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The map label for this gene is sdaC [H]

Identifier: 238893990

GI number: 238893990

Start: 1884807

End: 1886096

Strand: Direct

Name: sdaC [H]

Synonym: KP1_1934

Alternate gene names: 238893990

Gene position: 1884807-1886096 (Clockwise)

Preceding gene: 238893989

Following gene: 238893991

Centisome position: 35.91

GC content: 51.78

Gene sequence:

>1290_bases
ATGAATACTGAAAATATAATTATCAATAAAGGATATTCCGATCCCGCAAAGTGGCATAGCGAAGATACCGTTTGGGTCCT
TGGCCTGTTCGGTACCGCCATTGGCGCTGGGGTGCTGTTTCTGCCGATTAATGCCGGAATTGGCGGCTTCTGGCCGCTGC
TGATTGTTTTTGTCCTCGCTTTTCCTATTACTTATCTGGCTCACCGCGGTCTGGCGAGATTCATTTACTCTTCCAATACG
CCGGAAAGCAGTATTACCGATGTTATTGGCGAGCATTTTGGCGCGCTGGCGGGAAAAGTATTTACCGTCATCTATTTCTT
CGCCGTCTATACCATTCTGATTATGTATGCGGTAGCTATCACCAACACCGCGCAGAGCTTTATCACCCACCAGTTGGCAA
TGGCCGAGCCTCCCCGGTCGCTGGTGGCCATCGTTCTGATCCTCGGGCTGATGTTTATCGTCCGTTTCGGACAGCGTTTG
ATAATGCGGGTGATGAGCACCCTGGTTTATCCCTTCATCATCTCGCTTATTTTTATGGCACTTTTTCTGATTCCGTACTG
GAACGGCGCAATTTTGCAAACCGTAAGCTTCAGCGCCACGGGCGATACGCAGGGGATCATATTATCCCTGTGGATGACCT
TCCCGGTACTGGTGATGTCGTTTAACCACTATCCCATCATTTCGCCGATGGTGGTGCGCCAGAAGCAGCGTTACGGTCTG
GCGCTCGCTGAGGGTAAATGTGCGCAGATCCAGCGCTACGGTATCCTGCTCATGACGGTGGTGGTGCTGTTTTTTGTTCT
CAGCTGCGTGTTAAGCCTGTCGCCGCAGCAACTGGCGGAAGCCAAAGCCCAGAATCTGTCGATTTTGTCCTATCTGGCCA
ATCAGTACGATACACCGATTATTGCCTGGCTATCGCCGATTATCGCCTTTGTCGCTATTACTAAATCATTTCTTGGCCAC
TACATCGGCGCCTATGAATCGCTGCGCGACCTGATTCTGGAGGCCGCCGCCGCACGCGGGAAAAAACCTGGTATTCGCCT
CGTCGACGCGGTCATCCTGGTGTTTATGGTGCTTACCTGCTGGTTCGCCGCGTACAAGAACCCCAGTATCCTCGGTATTA
TCGAATGCATCAGCGGTCCCACCGGGGCGGCAATTCTGCTGCTGTTGCCTATGTACGCCATTCATAAATTACCGGTGCTT
GCCCCCTGGCGCGGTAAAGCGAGCAACGTTTTCGTCACCCTGATCGGTCTTATCACCGTATCTGCCATTTTTTACGGCAT
GTTCCAATAA

Upstream 100 bases:

>100_bases
GGCCATCTTACCTACCCTACAAGCCCTCGGTATGACAAGCGTTCTGACTCATAACGAAAACATACGCGCTTTCGCGTCAT
GCATAGAGAGAACCTGACCG

Downstream 100 bases:

>100_bases
CCACCATTATTAGCGAGATGTTATATGAGTCATTATCTGCAGATTAACGGCCAACGGCTTATCGATTCCCTGTATGCACT
TGGCGAACATGGTGCGCTGC

Product: serine/threonine transporter family protein

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MNTENIIINKGYSDPAKWHSEDTVWVLGLFGTAIGAGVLFLPINAGIGGFWPLLIVFVLAFPITYLAHRGLARFIYSSNT
PESSITDVIGEHFGALAGKVFTVIYFFAVYTILIMYAVAITNTAQSFITHQLAMAEPPRSLVAIVLILGLMFIVRFGQRL
IMRVMSTLVYPFIISLIFMALFLIPYWNGAILQTVSFSATGDTQGIILSLWMTFPVLVMSFNHYPIISPMVVRQKQRYGL
ALAEGKCAQIQRYGILLMTVVVLFFVLSCVLSLSPQQLAEAKAQNLSILSYLANQYDTPIIAWLSPIIAFVAITKSFLGH
YIGAYESLRDLILEAAAARGKKPGIRLVDAVILVFMVLTCWFAAYKNPSILGIIECISGPTGAAILLLLPMYAIHKLPVL
APWRGKASNVFVTLIGLITVSAIFYGMFQ

Sequences:

>Translated_429_residues
MNTENIIINKGYSDPAKWHSEDTVWVLGLFGTAIGAGVLFLPINAGIGGFWPLLIVFVLAFPITYLAHRGLARFIYSSNT
PESSITDVIGEHFGALAGKVFTVIYFFAVYTILIMYAVAITNTAQSFITHQLAMAEPPRSLVAIVLILGLMFIVRFGQRL
IMRVMSTLVYPFIISLIFMALFLIPYWNGAILQTVSFSATGDTQGIILSLWMTFPVLVMSFNHYPIISPMVVRQKQRYGL
ALAEGKCAQIQRYGILLMTVVVLFFVLSCVLSLSPQQLAEAKAQNLSILSYLANQYDTPIIAWLSPIIAFVAITKSFLGH
YIGAYESLRDLILEAAAARGKKPGIRLVDAVILVFMVLTCWFAAYKNPSILGIIECISGPTGAAILLLLPMYAIHKLPVL
APWRGKASNVFVTLIGLITVSAIFYGMFQ
>Mature_429_residues
MNTENIIINKGYSDPAKWHSEDTVWVLGLFGTAIGAGVLFLPINAGIGGFWPLLIVFVLAFPITYLAHRGLARFIYSSNT
PESSITDVIGEHFGALAGKVFTVIYFFAVYTILIMYAVAITNTAQSFITHQLAMAEPPRSLVAIVLILGLMFIVRFGQRL
IMRVMSTLVYPFIISLIFMALFLIPYWNGAILQTVSFSATGDTQGIILSLWMTFPVLVMSFNHYPIISPMVVRQKQRYGL
ALAEGKCAQIQRYGILLMTVVVLFFVLSCVLSLSPQQLAEAKAQNLSILSYLANQYDTPIIAWLSPIIAFVAITKSFLGH
YIGAYESLRDLILEAAAARGKKPGIRLVDAVILVFMVLTCWFAAYKNPSILGIIECISGPTGAAILLLLPMYAIHKLPVL
APWRGKASNVFVTLIGLITVSAIFYGMFQ

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=417, Percent_Identity=53.2374100719424, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1789504, Length=446, Percent_Identity=44.3946188340807, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI1789211, Length=416, Percent_Identity=35.0961538461538, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI145693183, Length=409, Percent_Identity=25.4278728606357, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789961, Length=389, Percent_Identity=24.9357326478149, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 47227; Mature: 47227

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTENIIINKGYSDPAKWHSEDTVWVLGLFGTAIGAGVLFLPINAGIGGFWPLLIVFVLA
CCCCCEEEECCCCCCHHHCCCCCEEHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH
FPITYLAHRGLARFIYSSNTPESSITDVIGEHFGALAGKVFTVIYFFAVYTILIMYAVAI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNTAQSFITHQLAMAEPPRSLVAIVLILGLMFIVRFGQRLIMRVMSTLVYPFIISLIFMA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLIPYWNGAILQTVSFSATGDTQGIILSLWMTFPVLVMSFNHYPIISPMVVRQKQRYGL
HHHHHCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
ALAEGKCAQIQRYGILLMTVVVLFFVLSCVLSLSPQQLAEAKAQNLSILSYLANQYDTPI
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
IAWLSPIIAFVAITKSFLGHYIGAYESLRDLILEAAAARGKKPGIRLVDAVILVFMVLTC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
WFAAYKNPSILGIIECISGPTGAAILLLLPMYAIHKLPVLAPWRGKASNVFVTLIGLITV
HHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
SAIFYGMFQ
HHHHHHHCC
>Mature Secondary Structure
MNTENIIINKGYSDPAKWHSEDTVWVLGLFGTAIGAGVLFLPINAGIGGFWPLLIVFVLA
CCCCCEEEECCCCCCHHHCCCCCEEHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH
FPITYLAHRGLARFIYSSNTPESSITDVIGEHFGALAGKVFTVIYFFAVYTILIMYAVAI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNTAQSFITHQLAMAEPPRSLVAIVLILGLMFIVRFGQRLIMRVMSTLVYPFIISLIFMA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLIPYWNGAILQTVSFSATGDTQGIILSLWMTFPVLVMSFNHYPIISPMVVRQKQRYGL
HHHHHCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
ALAEGKCAQIQRYGILLMTVVVLFFVLSCVLSLSPQQLAEAKAQNLSILSYLANQYDTPI
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
IAWLSPIIAFVAITKSFLGHYIGAYESLRDLILEAAAARGKKPGIRLVDAVILVFMVLTC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
WFAAYKNPSILGIIECISGPTGAAILLLLPMYAIHKLPVLAPWRGKASNVFVTLIGLITV
HHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
SAIFYGMFQ
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]