Click here to switch to the map view.

The map label for this gene is cpxR [H]

Identifier: 238892328

GI number: 238892328

Start: 78169

End: 78867

Strand: Reverse

Name: cpxR [H]

Synonym: KP1_0079

Alternate gene names: 238892328

Gene position: 78867-78169 (Counterclockwise)

Preceding gene: 238892332

Following gene: 238892327

Centisome position: 1.5

GC content: 56.37

Gene sequence:

>699_bases
ATGAATAAAATCCTGTTAGTTGATGATGACCGGGAGCTCACCTCCCTGTTAAAAGAGCTGCTCGATATGGAAGGTTTTAA
CGTGCTGGTGGCCCATGATGGGGAACAGGCGCTGGCCCTTCTGGACGACAGCGTTGATTTATTGCTGCTCGACGTGATGA
TGCCGAAGAAAAACGGTATTGATACGCTGAAAGAGCTGCGTCAGACACACCAGACTCCGGTTATCATGCTAACAGCGCGC
GGAAGCGAGCTGGATCGCGTTCTCGGCCTCGAGCTGGGCGCGGATGACTATTTGCCTAAGCCATTCAACGATCGCGAGCT
GGTGGCCCGTATACGCGCGATTCTGCGCCGTTCCCACTGGAGCGAGCAGCAGCAGACGACCGAAGCCGGCTCACCAACCC
TGGAAGTGGATGCCTTAAGCCTCAATCCGGGCCGTCAGGAAGCCAATTTCGATGGCCAGACGCTGGAGCTCACCGGCACC
GAGTTCACCCTGCTCTATCTGTTAGCGCAGCATCTCGGTCAGGTAGTCTCCCGTGAGCATTTAAGCCAGGAAGTGTTAGG
CAAGCGCCTGACGCCGTTCGACCGCGCCATCGATATGCATATTTCCAACCTGCGGCGTAAGCTGCCGGAGCGCAAAGATG
GCCATCCGTGGTTTAAAACGCTGCGTGGCCGCGGGTATCTGATGGTTTCCGCTTCATGA

Upstream 100 bases:

>100_bases
GATTCAGGCTGCAAACATGCGTCAGGGGGTGTAAAACAACGTAAAGTCATGGATTAGCGGGCCTTGATGACGTAATTTCT
GCCTCGGAGGTATTTAAACA

Downstream 100 bases:

>100_bases
TTGGAAGTTTGACTGCACGCATCTTCGCCATCTTCTGGCTCACGCTGGCGCTGGTGTTGATGCTGGTGCTGATGTTGCCC
AAACTGGATTCCCGGCAGAT

Product: DNA-binding transcriptional regulator CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNKILLVDDDRELTSLLKELLDMEGFNVLVAHDGEQALALLDDSVDLLLLDVMMPKKNGIDTLKELRQTHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQTTEAGSPTLEVDALSLNPGRQEANFDGQTLELTGT
EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPERKDGHPWFKTLRGRGYLMVSAS

Sequences:

>Translated_232_residues
MNKILLVDDDRELTSLLKELLDMEGFNVLVAHDGEQALALLDDSVDLLLLDVMMPKKNGIDTLKELRQTHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQTTEAGSPTLEVDALSLNPGRQEANFDGQTLELTGT
EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPERKDGHPWFKTLRGRGYLMVSAS
>Mature_232_residues
MNKILLVDDDRELTSLLKELLDMEGFNVLVAHDGEQALALLDDSVDLLLLDVMMPKKNGIDTLKELRQTHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQTTEAGSPTLEVDALSLNPGRQEANFDGQTLELTGT
EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPERKDGHPWFKTLRGRGYLMVSAS

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=94.8275862068966, Blast_Score=419, Evalue=1e-119,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=40.8510638297872, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=38.2222222222222, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=39.7379912663755, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI87082012, Length=234, Percent_Identity=36.7521367521368, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=32.4675324675325, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=37.9912663755458, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790552, Length=232, Percent_Identity=37.5, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=35.9649122807018, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786784, Length=230, Percent_Identity=36.5217391304348, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=31.1688311688312, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=33.0472103004292, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=30.8370044052863, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=28.0701754385965, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790299, Length=139, Percent_Identity=38.8489208633094, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=40, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=40.6779661016949, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787487, Length=112, Percent_Identity=36.6071428571429, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26273; Mature: 26273

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKILLVDDDRELTSLLKELLDMEGFNVLVAHDGEQALALLDDSVDLLLLDVMMPKKNGI
CCCEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHCCCHHHHHHHHHCCCCCCH
DTLKELRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHW
HHHHHHHHHCCCCEEEEEECCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
SEQQQTTEAGSPTLEVDALSLNPGRQEANFDGQTLELTGTEFTLLYLLAQHLGQVVSREH
CHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LSQEVLGKRLTPFDRAIDMHISNLRRKLPERKDGHPWFKTLRGRGYLMVSAS
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECC
>Mature Secondary Structure
MNKILLVDDDRELTSLLKELLDMEGFNVLVAHDGEQALALLDDSVDLLLLDVMMPKKNGI
CCCEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHCCCHHHHHHHHHCCCCCCH
DTLKELRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHW
HHHHHHHHHCCCCEEEEEECCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
SEQQQTTEAGSPTLEVDALSLNPGRQEANFDGQTLELTGTEFTLLYLLAQHLGQVVSREH
CHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LSQEVLGKRLTPFDRAIDMHISNLRRKLPERKDGHPWFKTLRGRGYLMVSAS
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]