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The map label for this gene is focA [H]

Identifier: 238893961

GI number: 238893961

Start: 1848286

End: 1849143

Strand: Reverse

Name: focA [H]

Synonym: KP1_1903

Alternate gene names: 238893961

Gene position: 1849143-1848286 (Counterclockwise)

Preceding gene: 238893962

Following gene: 238893960

Centisome position: 35.23

GC content: 52.33

Gene sequence:

>858_bases
GTGAAAGCTGACAACCCTTTTGATCTTTTGCTCCCTGCCGCGATGGCGAAAGTCGCCGAAGAAGCAGGTGTCTATAAAGC
AACGAAGCATCCGATGAAGACGTTTTATCTGGCGATCACCGCTGGCGTTTTCATCTCCATCGCTTTCGTATTCTATATCA
CCGCGACCACCGGCACTGCCGCGATGCCTTATGGGATTGCCAAACTTATCGGTGGGATCTGTTTTTCTCTGGGTCTGATT
CTGTGCGTTATCTGCGGCGCTGACCTCTTTACCTCTACGGTACTGATCGTGGTGGCCAAAGCCAGCGGTCGAATTACCTG
GGGGCAACTGGCAAAAAACTGGCTCAACGTCTATTTTGGTAACCTGGTGGGCGCGCTGCTGTTTGTGCTGCTGATGTGGT
TATCAGGCGAATATATGACTGCCAACGGCGGCTGGGGGCTAAACGTTCTGCAGACCGCCGACCACAAAATGCACCATACT
TTTGTGGAGGCCGTGAGCCTGGGTATCCTCGCTAACCTGATGGTTTGTCTCGCCGTATGGATGAGCTATTCCGGTCGTAG
CCTGATGGATAAAGCGATGATCATGGTCCTGCCGGTAGCGATGTTCGTTGCCAGCGGCTTTGAGCACAGCATCGCCAACA
TGTTTATGATCCCGATGGGTATCGTAATCCGCAACTTTGCAAGCCCGGAATTCTGGACCGCCATCGGTTCGACTCCGGAA
AGTTTCTCTCACTTGACCGTTATGAACTTCATCACTGATAACCTGATTCCGGTAACTATCGGGAACATTATCGGCGGGGG
TCTGCTGGTCGGGTTGACATACTGGGTCATTTACCTGCGTGGCAACGACCATCACTAA

Upstream 100 bases:

>100_bases
AAAAGGCATATAGTTCCGGTGAGATATGATCTATATCAATTTCCATTCTATAATGCTTTGTTAGTATCTCACCGCCAACT
TATATAAAGAGAGAGTTAGT

Downstream 100 bases:

>100_bases
GGGTTGTTTCAGGCAGTAAATAAAAAATCCACTTAAGAAGGTAGGTGTTACATGTCCGAGCTTAATGAAAAGTTAGCCAC
AGCCTGGGAAGGTTTTGCGA

Product: putative formate transporter

Products: formate [Periplasm]; formate [Cytoplasm] [C]

Alternate protein names: Formate channel 1 [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKADNPFDLLLPAAMAKVAEEAGVYKATKHPMKTFYLAITAGVFISIAFVFYITATTGTAAMPYGIAKLIGGICFSLGLI
LCVICGADLFTSTVLIVVAKASGRITWGQLAKNWLNVYFGNLVGALLFVLLMWLSGEYMTANGGWGLNVLQTADHKMHHT
FVEAVSLGILANLMVCLAVWMSYSGRSLMDKAMIMVLPVAMFVASGFEHSIANMFMIPMGIVIRNFASPEFWTAIGSTPE
SFSHLTVMNFITDNLIPVTIGNIIGGGLLVGLTYWVIYLRGNDHH

Sequences:

>Translated_285_residues
MKADNPFDLLLPAAMAKVAEEAGVYKATKHPMKTFYLAITAGVFISIAFVFYITATTGTAAMPYGIAKLIGGICFSLGLI
LCVICGADLFTSTVLIVVAKASGRITWGQLAKNWLNVYFGNLVGALLFVLLMWLSGEYMTANGGWGLNVLQTADHKMHHT
FVEAVSLGILANLMVCLAVWMSYSGRSLMDKAMIMVLPVAMFVASGFEHSIANMFMIPMGIVIRNFASPEFWTAIGSTPE
SFSHLTVMNFITDNLIPVTIGNIIGGGLLVGLTYWVIYLRGNDHH
>Mature_285_residues
MKADNPFDLLLPAAMAKVAEEAGVYKATKHPMKTFYLAITAGVFISIAFVFYITATTGTAAMPYGIAKLIGGICFSLGLI
LCVICGADLFTSTVLIVVAKASGRITWGQLAKNWLNVYFGNLVGALLFVLLMWLSGEYMTANGGWGLNVLQTADHKMHHT
FVEAVSLGILANLMVCLAVWMSYSGRSLMDKAMIMVLPVAMFVASGFEHSIANMFMIPMGIVIRNFASPEFWTAIGSTPE
SFSHLTVMNFITDNLIPVTIGNIIGGGLLVGLTYWVIYLRGNDHH

Specific function: Involved in the bidirectional transport of formate [H]

COG id: COG2116

COG function: function code P; Formate/nitrite family of transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FNT transporter (TC 2.A.44) family [H]

Homologues:

Organism=Escherichia coli, GI1787132, Length=285, Percent_Identity=94.0350877192982, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1788837, Length=280, Percent_Identity=50.7142857142857, Blast_Score=282, Evalue=2e-77,
Organism=Escherichia coli, GI87082249, Length=267, Percent_Identity=27.3408239700375, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321779, Length=207, Percent_Identity=29.951690821256, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000292 [H]

Pfam domain/function: PF01226 Form_Nir_trans [H]

EC number: NA

Molecular weight: Translated: 30878; Mature: 30878

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS01005 FORMATE_NITRITE_TP_1 ; PS01006 FORMATE_NITRITE_TP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKADNPFDLLLPAAMAKVAEEAGVYKATKHPMKTFYLAITAGVFISIAFVFYITATTGTA
CCCCCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AMPYGIAKLIGGICFSLGLILCVICGADLFTSTVLIVVAKASGRITWGQLAKNWLNVYFG
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHH
NLVGALLFVLLMWLSGEYMTANGGWGLNVLQTADHKMHHTFVEAVSLGILANLMVCLAVW
HHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSYSGRSLMDKAMIMVLPVAMFVASGFEHSIANMFMIPMGIVIRNFASPEFWTAIGSTPE
HCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCH
SFSHLTVMNFITDNLIPVTIGNIIGGGLLVGLTYWVIYLRGNDHH
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
>Mature Secondary Structure
MKADNPFDLLLPAAMAKVAEEAGVYKATKHPMKTFYLAITAGVFISIAFVFYITATTGTA
CCCCCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AMPYGIAKLIGGICFSLGLILCVICGADLFTSTVLIVVAKASGRITWGQLAKNWLNVYFG
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHH
NLVGALLFVLLMWLSGEYMTANGGWGLNVLQTADHKMHHTFVEAVSLGILANLMVCLAVW
HHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSYSGRSLMDKAMIMVLPVAMFVASGFEHSIANMFMIPMGIVIRNFASPEFWTAIGSTPE
HCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCH
SFSHLTVMNFITDNLIPVTIGNIIGGGLLVGLTYWVIYLRGNDHH
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formate [Cytoplasm]; formate [Periplasm] [C]

Specific reaction: formate [Cytoplasm] = formate [Periplasm] formate [Periplasm] = formate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]