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The map label for this gene is cpxA [H]

Identifier: 238892327

GI number: 238892327

Start: 76799

End: 78172

Strand: Reverse

Name: cpxA [H]

Synonym: KP1_0078

Alternate gene names: 238892327

Gene position: 78172-76799 (Counterclockwise)

Preceding gene: 238892328

Following gene: 238892324

Centisome position: 1.49

GC content: 60.04

Gene sequence:

>1374_bases
ATGATTGGAAGTTTGACTGCACGCATCTTCGCCATCTTCTGGCTCACGCTGGCGCTGGTGTTGATGCTGGTGCTGATGTT
GCCCAAACTGGATTCCCGGCAGATGACCGAGCTGCTGGAAAGCGAGCAGCGTCAGGGCATCATGATCGAGCAGCACGTCG
AGGCCGAGCTGGCCAACGATCCGCCAAACGACCTGATGTGGTGGCGTCGTTTGTTTCGCGCCATCGATAAATGGGCGCCT
CCGGGACAACGCCTGCTGCTGGTGACCAGCGAAGGCCGCGTGATCGGCGCAGAACGCAACGAAATGCAGATCATTCGTAA
CTTTATCGGCCAGGCCGATAACGCCGATCATCCGCAGAAAAAACGCTATGGCCGCCTGGAAATGGTGGGCCCGTTTTCCG
TCCGGGACGGGGAGGATAACTATCAGCTCTATCTGATTCGTCCCGCCAGCACCTCACAATCCGACTTTATTAACCTGCTG
TTTGACCGGCCGCTGCTGCTGCTGATCGTCACGATGCTGGTCAGCGCCCCGCTGCTGCTGTGGCTGGCGTGGAGCCTGGC
GAAACCGGCGCGTAAGCTGAAAAATGCCGCCGATGAAGTCGCCCAGGGCAACCTGCGCCAGCATCCGGAGCTGGAAGCCG
GGCCGCAGGAGTTTTTAGCCGCTGGCGCCAGTTTTAACCAGATGGTGACGGCCCTGGAGCGGATGATGACCAGCCAGCAG
CGGCTGCTGTCCGATATCTCGCACGAGCTGCGCACGCCGCTTACGCGCCTGCAATTAGGTACCGCCCTGCTGCGTCGCCG
CAGCGGAGAGAGCAAGGAGCTGGAGCGTATCGAAACTGAAGCGCACCGGCTGGACAGCATGATCAACGACCTGCTGGTGA
TGTCGCGCAATCAGGCGAAAAACGCCCTGGTCAGCGAGACGGTGAAAGCCAATCAGCTATGGAACGAAGTGTTGGACAAT
GCGGCGTTTGAAGCTGAGCAGATGGGGAAATCTTTCACCGTTGAGTATCCGCCGGGCCCATGGCCGCTGTACGGTAACCC
CAATGCGCTGGAAAGCGCGCTGGAGAATATCGTGCGCAACGCCCTGCGCTACTCGCATACGAAAATTTCCGTCAGCTTCT
CGGTGGATAAAGACGGGATTACGGTTAACGTCGATGACGACGGCCCGGGAGTCAGCCCGGAGGATCGCGAACAGATTTTC
CGGCCATTCTACCGGACCGACGAGGCGCGCGACCGCGAGTCCGGCGGCACCGGCCTGGGGCTGGCGATTGTCGAAACCGC
TATTCAGCAGCACCGCGGCTGGGTGAAGGCCGACGACAGCCCGCTGGGTGGTCTGCGTTTAACAATCTGGCTGCCGCTGT
ATAAACGAACCTGA

Upstream 100 bases:

>100_bases
TGCATATTTCCAACCTGCGGCGTAAGCTGCCGGAGCGCAAAGATGGCCATCCGTGGTTTAAAACGCTGCGTGGCCGCGGG
TATCTGATGGTTTCCGCTTC

Downstream 100 bases:

>100_bases
CGCCGACCCGGCCTGCGCTGTGCGGCGCTGCGCCGGGAGCATCCCCGGGAATACTTAATATGGGGGATTATTTCCCCCAT
AATCTCCGCGAACTATCCTC

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLESEQRQGIMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAP
PGQRLLLVTSEGRVIGAERNEMQIIRNFIGQADNADHPQKKRYGRLEMVGPFSVRDGEDNYQLYLIRPASTSQSDFINLL
FDRPLLLLIVTMLVSAPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAHRLDSMINDLLVMSRNQAKNALVSETVKANQLWNEVLDN
AAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIF
RPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKADDSPLGGLRLTIWLPLYKRT

Sequences:

>Translated_457_residues
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLESEQRQGIMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAP
PGQRLLLVTSEGRVIGAERNEMQIIRNFIGQADNADHPQKKRYGRLEMVGPFSVRDGEDNYQLYLIRPASTSQSDFINLL
FDRPLLLLIVTMLVSAPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAHRLDSMINDLLVMSRNQAKNALVSETVKANQLWNEVLDN
AAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIF
RPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKADDSPLGGLRLTIWLPLYKRT
>Mature_457_residues
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLESEQRQGIMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAP
PGQRLLLVTSEGRVIGAERNEMQIIRNFIGQADNADHPQKKRYGRLEMVGPFSVRDGEDNYQLYLIRPASTSQSDFINLL
FDRPLLLLIVTMLVSAPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAHRLDSMINDLLVMSRNQAKNALVSETVKANQLWNEVLDN
AAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRNALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIF
RPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKADDSPLGGLRLTIWLPLYKRT

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=457, Percent_Identity=94.7483588621444, Blast_Score=818, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=300, Percent_Identity=33, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789808, Length=274, Percent_Identity=29.9270072992701, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1786783, Length=333, Percent_Identity=30.03003003003, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=28.7769784172662, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=31.1688311688312, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=27.7310924369748, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788279, Length=283, Percent_Identity=26.1484098939929, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87082128, Length=297, Percent_Identity=25.2525252525253, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=26.9406392694064, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=29.9559471365639, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786912, Length=274, Percent_Identity=29.9270072992701, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789403, Length=241, Percent_Identity=28.2157676348548, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787374, Length=297, Percent_Identity=26.2626262626263, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790861, Length=287, Percent_Identity=25.4355400696864, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=279, Percent_Identity=25.4480286738351, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=204, Percent_Identity=28.921568627451, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=29.7413793103448, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788713, Length=236, Percent_Identity=26.271186440678, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=26.431718061674, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790300, Length=250, Percent_Identity=26, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51731; Mature: 51731

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLESEQRQGIMIEQHVEAELAND
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
PPNDLMWWRRLFRAIDKWAPPGQRLLLVTSEGRVIGAERNEMQIIRNFIGQADNADHPQK
CCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEECCCHHHHHHHHHHHCCCCCCCCCHH
KRYGRLEMVGPFSVRDGEDNYQLYLIRPASTSQSDFINLLFDRPLLLLIVTMLVSAPLLL
HHCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
WLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAHRLDSMINDLLVMSRNQAK
HHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
NALVSETVKANQLWNEVLDNAAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
ALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLG
HHHHCCEEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCHH
LAIVETAIQQHRGWVKADDSPLGGLRLTIWLPLYKRT
HHHHHHHHHHHCCCEECCCCCCCCEEEEEEEECCCCC
>Mature Secondary Structure
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLESEQRQGIMIEQHVEAELAND
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
PPNDLMWWRRLFRAIDKWAPPGQRLLLVTSEGRVIGAERNEMQIIRNFIGQADNADHPQK
CCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEECCCHHHHHHHHHHHCCCCCCCCCHH
KRYGRLEMVGPFSVRDGEDNYQLYLIRPASTSQSDFINLLFDRPLLLLIVTMLVSAPLLL
HHCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
WLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAHRLDSMINDLLVMSRNQAK
HHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
NALVSETVKANQLWNEVLDNAAFEAEQMGKSFTVEYPPGPWPLYGNPNALESALENIVRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
ALRYSHTKISVSFSVDKDGITVNVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLG
HHHHCCEEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCHH
LAIVETAIQQHRGWVKADDSPLGGLRLTIWLPLYKRT
HHHHHHHHHHHCCCEECCCCCCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]