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The map label for this gene is zraR [H]

Identifier: 238892480

GI number: 238892480

Start: 252670

End: 254001

Strand: Direct

Name: zraR [H]

Synonym: KP1_0246

Alternate gene names: 238892480

Gene position: 252670-254001 (Clockwise)

Preceding gene: 238892479

Following gene: 238892484

Centisome position: 4.81

GC content: 59.98

Gene sequence:

>1332_bases
ATGAGCAGCGATAAAGTACAGATTCTGGTCGTTGATGATGACATCAGCCACTGCACGATCCTGCAGGCGCTGCTGCGCGG
CTGGGGCTATCAGGTGGGGGTGGCTCACAACGGCCTGCAGGCGCTGGAGCAGATCCATCAGCAGGTCTTCGACCTGGTGC
TGTGCGATATCCGTATGGCGGAGATGGACGGTATCGCAACGTTAAAAGAGATTAAGGCCTATAACCCGGCGATACCGGTG
CTGATCATGACGGCGTTTTCCAGCGTCGGTACGGCGGTAGAAGCTATTAAGTCCGGGGCGCTGGATTATCTGGTTAAACC
GCTGGATTTTGACACCCTGCAGCAGACGCTGGTTCAGGCATTGGCGCACACCCGGCAGAGCGAGAGCGACCCCAGCGTTG
CGACGGATTCACGGTGGGGCATGATTGGCGACAGCCCGGCGATGCAGGCGCTTCTTAACGATATTACGCTGGTGGCCCCT
TCGGACGCGACGGTGCTGATTTATGGGGAGTCGGGAACCGGTAAGGAGCTGGTGGCGCACGCCATCCACGCCTGCAGCGA
GCGTCGTGACAAGCCGTTGGTCACGCTCAACTGCGCGGCGCTGAATGAGTCACTGCTGGAATCCGAGCTGTTCGGTCATG
AAAAAGGGGCGTTTACCGGGGCGGATCGGCGACGGGAAGGACGCTTTGTCGAGGCGGATGGCGGCACGCTGTTCCTTGAT
GAAATTGGCGATATCTCGCCGCTGATGCAGGTGCGTCTGCTGCGGGCGATTCAGGAGCGGGAGGTGCAGCGGGTCGGCAG
CAACCAGACGCTTGCCGTTGATGTGCGGCTTATCGCCGCCACCCATCGCAACCTTGCGGAAGAGGTGAGCGCCGGGCGCT
TTCGCCAGGATCTCTATTACCGACTCAACGTCGTGACCATCGAGATACCGCCGCTGCGCCGGCGACGGGAAGATATTCCG
CAGCTGGCGCAGCATTTTCTCAAACGCTATACCGAACGCAATCGTAAGACGGTAAAGGGGTTCACGCCACAGGCGATGGA
CCTGCTGATCCACTACCCCTGGCCGGGCAATATACGCGAGCTGGAAAACGCGGTGGAGCGGGCGGTGGTGCTACTGACCG
GAAACTATATCTCTGAGCGAGAACTGCCCCTGGCGATCGCCGGTACGCCGCTGCCATCAGGCGGGAGCGAGGAGGGAGGA
ATTCAGCCGTTAGTGGAAGTGGAGAAAGAGGTGATTCTGGCGGCGCTGGAAAAAACGGGCGGCAACAAAACCGAAGCCGC
CCGTCAGTTAGGCATTACGCGCAAAACGCTGCTGGCGAAACTTAGCCGTTAG

Upstream 100 bases:

>100_bases
ATTATCGAACAACATGGCGGGACGATCCGCGCCGAAAGTCAGCCGGGAGCTGGAGCGATATTTACGCTTTGGTTACCGGT
GGATGCTCAACGGAGGGAAG

Downstream 100 bases:

>100_bases
CCTTTTCACGTTCGATGGCGCGCCAGCCGATATCGCTACGGCTAAAGCTACCGTCCCAGCGAATGTCGGTCAGCAGCTGA
TAGGCGCGCTGCTGCGCCTG

Product: transcriptional regulatory protein ZraR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSSDKVQILVVDDDISHCTILQALLRGWGYQVGVAHNGLQALEQIHQQVFDLVLCDIRMAEMDGIATLKEIKAYNPAIPV
LIMTAFSSVGTAVEAIKSGALDYLVKPLDFDTLQQTLVQALAHTRQSESDPSVATDSRWGMIGDSPAMQALLNDITLVAP
SDATVLIYGESGTGKELVAHAIHACSERRDKPLVTLNCAALNESLLESELFGHEKGAFTGADRRREGRFVEADGGTLFLD
EIGDISPLMQVRLLRAIQEREVQRVGSNQTLAVDVRLIAATHRNLAEEVSAGRFRQDLYYRLNVVTIEIPPLRRRREDIP
QLAQHFLKRYTERNRKTVKGFTPQAMDLLIHYPWPGNIRELENAVERAVVLLTGNYISERELPLAIAGTPLPSGGSEEGG
IQPLVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR

Sequences:

>Translated_443_residues
MSSDKVQILVVDDDISHCTILQALLRGWGYQVGVAHNGLQALEQIHQQVFDLVLCDIRMAEMDGIATLKEIKAYNPAIPV
LIMTAFSSVGTAVEAIKSGALDYLVKPLDFDTLQQTLVQALAHTRQSESDPSVATDSRWGMIGDSPAMQALLNDITLVAP
SDATVLIYGESGTGKELVAHAIHACSERRDKPLVTLNCAALNESLLESELFGHEKGAFTGADRRREGRFVEADGGTLFLD
EIGDISPLMQVRLLRAIQEREVQRVGSNQTLAVDVRLIAATHRNLAEEVSAGRFRQDLYYRLNVVTIEIPPLRRRREDIP
QLAQHFLKRYTERNRKTVKGFTPQAMDLLIHYPWPGNIRELENAVERAVVLLTGNYISERELPLAIAGTPLPSGGSEEGG
IQPLVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR
>Mature_442_residues
SSDKVQILVVDDDISHCTILQALLRGWGYQVGVAHNGLQALEQIHQQVFDLVLCDIRMAEMDGIATLKEIKAYNPAIPVL
IMTAFSSVGTAVEAIKSGALDYLVKPLDFDTLQQTLVQALAHTRQSESDPSVATDSRWGMIGDSPAMQALLNDITLVAPS
DATVLIYGESGTGKELVAHAIHACSERRDKPLVTLNCAALNESLLESELFGHEKGAFTGADRRREGRFVEADGGTLFLDE
IGDISPLMQVRLLRAIQEREVQRVGSNQTLAVDVRLIAATHRNLAEEVSAGRFRQDLYYRLNVVTIEIPPLRRRREDIPQ
LAQHFLKRYTERNRKTVKGFTPQAMDLLIHYPWPGNIRELENAVERAVVLLTGNYISERELPLAIAGTPLPSGGSEEGGI
QPLVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=443, Percent_Identity=81.941309255079, Blast_Score=743, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=46.119733924612, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1788905, Length=449, Percent_Identity=44.7661469933185, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1790299, Length=459, Percent_Identity=42.9193899782135, Blast_Score=345, Evalue=2e-96,
Organism=Escherichia coli, GI87082117, Length=317, Percent_Identity=48.2649842271293, Blast_Score=280, Evalue=9e-77,
Organism=Escherichia coli, GI1789087, Length=314, Percent_Identity=46.8152866242038, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1789233, Length=316, Percent_Identity=43.9873417721519, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI87082152, Length=231, Percent_Identity=56.2770562770563, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1786524, Length=324, Percent_Identity=44.1358024691358, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=42.4528301886792, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1787583, Length=303, Percent_Identity=36.963696369637, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1789828, Length=249, Percent_Identity=36.5461847389558, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI87081858, Length=312, Percent_Identity=33.0128205128205, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI145693157, Length=125, Percent_Identity=32, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1787487, Length=202, Percent_Identity=27.7227722772277, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789149, Length=114, Percent_Identity=32.4561403508772, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=34.1666666666667, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1788713, Length=116, Percent_Identity=31.0344827586207, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48780; Mature: 48648

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDKVQILVVDDDISHCTILQALLRGWGYQVGVAHNGLQALEQIHQQVFDLVLCDIRMA
CCCCCEEEEEEECCCCHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMDGIATLKEIKAYNPAIPVLIMTAFSSVGTAVEAIKSGALDYLVKPLDFDTLQQTLVQA
HHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHH
LAHTRQSESDPSVATDSRWGMIGDSPAMQALLNDITLVAPSDATVLIYGESGTGKELVAH
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCCCCEEEEECCCCCCHHHHHH
AIHACSERRDKPLVTLNCAALNESLLESELFGHEKGAFTGADRRREGRFVEADGGTLFLD
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEECCCCEEEEC
EIGDISPLMQVRLLRAIQEREVQRVGSNQTLAVDVRLIAATHRNLAEEVSAGRFRQDLYY
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHEE
RLNVVTIEIPPLRRRREDIPQLAQHFLKRYTERNRKTVKGFTPQAMDLLIHYPWPGNIRE
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCEEEEEECCCCCCHHH
LENAVERAVVLLTGNYISERELPLAIAGTPLPSGGSEEGGIQPLVEVEKEVILAALEKTG
HHHHHHHEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
GNKTEAARQLGITRKTLLAKLSR
CCHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
SSDKVQILVVDDDISHCTILQALLRGWGYQVGVAHNGLQALEQIHQQVFDLVLCDIRMA
CCCCEEEEEEECCCCHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMDGIATLKEIKAYNPAIPVLIMTAFSSVGTAVEAIKSGALDYLVKPLDFDTLQQTLVQA
HHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHH
LAHTRQSESDPSVATDSRWGMIGDSPAMQALLNDITLVAPSDATVLIYGESGTGKELVAH
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCCCCEEEEECCCCCCHHHHHH
AIHACSERRDKPLVTLNCAALNESLLESELFGHEKGAFTGADRRREGRFVEADGGTLFLD
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEECCCCEEEEC
EIGDISPLMQVRLLRAIQEREVQRVGSNQTLAVDVRLIAATHRNLAEEVSAGRFRQDLYY
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHEE
RLNVVTIEIPPLRRRREDIPQLAQHFLKRYTERNRKTVKGFTPQAMDLLIHYPWPGNIRE
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCEEEEEECCCCCCHHH
LENAVERAVVLLTGNYISERELPLAIAGTPLPSGGSEEGGIQPLVEVEKEVILAALEKTG
HHHHHHHEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
GNKTEAARQLGITRKTLLAKLSR
CCHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]