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The map label for this gene is purK [H]

Identifier: 238893483

GI number: 238893483

Start: 1331755

End: 1332822

Strand: Reverse

Name: purK [H]

Synonym: KP1_1379

Alternate gene names: 238893483

Gene position: 1332822-1331755 (Counterclockwise)

Preceding gene: 238893484

Following gene: 238893478

Centisome position: 25.39

GC content: 63.95

Gene sequence:

>1068_bases
ATGAAACAGGTATGCGTGCTCGGTAACGGCCAGTTAGGCCGTATGCTGCGCCAGGCCGGCGAGCCGCTGGGCATCGCCGT
TTGGCCGGTCGGCCTGGAAGCCGACCCGGAAGCGGTGCCGTTCCAGCAGAGCGTCATCACGGCAGAAATTGAACGCTGGC
CGGAAACCGCCCTCACCCGCGAGCTGGCCCGCCACCCGGCGTTCGTCAACCGCGATGTCTTCCCGATTATCGCCGACCGC
CTGACGCAAAAGCAGCTGTTTGACAAGCTTGGCCTCGCCACCGCCCCGTGGCAGCTGCTGGCGGATAAAAGCGAGTGGCC
GGCGGTGTTTGCCCGCCTTGGCGAACTGGCGATCGTTAAGCGTCGCGTTGGCGGTTACGACGGCCGCGGCCAGTGGCGTC
TGCGGGAAAACGAGATCGATCAGCTACCGGCCGATAACTACGGCGAGTGCATCGTCGAGCAGGGGATTAACTTCTCCGGC
GAGGTATCGCTGGTGGGCGCCCGCGCTCATGACGGTAGCACCGTCTTCTACCCGCTGACCCGAAACCTGCATCAGGACGG
TATTCTGCGCGCCAGCGTCGCCTTCCCGCAGGCCAACGCTCGCCAGCAGGAACAGGCGGAAAGCATGCTGACGGCGATCA
TGAACGAGCTGAACTATGTCGGCGTGATGGCGATGGAGTGCTTCGTTACCGCCGAGGGGCTGCTGATTAACGAGCTGGCG
CCGCGGGTGCACAACAGCGGCCACTGGACGCAGAACGGCGCGTCTATCAGCCAGTTCGAGCTGCATCTACGGGCGATTAC
CGGCCTGCCGCTGCCGCCGCCGGTGGTCAACAGCCCGTCGGTGATGATCAACCTGATCGGCACCGATCTTAACTACGACT
GGCTGAAGCTGCCGCTGGTGCACCTGCACTGGTATGACAAAGAGGTGCGCCCGGGTCGTAAAGTCGGCCACCTGAACCTC
ACCGACAGCGATACCGATCGCCTGAGCGCGACGCTGGAAGCGATCAAGCCGCTGCTACCGCCGGAGTACACCAGCGGCCT
GTTCTGGGCGCAATCGCAACTGGCGTAA

Upstream 100 bases:

>100_bases
TCCTTGCCCAGCATGATGCAGAACTGCACCAGCGCCTGAGCGCCTGGCGTCAGGCGCAAACCGATGAAGTGCTGGATAAT
CCGGATCCGCGGGGTGCGGC

Downstream 100 bases:

>100_bases
CGCCTTACCTTTGTCTTGCCGGGCGGCGGCTGACGCTTGCCCGGCCGATAAAAACCCAGCTATTCAGAACTCGTCGCCCT
GGCAACGCGCCTCCGTCGCC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLEADPEAVPFQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADR
LTQKQLFDKLGLATAPWQLLADKSEWPAVFARLGELAIVKRRVGGYDGRGQWRLRENEIDQLPADNYGECIVEQGINFSG
EVSLVGARAHDGSTVFYPLTRNLHQDGILRASVAFPQANARQQEQAESMLTAIMNELNYVGVMAMECFVTAEGLLINELA
PRVHNSGHWTQNGASISQFELHLRAITGLPLPPPVVNSPSVMINLIGTDLNYDWLKLPLVHLHWYDKEVRPGRKVGHLNL
TDSDTDRLSATLEAIKPLLPPEYTSGLFWAQSQLA

Sequences:

>Translated_355_residues
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLEADPEAVPFQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADR
LTQKQLFDKLGLATAPWQLLADKSEWPAVFARLGELAIVKRRVGGYDGRGQWRLRENEIDQLPADNYGECIVEQGINFSG
EVSLVGARAHDGSTVFYPLTRNLHQDGILRASVAFPQANARQQEQAESMLTAIMNELNYVGVMAMECFVTAEGLLINELA
PRVHNSGHWTQNGASISQFELHLRAITGLPLPPPVVNSPSVMINLIGTDLNYDWLKLPLVHLHWYDKEVRPGRKVGHLNL
TDSDTDRLSATLEAIKPLLPPEYTSGLFWAQSQLA
>Mature_355_residues
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLEADPEAVPFQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADR
LTQKQLFDKLGLATAPWQLLADKSEWPAVFARLGELAIVKRRVGGYDGRGQWRLRENEIDQLPADNYGECIVEQGINFSG
EVSLVGARAHDGSTVFYPLTRNLHQDGILRASVAFPQANARQQEQAESMLTAIMNELNYVGVMAMECFVTAEGLLINELA
PRVHNSGHWTQNGASISQFELHLRAITGLPLPPPVVNSPSVMINLIGTDLNYDWLKLPLVHLHWYDKEVRPGRKVGHLNL
TDSDTDRLSATLEAIKPLLPPEYTSGLFWAQSQLA

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=355, Percent_Identity=88.4507042253521, Blast_Score=624, Evalue=1e-180,
Organism=Escherichia coli, GI1788155, Length=304, Percent_Identity=25.6578947368421, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324702, Length=364, Percent_Identity=28.5714285714286, Blast_Score=134, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 39447; Mature: 39447

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLEADPEAVPFQQSVITAEIERWPETALTR
CCCEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCHHHHHH
ELARHPAFVNRDVFPIIADRLTQKQLFDKLGLATAPWQLLADKSEWPAVFARLGELAIVK
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHH
RRVGGYDGRGQWRLRENEIDQLPADNYGECIVEQGINFSGEVSLVGARAHDGSTVFYPLT
HHHCCCCCCCEEEEECCCHHCCCCCCHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEECC
RNLHQDGILRASVAFPQANARQQEQAESMLTAIMNELNYVGVMAMECFVTAEGLLINELA
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
PRVHNSGHWTQNGASISQFELHLRAITGLPLPPPVVNSPSVMINLIGTDLNYDWLKLPLV
HHHCCCCCCCCCCCCHHHHHEEEHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEE
HLHWYDKEVRPGRKVGHLNLTDSDTDRLSATLEAIKPLLPPEYTSGLFWAQSQLA
EEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLEADPEAVPFQQSVITAEIERWPETALTR
CCCEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCHHHHHH
ELARHPAFVNRDVFPIIADRLTQKQLFDKLGLATAPWQLLADKSEWPAVFARLGELAIVK
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHH
RRVGGYDGRGQWRLRENEIDQLPADNYGECIVEQGINFSGEVSLVGARAHDGSTVFYPLT
HHHCCCCCCCEEEEECCCHHCCCCCCHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEECC
RNLHQDGILRASVAFPQANARQQEQAESMLTAIMNELNYVGVMAMECFVTAEGLLINELA
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
PRVHNSGHWTQNGASISQFELHLRAITGLPLPPPVVNSPSVMINLIGTDLNYDWLKLPLV
HHHCCCCCCCCCCCCHHHHHEEEHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEE
HLHWYDKEVRPGRKVGHLNLTDSDTDRLSATLEAIKPLLPPEYTSGLFWAQSQLA
EEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2464576; 2644189; 9278503; 1534690; 10569930 [H]