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The map label for this gene is hemL [H]

Identifier: 238893152

GI number: 238893152

Start: 987056

End: 988336

Strand: Reverse

Name: hemL [H]

Synonym: KP1_1006

Alternate gene names: 238893152

Gene position: 988336-987056 (Counterclockwise)

Preceding gene: 238893155

Following gene: 238893145

Centisome position: 18.83

GC content: 62.61

Gene sequence:

>1281_bases
ATGAGCAAATCTGAAAATCTGTATCACGCTGCGCGCGAACTGATCCCCGGCGGCGTTAACTCGCCGGTGCGCGCTTTCAC
CGGCGTCGGCGGCACACCGCTGTTTATCGAACGCGCGGATGGCGCTTACCTCTATGACGTGGATGGGAAAGCCTATATCG
ATTATGTCGGTTCCTGGGGTCCGATGGTGCTGGGCCACAACCACCCGGCTATCCGCAATGCGGTGATCGAGGCGGCAACC
CGCGGCCTGAGCTTTGGCGCGCCGACCGAAATGGAAGTGAAAATGGCGGCCCTGGTGACCGAGCTGGTGCCGACCATGGA
TATGGTGCGGATGGTGAACTCCGGTACCGAAGCCACCATGAGCGCCATTCGCCTGGCGCGCGGCTTCACCGGTCGCGACA
AAATCATTAAGTTCGAAGGCTGCTACCACGGCCATGCCGACTGCCTGCTGGTGAAAGCCGGTTCCGGCGCGTTGACCCTC
GGCCAGCCGAACTCGCCGGGCGTCCCGGCCGATTTCGCCAAACATACCCTGACCTGCACTTATAACGACCTCGCCTCGGT
GCGCGCGGCGTTCGAGCAGTATCCGCAGGAGATCGCCTGCATCATCGTCGAGCCGGTGGCCGGAAATATGAACTGCATTC
CGCCGCAGCCGGAATTCCTGCCGGGCCTGCGCGCCCTGTGCGATGAATTTGGCGCCCTGCTGATTATCGACGAAGTGATG
ACCGGCTTCCGCGTGGCGCTGGCAGGCGCTCAGGCTTACTACGGCGTGGAGCCGGATCTGACCTGTCTGGGGAAAATCAT
CGGCGGCGGGATGCCGGTAGGCGCCTTCGGCGGCCGTCGTGAGGTAATGGACGCTCTGGCGCCCACCGGTCCGGTCTATC
AGGCGGGCACCCTCTCCGGCAACCCGATCGCCATGGCGGCTGGCTTCGCCTGCCTGAACGAAGTGGCGCAGCCGGGGGTC
CATGAAACCCTGACTGAACTGACTAACCAGCTGGCGCAAGGCCTGCTGGACGCGGCGCGTGACGCCGGGATCCCGCTGGT
GGTCAATAACGTCGGCGGCATGTTCGGCATCTTCTTTACCGATGCCGAAACCGTCACCTGCTATCAGGACGTGGTGAAGT
GCGACGTTGAACGCTTCAAGCGCTTCTTCCATCTGATGCTGGAGGAAGGCGTGTACCTCGCGCCGTCAGCGTTTGAGGCC
GGCTTTATGTCCGTGGCCCACAGCGAAGAAGATATCGACAACACCATCGACGCCGCGCGCCGGGTATTTGCCAAGCTGTA
A

Upstream 100 bases:

>100_bases
CCTTGCGGCACATTGTTTCAATTGGGCAAAACTTTCATAACCATCCTGGAATAACTTAGAATAGCCGATAAAACATTTTT
CACGAACCAGGACCCTGGCC

Downstream 100 bases:

>100_bases
GGTGCTTGAATGCCTGGTGGCGCAGGGATTTTCCCGGAGGAGGCGCATTGCGCCTTATCCGGGCTACCAAATCGCACAGC
GCTGTAGCCCCGGTAAGCGA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSKSENLYHAARELIPGGVNSPVRAFTGVGGTPLFIERADGAYLYDVDGKAYIDYVGSWGPMVLGHNHPAIRNAVIEAAT
RGLSFGAPTEMEVKMAALVTELVPTMDMVRMVNSGTEATMSAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTL
GQPNSPGVPADFAKHTLTCTYNDLASVRAAFEQYPQEIACIIVEPVAGNMNCIPPQPEFLPGLRALCDEFGALLIIDEVM
TGFRVALAGAQAYYGVEPDLTCLGKIIGGGMPVGAFGGRREVMDALAPTGPVYQAGTLSGNPIAMAAGFACLNEVAQPGV
HETLTELTNQLAQGLLDAARDAGIPLVVNNVGGMFGIFFTDAETVTCYQDVVKCDVERFKRFFHLMLEEGVYLAPSAFEA
GFMSVAHSEEDIDNTIDAARRVFAKL

Sequences:

>Translated_426_residues
MSKSENLYHAARELIPGGVNSPVRAFTGVGGTPLFIERADGAYLYDVDGKAYIDYVGSWGPMVLGHNHPAIRNAVIEAAT
RGLSFGAPTEMEVKMAALVTELVPTMDMVRMVNSGTEATMSAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTL
GQPNSPGVPADFAKHTLTCTYNDLASVRAAFEQYPQEIACIIVEPVAGNMNCIPPQPEFLPGLRALCDEFGALLIIDEVM
TGFRVALAGAQAYYGVEPDLTCLGKIIGGGMPVGAFGGRREVMDALAPTGPVYQAGTLSGNPIAMAAGFACLNEVAQPGV
HETLTELTNQLAQGLLDAARDAGIPLVVNNVGGMFGIFFTDAETVTCYQDVVKCDVERFKRFFHLMLEEGVYLAPSAFEA
GFMSVAHSEEDIDNTIDAARRVFAKL
>Mature_425_residues
SKSENLYHAARELIPGGVNSPVRAFTGVGGTPLFIERADGAYLYDVDGKAYIDYVGSWGPMVLGHNHPAIRNAVIEAATR
GLSFGAPTEMEVKMAALVTELVPTMDMVRMVNSGTEATMSAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLG
QPNSPGVPADFAKHTLTCTYNDLASVRAAFEQYPQEIACIIVEPVAGNMNCIPPQPEFLPGLRALCDEFGALLIIDEVMT
GFRVALAGAQAYYGVEPDLTCLGKIIGGGMPVGAFGGRREVMDALAPTGPVYQAGTLSGNPIAMAAGFACLNEVAQPGVH
ETLTELTNQLAQGLLDAARDAGIPLVVNNVGGMFGIFFTDAETVTCYQDVVKCDVERFKRFFHLMLEEGVYLAPSAFEAG
FMSVAHSEEDIDNTIDAARRVFAKL

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=319, Percent_Identity=28.8401253918495, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI13994255, Length=345, Percent_Identity=27.2463768115942, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI284507298, Length=234, Percent_Identity=28.6324786324786, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=94.131455399061, Blast_Score=824, Evalue=0.0,
Organism=Escherichia coli, GI1789016, Length=383, Percent_Identity=32.3759791122715, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1787560, Length=346, Percent_Identity=32.0809248554913, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788044, Length=330, Percent_Identity=33.030303030303, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI145693181, Length=336, Percent_Identity=29.7619047619048, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1789759, Length=300, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1786991, Length=383, Percent_Identity=26.8929503916449, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71992977, Length=340, Percent_Identity=30.2941176470588, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=323, Percent_Identity=26.9349845201238, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144274, Length=166, Percent_Identity=30.1204819277108, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=341, Percent_Identity=29.0322580645161, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324432, Length=353, Percent_Identity=26.628895184136, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356575, Length=334, Percent_Identity=28.1437125748503, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357415, Length=319, Percent_Identity=25.3918495297806, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 45343; Mature: 45211

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSENLYHAARELIPGGVNSPVRAFTGVGGTPLFIERADGAYLYDVDGKAYIDYVGSWG
CCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEEECCCEEEEECCCCEEEEEECCCC
PMVLGHNHPAIRNAVIEAATRGLSFGAPTEMEVKMAALVTELVPTMDMVRMVNSGTEATM
CEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPADFAKHTLTCT
HHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEECCCCCCCCCHHHHHCEEEEE
YNDLASVRAAFEQYPQEIACIIVEPVAGNMNCIPPQPEFLPGLRALCDEFGALLIIDEVM
HHHHHHHHHHHHHCCHHEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHH
TGFRVALAGAQAYYGVEPDLTCLGKIIGGGMPVGAFGGRREVMDALAPTGPVYQAGTLSG
HHHHHHHHCCHHCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPIAMAAGFACLNEVAQPGVHETLTELTNQLAQGLLDAARDAGIPLVVNNVGGMFGIFFT
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEE
DAETVTCYQDVVKCDVERFKRFFHLMLEEGVYLAPSAFEAGFMSVAHSEEDIDNTIDAAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHCCHHHHHHHHHHHH
RVFAKL
HHHHCC
>Mature Secondary Structure 
SKSENLYHAARELIPGGVNSPVRAFTGVGGTPLFIERADGAYLYDVDGKAYIDYVGSWG
CCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEEECCCEEEEECCCCEEEEEECCCC
PMVLGHNHPAIRNAVIEAATRGLSFGAPTEMEVKMAALVTELVPTMDMVRMVNSGTEATM
CEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPADFAKHTLTCT
HHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEECCCCCCCCCHHHHHCEEEEE
YNDLASVRAAFEQYPQEIACIIVEPVAGNMNCIPPQPEFLPGLRALCDEFGALLIIDEVM
HHHHHHHHHHHHHCCHHEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHH
TGFRVALAGAQAYYGVEPDLTCLGKIIGGGMPVGAFGGRREVMDALAPTGPVYQAGTLSG
HHHHHHHHCCHHCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPIAMAAGFACLNEVAQPGVHETLTELTNQLAQGLLDAARDAGIPLVVNNVGGMFGIFFT
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEE
DAETVTCYQDVVKCDVERFKRFFHLMLEEGVYLAPSAFEAGFMSVAHSEEDIDNTIDAAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHCCHHHHHHHHHHHH
RVFAKL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA