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The map label for this gene is pepD [H]

Identifier: 238893226

GI number: 238893226

Start: 1067521

End: 1068978

Strand: Reverse

Name: pepD [H]

Synonym: KP1_1095

Alternate gene names: 238893226

Gene position: 1068978-1067521 (Counterclockwise)

Preceding gene: 238893230

Following gene: 238893223

Centisome position: 20.37

GC content: 58.37

Gene sequence:

>1458_bases
GTGTCTGAACTGTCTCAACTATCCCCGCAGCCGCTTTGGGATATTTTTGCCAAGATTTGCTCCATCCCGCACCCGTCCTA
TCACGAAGCACAGCTCGCCGAGCACATTATGGGTTGGGCAAAAGAAAAAGGCTTACATGCGGAACGCGACCAGGTTGGCA
ACATTCTGATTCGTAAAGGCGCGACTGCCGGTATGGAAAACCGTAAGCCGGTAGCGCTGCAGGCGCACCTCGATATGGTG
CCGCAGAAAAATAACGACACCGTCCACGACTTCGTTAAAGATCCGATCCAGCCGTACATTGACGGCGAATGGGTGAAAGC
GCGCGGCACCACGCTGGGCGCGGACAACGGTATCGGAATGGCGTCCGCACTGGCGGTACTGGCCGACGATAGCGTCGCTC
ACGGCCCGCTGGAAGTGCTGCTGACCATGACCGAAGAAGCCGGCATGGACGGCGCGTTTGGTCTGCAGGCCAACTGGCTA
CAGGCCGATATCCTGATCAACACCGACTCCGAAGAAGAAGGCGAAATCTACATGGGTTGCGCCGGCGGGATCGATTTCAC
CTCTAACCTGGCGCTGACCCGCGAAGCGATTCCCGCCGGGTTCCAGAGCTTTAAAGTCACCTTAAAAGGGCTGAAAGGCG
GCCACTCCGGCGGTGATATTCACCTTGGTCTGGGTAACGCCAACAAGCTGCTGTCGCGCTTCCTCGCCGGCCACGCCGAT
GAGCTGGATCTGCGTCTGGTCGATTTCAACGGCGGCACGTTGCGCAACGCCATCCCGCGTGAAGCTTACGCTACTGTCGC
CGTCGCCGCGGATACAGCCGATGCGCTGAAAGCGCTGGTGAATACTTACCAGGCGCTGCTGAAAAACGAGCTGGAGGCCA
AAGAGAAGAACCTGGTGGTGCTCGTGGAAGCGGTCGATAACGACAAAGCGGCGCTGACTCAGGCTTCCCGCGACACTTTC
ATCCGTCTGCTGAACGCCACGCCGAACGGGGTTATCCGCAACTCTGACGTGGCGAAAGGCGTCGTGGAAACTTCGCTGAA
CGTCGGCGTCGTCACCATGACCGATGACAACGTACAGATCCACTGCCTGATCCGCTCGCTGATCGACAGCGGCAAAGACT
ACGTGGTCAGCATGCTGGATTCTCTGGGTAAGCTGGCGGGGGCGAAAACCGAAGCCAAAGGCGCTTACCCTGGCTGGCAA
CCGGACGCCAATTCGCCGGTGATGCACCTGGTGCGCGAGACTTACCAGCGTCTGTTCAACAAGACGCCGAACATCCAGAT
CATTCACGCCGGTCTGGAATGCGGTCTGTTCAAAAAACCGTATCCGGAGATGGACATGGTCTCCATCGGGCCAACCATTA
CCGGTCCGCACTCCCCGGATGAGCAGGTCCATATCGAGAGCGTCGGTCAGTACTGGACGCTGCTGACCGAGCTGCTGAAA
GCCATTCCGGCTAAATAA

Upstream 100 bases:

>100_bases
TATTCTCAACCCCATCGCGCAAGCCCGGGCTTGTTGTGTATTTTAACGCTAACCCTCGTCCTGCAACCGCTGTATGCAGG
AGTCTGTAAGGAGACTTACC

Downstream 100 bases:

>100_bases
GCCCCACAACCGGCGGCGGCCCGCCGCCGGTTTTACCCAGCATCACCTTAGCGCCACGCGTTTTTCCATCCGGTAATTAA
TAAACCACTCCCCGCGCGCC

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSELSQLSPQPLWDIFAKICSIPHPSYHEAQLAEHIMGWAKEKGLHAERDQVGNILIRKGATAGMENRKPVALQAHLDMV
PQKNNDTVHDFVKDPIQPYIDGEWVKARGTTLGADNGIGMASALAVLADDSVAHGPLEVLLTMTEEAGMDGAFGLQANWL
QADILINTDSEEEGEIYMGCAGGIDFTSNLALTREAIPAGFQSFKVTLKGLKGGHSGGDIHLGLGNANKLLSRFLAGHAD
ELDLRLVDFNGGTLRNAIPREAYATVAVAADTADALKALVNTYQALLKNELEAKEKNLVVLVEAVDNDKAALTQASRDTF
IRLLNATPNGVIRNSDVAKGVVETSLNVGVVTMTDDNVQIHCLIRSLIDSGKDYVVSMLDSLGKLAGAKTEAKGAYPGWQ
PDANSPVMHLVRETYQRLFNKTPNIQIIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIESVGQYWTLLTELLK
AIPAK

Sequences:

>Translated_485_residues
MSELSQLSPQPLWDIFAKICSIPHPSYHEAQLAEHIMGWAKEKGLHAERDQVGNILIRKGATAGMENRKPVALQAHLDMV
PQKNNDTVHDFVKDPIQPYIDGEWVKARGTTLGADNGIGMASALAVLADDSVAHGPLEVLLTMTEEAGMDGAFGLQANWL
QADILINTDSEEEGEIYMGCAGGIDFTSNLALTREAIPAGFQSFKVTLKGLKGGHSGGDIHLGLGNANKLLSRFLAGHAD
ELDLRLVDFNGGTLRNAIPREAYATVAVAADTADALKALVNTYQALLKNELEAKEKNLVVLVEAVDNDKAALTQASRDTF
IRLLNATPNGVIRNSDVAKGVVETSLNVGVVTMTDDNVQIHCLIRSLIDSGKDYVVSMLDSLGKLAGAKTEAKGAYPGWQ
PDANSPVMHLVRETYQRLFNKTPNIQIIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIESVGQYWTLLTELLK
AIPAK
>Mature_484_residues
SELSQLSPQPLWDIFAKICSIPHPSYHEAQLAEHIMGWAKEKGLHAERDQVGNILIRKGATAGMENRKPVALQAHLDMVP
QKNNDTVHDFVKDPIQPYIDGEWVKARGTTLGADNGIGMASALAVLADDSVAHGPLEVLLTMTEEAGMDGAFGLQANWLQ
ADILINTDSEEEGEIYMGCAGGIDFTSNLALTREAIPAGFQSFKVTLKGLKGGHSGGDIHLGLGNANKLLSRFLAGHADE
LDLRLVDFNGGTLRNAIPREAYATVAVAADTADALKALVNTYQALLKNELEAKEKNLVVLVEAVDNDKAALTQASRDTFI
RLLNATPNGVIRNSDVAKGVVETSLNVGVVTMTDDNVQIHCLIRSLIDSGKDYVVSMLDSLGKLAGAKTEAKGAYPGWQP
DANSPVMHLVRETYQRLFNKTPNIQIIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIESVGQYWTLLTELLKA
IPAK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=485, Percent_Identity=90.5154639175258, Blast_Score=919, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52349; Mature: 52218

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELSQLSPQPLWDIFAKICSIPHPSYHEAQLAEHIMGWAKEKGLHAERDQVGNILIRKG
CCCHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEECC
ATAGMENRKPVALQAHLDMVPQKNNDTVHDFVKDPIQPYIDGEWVKARGTTLGADNGIGM
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCH
ASALAVLADDSVAHGPLEVLLTMTEEAGMDGAFGLQANWLQADILINTDSEEEGEIYMGC
HHHHHHHCCCCCCCCCHHHEEEEHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEE
AGGIDFTSNLALTREAIPAGFQSFKVTLKGLKGGHSGGDIHLGLGNANKLLSRFLAGHAD
CCCCCCCCCCHHHHHHHHCCHHHHHHEEEECCCCCCCCEEEEECCCHHHHHHHHHCCCCC
ELDLRLVDFNGGTLRNAIPREAYATVAVAADTADALKALVNTYQALLKNELEAKEKNLVV
CCEEEEEECCCCCHHCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LVEAVDNDKAALTQASRDTFIRLLNATPNGVIRNSDVAKGVVETSLNVGVVTMTDDNVQI
EEEECCCCHHHHHHHHHHHHHEEECCCCCCEEECCHHHHHHHHHCCCEEEEEEECCCEEE
HCLIRSLIDSGKDYVVSMLDSLGKLAGAKTEAKGAYPGWQPDANSPVMHLVRETYQRLFN
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
KTPNIQIIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIESVGQYWTLLTELLK
CCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHHH
AIPAK
HCCCC
>Mature Secondary Structure 
SELSQLSPQPLWDIFAKICSIPHPSYHEAQLAEHIMGWAKEKGLHAERDQVGNILIRKG
CCHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEECC
ATAGMENRKPVALQAHLDMVPQKNNDTVHDFVKDPIQPYIDGEWVKARGTTLGADNGIGM
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCH
ASALAVLADDSVAHGPLEVLLTMTEEAGMDGAFGLQANWLQADILINTDSEEEGEIYMGC
HHHHHHHCCCCCCCCCHHHEEEEHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEE
AGGIDFTSNLALTREAIPAGFQSFKVTLKGLKGGHSGGDIHLGLGNANKLLSRFLAGHAD
CCCCCCCCCCHHHHHHHHCCHHHHHHEEEECCCCCCCCEEEEECCCHHHHHHHHHCCCCC
ELDLRLVDFNGGTLRNAIPREAYATVAVAADTADALKALVNTYQALLKNELEAKEKNLVV
CCEEEEEECCCCCHHCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LVEAVDNDKAALTQASRDTFIRLLNATPNGVIRNSDVAKGVVETSLNVGVVTMTDDNVQI
EEEECCCCHHHHHHHHHHHHHEEECCCCCCEEECCHHHHHHHHHCCCEEEEEEECCCEEE
HCLIRSLIDSGKDYVVSMLDSLGKLAGAKTEAKGAYPGWQPDANSPVMHLVRETYQRLFN
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
KTPNIQIIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIESVGQYWTLLTELLK
CCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHHH
AIPAK
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]