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The map label for this gene is aceK [H]

Identifier: 238892488

GI number: 238892488

Start: 267673

End: 269457

Strand: Direct

Name: aceK [H]

Synonym: KP1_0255

Alternate gene names: 238892488

Gene position: 267673-269457 (Clockwise)

Preceding gene: 238892487

Following gene: 238892490

Centisome position: 5.1

GC content: 57.7

Gene sequence:

>1785_bases
ATGACGCGTGGTCTGGAATTACTGATTGCCCAAACGATATTGCAGGGATTTGACGCGCAGTATGGGCGTTTTCTTGAAGT
CACTTCCGGCGCGCAGCAGCGCTTTGAACAGGCTGACTGGCACGCCGTGCAGCAGGCGATGAAGCAGCGGATCCATCTCT
ACGATCACCACGTGGGCCTGGTAGTAGAGCAGCTGCGCTGCATCACCGAAGGGAAAAGCACCGACGTCGATTTTCTTCTG
CGGGTGAAACAGCAGTACACCCAACTTTTACCGGATTACCCTCGCTTTGAAATTGCTGAGAGCTTTTTCAATTCGGTCTA
CTGCCGCCTGTTTGACCACCGCTCGCTGACCCCCGAGCGGCTCTTTATTTTCAGCTCGCAGCCCGAGCGACCCTTTCGTA
CCCTCCCGCGACCGCTGGCGAAAGATTTCTTTCCGGAACGCGGTTGGTCGCACCTGCTGGGTAAAGTACTGTCCGATCTG
CCGCTGCGGCTACCGTGGCAAAACAAAGCGCGGGATATCGGCTATATCATTGCCAGTCTGCAGGAGGCGCTGGGGGAGGA
ACTGCTCGCCACCTGTCATCTGCAGGTCGCCAATGAGCTGTTCTACCGCAATAAAGCCGCCTGGCTGGTGGGCAAACTGG
TCATGCCGATGGCGACGCTGCCTTTTTTGCTGCCGATCCACCGCAGCGAAGAGGGTGAGCTGTTTGTTGACACCTGCCTC
ACAACCCATGCCGAAGCGAGTATCGTTTTTGGCTTCGCGCGTTCCTATTTTATGGTTTATGCGCCGTTGCCCGGCGCCCT
GGTGGAATGGCTGCGCGAGATCTTGCCGGGTAAAACGACGGCCGAGCTGTACATGGCGATTGGCTGTCAGAAGCACGCCA
AAACCGAAAGCTATCGCGAATATCTACACTACATTACTCGCTGCGATGAGCAGTTTATTGAAGCGCCGGGTATTCGCGGG
ATGGTGATGCTGGTGTTTACCCTGCCGGGCTTTGACCGGGTGTTTAAGGTGATCAAGGACCGCTTCGCGCCGCAGAAAGA
GATGACCGCCGCCCATGTGCGTGCTTGCTATCAGCTGGTAAAGGAGCATGACCGCGTCGGGCGGATGGCGGACACCCAGG
AGTTTGAAAATTTCGTGCTGGATAAACGGCAAATCGCGCCGGCGCTGCTGGCGCTGCTGCAGGCGGAAGCGGGGAACAAA
CTCACCGATCTCGGCGACCGCATCGTCATCAGCCATCTCTATATTGAACGGCGAATGGTGCCGCTCAACCTGTGGCTGGA
GCAGGTTAACGGCCAGGCATTGCGTGATGCGGTAGAAGAGTATGGCAATGCTATCCGCCAGCTGGCCGCCGCCAACATCT
TTCCCGGCGATATGTTATTTAAAAACTTCGGCGTCACCCGCCATGGCCGGGTGGTGTTCTACGACTATGATGAAATCTGC
TATATGACGGAAGTGAATTTTCGCGAGATCCCGCCGCCGCGCTATCCGGAGGATGAGCTGGCCAGCGAGCCGTGGTACAG
CGTTTCGCCTGGCGATGTGTTTCCGGAGGAGTTCCGCCACTGGCTGTGCGCCGACCCGCGCATTGGGCCACTGTTTGAAG
AGATGCATGCCGACCTGCTGCGCGCCGACTACTGGCGCGCACTGCAGATGCGGATTAAAAACGGCCATGTGGAAGATGTC
TACGCCTACCGGCGCAAGCAGCGTTTTAGCGTGCGCTATGGCGCCGACAGTAGACCGGATAAGGCGTTTACGCCGCCATC
CGGCAAGGTGCGCCGATCTGCCTGA

Upstream 100 bases:

>100_bases
CATGCCCGGTGGCGCGACGCTGACCGGGCCTGCAAGAGGACGCAGGCCGGATAAGCGAGCGCGCCATCCGGCATGACGTG
GCGCCGGATGGGGGAAAGCG

Downstream 100 bases:

>100_bases
TGGCGCTACGCTTATCAGGCCTACTTAAAATGCCCCTCTGGGGCATTTTTTTATTTAACCCCGCCATACGCCAGCGTCAC
TTCCTTCGCCGCCTTGATCA

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MTRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKQRIHLYDHHVGLVVEQLRCITEGKSTDVDFLL
RVKQQYTQLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPERPFRTLPRPLAKDFFPERGWSHLLGKVLSDL
PLRLPWQNKARDIGYIIASLQEALGEELLATCHLQVANELFYRNKAAWLVGKLVMPMATLPFLLPIHRSEEGELFVDTCL
TTHAEASIVFGFARSYFMVYAPLPGALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLHYITRCDEQFIEAPGIRG
MVMLVFTLPGFDRVFKVIKDRFAPQKEMTAAHVRACYQLVKEHDRVGRMADTQEFENFVLDKRQIAPALLALLQAEAGNK
LTDLGDRIVISHLYIERRMVPLNLWLEQVNGQALRDAVEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
YMTEVNFREIPPPRYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLLRADYWRALQMRIKNGHVEDV
YAYRRKQRFSVRYGADSRPDKAFTPPSGKVRRSA

Sequences:

>Translated_594_residues
MTRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKQRIHLYDHHVGLVVEQLRCITEGKSTDVDFLL
RVKQQYTQLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPERPFRTLPRPLAKDFFPERGWSHLLGKVLSDL
PLRLPWQNKARDIGYIIASLQEALGEELLATCHLQVANELFYRNKAAWLVGKLVMPMATLPFLLPIHRSEEGELFVDTCL
TTHAEASIVFGFARSYFMVYAPLPGALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLHYITRCDEQFIEAPGIRG
MVMLVFTLPGFDRVFKVIKDRFAPQKEMTAAHVRACYQLVKEHDRVGRMADTQEFENFVLDKRQIAPALLALLQAEAGNK
LTDLGDRIVISHLYIERRMVPLNLWLEQVNGQALRDAVEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
YMTEVNFREIPPPRYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLLRADYWRALQMRIKNGHVEDV
YAYRRKQRFSVRYGADSRPDKAFTPPSGKVRRSA
>Mature_593_residues
TRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKQRIHLYDHHVGLVVEQLRCITEGKSTDVDFLLR
VKQQYTQLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPERPFRTLPRPLAKDFFPERGWSHLLGKVLSDLP
LRLPWQNKARDIGYIIASLQEALGEELLATCHLQVANELFYRNKAAWLVGKLVMPMATLPFLLPIHRSEEGELFVDTCLT
THAEASIVFGFARSYFMVYAPLPGALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLHYITRCDEQFIEAPGIRGM
VMLVFTLPGFDRVFKVIKDRFAPQKEMTAAHVRACYQLVKEHDRVGRMADTQEFENFVLDKRQIAPALLALLQAEAGNKL
TDLGDRIVISHLYIERRMVPLNLWLEQVNGQALRDAVEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICY
MTEVNFREIPPPRYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLLRADYWRALQMRIKNGHVEDVY
AYRRKQRFSVRYGADSRPDKAFTPPSGKVRRSA

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=574, Percent_Identity=87.6306620209059, Blast_Score=1053, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 68845; Mature: 68714

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKQRIHLYDHHVGL
CCCHHHHHHHHHHHHHCCHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVEQLRCITEGKSTDVDFLLRVKQQYTQLLPDYPRFEIAESFFNSVYCRLFDHRSLTPER
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
LFIFSSQPERPFRTLPRPLAKDFFPERGWSHLLGKVLSDLPLRLPWQNKARDIGYIIASL
EEEECCCCCCCHHHCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
QEALGEELLATCHLQVANELFYRNKAAWLVGKLVMPMATLPFLLPIHRSEEGELFVDTCL
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEHHHHH
TTHAEASIVFGFARSYFMVYAPLPGALVEWLREILPGKTTAELYMAIGCQKHAKTESYRE
HHCCCHHHHHHHHHCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHCCHHHCCHHHHHH
YLHYITRCDEQFIEAPGIRGMVMLVFTLPGFDRVFKVIKDRFAPQKEMTAAHVRACYQLV
HHHHHHHHHHHHHHCCCCCCEEEHEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KEHDRVGRMADTQEFENFVLDKRQIAPALLALLQAEAGNKLTDLGDRIVISHLYIERRMV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCC
PLNLWLEQVNGQALRDAVEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCCEE
YMTEVNFREIPPPRYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLL
EEECCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
RADYWRALQMRIKNGHVEDVYAYRRKQRFSVRYGADSRPDKAFTPPSGKVRRSA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKQRIHLYDHHVGL
CCHHHHHHHHHHHHHCCHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVEQLRCITEGKSTDVDFLLRVKQQYTQLLPDYPRFEIAESFFNSVYCRLFDHRSLTPER
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
LFIFSSQPERPFRTLPRPLAKDFFPERGWSHLLGKVLSDLPLRLPWQNKARDIGYIIASL
EEEECCCCCCCHHHCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
QEALGEELLATCHLQVANELFYRNKAAWLVGKLVMPMATLPFLLPIHRSEEGELFVDTCL
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEHHHHH
TTHAEASIVFGFARSYFMVYAPLPGALVEWLREILPGKTTAELYMAIGCQKHAKTESYRE
HHCCCHHHHHHHHHCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHCCHHHCCHHHHHH
YLHYITRCDEQFIEAPGIRGMVMLVFTLPGFDRVFKVIKDRFAPQKEMTAAHVRACYQLV
HHHHHHHHHHHHHHCCCCCCEEEHEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KEHDRVGRMADTQEFENFVLDKRQIAPALLALLQAEAGNKLTDLGDRIVISHLYIERRMV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCC
PLNLWLEQVNGQALRDAVEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEIC
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCCEE
YMTEVNFREIPPPRYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLL
EEECCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
RADYWRALQMRIKNGHVEDVYAYRRKQRFSVRYGADSRPDKAFTPPSGKVRRSA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA