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The map label for this gene is scrR [H]

Identifier: 238893526

GI number: 238893526

Start: 1373462

End: 1374511

Strand: Reverse

Name: scrR [H]

Synonym: KP1_1428

Alternate gene names: 238893526

Gene position: 1374511-1373462 (Counterclockwise)

Preceding gene: 238893527

Following gene: 238893520

Centisome position: 26.19

GC content: 62.67

Gene sequence:

>1050_bases
ATGCATGGTAGAATAAGCGTTTTGCTTTCAGGCTCCCGGGTGCTGATGAAAACCAAACGCGTAACTATCAAAGATATCGC
CGAACTGGCGGGCGTCTCCAAAGCGACCGCCAGCCTGGTACTCAACGGTCGTGGTAAAGAGCTGCGCGTGGCGCAGGAGA
CGCGCGAGCGCGTGCTGGCGATCGCTCGCGAACAGCACTATCAGCCGAGCATTCACGCGCGCTCGCTGCGCGATAACCGC
AGCCATACCATTGGTCTGGTGGTGCCGGAGATCACCAACTACGGGTTTGCCGTTTTCTCCCACGAGCTTGAGACGCTCTG
CCGGGAAGCCGGCGTGCAGCTGCTTATCTCCTGCACCGACGAAAACCCTGGCCAGGAGAGCGTGGTGGTCAATAACATGA
TCGCCCGCCAGGTCGACGGCCTGATTGTCGCCTCTTGTATGCACAGCGATGCCGACTATCAGAAGCTCAGCGAACAGCTG
CCGGTGGTGCTGTTTGACCGCTCCCCCAGTGACAGCGCCCTGCCGCTGGTGATGACCGACTCGGTCACCCCAACGGCCGA
GCTGATCTCCCGTATCGCGCCTCAGCATGCGGACGAGTTCTGGTTTCTCGGCGGCCAGCCGCGGCTGTCGCCGTCGCGCG
ACCGGCTGGCGGGGTTCACCCAGGGCCTGGCCCAGGCGGGGATCACGCTGCGCCCCGAGTGGGTGATCAACGGCAACTAC
CACCCCAGCTCCGGCTATGAGATGTTCGCGGCGCTCTGCGCGCGGCTGGGGCGTCCGCCGAAGGCGCTCTTCACCGCGGC
CTGCGGGCTGCTCGAAGGGGTGCTGCGCTATATGAGCCAGCATCATCTGCTGGATTCCAATATTCATCTCGCCAGCTTCG
ACGATCACTATCTGTATGATTCGCTTTCCCTGCGCATTGATACCGTGCAGCAGGATAATCGCCAGCTGGCCTGGCACTGC
TACGATCTGCTCAGCCAGCTGATCGACGGTCAGGCCCCGGAGCCGCTTCAGCGCTACCTGCCCGCCACCCTGCAGATTCG
CCATCCCTGA

Upstream 100 bases:

>100_bases
GCGAGGGGGTGATGAGCAGCCGCTTCTTCCCGGGCTATCCGGGGCAGCTCATCTTCAGCGGTGCGACGCCGGTGGCATTC
TGCCGCTGGCTGCTGCGGCC

Downstream 100 bases:

>100_bases
CGGCGCGGTTGGCAATTAGCGTTTTCGCCTGGCGCGCGCCGCCTGCCTCAGCGCCAGCAGCGCGCTGGCGAGCACCGCGC
CAAGGCCGATAGTCACCGGC

Product: putative LacI family regulatory protein

Products: NA

Alternate protein names: Scr operon regulatory protein [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MHGRISVLLSGSRVLMKTKRVTIKDIAELAGVSKATASLVLNGRGKELRVAQETRERVLAIAREQHYQPSIHARSLRDNR
SHTIGLVVPEITNYGFAVFSHELETLCREAGVQLLISCTDENPGQESVVVNNMIARQVDGLIVASCMHSDADYQKLSEQL
PVVLFDRSPSDSALPLVMTDSVTPTAELISRIAPQHADEFWFLGGQPRLSPSRDRLAGFTQGLAQAGITLRPEWVINGNY
HPSSGYEMFAALCARLGRPPKALFTAACGLLEGVLRYMSQHHLLDSNIHLASFDDHYLYDSLSLRIDTVQQDNRQLAWHC
YDLLSQLIDGQAPEPLQRYLPATLQIRHP

Sequences:

>Translated_349_residues
MHGRISVLLSGSRVLMKTKRVTIKDIAELAGVSKATASLVLNGRGKELRVAQETRERVLAIAREQHYQPSIHARSLRDNR
SHTIGLVVPEITNYGFAVFSHELETLCREAGVQLLISCTDENPGQESVVVNNMIARQVDGLIVASCMHSDADYQKLSEQL
PVVLFDRSPSDSALPLVMTDSVTPTAELISRIAPQHADEFWFLGGQPRLSPSRDRLAGFTQGLAQAGITLRPEWVINGNY
HPSSGYEMFAALCARLGRPPKALFTAACGLLEGVLRYMSQHHLLDSNIHLASFDDHYLYDSLSLRIDTVQQDNRQLAWHC
YDLLSQLIDGQAPEPLQRYLPATLQIRHP
>Mature_349_residues
MHGRISVLLSGSRVLMKTKRVTIKDIAELAGVSKATASLVLNGRGKELRVAQETRERVLAIAREQHYQPSIHARSLRDNR
SHTIGLVVPEITNYGFAVFSHELETLCREAGVQLLISCTDENPGQESVVVNNMIARQVDGLIVASCMHSDADYQKLSEQL
PVVLFDRSPSDSALPLVMTDSVTPTAELISRIAPQHADEFWFLGGQPRLSPSRDRLAGFTQGLAQAGITLRPEWVINGNY
HPSSGYEMFAALCARLGRPPKALFTAACGLLEGVLRYMSQHHLLDSNIHLASFDDHYLYDSLSLRIDTVQQDNRQLAWHC
YDLLSQLIDGQAPEPLQRYLPATLQIRHP

Specific function: Repressor for the scr operon. Binds D-fructose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786268, Length=320, Percent_Identity=30.3125, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1790194, Length=307, Percent_Identity=25.7328990228013, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787948, Length=318, Percent_Identity=26.4150943396226, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790369, Length=339, Percent_Identity=27.1386430678466, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789068, Length=279, Percent_Identity=26.8817204301075, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1789202, Length=293, Percent_Identity=28.3276450511945, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789456, Length=341, Percent_Identity=27.5659824046921, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787906, Length=240, Percent_Identity=25.4166666666667, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1787580, Length=323, Percent_Identity=25.077399380805, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786540, Length=350, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790715, Length=149, Percent_Identity=32.2147651006711, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788474, Length=280, Percent_Identity=25.3571428571429, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012781
- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38794; Mature: 38794

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGRISVLLSGSRVLMKTKRVTIKDIAELAGVSKATASLVLNGRGKELRVAQETRERVLA
CCCEEEEEECCCEEEEHHHCCHHHHHHHHHCCCHHHEEEEECCCCCEEEHHHHHHHHHHH
IAREQHYQPSIHARSLRDNRSHTIGLVVPEITNYGFAVFSHELETLCREAGVQLLISCTD
HHHHHCCCCCHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECC
ENPGQESVVVNNMIARQVDGLIVASCMHSDADYQKLSEQLPVVLFDRSPSDSALPLVMTD
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCCCCCCCEEEEEC
SVTPTAELISRIAPQHADEFWFLGGQPRLSPSRDRLAGFTQGLAQAGITLRPEWVINGNY
CCCCHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCEECCEEEECCCC
HPSSGYEMFAALCARLGRPPKALFTAACGLLEGVLRYMSQHHLLDSNIHLASFDDHYLYD
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEC
SLSLRIDTVQQDNRQLAWHCYDLLSQLIDGQAPEPLQRYLPATLQIRHP
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEECCC
>Mature Secondary Structure
MHGRISVLLSGSRVLMKTKRVTIKDIAELAGVSKATASLVLNGRGKELRVAQETRERVLA
CCCEEEEEECCCEEEEHHHCCHHHHHHHHHCCCHHHEEEEECCCCCEEEHHHHHHHHHHH
IAREQHYQPSIHARSLRDNRSHTIGLVVPEITNYGFAVFSHELETLCREAGVQLLISCTD
HHHHHCCCCCHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECC
ENPGQESVVVNNMIARQVDGLIVASCMHSDADYQKLSEQLPVVLFDRSPSDSALPLVMTD
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCCCCCCCEEEEEC
SVTPTAELISRIAPQHADEFWFLGGQPRLSPSRDRLAGFTQGLAQAGITLRPEWVINGNY
CCCCHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCEECCEEEECCCC
HPSSGYEMFAALCARLGRPPKALFTAACGLLEGVLRYMSQHHLLDSNIHLASFDDHYLYD
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEC
SLSLRIDTVQQDNRQLAWHCYDLLSQLIDGQAPEPLQRYLPATLQIRHP
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412665 [H]