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The map label for this gene is betT [H]

Identifier: 238893617

GI number: 238893617

Start: 1471290

End: 1473323

Strand: Direct

Name: betT [H]

Synonym: KP1_1531

Alternate gene names: 238893617

Gene position: 1471290-1473323 (Clockwise)

Preceding gene: 238893613

Following gene: 238893619

Centisome position: 28.03

GC content: 59.78

Gene sequence:

>2034_bases
ATGACAGATCTTTCGCAAAGCAGAGAAAAGGACAAAATCAATCCGGTGGTTTTTTATACCTCGGCCGGACTGATTTTGTT
GTTTTCCCTGATGACGATCTTTTTTCGCGATTTTTCTGCCGAGTGGATTGGGCGCACCCTGGACTGGGTGTCGAAAACCT
TCGGCTGGTACTATCTGCTGGCGGCGACGCTGTATATCGTCTTCGTCGTCTGCATTGCCTGCTCGCGCTTCGGCTCGGTG
AAGCTCGGGCCGGAGCAGTCAAAGCCCGAGTTCAGCCTGCTGAGCTGGGCGGCGATGCTGTTCGCCGCCGGCATCGGCAT
CGACCTGATGTTCTTCTCGGTCGCCGAGCCGGTGACGCAATATATGCAGCCGCCGGAAGGGGCGGGGCAGACCATCGAAG
CGGCGCGCCAGGCGATGGTCTGGACCCTGTTTCACTATGGCTTAACCGGATGGTCAATGTATGCCCTGATGGGCATGGCG
CTGGGATACTTTAGCTATCGTTATAATTTGCCTCTCACCATCCGCTCGGCGCTGTACCCGATTTTTGGCAAACGGATCAA
TGGGCCCATCGGCCACAGCGTCGATATTGCGGCGGTGATCGGCACCATCTTCGGCATCGCCACCACCCTCGGTATCGGCG
TCGTGCAGCTCAACTACGGTCTGAGCGTGCTGTTCGATATTCCGGACTCGCTGGCGGCGAAAGCGGCCCTGATTGCGCTG
TCGGTGATCATCGCCACCATCTCGGTCACCTCCGGGGTGGACAAGGGCATCCGCGTGCTCTCCGAGCTGAACGTCGCCCT
CGCGCTGGGGCTGATCCTGTTCGTGCTGTTCATGGGCGATACCTCCTTCCTGCTCAATGCGTTAGTGCTCAACGTCGGCG
ACTACGTCAATCGCTTTATGGGCATGACGCTGAACAGCTTCGCCTTCGACCGGCCGGTAGAATGGATGAACAACTGGACG
CTCTTTTTCTGGGCGTGGTGGGTGGCCTGGTCGCCGTTTGTGGGCCTGTTCCTGGCGCGCATTTCGCGCGGGCGCACCAT
CCGCCAGTTTGTGATGGGCACCCTGATTATTCCCTTCACCTTTACCCTGCTGTGGCTGTCGGTGTTCGGCAACAGCGCGC
TGTATGAGATCATCCACGGCGACGCGGCCTTTGCCCAGGAGGCGATGGCCCACCCGGAGCGCGGCTTCTACAGCCTGCTG
GCGCAGTATCCGGCGTTTACCTTTAGCGCGTCGGTGGCGACCATCACCGGTCTGCTGTTTTACGTTACCTCCGCCGACTC
CGGCGCGCTGGTGCTGGGGAATTTCACCTCGAAGCTGAAGGACATCAACAGCGACGCCCCGAACTGGCTGCGCATCTTCT
GGTCGGTGGCCATCGGTCTGTTGACCCTCGGGATGCTGATGACCAACGGCATCTCGGCGCTGCAGAACACCACGGTGATC
ATGGGGCTGCCGTTCAGCTTTGTGATTTTCTTCGTGATGGCCGGACTGTATAAATCTCTGAAAGTGGAAGATTACCGCCG
GGTCAGCGCCAGCCGCGACACCGCCCCGCGCCCGATGGGCCTCCAGGATCGTCTGAGCTGGAAGAAGCGCCTGTCGCGGC
TGATGAATTACCCCGGCACGCGCTATACCAAACTGATGATGGAGACGGTGTGCTACCCGGCGATGGAGGAGGTGGCCCAG
GAGCTGCGGCTGCGCGGCGCGGCGGTGGAACTGAAGAGCCTGCCGCCGGAAGAGGGTGAGAACCTTGGCCACCTCGATCT
GCTGGTGCACATGGGCGACGAGCAGAACTTTATCTACAAGATCTGGCCGCAGCAGTACTCGGTGCCGGGCTTTACCTATC
GGGCGCGCAGCGGGAAATCCACCTATTACCGGCTGGAGACCTTCCTGCTGGAGGGCAGTCAGGGTAACGACCTGATGGAC
TACAGCAAAGAGCAGGTGATCACCGATATTCTCGACCAGTACGAGCGGCACCTGAACTTTATCCATCTGCATCGGGAAGC
GCCGGGGAACAGCGTGATGTTCCCGGATGGCTAA

Upstream 100 bases:

>100_bases
TAACTATTAAAGCGGTTTTTGATTGGACGTTCAATATAAAATGTGTCTTAATTGTTGCGGATTTGGATTTTAATAGTTAC
AAAAACAGTGGGGATACTGG

Downstream 100 bases:

>100_bases
TCAGGGAAGCCCCCGTCGGGGAAAGGCTGACGGGGGCGATGGTCGTTACTGGTAGTTAAAGGCGTCCGGGTGGTTGTCGA
GGCTGCCGCTGAGGGCGGCA

Product: choline transport protein BetT

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 677; Mature: 676

Protein sequence:

>677_residues
MTDLSQSREKDKINPVVFYTSAGLILLFSLMTIFFRDFSAEWIGRTLDWVSKTFGWYYLLAATLYIVFVVCIACSRFGSV
KLGPEQSKPEFSLLSWAAMLFAAGIGIDLMFFSVAEPVTQYMQPPEGAGQTIEAARQAMVWTLFHYGLTGWSMYALMGMA
LGYFSYRYNLPLTIRSALYPIFGKRINGPIGHSVDIAAVIGTIFGIATTLGIGVVQLNYGLSVLFDIPDSLAAKAALIAL
SVIIATISVTSGVDKGIRVLSELNVALALGLILFVLFMGDTSFLLNALVLNVGDYVNRFMGMTLNSFAFDRPVEWMNNWT
LFFWAWWVAWSPFVGLFLARISRGRTIRQFVMGTLIIPFTFTLLWLSVFGNSALYEIIHGDAAFAQEAMAHPERGFYSLL
AQYPAFTFSASVATITGLLFYVTSADSGALVLGNFTSKLKDINSDAPNWLRIFWSVAIGLLTLGMLMTNGISALQNTTVI
MGLPFSFVIFFVMAGLYKSLKVEDYRRVSASRDTAPRPMGLQDRLSWKKRLSRLMNYPGTRYTKLMMETVCYPAMEEVAQ
ELRLRGAAVELKSLPPEEGENLGHLDLLVHMGDEQNFIYKIWPQQYSVPGFTYRARSGKSTYYRLETFLLEGSQGNDLMD
YSKEQVITDILDQYERHLNFIHLHREAPGNSVMFPDG

Sequences:

>Translated_677_residues
MTDLSQSREKDKINPVVFYTSAGLILLFSLMTIFFRDFSAEWIGRTLDWVSKTFGWYYLLAATLYIVFVVCIACSRFGSV
KLGPEQSKPEFSLLSWAAMLFAAGIGIDLMFFSVAEPVTQYMQPPEGAGQTIEAARQAMVWTLFHYGLTGWSMYALMGMA
LGYFSYRYNLPLTIRSALYPIFGKRINGPIGHSVDIAAVIGTIFGIATTLGIGVVQLNYGLSVLFDIPDSLAAKAALIAL
SVIIATISVTSGVDKGIRVLSELNVALALGLILFVLFMGDTSFLLNALVLNVGDYVNRFMGMTLNSFAFDRPVEWMNNWT
LFFWAWWVAWSPFVGLFLARISRGRTIRQFVMGTLIIPFTFTLLWLSVFGNSALYEIIHGDAAFAQEAMAHPERGFYSLL
AQYPAFTFSASVATITGLLFYVTSADSGALVLGNFTSKLKDINSDAPNWLRIFWSVAIGLLTLGMLMTNGISALQNTTVI
MGLPFSFVIFFVMAGLYKSLKVEDYRRVSASRDTAPRPMGLQDRLSWKKRLSRLMNYPGTRYTKLMMETVCYPAMEEVAQ
ELRLRGAAVELKSLPPEEGENLGHLDLLVHMGDEQNFIYKIWPQQYSVPGFTYRARSGKSTYYRLETFLLEGSQGNDLMD
YSKEQVITDILDQYERHLNFIHLHREAPGNSVMFPDG
>Mature_676_residues
TDLSQSREKDKINPVVFYTSAGLILLFSLMTIFFRDFSAEWIGRTLDWVSKTFGWYYLLAATLYIVFVVCIACSRFGSVK
LGPEQSKPEFSLLSWAAMLFAAGIGIDLMFFSVAEPVTQYMQPPEGAGQTIEAARQAMVWTLFHYGLTGWSMYALMGMAL
GYFSYRYNLPLTIRSALYPIFGKRINGPIGHSVDIAAVIGTIFGIATTLGIGVVQLNYGLSVLFDIPDSLAAKAALIALS
VIIATISVTSGVDKGIRVLSELNVALALGLILFVLFMGDTSFLLNALVLNVGDYVNRFMGMTLNSFAFDRPVEWMNNWTL
FFWAWWVAWSPFVGLFLARISRGRTIRQFVMGTLIIPFTFTLLWLSVFGNSALYEIIHGDAAFAQEAMAHPERGFYSLLA
QYPAFTFSASVATITGLLFYVTSADSGALVLGNFTSKLKDINSDAPNWLRIFWSVAIGLLTLGMLMTNGISALQNTTVIM
GLPFSFVIFFVMAGLYKSLKVEDYRRVSASRDTAPRPMGLQDRLSWKKRLSRLMNYPGTRYTKLMMETVCYPAMEEVAQE
LRLRGAAVELKSLPPEEGENLGHLDLLVHMGDEQNFIYKIWPQQYSVPGFTYRARSGKSTYYRLETFLLEGSQGNDLMDY
SKEQVITDILDQYERHLNFIHLHREAPGNSVMFPDG

Specific function: High-affinity uptake of choline driven by a proton- motive force [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=677, Percent_Identity=96.4549483013294, Blast_Score=1339, Evalue=0.0,
Organism=Escherichia coli, GI1788102, Length=453, Percent_Identity=28.476821192053, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1786224, Length=515, Percent_Identity=26.4077669902913, Blast_Score=155, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 75818; Mature: 75687

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLSQSREKDKINPVVFYTSAGLILLFSLMTIFFRDFSAEWIGRTLDWVSKTFGWYYLL
CCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AATLYIVFVVCIACSRFGSVKLGPEQSKPEFSLLSWAAMLFAAGIGIDLMFFSVAEPVTQ
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YMQPPEGAGQTIEAARQAMVWTLFHYGLTGWSMYALMGMALGYFSYRYNLPLTIRSALYP
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCEEHHHHHHH
IFGKRINGPIGHSVDIAAVIGTIFGIATTLGIGVVQLNYGLSVLFDIPDSLAAKAALIAL
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCHHHHHHHHHHHH
SVIIATISVTSGVDKGIRVLSELNVALALGLILFVLFMGDTSFLLNALVLNVGDYVNRFM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
GMTLNSFAFDRPVEWMNNWTLFFWAWWVAWSPFVGLFLARISRGRTIRQFVMGTLIIPFT
CCHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FTLLWLSVFGNSALYEIIHGDAAFAQEAMAHPERGFYSLLAQYPAFTFSASVATITGLLF
HHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
YVTSADSGALVLGNFTSKLKDINSDAPNWLRIFWSVAIGLLTLGMLMTNGISALQNTTVI
HEECCCCCEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
MGLPFSFVIFFVMAGLYKSLKVEDYRRVSASRDTAPRPMGLQDRLSWKKRLSRLMNYPGT
EECCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
RYTKLMMETVCYPAMEEVAQELRLRGAAVELKSLPPEEGENLGHLDLLVHMGDEQNFIYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEEEEEECCCCCEEEE
IWPQQYSVPGFTYRARSGKSTYYRLETFLLEGSQGNDLMDYSKEQVITDILDQYERHLNF
ECCCCCCCCCCEEECCCCCCHHEEEEEHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCE
IHLHREAPGNSVMFPDG
EEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TDLSQSREKDKINPVVFYTSAGLILLFSLMTIFFRDFSAEWIGRTLDWVSKTFGWYYLL
CCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AATLYIVFVVCIACSRFGSVKLGPEQSKPEFSLLSWAAMLFAAGIGIDLMFFSVAEPVTQ
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YMQPPEGAGQTIEAARQAMVWTLFHYGLTGWSMYALMGMALGYFSYRYNLPLTIRSALYP
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCEEHHHHHHH
IFGKRINGPIGHSVDIAAVIGTIFGIATTLGIGVVQLNYGLSVLFDIPDSLAAKAALIAL
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCHHHHHHHHHHHH
SVIIATISVTSGVDKGIRVLSELNVALALGLILFVLFMGDTSFLLNALVLNVGDYVNRFM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
GMTLNSFAFDRPVEWMNNWTLFFWAWWVAWSPFVGLFLARISRGRTIRQFVMGTLIIPFT
CCHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FTLLWLSVFGNSALYEIIHGDAAFAQEAMAHPERGFYSLLAQYPAFTFSASVATITGLLF
HHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
YVTSADSGALVLGNFTSKLKDINSDAPNWLRIFWSVAIGLLTLGMLMTNGISALQNTTVI
HEECCCCCEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
MGLPFSFVIFFVMAGLYKSLKVEDYRRVSASRDTAPRPMGLQDRLSWKKRLSRLMNYPGT
EECCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
RYTKLMMETVCYPAMEEVAQELRLRGAAVELKSLPPEEGENLGHLDLLVHMGDEQNFIYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEEEEEECCCCCEEEE
IWPQQYSVPGFTYRARSGKSTYYRLETFLLEGSQGNDLMDYSKEQVITDILDQYERHLNF
ECCCCCCCCCCEEECCCCCCHHEEEEEHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCE
IHLHREAPGNSVMFPDG
EEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]