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The map label for this gene is phrB [H]

Identifier: 238893748

GI number: 238893748

Start: 1615632

End: 1617074

Strand: Direct

Name: phrB [H]

Synonym: KP1_1672

Alternate gene names: 238893748

Gene position: 1615632-1617074 (Clockwise)

Preceding gene: 238893747

Following gene: 238893750

Centisome position: 30.78

GC content: 63.06

Gene sequence:

>1443_bases
ATGGCCACCCATCTGGTCTGGTTACGCACGGATTTACGCATTCACGATAACCTGGCGCTGGCTGCCGCCTGCCGCGATCC
GCAGGCGCAGGTGCTGGCGCTGTATATCGCCACCCCGGGGCAGTGGCGTGAACATCACCTGGCGCCACGGCAGGCCGCTT
TTATCGCCAGCCATTTACAGAGTCTGCATGCCGCGCTGGCGGAACGGGGCATACCGCTGTGGGTAGAAGAGGCGGACGAT
TTTACCGCCAGCGTCGAACGGCTGGCCGATTTTTGCCAGCAGCATCAGGCCAGTCACCTGTTCTACAACTATCAGTACGA
ATTCAATGAACGCCAGCGCGATGCCGCCGTTGAGAACACCTTGCGCGACGTGATTTGCCAGGGCTTTGACGACAGCGTCC
TGTTGCCGCCCGGCAGCGTACTGACCGGTGGCGGCGAAATGTATAAAGTCTTCACCCCGTTTAAAAATGCGTTTATTCGC
CGTCTGCGGGACGGGCTGCCGGCGTGCGTGGCGGCCCCGAAGCCGCGCCAGGCGCCTGCCCGCCAGGCGCCGCCGCTGCC
TGAGCTTAACTACCCGCAAACGCCGTTTGACGGGCTGCTGTTTGCCGCGGATGAAAAAACGGCGCTGGCGCGTCTGCGCG
CGTTTTGTCAGCAAGCGGCGGCGGATTACGAGGGGCAGCGCGACTTCCCGGCCGTGGAAGGGACCAGTCGCCTGTCGCCC
TGCCTGGCCATCGGCGTGCTGTCCCCCCGCCAGTGCCTGCATCGTCTGCTGACGGAACATCCCGCCGCGCTGGACGGCGG
AGCCGGCGCCACCTGGCTTAATGAGCTGATCTGGCGCGAGTTTTATCGCCATCTGATGGTCTACTATCCGAAGCTCTGTA
AAGGACGGCCATTTACTGCCTGGACAGATAAGGTCGCCTGGCGCGCAGAGGAGGCCGCCCTGCAGGCCTGGCAGCGCGGG
GAGACCGGTTTTCCGATTGTTGATGCCGCCATGCGCCAGCTGAACGCCACCGGCTGGATGCATAACCGGTTGCGCATGAT
TGTCGCCAGCTTCCTGACCAAAGATTTGCGCCTCGACTGGCGGGCGGGCGAGCGCTATTTCATGAGCCAGCTGATTGATG
GCGACCTGGCGGCGAATAACGGCGGCTGGCAGTGGGCGGCTTCAACGGGCACCGACGCCGCGCCCTATTTCCGCATATTT
AACCCCACCACCCAGGGCGAAAAGTTTGATAAACAGGGGGTGTTTATACGTCGCTGGCTGCCGGAGCTGGCAAAGGTGCC
GGAGAAGGCCCTGCATCAGCCGTGGGCGTGGGCGGATAAACAAGGGATCACGCTGGACTATTCGCGCCCGATAGTTGATC
ACAAGCAGGCGCGGCAGGAGACGCTGGCGGCCTGGGAGGCCGCCAGAAAAGGAATTACTCCACCGCCAGACGGCGGGTCC
TGA

Upstream 100 bases:

>100_bases
CGCCGCCTTGGAATTGGCAGGTGCGTATTTTGCCGGAGCGCGCTATTTTTGCCGGCTTAGATCATAAGATGAATATTGCT
GACGGATAATAAGGAGTGAT

Downstream 100 bases:

>100_bases
CTTTCAGCGAATGATACAGCCAGATGACCAGCACCACGCCGACGCAGGCCAGCGCGCCCCAGGTGATCTGGCTGAAGACG
GTAATGTAGGCGTCAATGGA

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MATHLVWLRTDLRIHDNLALAAACRDPQAQVLALYIATPGQWREHHLAPRQAAFIASHLQSLHAALAERGIPLWVEEADD
FTASVERLADFCQQHQASHLFYNYQYEFNERQRDAAVENTLRDVICQGFDDSVLLPPGSVLTGGGEMYKVFTPFKNAFIR
RLRDGLPACVAAPKPRQAPARQAPPLPELNYPQTPFDGLLFAADEKTALARLRAFCQQAAADYEGQRDFPAVEGTSRLSP
CLAIGVLSPRQCLHRLLTEHPAALDGGAGATWLNELIWREFYRHLMVYYPKLCKGRPFTAWTDKVAWRAEEAALQAWQRG
ETGFPIVDAAMRQLNATGWMHNRLRMIVASFLTKDLRLDWRAGERYFMSQLIDGDLAANNGGWQWAASTGTDAAPYFRIF
NPTTQGEKFDKQGVFIRRWLPELAKVPEKALHQPWAWADKQGITLDYSRPIVDHKQARQETLAAWEAARKGITPPPDGGS

Sequences:

>Translated_480_residues
MATHLVWLRTDLRIHDNLALAAACRDPQAQVLALYIATPGQWREHHLAPRQAAFIASHLQSLHAALAERGIPLWVEEADD
FTASVERLADFCQQHQASHLFYNYQYEFNERQRDAAVENTLRDVICQGFDDSVLLPPGSVLTGGGEMYKVFTPFKNAFIR
RLRDGLPACVAAPKPRQAPARQAPPLPELNYPQTPFDGLLFAADEKTALARLRAFCQQAAADYEGQRDFPAVEGTSRLSP
CLAIGVLSPRQCLHRLLTEHPAALDGGAGATWLNELIWREFYRHLMVYYPKLCKGRPFTAWTDKVAWRAEEAALQAWQRG
ETGFPIVDAAMRQLNATGWMHNRLRMIVASFLTKDLRLDWRAGERYFMSQLIDGDLAANNGGWQWAASTGTDAAPYFRIF
NPTTQGEKFDKQGVFIRRWLPELAKVPEKALHQPWAWADKQGITLDYSRPIVDHKQARQETLAAWEAARKGITPPPDGGS
>Mature_479_residues
ATHLVWLRTDLRIHDNLALAAACRDPQAQVLALYIATPGQWREHHLAPRQAAFIASHLQSLHAALAERGIPLWVEEADDF
TASVERLADFCQQHQASHLFYNYQYEFNERQRDAAVENTLRDVICQGFDDSVLLPPGSVLTGGGEMYKVFTPFKNAFIRR
LRDGLPACVAAPKPRQAPARQAPPLPELNYPQTPFDGLLFAADEKTALARLRAFCQQAAADYEGQRDFPAVEGTSRLSPC
LAIGVLSPRQCLHRLLTEHPAALDGGAGATWLNELIWREFYRHLMVYYPKLCKGRPFTAWTDKVAWRAEEAALQAWQRGE
TGFPIVDAAMRQLNATGWMHNRLRMIVASFLTKDLRLDWRAGERYFMSQLIDGDLAANNGGWQWAASTGTDAAPYFRIFN
PTTQGEKFDKQGVFIRRWLPELAKVPEKALHQPWAWADKQGITLDYSRPIVDHKQARQETLAAWEAARKGITPPPDGGS

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=490, Percent_Identity=27.9591836734694, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI188536103, Length=306, Percent_Identity=31.3725490196078, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4758072, Length=481, Percent_Identity=27.2349272349272, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1786926, Length=471, Percent_Identity=69.8513800424628, Blast_Score=704, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6324962, Length=508, Percent_Identity=31.1023622047244, Blast_Score=256, Evalue=5e-69,
Organism=Drosophila melanogaster, GI17137248, Length=505, Percent_Identity=26.5346534653465, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24585455, Length=505, Percent_Identity=26.5346534653465, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24648152, Length=538, Percent_Identity=26.5799256505576, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54064; Mature: 53933

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHLVWLRTDLRIHDNLALAAACRDPQAQVLALYIATPGQWREHHLAPRQAAFIASHLQ
CCCEEEEEEECCEEECCEEEEECCCCCCCEEEEEEEECCCCHHHHCCCHHHHHHHHHHHH
SLHAALAERGIPLWVEEADDFTASVERLADFCQQHQASHLFYNYQYEFNERQRDAAVENT
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHH
LRDVICQGFDDSVLLPPGSVLTGGGEMYKVFTPFKNAFIRRLRDGLPACVAAPKPRQAPA
HHHHHHCCCCCCEECCCCCEEECCCCEEEEEHHHHHHHHHHHHCCCCEECCCCCCCCCCC
RQAPPLPELNYPQTPFDGLLFAADEKTALARLRAFCQQAAADYEGQRDFPAVEGTSRLSP
CCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCH
CLAIGVLSPRQCLHRLLTEHPAALDGGAGATWLNELIWREFYRHLMVYYPKLCKGRPFTA
HHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
WTDKVAWRAEEAALQAWQRGETGFPIVDAAMRQLNATGWMHNRLRMIVASFLTKDLRLDW
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RAGERYFMSQLIDGDLAANNGGWQWAASTGTDAAPYFRIFNPTTQGEKFDKQGVFIRRWL
CCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHH
PELAKVPEKALHQPWAWADKQGITLDYSRPIVDHKQARQETLAAWEAARKGITPPPDGGS
HHHHHCCHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ATHLVWLRTDLRIHDNLALAAACRDPQAQVLALYIATPGQWREHHLAPRQAAFIASHLQ
CCEEEEEEECCEEECCEEEEECCCCCCCEEEEEEEECCCCHHHHCCCHHHHHHHHHHHH
SLHAALAERGIPLWVEEADDFTASVERLADFCQQHQASHLFYNYQYEFNERQRDAAVENT
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHH
LRDVICQGFDDSVLLPPGSVLTGGGEMYKVFTPFKNAFIRRLRDGLPACVAAPKPRQAPA
HHHHHHCCCCCCEECCCCCEEECCCCEEEEEHHHHHHHHHHHHCCCCEECCCCCCCCCCC
RQAPPLPELNYPQTPFDGLLFAADEKTALARLRAFCQQAAADYEGQRDFPAVEGTSRLSP
CCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCH
CLAIGVLSPRQCLHRLLTEHPAALDGGAGATWLNELIWREFYRHLMVYYPKLCKGRPFTA
HHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
WTDKVAWRAEEAALQAWQRGETGFPIVDAAMRQLNATGWMHNRLRMIVASFLTKDLRLDW
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RAGERYFMSQLIDGDLAANNGGWQWAASTGTDAAPYFRIFNPTTQGEKFDKQGVFIRRWL
CCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHH
PELAKVPEKALHQPWAWADKQGITLDYSRPIVDHKQARQETLAAWEAARKGITPPPDGGS
HHHHHCCHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6325460; 8905232; 9278503; 2200511; 7604260 [H]