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The map label for this gene is mscM [H]

Identifier: 238893619

GI number: 238893619

Start: 1474040

End: 1475296

Strand: Direct

Name: mscM [H]

Synonym: KP1_1533

Alternate gene names: 238893619

Gene position: 1474040-1475296 (Clockwise)

Preceding gene: 238893617

Following gene: 238893621

Centisome position: 28.08

GC content: 53.62

Gene sequence:

>1257_bases
ATGGCGTATGTGAATCATCTACTGACGTTTATTGAGAGTAATCCGGCGCTGGCGGTGGGGTTTAATCTTATTCTGCTGCT
GCTCTCCGGCATATTTGCCCATCTTTTATGCAAGTTCTTGCTGATTAAAGTGGTGCGTAAGGTCTTCTTTAGTAGCCACA
AACAGGATGTGCCGCTGGAGAAGGATCGACGCATCGCCGAAAAGCTGTCCAATTTCATTCCGGTTATTATCGTCTATTAC
GTTCTGCAGTTTATGCCGGCGATGCCGGCATCGCTGGTGACGGCGATTAATACTATCTGCGGGATCTTGTTTTTTATTTT
TATGTCGTTGTTTTTCAACGAGATGCTGGATATTGTCAACAGCTCCTATCTGCGAAAGACCAAACGTAAAAATCATTCCA
TTAAGGGCTATATCCAGATAGGCAAAATCTTAGTCCACATCCTGGCGGCGATTATGATCCTCGCCGTGATGTCGAACAAA
TCGCCGATCATTATCATCTCCAGTCTGGGGGCCGTGGCGGCGGTACTGATGATCGTGTTCCAGCATACTCTGCTGTCGCT
GGTGGCGAACGTTCAGCTGTCGTCCAACGACGTGCTCCAGCTGGGGGACTGGATTGAAATGCCTGACAAGAACCTCAGCG
GTGAGGTGACGGATATCGCGCTGCACACCATTACCATCCGTAACTGGGACAATACCATCTCCCGTATCCCGACCAAGAAT
TTCCTCACCGAGACCTATACCAACTGGCAGGCGATGTTCTCCTCCGGGGCGCGGCGGATCATGCGCAGTATCGCCATCGA
TCAACACTCGGTGCGTTTTCTCGACCAGGAGATGCTCTCCTCGATGCTGACCATCCGCGGGGTGAGTGAGCCTCTGGCGA
CGCTGCTTGACGGCCGGGATCCCGGCGGCGTGGCCGACCGCTGGTTTATCGATAACGGGCTGACCAACCTGACCCTGTTT
CGCCACTATCTGATGCACTATCTCGCCGAGCGGCCGGATATTATTAAGGAGATGTACATTGTAGCGAGAACGCTGAAACC
GTCGCCGTCGGGTATCCCGCTGGAGATTTACTGCTTCACCTCCTCGACGCTGTGGAAAGACTACGAAAACACCCAGTCGG
CGATATTTGAGTACATTACCGCGGTGGCCGGACAGTTTTCCCTGCGCCTCTATCAGTATCCCGCCGGGCACGATTTCTGG
CGTCTCTCCCAGGAGCACGCCGCCCGGACGGGCCTGCCGCCGTCGGCCGAAGGCTAA

Upstream 100 bases:

>100_bases
GCTAAGCGATATGCCATGATGCGGATTGATTTATTTTCCAAATATATGCCCTTGGGATAAAGCAGTTAGCGAAGTGGCAT
AGTTATTCAGGCGATAAAGC

Downstream 100 bases:

>100_bases
GCGCTGATCTGCTGGCGCCAGAGGGCGATCTCCTCCTCCAGCCAGGCGATGAACCGGGCGACTTCCGGCCGGTTCTCCGC
CTGCGGGGAGACGGTTAGCC

Product: putative MscS mechanosensitive ion channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MAYVNHLLTFIESNPALAVGFNLILLLLSGIFAHLLCKFLLIKVVRKVFFSSHKQDVPLEKDRRIAEKLSNFIPVIIVYY
VLQFMPAMPASLVTAINTICGILFFIFMSLFFNEMLDIVNSSYLRKTKRKNHSIKGYIQIGKILVHILAAIMILAVMSNK
SPIIIISSLGAVAAVLMIVFQHTLLSLVANVQLSSNDVLQLGDWIEMPDKNLSGEVTDIALHTITIRNWDNTISRIPTKN
FLTETYTNWQAMFSSGARRIMRSIAIDQHSVRFLDQEMLSSMLTIRGVSEPLATLLDGRDPGGVADRWFIDNGLTNLTLF
RHYLMHYLAERPDIIKEMYIVARTLKPSPSGIPLEIYCFTSSTLWKDYENTQSAIFEYITAVAGQFSLRLYQYPAGHDFW
RLSQEHAARTGLPPSAEG

Sequences:

>Translated_418_residues
MAYVNHLLTFIESNPALAVGFNLILLLLSGIFAHLLCKFLLIKVVRKVFFSSHKQDVPLEKDRRIAEKLSNFIPVIIVYY
VLQFMPAMPASLVTAINTICGILFFIFMSLFFNEMLDIVNSSYLRKTKRKNHSIKGYIQIGKILVHILAAIMILAVMSNK
SPIIIISSLGAVAAVLMIVFQHTLLSLVANVQLSSNDVLQLGDWIEMPDKNLSGEVTDIALHTITIRNWDNTISRIPTKN
FLTETYTNWQAMFSSGARRIMRSIAIDQHSVRFLDQEMLSSMLTIRGVSEPLATLLDGRDPGGVADRWFIDNGLTNLTLF
RHYLMHYLAERPDIIKEMYIVARTLKPSPSGIPLEIYCFTSSTLWKDYENTQSAIFEYITAVAGQFSLRLYQYPAGHDFW
RLSQEHAARTGLPPSAEG
>Mature_417_residues
AYVNHLLTFIESNPALAVGFNLILLLLSGIFAHLLCKFLLIKVVRKVFFSSHKQDVPLEKDRRIAEKLSNFIPVIIVYYV
LQFMPAMPASLVTAINTICGILFFIFMSLFFNEMLDIVNSSYLRKTKRKNHSIKGYIQIGKILVHILAAIMILAVMSNKS
PIIIISSLGAVAAVLMIVFQHTLLSLVANVQLSSNDVLQLGDWIEMPDKNLSGEVTDIALHTITIRNWDNTISRIPTKNF
LTETYTNWQAMFSSGARRIMRSIAIDQHSVRFLDQEMLSSMLTIRGVSEPLATLLDGRDPGGVADRWFIDNGLTNLTLFR
HYLMHYLAERPDIIKEMYIVARTLKPSPSGIPLEIYCFTSSTLWKDYENTQSAIFEYITAVAGQFSLRLYQYPAGHDFWR
LSQEHAARTGLPPSAEG

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=387, Percent_Identity=34.625322997416, Blast_Score=236, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 47269; Mature: 47138

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYVNHLLTFIESNPALAVGFNLILLLLSGIFAHLLCKFLLIKVVRKVFFSSHKQDVPLE
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
KDRRIAEKLSNFIPVIIVYYVLQFMPAMPASLVTAINTICGILFFIFMSLFFNEMLDIVN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSYLRKTKRKNHSIKGYIQIGKILVHILAAIMILAVMSNKSPIIIISSLGAVAAVLMIVF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHH
QHTLLSLVANVQLSSNDVLQLGDWIEMPDKNLSGEVTDIALHTITIRNWDNTISRIPTKN
HHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCHHEEEEEEEEEECCHHHHHHCCCHH
FLTETYTNWQAMFSSGARRIMRSIAIDQHSVRFLDQEMLSSMLTIRGVSEPLATLLDGRD
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
PGGVADRWFIDNGLTNLTLFRHYLMHYLAERPDIIKEMYIVARTLKPSPSGIPLEIYCFT
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEC
SSTLWKDYENTQSAIFEYITAVAGQFSLRLYQYPAGHDFWRLSQEHAARTGLPPSAEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHCCHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AYVNHLLTFIESNPALAVGFNLILLLLSGIFAHLLCKFLLIKVVRKVFFSSHKQDVPLE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
KDRRIAEKLSNFIPVIIVYYVLQFMPAMPASLVTAINTICGILFFIFMSLFFNEMLDIVN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSYLRKTKRKNHSIKGYIQIGKILVHILAAIMILAVMSNKSPIIIISSLGAVAAVLMIVF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHH
QHTLLSLVANVQLSSNDVLQLGDWIEMPDKNLSGEVTDIALHTITIRNWDNTISRIPTKN
HHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCHHEEEEEEEEEECCHHHHHHCCCHH
FLTETYTNWQAMFSSGARRIMRSIAIDQHSVRFLDQEMLSSMLTIRGVSEPLATLLDGRD
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
PGGVADRWFIDNGLTNLTLFRHYLMHYLAERPDIIKEMYIVARTLKPSPSGIPLEIYCFT
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEC
SSTLWKDYENTQSAIFEYITAVAGQFSLRLYQYPAGHDFWRLSQEHAARTGLPPSAEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]