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The map label for this gene is hisQ [H]

Identifier: 238893601

GI number: 238893601

Start: 1455465

End: 1456130

Strand: Direct

Name: hisQ [H]

Synonym: KP1_1514

Alternate gene names: 238893601

Gene position: 1455465-1456130 (Clockwise)

Preceding gene: 238893600

Following gene: 238893602

Centisome position: 27.73

GC content: 50.6

Gene sequence:

>666_bases
ATGAATCAGTGGGGCGTTATCTGGTCGGTTCGCGATAGCTTTATTGCCGGGTTATTCGCGACCCTCGAACTGTTTATTAC
CGCCGCCCTGGCGGCGCTGATTATCGGTATTGCGCTGTGTTATTTTAGCGAATATCAAAAGAAAGTGATTAACCGGATTA
TTATTGGTTTCGTCAGCCTGATGCGCGCGATCCCTTTTTTGATCCTCGCTTATCTTCTGTATTACGGACTGCCGCAGCTC
GGTATTAGCATGGAGCCGTGGACCGCCGGTTTACTGGCCCTGATTATTTATCATGGCGCCTATTTCTTTGAAATATTGCG
CAGCCAGCGGCGGGTATTTTCCGGCGGATATATTGAAGCGGCGATTGCTCAGGGCTTTTCTCGCTATGCCATTTTTCGGC
GGATTATTTTACCCAATATCGTCTCTTCCGCCTTACCGCTGATCGGCAATCAGCTGATTATTTGCCTGAAGGACACCGCT
TTCCTGAGCATTATTACCGTTCAGGAGATCACCGCCGCCGCCAACAGCGTCCAGGCGACCTATTTTATTCCGTTTAACGC
CTTTATCGTCGCCATTGGGCTTTACTGGGCGATCAGCATTCTGCTGGAGCTGCTGATTAAGCGCCTGACCGCCTGGGGAG
CCAAAAGAGGAATGAGCCATGCCTGA

Upstream 100 bases:

>100_bases
CCGGCCTGCTGTATGTGGCGATCATCGGCTGTTTGTTGAAGCTGCAGGGTATCGCGGAACGTAAAGCCAGGCGTCTGGCG
CGCTAGGAACGGGAGGCATT

Downstream 100 bases:

>100_bases
GTCTATTGCCGTAAGCGTCAAAAACGTCTCCAAACAGTTCGATAATGTGGAAGTCCTGCGGGATATTAACCTGACGGTGG
AGAAGGGGACCGTGGTGAGT

Product: putative binding-protein-dependent transport system inner membrane component

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MNQWGVIWSVRDSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQL
GISMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTA
FLSIITVQEITAAANSVQATYFIPFNAFIVAIGLYWAISILLELLIKRLTAWGAKRGMSHA

Sequences:

>Translated_221_residues
MNQWGVIWSVRDSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQL
GISMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTA
FLSIITVQEITAAANSVQATYFIPFNAFIVAIGLYWAISILLELLIKRLTAWGAKRGMSHA
>Mature_221_residues
MNQWGVIWSVRDSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQL
GISMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTA
FLSIITVQEITAAANSVQATYFIPFNAFIVAIGLYWAISILLELLIKRLTAWGAKRGMSHA

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=216, Percent_Identity=32.4074074074074, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787030, Length=209, Percent_Identity=28.2296650717703, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1787087, Length=210, Percent_Identity=28.0952380952381, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788226, Length=149, Percent_Identity=30.8724832214765, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788645, Length=130, Percent_Identity=37.6923076923077, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24638; Mature: 24638

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQWGVIWSVRDSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRAIPFLILAYLLYYGLPQLGISMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEA
HHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFLSIITVQEITAAANSVQAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHCCCEE
YFIPFNAFIVAIGLYWAISILLELLIKRLTAWGAKRGMSHA
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNQWGVIWSVRDSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRAIPFLILAYLLYYGLPQLGISMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEA
HHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFLSIITVQEITAAANSVQAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHCCCEE
YFIPFNAFIVAIGLYWAISILLELLIKRLTAWGAKRGMSHA
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]