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The map label for this gene is dmsA [H]

Identifier: 238893675

GI number: 238893675

Start: 1538400

End: 1540709

Strand: Direct

Name: dmsA [H]

Synonym: KP1_1593

Alternate gene names: 238893675

Gene position: 1538400-1540709 (Clockwise)

Preceding gene: 238893669

Following gene: 238893678

Centisome position: 29.31

GC content: 64.16

Gene sequence:

>2310_bases
ATGAAGAAACAGCATAATTATACGGTGATGCACTGGGGAACCTGGCAGGTGGAGAGCAGTGAGGGCGAGATCGTGGCGGT
TAAGCCGGTGCCCTGGGATAAAAATCCCTCACGCATCGGCCAGTCGCTTCCCGACGCGGTGACCAGCCAAACGCGCATTC
GCCGTCCGGCGGTGCGCGCCGGCTATCTCCAGCACGGGCCGGCGTCACGAGAAGGGCGAGGTAAAGAGCCCTTTGTCGAA
GTCAGCTGGGAGGTGGCCCTGGACCTGCTGGCGCGCGAGCTGCGCTCGGTCAAGGCGCGCTGCGGCAATGAGGCGATCTA
CGGCGGCTCCTACGGCTGGGCCAGCGCTGGACGCTTTCACCATGCGCAGAGCCAGCTGCACCGGTTTCTCAAGGGCCTTG
GCGGGTACACCGCCAGCACCAATACCTATAGCAGCGCCGCGGGCGAGCGTATTCTGCCGCATATTCTCGGGCCGCTGAGC
CCGCTGCACCGGCAGCATACCCATTTTTCCGAGCTGGCCCGGGAGTGTCAGCTGTTTGTCGCCATTGGTGGTCTGCCGCT
GCGCAATGCCCAGGTCAACGGCGGCGGCGCCAATGACCATATGCTCCAGTACTGGCTGGATAAGATGCAGGCCAACGGCA
CGCGGTTTATCAATATCAGTCCGGTGCGCAATGACCTCAGCGCGGTGCCCGACGCCGAGTGGCTGGCCATTCGGCCGGGC
ACCGATACCGCACTGCTGCTGGCCCTGAGCTATGTGCTGATCGCTGAGTCCCTTTACGACCAGGCGTTTGTTGCCAGCCA
TACCGTCGGGTTTGCCCCCTATCGCGCTTATCTGTTGGGCGAGCACGATGGCGTAGCGAAAACCCCGGCGTGGGCGGCGG
CGATTACCGGCCTGGACGCCCAGCGCATCGCCGACCTGGCGCGGGAGATGGCCCGCCACCGGACGATGGTGAATATCTCC
TGGTCTATCCAGCGCGCCCGTCAAGGGGAGCAGGCCTACTGGGCGACGGTGGCCCTGACCGCGCTGCTGGGACAGCTCGG
CACCCCGGGCGGCGGCCTCGGGTTTGGCTACGCCTGCACCAACCTGGCGGGCGCGGTGCGAAAAGCGTTTTCCGGCCCGC
GCTTACCCGCCGGAGAGAATGCGGTGGACAGCGTTATCCCGGTGGCGCGGCTGTCCGATATGCTGCTGCACCCGGGAGAA
ACCTATGAGTTCGACGGCCAGCAGCGGCGCTATCCCGATATCCGTTTAGTCTACTGGGCGGGAGGCAATGCGTTTCATCA
TCATCAGGACATCAACCGACTGTGCGAGGCCTGGCGCCGCCCGGAGACGGTGGTGGTGCATGAGCAGTACTGGACCGCGC
AGGCCAAATTCTCCGATATCGTTCTGCCGGCCACCACCTCGCTGGAGCGAGAGGATATCGGCAGCGGCGGTCACGACGGG
TTTATGATCGCCATGAGCGCGCAGATCCCGCCGGTGGGCGAGGCGCGTGACGATTACGCTATTTTCTGCGATCTCGCCGA
TCGGCTGGGATTCGGAGAAGCGTTCAGCGAAGGGCGGGACGCCGGGCAGTGGCTGCGTCATCTCTATGAGGAGTCAAGAC
CGCGGGCGCAGGAGGAGGGTATTGCGCTGCCCTCGTTCGATGACTTCTGGCAGCAAGGGGTGCTGGAATACAGCGCGCCG
GAGCGGCCGCAAATTTTTCTCGCCGATTTTCGCGCCGATCCTGAGCGCTATCCGCTTTCCACGCCCTCCGGCAAAATTGA
ACTCTTTTCCGCCACCGTCGCCGGGTTTGGCTATCGCGAATGCCCTGGCCATCCGTGGTGGGATGAACAGGAGGCCGCCC
GCCAGCGGCAGGAGGCGGCGCGCTGGCCGCTTCATCTGCTCTCCAGCCAGCCGCGCGCCCGCCTGCACAGTCAGTACGAC
CACGGCAGCGTCAGCCGGGCGACGAAAGTTCAGGGACGCGAGCCGCTGTGGATGCATCCGAGCGATGCGCAGGCAAGAGA
CATCCGCGAAGGCAGCGTGGTGAAGGTCTATAACGACCGCGGGGCGATTCTGGCGGGCGTGCACCTGAGCGAGCAGATTT
TGCCCGGCGTGGTACAGATGTCCACCGGCGCCTGGTATGACCCGCTGGATCCCAATGAAAAAGGAACGCTCGATAAGCAC
GGTAATCCCAACGTGTTAACCGAGGATCGCGGCAGTTCGCGCCTGGGGCAGGGCTGTAGCGCCCAGAGCTGCTGGGTGGA
GATCGCCCCGTGGCGAGAGGAGCTGCCGCCGATCACTGCCTTTGATCCGCCGAAATTTATTGAAGTTTAG

Upstream 100 bases:

>100_bases
AAGCTTTTTTTAGCAGAGCAATGTCTGGCCGGGTAAGGATTATTACCCTATTTCCCCGCTTTATTGTAATGAACCTTAAG
CTGAGAAGAACGCGGGCGCT

Downstream 100 bases:

>100_bases
GCGTTGGCGCTCGCCGGCGGCGGGGCGGGTAGCCCGGAGAAGGCGCGGTATGCGCCGCCTCTGGCAAAGCCCGCGCCTGG
CGGTTTTAGACTGACGACAG

Product: biotin sulfoxide reductase

Products: Biotin [C]

Alternate protein names: DMSO reductase; DMSOR [H]

Number of amino acids: Translated: 769; Mature: 769

Protein sequence:

>769_residues
MKKQHNYTVMHWGTWQVESSEGEIVAVKPVPWDKNPSRIGQSLPDAVTSQTRIRRPAVRAGYLQHGPASREGRGKEPFVE
VSWEVALDLLARELRSVKARCGNEAIYGGSYGWASAGRFHHAQSQLHRFLKGLGGYTASTNTYSSAAGERILPHILGPLS
PLHRQHTHFSELARECQLFVAIGGLPLRNAQVNGGGANDHMLQYWLDKMQANGTRFINISPVRNDLSAVPDAEWLAIRPG
TDTALLLALSYVLIAESLYDQAFVASHTVGFAPYRAYLLGEHDGVAKTPAWAAAITGLDAQRIADLAREMARHRTMVNIS
WSIQRARQGEQAYWATVALTALLGQLGTPGGGLGFGYACTNLAGAVRKAFSGPRLPAGENAVDSVIPVARLSDMLLHPGE
TYEFDGQQRRYPDIRLVYWAGGNAFHHHQDINRLCEAWRRPETVVVHEQYWTAQAKFSDIVLPATTSLEREDIGSGGHDG
FMIAMSAQIPPVGEARDDYAIFCDLADRLGFGEAFSEGRDAGQWLRHLYEESRPRAQEEGIALPSFDDFWQQGVLEYSAP
ERPQIFLADFRADPERYPLSTPSGKIELFSATVAGFGYRECPGHPWWDEQEAARQRQEAARWPLHLLSSQPRARLHSQYD
HGSVSRATKVQGREPLWMHPSDAQARDIREGSVVKVYNDRGAILAGVHLSEQILPGVVQMSTGAWYDPLDPNEKGTLDKH
GNPNVLTEDRGSSRLGQGCSAQSCWVEIAPWREELPPITAFDPPKFIEV

Sequences:

>Translated_769_residues
MKKQHNYTVMHWGTWQVESSEGEIVAVKPVPWDKNPSRIGQSLPDAVTSQTRIRRPAVRAGYLQHGPASREGRGKEPFVE
VSWEVALDLLARELRSVKARCGNEAIYGGSYGWASAGRFHHAQSQLHRFLKGLGGYTASTNTYSSAAGERILPHILGPLS
PLHRQHTHFSELARECQLFVAIGGLPLRNAQVNGGGANDHMLQYWLDKMQANGTRFINISPVRNDLSAVPDAEWLAIRPG
TDTALLLALSYVLIAESLYDQAFVASHTVGFAPYRAYLLGEHDGVAKTPAWAAAITGLDAQRIADLAREMARHRTMVNIS
WSIQRARQGEQAYWATVALTALLGQLGTPGGGLGFGYACTNLAGAVRKAFSGPRLPAGENAVDSVIPVARLSDMLLHPGE
TYEFDGQQRRYPDIRLVYWAGGNAFHHHQDINRLCEAWRRPETVVVHEQYWTAQAKFSDIVLPATTSLEREDIGSGGHDG
FMIAMSAQIPPVGEARDDYAIFCDLADRLGFGEAFSEGRDAGQWLRHLYEESRPRAQEEGIALPSFDDFWQQGVLEYSAP
ERPQIFLADFRADPERYPLSTPSGKIELFSATVAGFGYRECPGHPWWDEQEAARQRQEAARWPLHLLSSQPRARLHSQYD
HGSVSRATKVQGREPLWMHPSDAQARDIREGSVVKVYNDRGAILAGVHLSEQILPGVVQMSTGAWYDPLDPNEKGTLDKH
GNPNVLTEDRGSSRLGQGCSAQSCWVEIAPWREELPPITAFDPPKFIEV
>Mature_769_residues
MKKQHNYTVMHWGTWQVESSEGEIVAVKPVPWDKNPSRIGQSLPDAVTSQTRIRRPAVRAGYLQHGPASREGRGKEPFVE
VSWEVALDLLARELRSVKARCGNEAIYGGSYGWASAGRFHHAQSQLHRFLKGLGGYTASTNTYSSAAGERILPHILGPLS
PLHRQHTHFSELARECQLFVAIGGLPLRNAQVNGGGANDHMLQYWLDKMQANGTRFINISPVRNDLSAVPDAEWLAIRPG
TDTALLLALSYVLIAESLYDQAFVASHTVGFAPYRAYLLGEHDGVAKTPAWAAAITGLDAQRIADLAREMARHRTMVNIS
WSIQRARQGEQAYWATVALTALLGQLGTPGGGLGFGYACTNLAGAVRKAFSGPRLPAGENAVDSVIPVARLSDMLLHPGE
TYEFDGQQRRYPDIRLVYWAGGNAFHHHQDINRLCEAWRRPETVVVHEQYWTAQAKFSDIVLPATTSLEREDIGSGGHDG
FMIAMSAQIPPVGEARDDYAIFCDLADRLGFGEAFSEGRDAGQWLRHLYEESRPRAQEEGIALPSFDDFWQQGVLEYSAP
ERPQIFLADFRADPERYPLSTPSGKIELFSATVAGFGYRECPGHPWWDEQEAARQRQEAARWPLHLLSSQPRARLHSQYD
HGSVSRATKVQGREPLWMHPSDAQARDIREGSVVKVYNDRGAILAGVHLSEQILPGVVQMSTGAWYDPLDPNEKGTLDKH
GNPNVLTEDRGSSRLGQGCSAQSCWVEIAPWREELPPITAFDPPKFIEV

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081994, Length=778, Percent_Identity=37.146529562982, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI145693196, Length=771, Percent_Identity=39.2996108949416, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1787231, Length=788, Percent_Identity=38.9593908629442, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI87081797, Length=752, Percent_Identity=31.781914893617, Blast_Score=316, Evalue=4e-87,
Organism=Escherichia coli, GI1787870, Length=748, Percent_Identity=30.8823529411765, Blast_Score=286, Evalue=4e-78,
Organism=Escherichia coli, GI171474008, Length=752, Percent_Identity=30.186170212766, Blast_Score=282, Evalue=5e-77,
Organism=Escherichia coli, GI3868721, Length=478, Percent_Identity=24.6861924686192, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.7.2.3 [C]

Molecular weight: Translated: 85235; Mature: 85235

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQHNYTVMHWGTWQVESSEGEIVAVKPVPWDKNPSRIGQSLPDAVTSQTRIRRPAVRA
CCCCCCEEEEEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHCHHHHHHHHHHHCCHHHH
GYLQHGPASREGRGKEPFVEVSWEVALDLLARELRSVKARCGNEAIYGGSYGWASAGRFH
CCHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHH
HAQSQLHRFLKGLGGYTASTNTYSSAAGERILPHILGPLSPLHRQHTHFSELARECQLFV
HHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEE
AIGGLPLRNAQVNGGGANDHMLQYWLDKMQANGTRFINISPVRNDLSAVPDAEWLAIRPG
EECCCEECCCEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCEEEEECC
TDTALLLALSYVLIAESLYDQAFVASHTVGFAPYRAYLLGEHDGVAKTPAWAAAITGLDA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCH
QRIADLAREMARHRTMVNISWSIQRARQGEQAYWATVALTALLGQLGTPGGGLGFGYACT
HHHHHHHHHHHHCCEEEEEEEEHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
NLAGAVRKAFSGPRLPAGENAVDSVIPVARLSDMLLHPGETYEFDGQQRRYPDIRLVYWA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEE
GGNAFHHHQDINRLCEAWRRPETVVVHEQYWTAQAKFSDIVLPATTSLEREDIGSGGHDG
CCCCCHHHHHHHHHHHHHCCCCEEEEECCHHCCCCCCCCEEECCCCCCCHHHCCCCCCCC
FMIAMSAQIPPVGEARDDYAIFCDLADRLGFGEAFSEGRDAGQWLRHLYEESRPRAQEEG
EEEEEECCCCCCCCCCCCCEEEEEHHHHCCCCHHHHCCCCHHHHHHHHHHHCCCCHHHCC
IALPSFDDFWQQGVLEYSAPERPQIFLADFRADPERYPLSTPSGKIELFSATVAGFGYRE
CCCCCHHHHHHHCCEECCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHCCCCCC
CPGHPWWDEQEAARQRQEAARWPLHLLSSQPRARLHSQYDHGSVSRATKVQGREPLWMHP
CCCCCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHCCCCCCCCCHHHHCCCCCCCEECC
SDAQARDIREGSVVKVYNDRGAILAGVHLSEQILPGVVQMSTGAWYDPLDPNEKGTLDKH
CCCCHHHCCCCCEEEEECCCCCEEEECCHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCC
GNPNVLTEDRGSSRLGQGCSAQSCWVEIAPWREELPPITAFDPPKFIEV
CCCCEEECCCCCHHHCCCCCCCCCEEEECCCHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKQHNYTVMHWGTWQVESSEGEIVAVKPVPWDKNPSRIGQSLPDAVTSQTRIRRPAVRA
CCCCCCEEEEEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHCHHHHHHHHHHHCCHHHH
GYLQHGPASREGRGKEPFVEVSWEVALDLLARELRSVKARCGNEAIYGGSYGWASAGRFH
CCHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHH
HAQSQLHRFLKGLGGYTASTNTYSSAAGERILPHILGPLSPLHRQHTHFSELARECQLFV
HHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEE
AIGGLPLRNAQVNGGGANDHMLQYWLDKMQANGTRFINISPVRNDLSAVPDAEWLAIRPG
EECCCEECCCEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCEEEEECC
TDTALLLALSYVLIAESLYDQAFVASHTVGFAPYRAYLLGEHDGVAKTPAWAAAITGLDA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCH
QRIADLAREMARHRTMVNISWSIQRARQGEQAYWATVALTALLGQLGTPGGGLGFGYACT
HHHHHHHHHHHHCCEEEEEEEEHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
NLAGAVRKAFSGPRLPAGENAVDSVIPVARLSDMLLHPGETYEFDGQQRRYPDIRLVYWA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEE
GGNAFHHHQDINRLCEAWRRPETVVVHEQYWTAQAKFSDIVLPATTSLEREDIGSGGHDG
CCCCCHHHHHHHHHHHHHCCCCEEEEECCHHCCCCCCCCEEECCCCCCCHHHCCCCCCCC
FMIAMSAQIPPVGEARDDYAIFCDLADRLGFGEAFSEGRDAGQWLRHLYEESRPRAQEEG
EEEEEECCCCCCCCCCCCCEEEEEHHHHCCCCHHHHCCCCHHHHHHHHHHHCCCCHHHCC
IALPSFDDFWQQGVLEYSAPERPQIFLADFRADPERYPLSTPSGKIELFSATVAGFGYRE
CCCCCHHHHHHHCCEECCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHCCCCCC
CPGHPWWDEQEAARQRQEAARWPLHLLSSQPRARLHSQYDHGSVSRATKVQGREPLWMHP
CCCCCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHCCCCCCCCCHHHHCCCCCCCEECC
SDAQARDIREGSVVKVYNDRGAILAGVHLSEQILPGVVQMSTGAWYDPLDPNEKGTLDKH
CCCCHHHCCCCCEEEEECCCCCEEEECCHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCC
GNPNVLTEDRGSSRLGQGCSAQSCWVEIAPWREELPPITAFDPPKFIEV
CCCCEEECCCCCHHHCCCCCCCCCEEEECCCHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds) [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8645727; 8534974; 7625833; 8658134 [H]