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The map label for this gene is moeB [H]

Identifier: 238893885

GI number: 238893885

Start: 1760120

End: 1760920

Strand: Reverse

Name: moeB [H]

Synonym: KP1_1818

Alternate gene names: 238893885

Gene position: 1760920-1760120 (Counterclockwise)

Preceding gene: 238893886

Following gene: 238893884

Centisome position: 33.55

GC content: 62.92

Gene sequence:

>801_bases
ATGGGTCGAGGTCGAACCCTTCAGTCACCTGTTTGGGGGGCTGTAATGACCGTTGAGCTGAGCGATGAAGAGATGCTGCG
CTATAACCGGCAGATCGTCTTGCGCGGTTTTGATTTTGACGGCCAGGAGCGGTTAAAAGCCGCTCGCGTGCTGGTGGTCG
GCCTCGGCGGGCTCGGCTGCGCCGCCGCGCAGTATCTGGCCGCCGCCGGGGTCGGGCAGCTCACCCTGCTCGATTTCGAC
ACTGTCTCGCTCTCCAACCTGCAGCGCCAGACGCTGCACAGCGACGCCACCCTCGGCCAGCCGAAGGTGGATTCCGCCCG
CGAGGCGCTGGCGCGCATTAACCCGCACGTCCGTCTGGTCCCGCTCAATGCCTTGCTGGATGAGGCGGCGCTGGCAGCGC
AGATTGCCGATCACGATCTGGTGCTCGACTGCACCGACAACGTCGCCATTCGCAACCAGCTTAACGTCGGCTGCTTTCAG
CACAAAACCCCACAGGTCTCCGGAGCGGCGATCCGTATGGAGGGGCAAATCAGCGTCTTTACCTATCAGGATGGCGAACC
CTGCTACCGCTGCCTGAGCCGTCTGTTCGGCGAAAATGCCCTCACCTGCGTCGAAGCCGGGGTAATGGCCCCGCTGGTGG
GCACCATCGGTTCGCTGCAGGCGATGGAGGCGATTAAGCTGCTGAGCGGCTACGGCACCCCTGCCAGCGGAAAAATCGTC
ATCTACGATGCCATGACCTGCCAGTTTCGCGAAATGAGGCTGATGCGTCACCCGCAGTGCGAGGTATGCGGCTCGCACTG
A

Upstream 100 bases:

>100_bases
ACACCACCGGCCATCAGGGCTCGCACATTTTCAGCTCCTTCAGCCTCGGCAACTGCTTTATCGTGCTGGAGCGTGAGCGC
GGCCATGTTGAAGCAGGTGA

Downstream 100 bases:

>100_bases
CCCTCACACCGGCGACGAGAGTCGCCGGTGGTTTTGTGACCGCTCTCGTTATTTTCTCCTCTCTGACTTATCCCCATCCC
GCTTGTTGATTTGCGTCAAC

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MGRGRTLQSPVWGAVMTVELSDEEMLRYNRQIVLRGFDFDGQERLKAARVLVVGLGGLGCAAAQYLAAAGVGQLTLLDFD
TVSLSNLQRQTLHSDATLGQPKVDSAREALARINPHVRLVPLNALLDEAALAAQIADHDLVLDCTDNVAIRNQLNVGCFQ
HKTPQVSGAAIRMEGQISVFTYQDGEPCYRCLSRLFGENALTCVEAGVMAPLVGTIGSLQAMEAIKLLSGYGTPASGKIV
IYDAMTCQFREMRLMRHPQCEVCGSH

Sequences:

>Translated_266_residues
MGRGRTLQSPVWGAVMTVELSDEEMLRYNRQIVLRGFDFDGQERLKAARVLVVGLGGLGCAAAQYLAAAGVGQLTLLDFD
TVSLSNLQRQTLHSDATLGQPKVDSAREALARINPHVRLVPLNALLDEAALAAQIADHDLVLDCTDNVAIRNQLNVGCFQ
HKTPQVSGAAIRMEGQISVFTYQDGEPCYRCLSRLFGENALTCVEAGVMAPLVGTIGSLQAMEAIKLLSGYGTPASGKIV
IYDAMTCQFREMRLMRHPQCEVCGSH
>Mature_265_residues
GRGRTLQSPVWGAVMTVELSDEEMLRYNRQIVLRGFDFDGQERLKAARVLVVGLGGLGCAAAQYLAAAGVGQLTLLDFDT
VSLSNLQRQTLHSDATLGQPKVDSAREALARINPHVRLVPLNALLDEAALAAQIADHDLVLDCTDNVAIRNQLNVGCFQH
KTPQVSGAAIRMEGQISVFTYQDGEPCYRCLSRLFGENALTCVEAGVMAPLVGTIGSLQAMEAIKLLSGYGTPASGKIVI
YDAMTCQFREMRLMRHPQCEVCGSH

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=242, Percent_Identity=44.6280991735537, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI4885649, Length=158, Percent_Identity=29.746835443038, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI23510338, Length=164, Percent_Identity=27.4390243902439, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI23510340, Length=164, Percent_Identity=27.4390243902439, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI225543285, Length=98, Percent_Identity=39.7959183673469, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI225543288, Length=98, Percent_Identity=39.7959183673469, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4885585, Length=98, Percent_Identity=39.7959183673469, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787048, Length=246, Percent_Identity=84.5528455284553, Blast_Score=443, Evalue=1e-126,
Organism=Escherichia coli, GI87082356, Length=245, Percent_Identity=44.4897959183673, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1789177, Length=153, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17540406, Length=250, Percent_Identity=38.4, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI193203301, Length=156, Percent_Identity=27.5641025641026, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321903, Length=254, Percent_Identity=35.8267716535433, Blast_Score=149, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6322639, Length=165, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325438, Length=105, Percent_Identity=34.2857142857143, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24582879, Length=265, Percent_Identity=42.2641509433962, Blast_Score=210, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24660640, Length=154, Percent_Identity=31.1688311688312, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 28777; Mature: 28645

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRGRTLQSPVWGAVMTVELSDEEMLRYNRQIVLRGFDFDGQERLKAARVLVVGLGGLGC
CCCCCCCCCCCCCEEEEEEECHHHHHHCCCEEEEEECCCCCHHHHHHHEEEEEECCCHHH
AAAQYLAAAGVGQLTLLDFDTVSLSNLQRQTLHSDATLGQPKVDSAREALARINPHVRLV
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEE
PLNALLDEAALAAQIADHDLVLDCTDNVAIRNQLNVGCFQHKTPQVSGAAIRMEGQISVF
EHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCEECCCCCCCCCEEEEEECEEEEE
TYQDGEPCYRCLSRLFGENALTCVEAGVMAPLVGTIGSLQAMEAIKLLSGYGTPASGKIV
EECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
IYDAMTCQFREMRLMRHPQCEVCGSH
EEECCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GRGRTLQSPVWGAVMTVELSDEEMLRYNRQIVLRGFDFDGQERLKAARVLVVGLGGLGC
CCCCCCCCCCCCEEEEEEECHHHHHHCCCEEEEEECCCCCHHHHHHHEEEEEECCCHHH
AAAQYLAAAGVGQLTLLDFDTVSLSNLQRQTLHSDATLGQPKVDSAREALARINPHVRLV
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEE
PLNALLDEAALAAQIADHDLVLDCTDNVAIRNQLNVGCFQHKTPQVSGAAIRMEGQISVF
EHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCEECCCCCCCCCEEEEEECEEEEE
TYQDGEPCYRCLSRLFGENALTCVEAGVMAPLVGTIGSLQAMEAIKLLSGYGTPASGKIV
EECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
IYDAMTCQFREMRLMRHPQCEVCGSH
EEECCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]