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The map label for this gene is hemE [H]

Identifier: 238892472

GI number: 238892472

Start: 247040

End: 248104

Strand: Direct

Name: hemE [H]

Synonym: KP1_0237

Alternate gene names: 238892472

Gene position: 247040-248104 (Clockwise)

Preceding gene: 238892471

Following gene: 238892473

Centisome position: 4.71

GC content: 60.19

Gene sequence:

>1065_bases
ATGACCGAACTGAAGAACGATCGTTACCTGCGCGCGCTGCTGCGTCAGCCGGTTGATGTCACCCCGGTGTGGATGATGCG
CCAGGCGGGCCGCTATTTACCGGAGTACAAAGCCACCCGTGCGCAAGCGGGCGACTTTATGTCGCTGTGTAAAAATGCCG
AGCTGGCCTGCGAAGTGACGCTCCAGCCGCTGCGCCGTTACCCGCTGGACGCGGCGATCCTCTTTTCGGACATCCTGACC
ATCCCGGACGCCATGGGGCTGGGGCTGTACTTTGAAGCTGGCGAAGGTCCGCGCTTCACCTCGCCGGTAAAAAGTAAAGC
CGACGTCGACAAGCTGCCGATCCCGGATCCGGAGCAGGAGCTGGGCTATGTAATGAACGCCGTGCGCACCATTCGCCGCG
AACTGAAAGGCGAAGTGCCGCTGATCGGTTTTTCCGGTAGTCCATGGACGCTGGCTACGTACATGGTGGAGGGCGGCAGC
AGCAAGGCTTTCACCGTGATTAAAAAGATGATGTACGCCGAGCCGCAGGCGCTGCATGCGCTGCTGGATAAGCTGGCGAA
GAGCGTTACCCTGTATCTCAACGCGCAGATCAAAGCCGGCGCGCAGTCGGTGATGATTTTTGACACCTGGGGCGGGGTGC
TGACCGGCCGCGACTATCAGCAGTTCTCCCTCTACTACATGCATAAGATCGTCGATGGCCTGCTGCGGGAAAACGAAGGC
CGCCGCGTGCCGGTGACTCTGTTCACCAAAGGCGGTGGTCAGTGGCTGGAAGCGATGGCGGAGACCGGCTGCGATGCGTT
GGGTCTCGACTGGACCACCGATATTGCCGATGCCCGCCGTCGCGTGGGTAACAAAGTAGCGCTGCAGGGCAATATGGATC
CGTCGATGCTCTATGCGCCCGCCCCGCGTATTGAAGAAGAAGTGGCAACCATTCTTGCCGGCTTTGGCCAGGGGGAAGGC
CACGTCTTTAACCTTGGACACGGTATTCATCAGGACGTTGACCCCGAGCATGCGGGCGTCTTTGTTGAGGCTGTGCACCG
TCTGTCCGCACCCTATCACCAGTAG

Upstream 100 bases:

>100_bases
ACAGTGGCGCGGCGGCTTATCGAAGATACCGTCGCGATGTGTCGGGCAGAGTTCGAGTGACATGTTACACTGGGCGTATC
AACGCTAAAGGAATGTAAAA

Downstream 100 bases:

>100_bases
GAGATAAGCCCTATGGATTTAGCCGCACTACGTACCCAACAGCAACAGTTAGCCGCGTCGGTAGAGCGTGCGGATCGACT
GGATCGCGACCCGCCGGCGT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILT
IPDAMGLGLYFEAGEGPRFTSPVKSKADVDKLPIPDPEQELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTVIKKMMYAEPQALHALLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENEG
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPAPRIEEEVATILAGFGQGEG
HVFNLGHGIHQDVDPEHAGVFVEAVHRLSAPYHQ

Sequences:

>Translated_354_residues
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILT
IPDAMGLGLYFEAGEGPRFTSPVKSKADVDKLPIPDPEQELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTVIKKMMYAEPQALHALLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENEG
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPAPRIEEEVATILAGFGQGEG
HVFNLGHGIHQDVDPEHAGVFVEAVHRLSAPYHQ
>Mature_353_residues
TELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILTI
PDAMGLGLYFEAGEGPRFTSPVKSKADVDKLPIPDPEQELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSS
KAFTVIKKMMYAEPQALHALLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENEGR
RVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPAPRIEEEVATILAGFGQGEGH
VFNLGHGIHQDVDPEHAGVFVEAVHRLSAPYHQ

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=353, Percent_Identity=47.8753541076487, Blast_Score=321, Evalue=7e-88,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=96.045197740113, Blast_Score=704, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320252, Length=355, Percent_Identity=38.8732394366197, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=42.0749279538905, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=42.0749279538905, Blast_Score=278, Evalue=6e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39223; Mature: 39091

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEE
LQPLRRYPLDAAILFSDILTIPDAMGLGLYFEAGEGPRFTSPVKSKADVDKLPIPDPEQE
HHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYAEPQALHA
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENEG
HHHHHHHHEEEEEEEEEECCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAP
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEECC
APRIEEEVATILAGFGQGEGHVFNLGHGIHQDVDPEHAGVFVEAVHRLSAPYHQ
CCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEE
LQPLRRYPLDAAILFSDILTIPDAMGLGLYFEAGEGPRFTSPVKSKADVDKLPIPDPEQE
HHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYAEPQALHA
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENEG
HHHHHHHHEEEEEEEEEECCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAP
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEECC
APRIEEEVATILAGFGQGEGHVFNLGHGIHQDVDPEHAGVFVEAVHRLSAPYHQ
CCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA