Click here to switch to the map view.

The map label for this gene is dxs [H]

Identifier: 238893357

GI number: 238893357

Start: 1196244

End: 1198106

Strand: Reverse

Name: dxs [H]

Synonym: KP1_1238

Alternate gene names: 238893357

Gene position: 1198106-1196244 (Counterclockwise)

Preceding gene: 238893358

Following gene: 238893356

Centisome position: 22.83

GC content: 60.33

Gene sequence:

>1863_bases
ATGAGTTTTGATATTGCCAAATACCCGACCCTGGCGCTGGTAGATTCCACCCAGGAGTTGCGCCTGTTGCCAAAAGAGAG
CCTGCCGAAGCTATGTGATGAGCTGCGGCGCTATCTGCTGGACAGCGTCAGCCGTTCCAGCGGTCACTTTGCCTCTGGCC
TCGGCACGGTGGAACTGACCGTGGCGCTGCACTACGTGTATAACACGCCGTTCGATCGCCTGATCTGGGACGTCGGCCAT
CAGGCCTACCCGCATAAAATTCTGACCGGTCGCCGGGACAAAATCGGCACCATTCGTCAGAAAGGCGGCCTGCATCCCTT
CCCGTGGCGCGGTGAAAGCGAGTATGACGTGCTGAGCGTCGGTCACTCCTCCACTTCCATTTCCGCGGGTATCGGGGTGG
CTATCGCCGCCGCGAAAGAGGATAAGCAGCGGCGCGCGGTGTGCGTCATTGGCGACGGGGCGATCACCGCCGGCATGGCG
TTTGAGGCGATGAACCACGCCGGGGATATCAAACCCGACCTGCTGGTGGTGCTGAATGACAATGAAATGTCGATTTCCGA
GAACGTCGGCGCGCTGAACAATCATCTGGCGCAGCTGCTCTCCGGTAAGCTCTACTCCACCCTGCGCGAAGGGGGCAAAA
AGGTCTTCTCCGGGGTGCCGCCGATTAAAGAGCTGCTTAAGCGTACCGAAGAGCATATCAAAGGGATGGTGGTGCCGGGC
ACGCTGTTTGAAGAGCTGGGCTTTAACTACATTGGCCCGGTGGATGGCCATGACGTGCTCGGTCTGGTCAGCACGCTGAA
GAACATGCGCGACCTGAAAGGCCCGCAGTTCCTGCATATTATGACCAAAAAAGGCCGCGGCTATGAGCCCGCCGAGAAAG
ACCCGATCACCTTCCATGCGGTGCCAAAATTCGACCATACCAGCGGCGTACTGCCCAAAAGCAGCGGCGGCCTCCCTTCC
TACTCGAAAATCTTCGGCGACTGGCTGTGTGAAACGGCGGCCAAAGACAACAAGCTGATGGCGATCACGCCGGCGATGCG
CGAAGGTTCAGGGATGGTGGAGTTTTCGAAGAAATTCCCCGATCGGTACTTTGACGTCGCCATTGCCGAGCAGCATGCGG
TCACCTTCGCCGCCGGGCTGGCGATTGGCGACTACAAGCCGGTGGTGGCGATCTACTCCACCTTCCTGCAGCGAGCCTAC
GATCAGGTGATCCACGATGTGGCTATCCAGAAGCTGCCGGTGCTGTTTGCTATCGACCGCGCCGGGATCGTCGGCGCAGA
CGGCCAGACGCATCAGGGAGCGTTCGATCTCTCCTTCCTGCGCTGCATTCCGGATATGGTGGTAATGACCCCGAGCGATG
AAAATGAATGTCGCCAGATGCTGTACACCGGCTACCACTACAGCGACGGCCCCTGCGCGGTGCGCTATCCGCGCGGTAGC
GGCACCGGCGCGACGCTCGAGCCGCTGGCATCGCTGCCGATCGGCAAAGGGGTGGTGAAACGTCAGGGCGAGAAAATAGC
GATCCTCAACTTTGGCACCCTGCTGCCGGAAGCCGCGGCGGTAGCGGACAAACTCAACGCCACCCTGGTGGATATGCGCT
TTGTGAAGCCGCTGGATACCGCGCTGATCCTCCAGCTGGCCGGCGAGCACGACGCGCTGGTGACGCTGGAAGAGAACGCC
ATCATGGGCGGCGCCGGCAGCGGCGTGAACGAAGTGCTGATGGCCCATCGCCGGGCGGTACCGGTGCTCAATATTGGCCT
GCCGGATTATTTTATTCCTCAGGGCACTCAGGAAGAGATCCGCGCCGACCTCGGCCTTGATGCCGCCGGTATTGAAGCCA
AAATCCGCGACTGGCTGGCATAA

Upstream 100 bases:

>100_bases
GTTAGATGAGCTGGCCGCACAATCTCTGGATACTTCGGCACTGGAAGCGCTCGCGAATTACATTATTCAGCGCGATAAAT
AAACAAAAAATGAGTCTCTG

Downstream 100 bases:

>100_bases
TTGCCCCTTCCGCTCCTGCTATGCTTAAGGGATACCCTTGATGAATAGCAGGAGCGCACTATGCACTATATCCCCCTCGG
TGATACTGCCTTACGTGTTT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGH
QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGVAIAAAKEDKQRRAVCVIGDGAITAGMA
FEAMNHAGDIKPDLLVVLNDNEMSISENVGALNNHLAQLLSGKLYSTLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLVSTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDHTSGVLPKSSGGLPS
YSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSKKFPDRYFDVAIAEQHAVTFAAGLAIGDYKPVVAIYSTFLQRAY
DQVIHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSFLRCIPDMVVMTPSDENECRQMLYTGYHYSDGPCAVRYPRGS
GTGATLEPLASLPIGKGVVKRQGEKIAILNFGTLLPEAAAVADKLNATLVDMRFVKPLDTALILQLAGEHDALVTLEENA
IMGGAGSGVNEVLMAHRRAVPVLNIGLPDYFIPQGTQEEIRADLGLDAAGIEAKIRDWLA

Sequences:

>Translated_620_residues
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGH
QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGVAIAAAKEDKQRRAVCVIGDGAITAGMA
FEAMNHAGDIKPDLLVVLNDNEMSISENVGALNNHLAQLLSGKLYSTLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLVSTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDHTSGVLPKSSGGLPS
YSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSKKFPDRYFDVAIAEQHAVTFAAGLAIGDYKPVVAIYSTFLQRAY
DQVIHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSFLRCIPDMVVMTPSDENECRQMLYTGYHYSDGPCAVRYPRGS
GTGATLEPLASLPIGKGVVKRQGEKIAILNFGTLLPEAAAVADKLNATLVDMRFVKPLDTALILQLAGEHDALVTLEENA
IMGGAGSGVNEVLMAHRRAVPVLNIGLPDYFIPQGTQEEIRADLGLDAAGIEAKIRDWLA
>Mature_619_residues
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGHQ
AYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGVAIAAAKEDKQRRAVCVIGDGAITAGMAF
EAMNHAGDIKPDLLVVLNDNEMSISENVGALNNHLAQLLSGKLYSTLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGT
LFEELGFNYIGPVDGHDVLGLVSTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDHTSGVLPKSSGGLPSY
SKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSKKFPDRYFDVAIAEQHAVTFAAGLAIGDYKPVVAIYSTFLQRAYD
QVIHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSFLRCIPDMVVMTPSDENECRQMLYTGYHYSDGPCAVRYPRGSG
TGATLEPLASLPIGKGVVKRQGEKIAILNFGTLLPEAAAVADKLNATLVDMRFVKPLDTALILQLAGEHDALVTLEENAI
MGGAGSGVNEVLMAHRRAVPVLNIGLPDYFIPQGTQEEIRADLGLDAAGIEAKIRDWLA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=598, Percent_Identity=23.7458193979933, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI4507521, Length=598, Percent_Identity=23.7458193979933, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI225637463, Length=546, Percent_Identity=23.992673992674, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI225637459, Length=546, Percent_Identity=23.992673992674, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI225637461, Length=546, Percent_Identity=23.992673992674, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI133778974, Length=497, Percent_Identity=23.943661971831, Blast_Score=84, Evalue=6e-16,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=91.1290322580645, Blast_Score=1187, Evalue=0.0,
Organism=Drosophila melanogaster, GI45551847, Length=630, Percent_Identity=24.7619047619048, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45550715, Length=630, Percent_Identity=24.7619047619048, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24666278, Length=500, Percent_Identity=25.6, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24645119, Length=529, Percent_Identity=25.1417769376182, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67331; Mature: 67200

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
VALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE
GHSSTSISAGIGVAIAAAKEDKQRRAVCVIGDGAITAGMAFEAMNHAGDIKPDLLVVLND
CCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLLSGKLYSTLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
CCEEHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVLGLVSTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE
VPKFDHTSGVLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSKKFP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCHHHHHCC
DRYFDVAIAEQHAVTFAAGLAIGDYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVLFAIDR
CHHHEEEEHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
AGIVGADGQTHQGAFDLSFLRCIPDMVVMTPSDENECRQMLYTGYHYSDGPCAVRYPRGS
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCC
GTGATLEPLASLPIGKGVVKRQGEKIAILNFGTLLPEAAAVADKLNATLVDMRFVKPLDT
CCCCCHHHHHCCCCCCCHHHCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEHHHHCHHHH
ALILQLAGEHDALVTLEENAIMGGAGSGVNEVLMAHRRAVPVLNIGLPDYFIPQGTQEEI
HHHHHCCCCCCEEEEEECCEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHH
RADLGLDAAGIEAKIRDWLA
HHHCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
VALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE
GHSSTSISAGIGVAIAAAKEDKQRRAVCVIGDGAITAGMAFEAMNHAGDIKPDLLVVLND
CCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLLSGKLYSTLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
CCEEHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVLGLVSTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE
VPKFDHTSGVLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSKKFP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCHHHHHCC
DRYFDVAIAEQHAVTFAAGLAIGDYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVLFAIDR
CHHHEEEEHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
AGIVGADGQTHQGAFDLSFLRCIPDMVVMTPSDENECRQMLYTGYHYSDGPCAVRYPRGS
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCC
GTGATLEPLASLPIGKGVVKRQGEKIAILNFGTLLPEAAAVADKLNATLVDMRFVKPLDT
CCCCCHHHHHCCCCCCCHHHCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEHHHHCHHHH
ALILQLAGEHDALVTLEENAIMGGAGSGVNEVLMAHRRAVPVLNIGLPDYFIPQGTQEEI
HHHHHCCCCCCEEEEEECCEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHH
RADLGLDAAGIEAKIRDWLA
HHHCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA