Click here to switch to the map view.

The map label for this gene is grxA [H]

Identifier: 238893908

GI number: 238893908

Start: 1786223

End: 1786486

Strand: Reverse

Name: grxA [H]

Synonym: KP1_1843

Alternate gene names: 238893908

Gene position: 1786486-1786223 (Counterclockwise)

Preceding gene: 238893921

Following gene: 238893906

Centisome position: 34.04

GC content: 50.38

Gene sequence:

>264_bases
ATGTTTACCGTTATTTTTGGTCGTCCAGGCTGCCCTTACTGCGTTCGCGCTAAAGAACTGGCAGAAAAACTGACCAACGA
GCGTGATGATTTCAACTACCGCTACGTGGATATTCATGCCGAAGGCATCAGCAAAGCTGACCTGGAAAAAACCGTTGGCA
AACCGGTTGAAACCGTGCCGCAGATTTTCGTCGACCAGAAACACATCGGCGGCTGCACCGATTTTGAAGCCTGGGCAAAA
GAGAATCTCGGCCTGTTTGCCTGA

Upstream 100 bases:

>100_bases
AAACCATCGAAGTAAAAGGCAGAACCTTCTTTCCCTCCCCGCCCGTTGCAGGCATCATAAGCGCCATTCGCCATCCGGCT
GAGGTTTAAGGAGAGAAGCA

Downstream 100 bases:

>100_bases
GTCAATTTATTTGCTCGATGAATGACTGCGCCAGGTATCAAGCCAGGCGCAGATAAACAAAAAGCACAATGCCCCAAGCG
CGCACCAGAACACGGCGCTC

Product: glutaredoxin 1

Products: deoxyribonucleotides [C]

Alternate protein names: Grx1 [H]

Number of amino acids: Translated: 87; Mature: 87

Protein sequence:

>87_residues
MFTVIFGRPGCPYCVRAKELAEKLTNERDDFNYRYVDIHAEGISKADLEKTVGKPVETVPQIFVDQKHIGGCTDFEAWAK
ENLGLFA

Sequences:

>Translated_87_residues
MFTVIFGRPGCPYCVRAKELAEKLTNERDDFNYRYVDIHAEGISKADLEKTVGKPVETVPQIFVDQKHIGGCTDFEAWAK
ENLGLFA
>Mature_87_residues
MFTVIFGRPGCPYCVRAKELAEKLTNERDDFNYRYVDIHAEGISKADLEKTVGKPVETVPQIFVDQKHIGGCTDFEAWAK
ENLGLFA

Specific function: The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione re

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787073, Length=83, Percent_Identity=79.5180722891566, Blast_Score=144, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011902
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 9839; Mature: 9839

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTVIFGRPGCPYCVRAKELAEKLTNERDDFNYRYVDIHAEGISKADLEKTVGKPVETVP
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHHH
QIFVDQKHIGGCTDFEAWAKENLGLFA
HHHHCCCCCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MFTVIFGRPGCPYCVRAKELAEKLTNERDDFNYRYVDIHAEGISKADLEKTVGKPVETVP
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHHH
QIFVDQKHIGGCTDFEAWAKENLGLFA
HHHHCCCCCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ribonucleotides [C]

Specific reaction: ribonucleotides = deoxyribonucleotides [C]

General reaction: deoxyribonucleotide biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]