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The map label for this gene is ispA [H]

Identifier: 238893358

GI number: 238893358

Start: 1198125

End: 1199024

Strand: Reverse

Name: ispA [H]

Synonym: KP1_1239

Alternate gene names: 238893358

Gene position: 1199024-1198125 (Counterclockwise)

Preceding gene: 238893359

Following gene: 238893357

Centisome position: 22.84

GC content: 60.56

Gene sequence:

>900_bases
ATGGATTTCCCGCAACAATTGCAGGCCTGTGTGGAACAGGCAAACGAAGCGCTGCGCCGTTTCATCGCCCCGCAGCCCTT
TCAGAACACTCCGCTGGTGGAAGCGATGCATTATGGCGCATTGTTAGGCGGTAAACGCCTGCGTCCCTTCCTTGTCTACG
CCACCGGCGAGATGTTCGGCGTGTGCCGTACCACGCTGGATGCTCCTGCCGCGGCGGTCGAATGCATTCATGCCTACTCC
CTGATGCATGATGATTTGCCGGCGATGGATGATGACGATCTGCGCCGCGGCCTGCCGACCTGCCATATTAAATTTGGCGA
AGCCAACGCAATTCTTGCGGGAGATGCCCTGCAAACGCTGGCGTTCTCTATACTGAGTGATGCGCCGATGGTCGACGTTC
CTGACCGGGACCGGCTGGCGATGGTTTCCGAACTGGCGCAGGCCAGCGGCGTGGCGGGCATGTGCGGCGGCCAGGCGCTG
GATCTGCAGGCCGAGGGACAGCAGGTTGATTTACAGGCGCTGGAGCGTATCCATCGCCATAAAACGGGCGCCCTGATCCG
CGCCGCCGTCCGGATGGGAGCCCTGAGCGCCGGCGAACGCGGCCGCGCTGCCCTGCCCGCGCTGGATCGCTATGCGGAAA
ATATCGGTCTTGCCTTCCAGGTCCAGGATGACATTCTCGACGTGGTAGGGGATACTGCGACCCTTGGCAAACGTCAGGGT
GCCGACCAGCAATTGGGTAAAAGCACCTATCCCGCCCTCCTGGGTCTTGAGCAAGCCCGGAAGAAAGCGCACGACCTGAT
CGCTGATGCCCGCCGGTCGTTAGATGAGCTGGCCGCACAATCTCTGGATACTTCGGCACTGGAAGCGCTCGCGAATTACA
TTATTCAGCGCGATAAATAA

Upstream 100 bases:

>100_bases
GGGGCAAAGTCAGCTGCAGAAGGCCGAACAGCGCGTGCAGATCCTGCTGGCGGATAGTGAAGATTCCCCGACCACGCCTT
TTACGCCGGACGCTGAATAA

Downstream 100 bases:

>100_bases
ACAAAAAATGAGTCTCTGATGAGTTTTGATATTGCCAAATACCCGACCCTGGCGCTGGTAGATTCCACCCAGGAGTTGCG
CCTGTTGCCAAAAGAGAGCC

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MDFPQQLQACVEQANEALRRFIAPQPFQNTPLVEAMHYGALLGGKRLRPFLVYATGEMFGVCRTTLDAPAAAVECIHAYS
LMHDDLPAMDDDDLRRGLPTCHIKFGEANAILAGDALQTLAFSILSDAPMVDVPDRDRLAMVSELAQASGVAGMCGGQAL
DLQAEGQQVDLQALERIHRHKTGALIRAAVRMGALSAGERGRAALPALDRYAENIGLAFQVQDDILDVVGDTATLGKRQG
ADQQLGKSTYPALLGLEQARKKAHDLIADARRSLDELAAQSLDTSALEALANYIIQRDK

Sequences:

>Translated_299_residues
MDFPQQLQACVEQANEALRRFIAPQPFQNTPLVEAMHYGALLGGKRLRPFLVYATGEMFGVCRTTLDAPAAAVECIHAYS
LMHDDLPAMDDDDLRRGLPTCHIKFGEANAILAGDALQTLAFSILSDAPMVDVPDRDRLAMVSELAQASGVAGMCGGQAL
DLQAEGQQVDLQALERIHRHKTGALIRAAVRMGALSAGERGRAALPALDRYAENIGLAFQVQDDILDVVGDTATLGKRQG
ADQQLGKSTYPALLGLEQARKKAHDLIADARRSLDELAAQSLDTSALEALANYIIQRDK
>Mature_299_residues
MDFPQQLQACVEQANEALRRFIAPQPFQNTPLVEAMHYGALLGGKRLRPFLVYATGEMFGVCRTTLDAPAAAVECIHAYS
LMHDDLPAMDDDDLRRGLPTCHIKFGEANAILAGDALQTLAFSILSDAPMVDVPDRDRLAMVSELAQASGVAGMCGGQAL
DLQAEGQQVDLQALERIHRHKTGALIRAAVRMGALSAGERGRAALPALDRYAENIGLAFQVQDDILDVVGDTATLGKRQG
ADQQLGKSTYPALLGLEQARKKAHDLIADARRSLDELAAQSLDTSALEALANYIIQRDK

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=299, Percent_Identity=85.61872909699, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1789578, Length=254, Percent_Identity=29.9212598425197, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17505681, Length=278, Percent_Identity=27.6978417266187, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24651612, Length=187, Percent_Identity=31.5508021390374, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32229; Mature: 32229

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFPQQLQACVEQANEALRRFIAPQPFQNTPLVEAMHYGALLGGKRLRPFLVYATGEMFG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCHHHH
VCRTTLDAPAAAVECIHAYSLMHDDLPAMDDDDLRRGLPTCHIKFGEANAILAGDALQTL
HHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEECCCCEEEEHHHHHHH
AFSILSDAPMVDVPDRDRLAMVSELAQASGVAGMCGGQALDLQAEGQQVDLQALERIHRH
HHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEECHHHHHHHHHH
KTGALIRAAVRMGALSAGERGRAALPALDRYAENIGLAFQVQDDILDVVGDTATLGKRQG
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEHHHHHHHHCCHHHHHHCCC
ADQQLGKSTYPALLGLEQARKKAHDLIADARRSLDELAAQSLDTSALEALANYIIQRDK
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFPQQLQACVEQANEALRRFIAPQPFQNTPLVEAMHYGALLGGKRLRPFLVYATGEMFG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCHHHH
VCRTTLDAPAAAVECIHAYSLMHDDLPAMDDDDLRRGLPTCHIKFGEANAILAGDALQTL
HHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEECCCCEEEEHHHHHHH
AFSILSDAPMVDVPDRDRLAMVSELAQASGVAGMCGGQALDLQAEGQQVDLQALERIHRH
HHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEECHHHHHHHHHH
KTGALIRAAVRMGALSAGERGRAALPALDRYAENIGLAFQVQDDILDVVGDTATLGKRQG
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEHHHHHHHHCCHHHHHHCCC
ADQQLGKSTYPALLGLEQARKKAHDLIADARRSLDELAAQSLDTSALEALANYIIQRDK
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2089044; 9278503 [H]