSQIIGDVSTEEFYQVMLTNALAPMRVIERLQQAVKPQGLLGVMSSGQGSLTNNLTGQRE
HHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHH
LYRGSKAALNMFMRSFAARPTSASHPLVVMAPGWIRTELGGADAPLTIEETIPRLVNVLL
HHCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEHHCCCCCCCEEHHHHHHHHHHHHH
DKRQRPGLEYLDYQGRTVPW
HHCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]