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The map label for this gene is nupC [H]

Identifier: 238894083

GI number: 238894083

Start: 1981871

End: 1983055

Strand: Reverse

Name: nupC [H]

Synonym: KP1_2034

Alternate gene names: 238894083

Gene position: 1983055-1981871 (Counterclockwise)

Preceding gene: 238894089

Following gene: 238894080

Centisome position: 37.78

GC content: 53.5

Gene sequence:

>1185_bases
ATGACTGCATTTTTTCATTTCCTGCTGGCGCTGGCGGTGATCCTCGCCCTGGCCTGGCTTGTCAGCTACGACAGACAAAA
AATTCGTATTCATTATATTCTCCAGTTGATTATTATCGAAATAGCGCTCGCTTTCTTTTTCCTGCACGCCGAAAGCGGCC
TGTGGCTGGTAAAAAATATTTCCGGCTTTTTTGCTTCGCTGTTAGGCTTTGCCGCCGAAGGGACCAATTTCGTCTTTGGC
GGCATGAGCGAAAAAGGCTTAGCCTTTATTTTCCTGGGCGTCCTGTGTCCGATTGTGTTTATTTCCGCGCTGATTGGTAT
TCTCCAGCACTGGCGGATCCTGCCGATTTTTATTCGCGTGATTGGCACCCTGCTGTCGAAAGTAAACGGCATGGGTAAGC
TGGAATCTTTCAACGCCGTCAGCTCGCTGATCCTCGGCCAATCGGAGAACTTCATTGCCTACAAGGGCGTACTGAGCGAC
CTCTCCTCACGGCGACTGTTCACTATGGCGGCGACGGCCATGTCGACCGTATCGCTGTCGATTGTCGGCGCCTATATGAC
CATGCTGGACGCCAAATATGTCGTCGCAGCGCTGATCCTCAATATGTTCAGCACCTTTATCGTGCTGTCGGTAATTAACC
CGACGCGGCCGGGCAGCGAGCAGGAAATAAAACTCGAGAAGCTGCATGAATCGCAGAGTTTCTTTGAAATGCTCGGGGAA
TATATTCTGGCCGGCTTTAAAGTGGCGATGATTATTCTGGCGATGCTGATCGGTTTTATCGCCCTGATCAGCGCCATTAA
CGCGCTATTCGCCACCCTGTTTGGTCTCAGCTTCCAGCAGATCCTCGGCTACGTCTTTTATCCGCTGGCGTGGCTTATCG
GCATCCCGCTGAGCGATGCGCTAAACGCCGGCAGCATCATGGCCACCAAACTGGTCGCTAACGAATTTGTGGCGATGATT
GAGCTGCAAAAGATTGCCGCCAGCATGACCCCTCGCGGGCTCGGCATTCTCTCGGTATTCCTGGTGTCGTTTGCCAACTT
TGCCTCGATCGGCATTATCGCCGGGGCGATCAAAGGCCTGAATGAACCGCAGGGCAATATCGTCTCCCGCTTCGGCCTGC
GGCTGGTGTATAGCGCCACGCTGGTGAGCCTGCTTTCCGCCAGCTTCGCCGGGCTGGTGCTGTAA

Upstream 100 bases:

>100_bases
TGAAGGGAAAGAATAAACAAAGGATTTTTTACGCCAGATATTTACCCGCCGTAGCGGCTATGGCTAAATGGCGGCCTTAT
TGACTTGCGAAAAGAACAAC

Downstream 100 bases:

>100_bases
AACAAACGGCGGGGCTGCCCCCGCCGTTTACTCAGAACTGCACGCAGACCGGCTGGTCGACACGCATCACCGACTCCTGC
GCGAAGCGTGATTTATAGCC

Product: NUP family nucleoside transport protein

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: Nucleoside-transport system protein nupC [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTAFFHFLLALAVILALAWLVSYDRQKIRIHYILQLIIIEIALAFFFLHAESGLWLVKNISGFFASLLGFAAEGTNFVFG
GMSEKGLAFIFLGVLCPIVFISALIGILQHWRILPIFIRVIGTLLSKVNGMGKLESFNAVSSLILGQSENFIAYKGVLSD
LSSRRLFTMAATAMSTVSLSIVGAYMTMLDAKYVVAALILNMFSTFIVLSVINPTRPGSEQEIKLEKLHESQSFFEMLGE
YILAGFKVAMIILAMLIGFIALISAINALFATLFGLSFQQILGYVFYPLAWLIGIPLSDALNAGSIMATKLVANEFVAMI
ELQKIAASMTPRGLGILSVFLVSFANFASIGIIAGAIKGLNEPQGNIVSRFGLRLVYSATLVSLLSASFAGLVL

Sequences:

>Translated_394_residues
MTAFFHFLLALAVILALAWLVSYDRQKIRIHYILQLIIIEIALAFFFLHAESGLWLVKNISGFFASLLGFAAEGTNFVFG
GMSEKGLAFIFLGVLCPIVFISALIGILQHWRILPIFIRVIGTLLSKVNGMGKLESFNAVSSLILGQSENFIAYKGVLSD
LSSRRLFTMAATAMSTVSLSIVGAYMTMLDAKYVVAALILNMFSTFIVLSVINPTRPGSEQEIKLEKLHESQSFFEMLGE
YILAGFKVAMIILAMLIGFIALISAINALFATLFGLSFQQILGYVFYPLAWLIGIPLSDALNAGSIMATKLVANEFVAMI
ELQKIAASMTPRGLGILSVFLVSFANFASIGIIAGAIKGLNEPQGNIVSRFGLRLVYSATLVSLLSASFAGLVL
>Mature_393_residues
TAFFHFLLALAVILALAWLVSYDRQKIRIHYILQLIIIEIALAFFFLHAESGLWLVKNISGFFASLLGFAAEGTNFVFGG
MSEKGLAFIFLGVLCPIVFISALIGILQHWRILPIFIRVIGTLLSKVNGMGKLESFNAVSSLILGQSENFIAYKGVLSDL
SSRRLFTMAATAMSTVSLSIVGAYMTMLDAKYVVAALILNMFSTFIVLSVINPTRPGSEQEIKLEKLHESQSFFEMLGEY
ILAGFKVAMIILAMLIGFIALISAINALFATLFGLSFQQILGYVFYPLAWLIGIPLSDALNAGSIMATKLVANEFVAMIE
LQKIAASMTPRGLGILSVFLVSFANFASIGIIAGAIKGLNEPQGNIVSRFGLRLVYSATLVSLLSASFAGLVL

Specific function: Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force [H]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI42542381, Length=391, Percent_Identity=26.0869565217391, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI227116277, Length=391, Percent_Identity=21.9948849104859, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI11545853, Length=365, Percent_Identity=22.4657534246575, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788737, Length=400, Percent_Identity=72, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1788485, Length=404, Percent_Identity=27.7227722772277, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788488, Length=407, Percent_Identity=28.2555282555283, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17560276, Length=394, Percent_Identity=24.6192893401015, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71991794, Length=391, Percent_Identity=23.7851662404092, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45552519, Length=404, Percent_Identity=25, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45552517, Length=404, Percent_Identity=25, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19921868, Length=404, Percent_Identity=25, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281360430, Length=339, Percent_Identity=24.188790560472, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 42746; Mature: 42615

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFFHFLLALAVILALAWLVSYDRQKIRIHYILQLIIIEIALAFFFLHAESGLWLVKNI
CHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
SGFFASLLGFAAEGTNFVFGGMSEKGLAFIFLGVLCPIVFISALIGILQHWRILPIFIRV
HHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGTLLSKVNGMGKLESFNAVSSLILGQSENFIAYKGVLSDLSSRRLFTMAATAMSTVSLS
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVGAYMTMLDAKYVVAALILNMFSTFIVLSVINPTRPGSEQEIKLEKLHESQSFFEMLGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YILAGFKVAMIILAMLIGFIALISAINALFATLFGLSFQQILGYVFYPLAWLIGIPLSDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHH
LNAGSIMATKLVANEFVAMIELQKIAASMTPRGLGILSVFLVSFANFASIGIIAGAIKGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
NEPQGNIVSRFGLRLVYSATLVSLLSASFAGLVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAFFHFLLALAVILALAWLVSYDRQKIRIHYILQLIIIEIALAFFFLHAESGLWLVKNI
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
SGFFASLLGFAAEGTNFVFGGMSEKGLAFIFLGVLCPIVFISALIGILQHWRILPIFIRV
HHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGTLLSKVNGMGKLESFNAVSSLILGQSENFIAYKGVLSDLSSRRLFTMAATAMSTVSLS
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVGAYMTMLDAKYVVAALILNMFSTFIVLSVINPTRPGSEQEIKLEKLHESQSFFEMLGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YILAGFKVAMIILAMLIGFIALISAINALFATLFGLSFQQILGYVFYPLAWLIGIPLSDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHH
LNAGSIMATKLVANEFVAMIELQKIAASMTPRGLGILSVFLVSFANFASIGIIAGAIKGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
NEPQGNIVSRFGLRLVYSATLVSLLSASFAGLVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]