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The map label for this gene is yrbE [H]

Identifier: 238893520

GI number: 238893520

Start: 1366581

End: 1367651

Strand: Reverse

Name: yrbE [H]

Synonym: KP1_1420

Alternate gene names: 238893520

Gene position: 1367651-1366581 (Counterclockwise)

Preceding gene: 238893526

Following gene: 238893516

Centisome position: 26.06

GC content: 64.8

Gene sequence:

>1071_bases
GTGTCAGTGAGTTTAGCAAACCGATTATGGTGGCAGCGTCCCCTCGCCATTCTGGAGAAAAAAATGATCTGCAAACGTTT
TGCCCTGGTAGGCAGTGGTTTTATCGGTCAGGTTCATGCCGCCAGTCTTGCTCGTCATGAAGGAAGTGCGCTGACGATGG
TGGCCGATGCCGCCCCGGAGCGCGCCCAGGCGCTGGCCGCCCGCTATGGCGCCCGGGCGGTGACCGTGAGCGAGGCGATC
CATAGCGACGCCATCGACGCGGTGCTGATCGCCAGTTCAACCCCGTCGCATGCCGAACTGCTGGAAGCCGCCGCCCGGGC
GGGCAAGGCGGTCTATTGTGAAAAACCGATCGACCTCTCCCTGGCGCACGCCCGTGAGGTGGTGGAGCGGGTGCTCCCCC
TGAACGTGCCGGTCACTGTCGGCTTTAACCGGCGCTTCGATAGCAGCCATCAGCAGCTCCGCCGCCAGCTGGAGCAAGGG
CTGATCGGCCGGGTCGAGCTGGTGCAGATGGTCTGCCGCGCCTCCAGCATGCCGCCGCTCGACTATCTGCGCAGCTCCGG
CGGCCAGATGCGCGATCAGGCGATCCACTTCTTTGATCTCCTGCGCTTTCTCACTGGCGATGAAGTGCGCACCGTAGCAG
CGATGGGCGCGGCGCTGGCCCTGCCGGACATTGCCGAATTTGGCGATGTCGACACCTCCATCCTGATGATGCAGATGCGC
GGCGGTGCGCTGGCGCAGCTGGACAATACCCGCCGCACCGGCCACGGGTACGATGAACGGATCACCCTGCTGGGCGCCGA
GGGCGCGCTGGAGTCCGGTAGCCAGTCGCCGGCGGGCCCTACCCTGTGGCGCGGCAATCAGCGCATTGAGCCGGGCCTGT
GGCCGGACTGGTTCAGCCGTGTACAGGGATCTTATTACCAGCATCTTGACGCCTTTATTCGCTCCCTGAATGGTGAAACC
GTCGCCGACCTGCCCGGCCTGCTGGACGGCCTGCAGGCGCAGGCCATTGCCGAAGCGGCGGTTCAGTCCCTGCAGCATGG
CCAGTTTGTCGCCGTCGACGACTGTCGCTGA

Upstream 100 bases:

>100_bases
TCAACGGTGGCCACGCCGACGCCAATCTGTCTGGCCAGCATCGCCAGTGAAATGTTTTTCATCGCCCCTCTCTTCATGAT
GGAAATCCATCAAAACGGCA

Downstream 100 bases:

>100_bases
GCGGGTGCGATGCAACCGCTATCAGGCGCTGTACCTGCCTTTATGCCGGGCGGCGGCGTCGCCTTGCCCGGCCTACATAA
TACAGGCATTAATATGATTT

Product: putative oxidoreductase

Products: 2,4,6/3,5-pentahydroxycyclohexanone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSVSLANRLWWQRPLAILEKKMICKRFALVGSGFIGQVHAASLARHEGSALTMVADAAPERAQALAARYGARAVTVSEAI
HSDAIDAVLIASSTPSHAELLEAAARAGKAVYCEKPIDLSLAHAREVVERVLPLNVPVTVGFNRRFDSSHQQLRRQLEQG
LIGRVELVQMVCRASSMPPLDYLRSSGGQMRDQAIHFFDLLRFLTGDEVRTVAAMGAALALPDIAEFGDVDTSILMMQMR
GGALAQLDNTRRTGHGYDERITLLGAEGALESGSQSPAGPTLWRGNQRIEPGLWPDWFSRVQGSYYQHLDAFIRSLNGET
VADLPGLLDGLQAQAIAEAAVQSLQHGQFVAVDDCR

Sequences:

>Translated_356_residues
MSVSLANRLWWQRPLAILEKKMICKRFALVGSGFIGQVHAASLARHEGSALTMVADAAPERAQALAARYGARAVTVSEAI
HSDAIDAVLIASSTPSHAELLEAAARAGKAVYCEKPIDLSLAHAREVVERVLPLNVPVTVGFNRRFDSSHQQLRRQLEQG
LIGRVELVQMVCRASSMPPLDYLRSSGGQMRDQAIHFFDLLRFLTGDEVRTVAAMGAALALPDIAEFGDVDTSILMMQMR
GGALAQLDNTRRTGHGYDERITLLGAEGALESGSQSPAGPTLWRGNQRIEPGLWPDWFSRVQGSYYQHLDAFIRSLNGET
VADLPGLLDGLQAQAIAEAAVQSLQHGQFVAVDDCR
>Mature_355_residues
SVSLANRLWWQRPLAILEKKMICKRFALVGSGFIGQVHAASLARHEGSALTMVADAAPERAQALAARYGARAVTVSEAIH
SDAIDAVLIASSTPSHAELLEAAARAGKAVYCEKPIDLSLAHAREVVERVLPLNVPVTVGFNRRFDSSHQQLRRQLEQGL
IGRVELVQMVCRASSMPPLDYLRSSGGQMRDQAIHFFDLLRFLTGDEVRTVAAMGAALALPDIAEFGDVDTSILMMQMRG
GALAQLDNTRRTGHGYDERITLLGAEGALESGSQSPAGPTLWRGNQRIEPGLWPDWFSRVQGSYYQHLDAFIRSLNGETV
ADLPGLLDGLQAQAIAEAAVQSLQHGQFVAVDDCR

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI87082405, Length=266, Percent_Identity=25.5639097744361, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787574, Length=189, Percent_Identity=29.1005291005291, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: 1.1.1.18

Molecular weight: Translated: 38647; Mature: 38515

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSLANRLWWQRPLAILEKKMICKRFALVGSGFIGQVHAASLARHEGSALTMVADAAPE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCHH
RAQALAARYGARAVTVSEAIHSDAIDAVLIASSTPSHAELLEAAARAGKAVYCEKPIDLS
HHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCH
LAHAREVVERVLPLNVPVTVGFNRRFDSSHQQLRRQLEQGLIGRVELVQMVCRASSMPPL
HHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCH
DYLRSSGGQMRDQAIHFFDLLRFLTGDEVRTVAAMGAALALPDIAEFGDVDTSILMMQMR
HHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHC
GGALAQLDNTRRTGHGYDERITLLGAEGALESGSQSPAGPTLWRGNQRIEPGLWPDWFSR
CCCHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEECCCCCCCCCCCHHHHHH
VQGSYYQHLDAFIRSLNGETVADLPGLLDGLQAQAIAEAAVQSLQHGQFVAVDDCR
HCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
>Mature Secondary Structure 
SVSLANRLWWQRPLAILEKKMICKRFALVGSGFIGQVHAASLARHEGSALTMVADAAPE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCHH
RAQALAARYGARAVTVSEAIHSDAIDAVLIASSTPSHAELLEAAARAGKAVYCEKPIDLS
HHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCH
LAHAREVVERVLPLNVPVTVGFNRRFDSSHQQLRRQLEQGLIGRVELVQMVCRASSMPPL
HHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCH
DYLRSSGGQMRDQAIHFFDLLRFLTGDEVRTVAAMGAALALPDIAEFGDVDTSILMMQMR
HHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHC
GGALAQLDNTRRTGHGYDERITLLGAEGALESGSQSPAGPTLWRGNQRIEPGLWPDWFSR
CCCHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEECCCCCCCCCCCHHHHHH
VQGSYYQHLDAFIRSLNGETVADLPGLLDGLQAQAIAEAAVQSLQHGQFVAVDDCR
HCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: myo-inositol; NAD+

Specific reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9025289 [H]