Click here to switch to the map view.

The map label for this gene is metH [H]

Identifier: 238892490

GI number: 238892490

Start: 270443

End: 274216

Strand: Direct

Name: metH [H]

Synonym: KP1_0257

Alternate gene names: 238892490

Gene position: 270443-274216 (Clockwise)

Preceding gene: 238892488

Following gene: 238892491

Centisome position: 5.15

GC content: 58.64

Gene sequence:

>3774_bases
TTGCCCGTTGTTGTCTTTTCCGCTCCGGTGGTTTATGCCAGTATGGTTTGTTGGCTATTTGGCCTGAGTCGAGCGTTGTC
GGGAGCAAGTGTGAGCAGCAAAGTTGAGCAACTGCATCAGCAGTTAAAAGAACGTATTCTGGTTCTGGATGGGGGCATGG
GCACCATGATCCAGGGCTATCGTCTGAGTGAGCAGGACTTTCGCGGTGAGCGCTTTGCTGACTGGCCGTGCGACCTGAAA
GGCAACAACGACCTGCTGGTGCTCAGCAAACCCGAAGTGATCCGCGAGATCCACGACGCCTATTTCGAGGCCGGCGCGGA
TATCGTTGAGACCAACACCTTTAACTCGACGACCATCGCGATGGCGGATTACCAGATGGAATCCCTGTCGGCCGAGATCA
ACTTTGCCGCGGCGAAGCTGGCCCGCGCCAGCGCCGACGCCTGGACGGCCCGCACGCCGGAAAAACCGCGCTATGTCGCG
GGCGTGCTTGGCCCGACCAACCGCACCGCTTCTATTTCGCCTGATGTGAACGATCCGGCGTTCCGTAATATTACCTTTGA
CCAGCTGGTGGCCGCCTATCGCGAATCCACCCGGGCGCTGGTGGAAGGCGGCGTGGATCTGATCCTGATTGAAACGGTAT
TTGACACCCTGAACGCTAAAGCGGCTATCTATGCGGTGAAAGAGGAGCTGGAGGCGTTAGGCGTTGACCTGCCGCTGATG
ATCTCCGGGACCATTACCGATGCCTCCGGCCGCACGCTTTCCGGACAGACCACCGAAGCCTTTTATAACTCGCTGCGTCA
CGCCGAAGCCTTATCGTTTGGTCTGAACTGCGCCCTCGGGCCGGACGAGCTGCGGCAGTACGTCCAGGAGCTGTCGCGCA
TTGCCGAATGCTACGTCACCGCGCACCCGAACGCCGGCCTGCCCAACGCTTTCGGCGAATACGATCTGGACGCCGACACC
ATGGCGACGCAAATTCGCGAATGGGCGGAAGCCGGTTTCCTCAATATCGTTGGCGGCTGCTGCGGTACCACCCCGGAGCA
TATCGCCGCCATGAGCCGGGCGGTAGCGGGCCTGCCGCCGCGTCAGTTGCCGGAAATTGCGGTGGCCTGCCGCCTCGCCG
GCCTGGAGCCGTTGAATATCGGCGACGATAGCCTGTTCGTTAACGTCGGTGAACGAACTAACGTCACCGGCTCGGCGAAA
TTTAAGCGGCTGATTAAAGAAGAGAAGTACAGCGAAGCGCTGGACGTTGCGCGTCAGCAGGTGGAAAGCGGCGCGCAGAT
TATCGATATCAACATGGACGAGGGGATGCTCGACGCGGAAGCGGCGATGGTGCGTTTCCTTAACCTGATTGCCGGCGAGC
CGGACATTGCCCGCGTGCCGATCATGATTGACTCCTCCAAGTGGGAAGTCATTGAAAAGGGCCTGAAATGTATTCAGGGC
AAAGGCATCGTTAACTCGATTTCGATGAAAGAGGGCGTCGAATCCTTTATCCACCATGCGAAACTGGTTCGCCGCTACGG
CGCCGCGGTGGTGGTGATGGCTTTCGACGAGGTTGGTCAGGCCGACACCCGCGAACGTAAAATTGAGATTTGCCGTCGCG
CCTACAAAATCCTAACCGAAGAGGTCGGCTTCCCGCCGGAAGATATTATCTTCGACCCCAATATCTTTGCCGTCGCCACC
GGTATCGAAGAGCATAACAACTACGCACAGGACTTTATCGGCGCCTGCGAAGACATCAAACGCGAGCTGCCGCATGCGCT
AATCTCCGGCGGGGTCTCCAACGTCTCCTTCTCCTTCCGCGGTAATGACCCGGTACGTGAGGCGATCCACGCCGTATTCC
TCTACTACGCGATCCGCAACGGCATGGACATGGGGATCGTCAACGCCGGTCAGCTGGCCATCTATGATGACCTCCCGGGC
GAGCTGCGCGACGCGGTCGAAGACGTGATCCTCAACCGCCGCGATGACAGTACCGAACGGTTACTTGAGCTGGCGGAAAA
ATATCGCGGCAGCAAAGCGGACGACGGCGCGAATGCCCAGCAGGCGGAGTGGCGCACCTGGGAAGTGAAAAAACGCCTCG
AATATTCGCTGGTTAAGGGCATTACCGAATTTATCGAACAGGACACCGAAGAAGCGCGTCAGCAGGCCGCCCGCCCGATT
GAGGTCATTGAAGGGCCGCTGATGGACGGCATGAACGTGGTCGGCGATCTGTTCGGCGAAGGCAAAATGTTCCTGCCGCA
GGTGGTGAAATCCGCCCGTGTAATGAAACAGGCGGTGGCCTACCTTGAGCCGTTTATTGAAGCCAGTAAAGAGCAGGGCT
CCAGTAACGGCAAAATGGTGATTGCCACGGTAAAAGGCGACGTTCATGACATTGGCAAAAACATCGTCGGCGTGGTGCTG
CAGTGCAATAACTACGAAATCATCGATCTTGGCGTGATGGTCCCGGCGGATAAAATTCTCAAAACGGCCAAAGAGGTAAA
CGCGGATCTAATTGGTCTTTCCGGGCTGATTACCCCATCGCTGGACGAGATGGTTAATGTGGCGAAAGAGATGGAGCGCC
AGGGCTTTACCATCCCGCTGCTGATAGGCGGCGCGACCACCTCGAAAGCGCATACGGCGGTGAAAATCGAGCAGAACTAC
AGCGGCCCGACCGTTTACGTACAGAACGCCTCGCGCACCGTCGGCGTGGTGTCTGCGCTGCTCTCGGACACGCAGCGCGA
CGAGTTTGTCGCCCGCACGCGCAAAGAGTATGAAACGGTGCGTATCCAGCATGGGCGTAAAAAACCGCGTACGCCGCCAG
TGACCCTTGCCGCCGCGCGGGAAAACGATCTGGCCTTTGACTGGGAGAGCTACACGCCGCCGGTGGCTCATCGTCTGGGA
GTACAGACGGTGGAAGCCAGTATCGAGACTCTGCGCAACTACATCGACTGGACGCCGTTCTTCATGACCTGGTCGCTGGC
GGGTAAATATCCGCGCATTCTGGAAGATGAAGTGGTAGGGGAAGAGGCGCAGCGCCTGTTCAAAGATGCTAACGAGCTGC
TGGATAAGCTGAGCGCAGAGAAAACCCTGAACCCGCGCGGCGTGGTGGGTCTGTTCCCGGCCAACCGCGTGGGCGACGAT
ATTGAAATCTATCGCGATGAAACCCGCACCCACGTGCTGACGGTGAGCCATCATCTGCGCCAGCAGACGGAGAAGGTTGG
CTTCGCCAACTACTGCCTCGCCGATTTTGTCGCGCCGAAGCTGAGCGGCAAGGCGGACTACATCGGCGCCTTCGCCGTGA
CCGGCGGCCTGGAAGAGGACGCGCTGGCGGACGCCTATGAAGCGCAGCATGATGACTATAACAAGATCATGATCAAGGCC
ATCGCCGATCGCCTGGCGGAGGCCTTTGCCGAGTATCTGCATGAGAAAGTGCGCAAGGTTTACTGGGGATATGCGGCCAA
TGAGAACCTCAGCAATGAGGAGCTTATTCGCGAGAACTACCAGGGGATCCGACCGGCGCCGGGATATCCGGCCTGTCCGG
AGCACACCGAAAAGGGGACCATCTGGCAGCTACTGGACGTCGAAGCCCATACCGGCATGAAGCTCACCGAATCGTTCGCC
ATGTGGCCGGGCGCATCGGTTTCCGGCTGGTACTTCAGCCATCCGGATAGCAAGTACTTCGCCGTGGCGCAGATCCAGCG
CGATCAGGTCGAAGATTACGCGCTGCGTAAAGGAATGACGCCGGCGGAGGTCGAGCGCTGGTTAGCGCCTAATCTGGGCT
ATGATGCGGACTAG

Upstream 100 bases:

>100_bases
AACTCCTTTTTCTGTATCGTGGAAATAATTTTCGTTTTATTTGGCAATAATGCAATCACAACCGGACTCATCGGAGGAGT
GAAGCTGAACATGTCTCATA

Downstream 100 bases:

>100_bases
TCGTCATCTTTCCTTACAACAAACAAGGCGCTCTGTGAGCGCCTTGTCTCTTTATTGAGGTTAACCCCTTATACTGAGAT
AGGTTCCTGAACTTCGGAAA

Product: B12-dependent methionine synthase

Products: NA

Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS [H]

Number of amino acids: Translated: 1257; Mature: 1256

Protein sequence:

>1257_residues
MPVVVFSAPVVYASMVCWLFGLSRALSGASVSSKVEQLHQQLKERILVLDGGMGTMIQGYRLSEQDFRGERFADWPCDLK
GNNDLLVLSKPEVIREIHDAYFEAGADIVETNTFNSTTIAMADYQMESLSAEINFAAAKLARASADAWTARTPEKPRYVA
GVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTRALVEGGVDLILIETVFDTLNAKAAIYAVKEELEALGVDLPLM
ISGTITDASGRTLSGQTTEAFYNSLRHAEALSFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADT
MATQIREWAEAGFLNIVGGCCGTTPEHIAAMSRAVAGLPPRQLPEIAVACRLAGLEPLNIGDDSLFVNVGERTNVTGSAK
FKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKCIQG
KGIVNSISMKEGVESFIHHAKLVRRYGAAVVVMAFDEVGQADTRERKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVAT
GIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPG
ELRDAVEDVILNRRDDSTERLLELAEKYRGSKADDGANAQQAEWRTWEVKKRLEYSLVKGITEFIEQDTEEARQQAARPI
EVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQGSSNGKMVIATVKGDVHDIGKNIVGVVL
QCNNYEIIDLGVMVPADKILKTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNY
SGPTVYVQNASRTVGVVSALLSDTQRDEFVARTRKEYETVRIQHGRKKPRTPPVTLAAARENDLAFDWESYTPPVAHRLG
VQTVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGEEAQRLFKDANELLDKLSAEKTLNPRGVVGLFPANRVGDD
IEIYRDETRTHVLTVSHHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAYEAQHDDYNKIMIKA
IADRLAEAFAEYLHEKVRKVYWGYAANENLSNEELIRENYQGIRPAPGYPACPEHTEKGTIWQLLDVEAHTGMKLTESFA
MWPGASVSGWYFSHPDSKYFAVAQIQRDQVEDYALRKGMTPAEVERWLAPNLGYDAD

Sequences:

>Translated_1257_residues
MPVVVFSAPVVYASMVCWLFGLSRALSGASVSSKVEQLHQQLKERILVLDGGMGTMIQGYRLSEQDFRGERFADWPCDLK
GNNDLLVLSKPEVIREIHDAYFEAGADIVETNTFNSTTIAMADYQMESLSAEINFAAAKLARASADAWTARTPEKPRYVA
GVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTRALVEGGVDLILIETVFDTLNAKAAIYAVKEELEALGVDLPLM
ISGTITDASGRTLSGQTTEAFYNSLRHAEALSFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADT
MATQIREWAEAGFLNIVGGCCGTTPEHIAAMSRAVAGLPPRQLPEIAVACRLAGLEPLNIGDDSLFVNVGERTNVTGSAK
FKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKCIQG
KGIVNSISMKEGVESFIHHAKLVRRYGAAVVVMAFDEVGQADTRERKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVAT
GIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPG
ELRDAVEDVILNRRDDSTERLLELAEKYRGSKADDGANAQQAEWRTWEVKKRLEYSLVKGITEFIEQDTEEARQQAARPI
EVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQGSSNGKMVIATVKGDVHDIGKNIVGVVL
QCNNYEIIDLGVMVPADKILKTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNY
SGPTVYVQNASRTVGVVSALLSDTQRDEFVARTRKEYETVRIQHGRKKPRTPPVTLAAARENDLAFDWESYTPPVAHRLG
VQTVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGEEAQRLFKDANELLDKLSAEKTLNPRGVVGLFPANRVGDD
IEIYRDETRTHVLTVSHHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAYEAQHDDYNKIMIKA
IADRLAEAFAEYLHEKVRKVYWGYAANENLSNEELIRENYQGIRPAPGYPACPEHTEKGTIWQLLDVEAHTGMKLTESFA
MWPGASVSGWYFSHPDSKYFAVAQIQRDQVEDYALRKGMTPAEVERWLAPNLGYDAD
>Mature_1256_residues
PVVVFSAPVVYASMVCWLFGLSRALSGASVSSKVEQLHQQLKERILVLDGGMGTMIQGYRLSEQDFRGERFADWPCDLKG
NNDLLVLSKPEVIREIHDAYFEAGADIVETNTFNSTTIAMADYQMESLSAEINFAAAKLARASADAWTARTPEKPRYVAG
VLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTRALVEGGVDLILIETVFDTLNAKAAIYAVKEELEALGVDLPLMI
SGTITDASGRTLSGQTTEAFYNSLRHAEALSFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTM
ATQIREWAEAGFLNIVGGCCGTTPEHIAAMSRAVAGLPPRQLPEIAVACRLAGLEPLNIGDDSLFVNVGERTNVTGSAKF
KRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKCIQGK
GIVNSISMKEGVESFIHHAKLVRRYGAAVVVMAFDEVGQADTRERKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATG
IEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPGE
LRDAVEDVILNRRDDSTERLLELAEKYRGSKADDGANAQQAEWRTWEVKKRLEYSLVKGITEFIEQDTEEARQQAARPIE
VIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQGSSNGKMVIATVKGDVHDIGKNIVGVVLQ
CNNYEIIDLGVMVPADKILKTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYS
GPTVYVQNASRTVGVVSALLSDTQRDEFVARTRKEYETVRIQHGRKKPRTPPVTLAAARENDLAFDWESYTPPVAHRLGV
QTVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGEEAQRLFKDANELLDKLSAEKTLNPRGVVGLFPANRVGDDI
EIYRDETRTHVLTVSHHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAYEAQHDDYNKIMIKAI
ADRLAEAFAEYLHEKVRKVYWGYAANENLSNEELIRENYQGIRPAPGYPACPEHTEKGTIWQLLDVEAHTGMKLTESFAM
WPGASVSGWYFSHPDSKYFAVAQIQRDQVEDYALRKGMTPAEVERWLAPNLGYDAD

Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]

COG id: COG1410

COG function: function code E; Methionine synthase I, cobalamin-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=1253, Percent_Identity=53.5514764565044, Blast_Score=1316, Evalue=0.0,
Organism=Escherichia coli, GI1790450, Length=1227, Percent_Identity=93.561532192339, Blast_Score=2381, Evalue=0.0,
Organism=Escherichia coli, GI1786456, Length=318, Percent_Identity=24.8427672955975, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17535405, Length=1255, Percent_Identity=52.9083665338645, Blast_Score=1280, Evalue=0.0,

Paralogues:

None

Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006158
- InterPro:   IPR011005
- InterPro:   IPR003759
- InterPro:   IPR011822
- InterPro:   IPR000489
- InterPro:   IPR003726
- InterPro:   IPR004223 [H]

Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]

EC number: =2.1.1.13 [H]

Molecular weight: Translated: 138866; Mature: 138735

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50970 HCY ; PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVVVFSAPVVYASMVCWLFGLSRALSGASVSSKVEQLHQQLKERILVLDGGMGTMIQGY
CCEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCEEEEECCCCHHHCCC
RLSEQDFRGERFADWPCDLKGNNDLLVLSKPEVIREIHDAYFEAGADIVETNTFNSTTIA
CCCCHHCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEECCCCCCEEEE
MADYQMESLSAEINFAAAKLARASADAWTARTPEKPRYVAGVLGPTNRTASISPDVNDPA
EECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
FRNITFDQLVAAYRESTRALVEGGVDLILIETVFDTLNAKAAIYAVKEELEALGVDLPLM
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEE
ISGTITDASGRTLSGQTTEAFYNSLRHAEALSFGLNCALGPDELRQYVQELSRIAECYVT
EEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEE
AHPNAGLPNAFGEYDLDADTMATQIREWAEAGFLNIVGGCCGTTPEHIAAMSRAVAGLPP
ECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHCCCC
RQLPEIAVACRLAGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVARQQ
HHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VESGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKCIQG
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHCC
KGIVNSISMKEGVESFIHHAKLVRRYGAAVVVMAFDEVGQADTRERKIEICRRAYKILTE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHH
EVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSFSFR
HCCCCCHHEEECCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
GNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPGELRDAVEDVILNRRDDSTER
CCCHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCHHHHHHHHHHHHCCCCCHHHH
LLELAEKYRGSKADDGANAQQAEWRTWEVKKRLEYSLVKGITEFIEQDTEEARQQAARPI
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQGSSNGKMV
HHHCCCHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
IATVKGDVHDIGKNIVGVVLQCNNYEIIDLGVMVPADKILKTAKEVNADLIGLSGLITPS
EEEECCCHHHHHHHHEEEEEEECCEEEEEEEEECCHHHHHHHHHHCCCCEEECCCCCCCC
LDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVSAL
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEECCCCCCEEEEECCCHHHHHHHHH
LSDTQRDEFVARTRKEYETVRIQHGRKKPRTPPVTLAAARENDLAFDWESYTPPVAHRLG
HHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEECCCCCCCHHHHHHH
VQTVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGEEAQRLFKDANELLDKLSAE
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
KTLNPRGVVGLFPANRVGDDIEIYRDETRTHVLTVSHHLRQQTEKVGFANYCLADFVAPK
CCCCCCCEEEECCCCCCCCCHHEEECCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHC
LSGKADYIGAFAVTGGLEEDALADAYEAQHDDYNKIMIKAIADRLAEAFAEYLHEKVRKV
CCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YWGYAANENLSNEELIRENYQGIRPAPGYPACPEHTEKGTIWQLLDVEAHTGMKLTESFA
HHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHH
MWPGASVSGWYFSHPDSKYFAVAQIQRDQVEDYALRKGMTPAEVERWLAPNLGYDAD
CCCCCCCCCCEEECCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PVVVFSAPVVYASMVCWLFGLSRALSGASVSSKVEQLHQQLKERILVLDGGMGTMIQGY
CEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCEEEEECCCCHHHCCC
RLSEQDFRGERFADWPCDLKGNNDLLVLSKPEVIREIHDAYFEAGADIVETNTFNSTTIA
CCCCHHCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEECCCCCCEEEE
MADYQMESLSAEINFAAAKLARASADAWTARTPEKPRYVAGVLGPTNRTASISPDVNDPA
EECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
FRNITFDQLVAAYRESTRALVEGGVDLILIETVFDTLNAKAAIYAVKEELEALGVDLPLM
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEE
ISGTITDASGRTLSGQTTEAFYNSLRHAEALSFGLNCALGPDELRQYVQELSRIAECYVT
EEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEE
AHPNAGLPNAFGEYDLDADTMATQIREWAEAGFLNIVGGCCGTTPEHIAAMSRAVAGLPP
ECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHCCCC
RQLPEIAVACRLAGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVARQQ
HHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VESGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKCIQG
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHCC
KGIVNSISMKEGVESFIHHAKLVRRYGAAVVVMAFDEVGQADTRERKIEICRRAYKILTE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHH
EVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSFSFR
HCCCCCHHEEECCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
GNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPGELRDAVEDVILNRRDDSTER
CCCHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCHHHHHHHHHHHHCCCCCHHHH
LLELAEKYRGSKADDGANAQQAEWRTWEVKKRLEYSLVKGITEFIEQDTEEARQQAARPI
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQGSSNGKMV
HHHCCCHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
IATVKGDVHDIGKNIVGVVLQCNNYEIIDLGVMVPADKILKTAKEVNADLIGLSGLITPS
EEEECCCHHHHHHHHEEEEEEECCEEEEEEEEECCHHHHHHHHHHCCCCEEECCCCCCCC
LDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVSAL
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEECCCCCCEEEEECCCHHHHHHHHH
LSDTQRDEFVARTRKEYETVRIQHGRKKPRTPPVTLAAARENDLAFDWESYTPPVAHRLG
HHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEECCCCCCCHHHHHHH
VQTVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGEEAQRLFKDANELLDKLSAE
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
KTLNPRGVVGLFPANRVGDDIEIYRDETRTHVLTVSHHLRQQTEKVGFANYCLADFVAPK
CCCCCCCEEEECCCCCCCCCHHEEECCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHC
LSGKADYIGAFAVTGGLEEDALADAYEAQHDDYNKIMIKAIADRLAEAFAEYLHEKVRKV
CCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YWGYAANENLSNEELIRENYQGIRPAPGYPACPEHTEKGTIWQLLDVEAHTGMKLTESFA
HHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHH
MWPGASVSGWYFSHPDSKYFAVAQIQRDQVEDYALRKGMTPAEVERWLAPNLGYDAD
CCCCCCCCCCEEECCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2185137; 2668277; 8369296; 8265357; 9278503; 1593636; 7992050; 8939751 [H]