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The map label for this gene is purE [H]

Identifier: 238893484

GI number: 238893484

Start: 1332819

End: 1333328

Strand: Reverse

Name: purE [H]

Synonym: KP1_1380

Alternate gene names: 238893484

Gene position: 1333328-1332819 (Counterclockwise)

Preceding gene: 238893485

Following gene: 238893483

Centisome position: 25.4

GC content: 61.18

Gene sequence:

>510_bases
ATGTCTTCCCGCAATAATTCGGCGCGTATCGCCATCGTGATGGGGTCCAAAAGCGACTGGGCTACCATGCAATTTACCGC
AGAAATCCTTGATGCCCTGAACGTTCCGTACCATGTCGAAGTGGTCTCCGCCCACCGCACGCCCGATAAGCTGTTCAGCT
TTGCTGAAAGCGCCGAAAGCCACGGTTATCAGGTGATTATTGCAGGAGCAGGCGGCGCGGCGCATCTGCCGGGCATGATT
GCGGCGAAAACCCTGGTGCCGGTGCTCGGCGTACCGGTTCAGAGCGCAGCCTTAAGCGGTGTCGACAGCCTCTACTCCAT
TGTGCAGATGCCGCGCGGCATTCCGGTCGGTACCCTGGCCATCGGCAAAGCTGGCGCTGCGAACGCCGGCCTGCTCGCCG
CGCAGATCCTTGCCCAGCATGATGCAGAACTGCACCAGCGCCTGAGCGCCTGGCGTCAGGCGCAAACCGATGAAGTGCTG
GATAATCCGGATCCGCGGGGTGCGGCATGA

Upstream 100 bases:

>100_bases
CTAACCATGCGCACGCAACCGTTTTCCTTGCTGGCAGTTCATGCTATTCTCTGTGGCCTCTAAAGCAGTGTGAAACACAC
CCACAGGAGTTTTAAGACGC

Downstream 100 bases:

>100_bases
AACAGGTATGCGTGCTCGGTAACGGCCAGTTAGGCCGTATGCTGCGCCAGGCCGGCGAGCCGCTGGGCATCGCCGTTTGG
CCGGTCGGCCTGGAAGCCGA

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MSSRNNSARIAIVMGSKSDWATMQFTAEILDALNVPYHVEVVSAHRTPDKLFSFAESAESHGYQVIIAGAGGAAHLPGMI
AAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLAIGKAGAANAGLLAAQILAQHDAELHQRLSAWRQAQTDEVL
DNPDPRGAA

Sequences:

>Translated_169_residues
MSSRNNSARIAIVMGSKSDWATMQFTAEILDALNVPYHVEVVSAHRTPDKLFSFAESAESHGYQVIIAGAGGAAHLPGMI
AAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLAIGKAGAANAGLLAAQILAQHDAELHQRLSAWRQAQTDEVL
DNPDPRGAA
>Mature_168_residues
SSRNNSARIAIVMGSKSDWATMQFTAEILDALNVPYHVEVVSAHRTPDKLFSFAESAESHGYQVIIAGAGGAAHLPGMIA
AKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLAIGKAGAANAGLLAAQILAQHDAELHQRLSAWRQAQTDEVLD
NPDPRGAA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=169, Percent_Identity=90.5325443786982, Blast_Score=274, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=49.6688741721854, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17602; Mature: 17471

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRNNSARIAIVMGSKSDWATMQFTAEILDALNVPYHVEVVSAHRTPDKLFSFAESAES
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHC
HGYQVIIAGAGGAAHLPGMIAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLA
CCEEEEEEECCCCHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEE
IGKAGAANAGLLAAQILAQHDAELHQRLSAWRQAQTDEVLDNPDPRGAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
>Mature Secondary Structure 
SSRNNSARIAIVMGSKSDWATMQFTAEILDALNVPYHVEVVSAHRTPDKLFSFAESAES
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHC
HGYQVIIAGAGGAAHLPGMIAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLA
CCEEEEEEECCCCHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEE
IGKAGAANAGLLAAQILAQHDAELHQRLSAWRQAQTDEVLDNPDPRGAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]