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The map label for this gene is proC [H]

Identifier: 238893311

GI number: 238893311

Start: 1153681

End: 1154490

Strand: Reverse

Name: proC [H]

Synonym: KP1_1188

Alternate gene names: 238893311

Gene position: 1154490-1153681 (Counterclockwise)

Preceding gene: 238893313

Following gene: 238893305

Centisome position: 22.0

GC content: 59.51

Gene sequence:

>810_bases
ATGGATAAGAAAATTGGCTTTATCGGCTGCGGCAATATGGGTAAGGCCATTCTGGGCGGGCTGATCGCCAGCGGTCAGGT
ACAGCCGGGACAAATCTGGGTCTACACCCCGTCGCCGGACAAGGTTGCAGCTCTGCGCGACCAGTATGGCATCAACGCCG
CCAGCAGCGCCCAGGAAGTGGCGCAGATTGCCGATATCGTCTTCGGCGCGGTTAAACCAGGGATCATGACCAAAGTGCTG
GGCGATATCGCCTCCAGCCTGAATAAAGAGTCGCTGGTGGTCTCTATCGCCGCCGGCGTTACGCTTGAGCAGCTGGCGCG
CGCCCTTGGCCACGATCGCAAAATCATTCGCGCGATGCCGAATACGCCGTCGCTGGTTAACGCCGGTATGACCTCCGTCA
CGCCTAACGCCCTGGTGAGCAGCGAAGATGTTGCCGAAGTGCTGACTATTTTCCGTTGCTTTGGCCAGGCGGAGCAAATT
GCCGAGCCGATGATCCATCCGGTGGTGGGGGTAAGCGGTTCGGCGCCGGCCTATGTCTTTATGTTTATCGAAGCGATGGC
TGATGCCGCCGTCCTCGGCGGAATGCCGCGCGCTCAGGCCTATAAATTCGCCGCCCAGGCGGTGATGGGCTCCGCCAAAA
TGGTGCTGGAGAGCGGAGAACACCCAGGGGCGCTGAAAGATATGGTCTGTTCCCCTGGCGGGACCACCATCGAAGCCGTG
CGCGTGCTGGAAGAGAAAGGGTTCCGCTCGGCGGTAATCGAAGCCATCACCCAGTGTATGGAAAAATCAGAGAAACTGAG
CCGCTCCTGA

Upstream 100 bases:

>100_bases
TGCAATAAGTGACGCCAATGTTACCTGCTTTTCTCCCCCAGGAAAGCGCCAGGATGGTAAGCTAATCAGATCGTAACGAA
AAAAGCAGAGGGGAATGGTG

Downstream 100 bases:

>100_bases
AGCTGAGCTGGCGGGCTTCAAGCCCTGAGAGGTTAAAGAACAAGGGAGCGCGAGCGCTCCCTTTTTTTCAGGCTTTCTTC
AGGCAGCTACTCATGAAGGT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MDKKIGFIGCGNMGKAILGGLIASGQVQPGQIWVYTPSPDKVAALRDQYGINAASSAQEVAQIADIVFGAVKPGIMTKVL
GDIASSLNKESLVVSIAAGVTLEQLARALGHDRKIIRAMPNTPSLVNAGMTSVTPNALVSSEDVAEVLTIFRCFGQAEQI
AEPMIHPVVGVSGSAPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLESGEHPGALKDMVCSPGGTTIEAV
RVLEEKGFRSAVIEAITQCMEKSEKLSRS

Sequences:

>Translated_269_residues
MDKKIGFIGCGNMGKAILGGLIASGQVQPGQIWVYTPSPDKVAALRDQYGINAASSAQEVAQIADIVFGAVKPGIMTKVL
GDIASSLNKESLVVSIAAGVTLEQLARALGHDRKIIRAMPNTPSLVNAGMTSVTPNALVSSEDVAEVLTIFRCFGQAEQI
AEPMIHPVVGVSGSAPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLESGEHPGALKDMVCSPGGTTIEAV
RVLEEKGFRSAVIEAITQCMEKSEKLSRS
>Mature_269_residues
MDKKIGFIGCGNMGKAILGGLIASGQVQPGQIWVYTPSPDKVAALRDQYGINAASSAQEVAQIADIVFGAVKPGIMTKVL
GDIASSLNKESLVVSIAAGVTLEQLARALGHDRKIIRAMPNTPSLVNAGMTSVTPNALVSSEDVAEVLTIFRCFGQAEQI
AEPMIHPVVGVSGSAPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLESGEHPGALKDMVCSPGGTTIEAV
RVLEEKGFRSAVIEAITQCMEKSEKLSRS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=38.7218045112782, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=38.7218045112782, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI21361454, Length=277, Percent_Identity=38.2671480144404, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=35.3383458646617, Blast_Score=172, Evalue=2e-43,
Organism=Escherichia coli, GI1786585, Length=269, Percent_Identity=89.9628252788104, Blast_Score=499, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17569021, Length=264, Percent_Identity=40.530303030303, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=36.2007168458781, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320861, Length=277, Percent_Identity=29.2418772563177, Blast_Score=115, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=40.072202166065, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=38.4905660377359, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=40.8284023668639, Blast_Score=131, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28068; Mature: 28068

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKIGFIGCGNMGKAILGGLIASGQVQPGQIWVYTPSPDKVAALRDQYGINAASSAQEV
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHH
AQIADIVFGAVKPGIMTKVLGDIASSLNKESLVVSIAAGVTLEQLARALGHDRKIIRAMP
HHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHEEEEHHHCCCHHHHHHHHCCCCHHHHHCC
NTPSLVNAGMTSVTPNALVSSEDVAEVLTIFRCFGQAEQIAEPMIHPVVGVSGSAPAYVF
CCCHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHH
MFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLESGEHPGALKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHH
RVLEEKGFRSAVIEAITQCMEKSEKLSRS
HHHHHCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKKIGFIGCGNMGKAILGGLIASGQVQPGQIWVYTPSPDKVAALRDQYGINAASSAQEV
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHH
AQIADIVFGAVKPGIMTKVLGDIASSLNKESLVVSIAAGVTLEQLARALGHDRKIIRAMP
HHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHEEEEHHHCCCHHHHHHHHCCCCHHHHHCC
NTPSLVNAGMTSVTPNALVSSEDVAEVLTIFRCFGQAEQIAEPMIHPVVGVSGSAPAYVF
CCCHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHH
MFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLESGEHPGALKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHH
RVLEEKGFRSAVIEAITQCMEKSEKLSRS
HHHHHCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]