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The map label for this gene is ybdL [H]

Identifier: 238893678

GI number: 238893678

Start: 1542172

End: 1543332

Strand: Direct

Name: ybdL [H]

Synonym: KP1_1596

Alternate gene names: 238893678

Gene position: 1542172-1543332 (Clockwise)

Preceding gene: 238893675

Following gene: 238893684

Centisome position: 29.38

GC content: 63.39

Gene sequence:

>1161_bases
ATGAACAATAACCCCTTGATTCCAGAGAGTAAACTTCCTGCGCTCGGCACCACGATTTTTACCCAGATGAGCGCCCTGGC
CCAGCAGCATCAGGCCATAAACCTGTCCCAGGGCTTTCCCGATTTTGACGGCCCGCGCTATCTGCAGGAGCGTCTGGCGT
ACCACGTGGCGCAGGGGGCGAATCAGTACGCCCCGATGACCGGCGTGCCGGCGCTGCGCGAGGCGATCGCCGGGAAGACG
GCGGAGCTGTATGGTTACCAGCCCGACGTTAACAGCGAGATCACGGTCACCGCCGGCGCGACGGAGGCCCTGTATGCGGC
GATCACCGCCCTGGTGCGCCGCGGCGACGAGGTGATCTGTTTCGATCCCAGCTATGACAGCTACGCCCCCGCGGTGGCGC
TGGCCGGCGGCGAGTTACGTCGTATTGCGCTGCAGCCGCCGCATTTTCGCGTCGACTGGCGGCAATTTGCCGCCGCCCTG
AGCGAGAAAACCCGGCTGGTGATCCTCAACACCCCGCACAACCCTTCGGCCACCGTCTGGCAGCGCGAGGATTTTGCCGC
CCTGTGGCAGGCGATCGCCGAACGCGAGATCTATGTCCTGAGCGATGAAGTCTATGAGCATATCTGCTTTGCTGAGGGCG
GCCACGCCAGCGTGCTGGCGCATCCCCAGCTTCGCGAGCGGGCGGTGGCGGTCTCCTCGTTTGGCAAAACGTTTCATATG
ACCGGCTGGAAGGTCGGCTACTGCGTGGCCCCGGCAGCCATCAGCGCCGAACTGCGCAAGGTGCATCAGTATCTGACCTT
CTCGGTGAATACCCCGGCGCAGCTGGCGATCGCCGACATGCTGCGCGAAGCGCCGGAGCATTATCGTGAGCTGCCGGCGT
TTTATCGGGAACGTCGCGATCTGTTTATTGAAGCGCTGCGCCCAAGCCGGCTGGAAATCCTGCCCTGTGAAGGGACCTAT
TTCCTGCTGGCGGACTACAGCGCCATCTCCGATCTAGACGATGTCAGCTTCTGCCGCTGGCTGACGACCGAAGTCGGGGT
AGCGGCGATCCCGCTCTCCGTCTTCTGCGCCGATCCGTTCCCGCACAAGCTGATCCGCTTGTGCTTCGCCAAACAGCCGG
CGACTCTGCTGGCTGCGGCGACGCGTTTGTGCCAGCTGTAG

Upstream 100 bases:

>100_bases
GAATAACATTAGCATTTAGACGTCTAAGCGTCTTGATTGCCAAATATTAACATCGTGTTATAGTGGCTTCAACAACAGCA
TTACAATCGGTATAAAAAGA

Downstream 100 bases:

>100_bases
TTACTTAATCGTCCACGCCTGGGAGAACTGGCGGCCGGCGAACATCTCTGTCAGGCCGCTAATTTGCTTCAGACGCAGCA
CTTCATCGGCATCCATCCCC

Product: putative aminotransferase

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MNNNPLIPESKLPALGTTIFTQMSALAQQHQAINLSQGFPDFDGPRYLQERLAYHVAQGANQYAPMTGVPALREAIAGKT
AELYGYQPDVNSEITVTAGATEALYAAITALVRRGDEVICFDPSYDSYAPAVALAGGELRRIALQPPHFRVDWRQFAAAL
SEKTRLVILNTPHNPSATVWQREDFAALWQAIAEREIYVLSDEVYEHICFAEGGHASVLAHPQLRERAVAVSSFGKTFHM
TGWKVGYCVAPAAISAELRKVHQYLTFSVNTPAQLAIADMLREAPEHYRELPAFYRERRDLFIEALRPSRLEILPCEGTY
FLLADYSAISDLDDVSFCRWLTTEVGVAAIPLSVFCADPFPHKLIRLCFAKQPATLLAAATRLCQL

Sequences:

>Translated_386_residues
MNNNPLIPESKLPALGTTIFTQMSALAQQHQAINLSQGFPDFDGPRYLQERLAYHVAQGANQYAPMTGVPALREAIAGKT
AELYGYQPDVNSEITVTAGATEALYAAITALVRRGDEVICFDPSYDSYAPAVALAGGELRRIALQPPHFRVDWRQFAAAL
SEKTRLVILNTPHNPSATVWQREDFAALWQAIAEREIYVLSDEVYEHICFAEGGHASVLAHPQLRERAVAVSSFGKTFHM
TGWKVGYCVAPAAISAELRKVHQYLTFSVNTPAQLAIADMLREAPEHYRELPAFYRERRDLFIEALRPSRLEILPCEGTY
FLLADYSAISDLDDVSFCRWLTTEVGVAAIPLSVFCADPFPHKLIRLCFAKQPATLLAAATRLCQL
>Mature_386_residues
MNNNPLIPESKLPALGTTIFTQMSALAQQHQAINLSQGFPDFDGPRYLQERLAYHVAQGANQYAPMTGVPALREAIAGKT
AELYGYQPDVNSEITVTAGATEALYAAITALVRRGDEVICFDPSYDSYAPAVALAGGELRRIALQPPHFRVDWRQFAAAL
SEKTRLVILNTPHNPSATVWQREDFAALWQAIAEREIYVLSDEVYEHICFAEGGHASVLAHPQLRERAVAVSSFGKTFHM
TGWKVGYCVAPAAISAELRKVHQYLTFSVNTPAQLAIADMLREAPEHYRELPAFYRERRDLFIEALRPSRLEILPCEGTY
FLLADYSAISDLDDVSFCRWLTTEVGVAAIPLSVFCADPFPHKLIRLCFAKQPATLLAAATRLCQL

Specific function: Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine [H]

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=399, Percent_Identity=33.5839598997494, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI56713256, Length=399, Percent_Identity=33.5839598997494, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI95147551, Length=408, Percent_Identity=31.6176470588235, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI169881279, Length=408, Percent_Identity=31.6176470588235, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI169881281, Length=406, Percent_Identity=27.0935960591133, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI4507369, Length=343, Percent_Identity=23.6151603498542, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1786816, Length=386, Percent_Identity=84.1968911917098, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1788722, Length=340, Percent_Identity=26.4705882352941, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788627, Length=263, Percent_Identity=23.574144486692, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=403, Percent_Identity=32.0099255583127, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71994472, Length=403, Percent_Identity=32.0099255583127, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17567369, Length=398, Percent_Identity=27.8894472361809, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17567663, Length=348, Percent_Identity=21.264367816092, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322401, Length=395, Percent_Identity=29.873417721519, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28573069, Length=401, Percent_Identity=32.6683291770574, Blast_Score=214, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24646114, Length=401, Percent_Identity=32.6683291770574, Blast_Score=214, Evalue=6e-56,
Organism=Drosophila melanogaster, GI28573067, Length=401, Percent_Identity=32.6683291770574, Blast_Score=214, Evalue=6e-56,
Organism=Drosophila melanogaster, GI28573065, Length=401, Percent_Identity=32.6683291770574, Blast_Score=214, Evalue=6e-56,
Organism=Drosophila melanogaster, GI18859735, Length=241, Percent_Identity=28.6307053941909, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 42814; Mature: 42814

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNPLIPESKLPALGTTIFTQMSALAQQHQAINLSQGFPDFDGPRYLQERLAYHVAQGA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHCC
NQYAPMTGVPALREAIAGKTAELYGYQPDVNSEITVTAGATEALYAAITALVRRGDEVIC
CCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEE
FDPSYDSYAPAVALAGGELRRIALQPPHFRVDWRQFAAALSEKTRLVILNTPHNPSATVW
ECCCCCCCCCEEEECCCCEEEEEECCCCCEECHHHHHHHHCCCCEEEEEECCCCCCCCEE
QREDFAALWQAIAEREIYVLSDEVYEHICFAEGGHASVLAHPQLRERAVAVSSFGKTFHM
ECHHHHHHHHHHHCCCEEEECHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCEEEE
TGWKVGYCVAPAAISAELRKVHQYLTFSVNTPAQLAIADMLREAPEHYRELPAFYRERRD
CCCEEEEEECCHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFIEALRPSRLEILPCEGTYFLLADYSAISDLDDVSFCRWLTTEVGVAAIPLSVFCADPF
HHHHHCCCCCEEEEECCCCEEEEECCHHHCCCCHHHHHHHHHHHCCHHHCCCEEEECCCC
PHKLIRLCFAKQPATLLAAATRLCQL
HHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNNNPLIPESKLPALGTTIFTQMSALAQQHQAINLSQGFPDFDGPRYLQERLAYHVAQGA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHCC
NQYAPMTGVPALREAIAGKTAELYGYQPDVNSEITVTAGATEALYAAITALVRRGDEVIC
CCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEE
FDPSYDSYAPAVALAGGELRRIALQPPHFRVDWRQFAAALSEKTRLVILNTPHNPSATVW
ECCCCCCCCCEEEECCCCEEEEEECCCCCEECHHHHHHHHCCCCEEEEEECCCCCCCCEE
QREDFAALWQAIAEREIYVLSDEVYEHICFAEGGHASVLAHPQLRERAVAVSSFGKTFHM
ECHHHHHHHHHHHCCCEEEECHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCEEEE
TGWKVGYCVAPAAISAELRKVHQYLTFSVNTPAQLAIADMLREAPEHYRELPAFYRERRD
CCCEEEEEECCHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFIEALRPSRLEILPCEGTYFLLADYSAISDLDDVSFCRWLTTEVGVAAIPLSVFCADPF
HHHHHCCCCCEEEEECCCCEEEEECCHHHCCCCHHHHHHHHHHHCCHHHCCCEEEECCCC
PHKLIRLCFAKQPATLLAAATRLCQL
HHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]