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The map label for this gene is rnhA [H]

Identifier: 238893207

GI number: 238893207

Start: 1049347

End: 1049925

Strand: Reverse

Name: rnhA [H]

Synonym: KP1_1073

Alternate gene names: 238893207

Gene position: 1049925-1049347 (Counterclockwise)

Preceding gene: 238893209

Following gene: 238893205

Centisome position: 20.0

GC content: 53.89

Gene sequence:

>579_bases
GTGGTTTCGGTATCGAGAACAATCTGGCGCGTAATTGCAGTGCTCATAGCGGTCATTTATGTCAGACTTATCGTTTACAA
ATCGATTTCAATTACAGGAAGTCTACCAGAGATGCTCAAACAGGTAGAAATTTTCACCGACGGCTCTTGCCTGGGTAATC
CAGGACCTGGCGGCTACGGCGCCATCATGCGCTACCGCCAGCACGAAAAAACCTTCAGCGCTGGCTACCGTCTGACCACC
AATAACCGCATGGAACTGATGGCGGCAATTGTTGCCCTGGAAGCGTTAAAAGAGCATTGCGAAGTGGTGCTCAGCACTGA
CAGCCAGTATGTTCGTCAGGGGATCACCCAGTGGATCCACAACTGGAAAAAGCGCGGCTGGAAAACGGCAGAGAAAAAGC
CGGTGAAAAATGTCGACCTCTGGCAGCGGCTGGACGCCGCGCTTGGCCAGCATAAAATTAAATGGGAATGGGTAAAGGGC
CACGCCGGCCATCCTGAAAATGAACGCTGCGACGAGTTGGCGCGCGCGGCGGCCTCCCACCCCACACTGGACGATGTCGG
CTACCTGCCTGAGAGTTAA

Upstream 100 bases:

>100_bases
GTGAAAATTGTTACCGGTCAGGCGGCGGTTGATCACCTCCACGGCGCCGATCTCAATGATCTTGTGTCCTTCGTAGTGTG
CCCCGATCTGGTTCATACCG

Downstream 100 bases:

>100_bases
TTCTGCCCTTTGCGCCACTGCCGGGTGGCGCCCACCGCCGGCCGCAGCTGAGTTTTCGCTTTGCCGGATTTCATCGGATT
GAGCGTCAGCGGAATGGTCC

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MVSVSRTIWRVIAVLIAVIYVRLIVYKSISITGSLPEMLKQVEIFTDGSCLGNPGPGGYGAIMRYRQHEKTFSAGYRLTT
NNRMELMAAIVALEALKEHCEVVLSTDSQYVRQGITQWIHNWKKRGWKTAEKKPVKNVDLWQRLDAALGQHKIKWEWVKG
HAGHPENERCDELARAAASHPTLDDVGYLPES

Sequences:

>Translated_192_residues
MVSVSRTIWRVIAVLIAVIYVRLIVYKSISITGSLPEMLKQVEIFTDGSCLGNPGPGGYGAIMRYRQHEKTFSAGYRLTT
NNRMELMAAIVALEALKEHCEVVLSTDSQYVRQGITQWIHNWKKRGWKTAEKKPVKNVDLWQRLDAALGQHKIKWEWVKG
HAGHPENERCDELARAAASHPTLDDVGYLPES
>Mature_192_residues
MVSVSRTIWRVIAVLIAVIYVRLIVYKSISITGSLPEMLKQVEIFTDGSCLGNPGPGGYGAIMRYRQHEKTFSAGYRLTT
NNRMELMAAIVALEALKEHCEVVLSTDSQYVRQGITQWIHNWKKRGWKTAEKKPVKNVDLWQRLDAALGQHKIKWEWVKG
HAGHPENERCDELARAAASHPTLDDVGYLPES

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=142, Percent_Identity=37.3239436619718, Blast_Score=77, Evalue=7e-15,
Organism=Escherichia coli, GI1786408, Length=154, Percent_Identity=90.9090909090909, Blast_Score=299, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI115532542, Length=148, Percent_Identity=37.1621621621622, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17505482, Length=132, Percent_Identity=34.0909090909091, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45552509, Length=145, Percent_Identity=37.2413793103448, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137476, Length=145, Percent_Identity=37.2413793103448, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 21742; Mature: 21742

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVSRTIWRVIAVLIAVIYVRLIVYKSISITGSLPEMLKQVEIFTDGSCLGNPGPGGYG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHH
AIMRYRQHEKTFSAGYRLTTNNRMELMAAIVALEALKEHCEVVLSTDSQYVRQGITQWIH
HHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NWKKRGWKTAEKKPVKNVDLWQRLDAALGQHKIKWEWVKGHAGHPENERCDELARAAASH
HHHHCCCCCHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCC
PTLDDVGYLPES
CCHHHCCCCCCC
>Mature Secondary Structure
MVSVSRTIWRVIAVLIAVIYVRLIVYKSISITGSLPEMLKQVEIFTDGSCLGNPGPGGYG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHH
AIMRYRQHEKTFSAGYRLTTNNRMELMAAIVALEALKEHCEVVLSTDSQYVRQGITQWIH
HHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NWKKRGWKTAEKKPVKNVDLWQRLDAALGQHKIKWEWVKGHAGHPENERCDELARAAASH
HHHHCCCCCHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCC
PTLDDVGYLPES
CCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA