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The map label for this gene is ada [H]

Identifier: 339905984

GI number: 339905984

Start: 3888290

End: 3889378

Strand: Reverse

Name: ada [H]

Synonym: NA

Alternate gene names: 339905984

Gene position: 3889378-3888290 (Counterclockwise)

Preceding gene: 238028957

Following gene: 238028954

Centisome position: 99.56

GC content: 72.64

Gene sequence:

>1089_bases
ATGCAATCTCCCAGGTACTCGACCGATGCCGCGCGCTGGGCCGCCCTCGTCGCACGCGATGCCGAGGCCGACGGCGCGTT
TTTCTACGCGGTGAAGACCACCGGCGTGTTCTGCCGGCCGAGTTGCGCATCGCGCATGCCGCGCCGCGAGAACGTGGCGT
TCTTCGAGACGCCGGCTGCGGCGCGCGAGGCGGGGTTCCGGCCCTGCAAGCGCTGCCAGCCCGAGCGTGAACCGCGCGAG
ATCGAAATCGTGCGGCGTGCCTGCGCGGTGCTAGACGCGAGCGACCGCGCGACGCTGGCCGAGCTCAGCGCGGCCGTTCA
CGTGAGCCCGTTTCATCTGCAGCGGCTGTTCAAGCGCGTGGTCGGCGTGACGCCGCGCCAATACCAGGCGGCGCGGCGCG
GCGCCGCCTTGCGCGACGCGCTGCAAGGCGGCGCCGCCGTCACGCGCGCGGCGGTCGATGCCGGCTATCAGTCGGCCTCG
CGCGTCTACGAGGCGGTGCCGCGCGAGCTCGGCATGGCGCCGTCCGATTTTCGTCGCAAGGGCGCGGGGCTGCGCATCGC
ATACGCCACTGCGCCGACGCCGCTCGGCTACGTGCTGGTCGGCGCGACCGAGCGCGGTATCTGCCAGATTGCGTTTGGCG
ACGCGATCGCGCCGCTCGTCGACGCGCTCGCGGCGGCGTTCGAGAATGCCGAATGCGTGGCAGCGCCAGAGCGGCTCGCG
CCGTTCCTTGCGCAGATCGACGCCTATCTGCGCGGCGCGAGCGAGCAGGTGGCGCTGCCGCTCGACATCAGCGCGACGGC
GTTCCAGCAGCGCGTATGGGAAGCACTGCAGAAGATCCCCTATGGCCAGACGCGCAGCTACGCGCAGATCGCCGAGGCGG
TGGGCTCGCCGCGCGCCGTGCGTGCCGTGGCCAATGCCTGCGCGTCCAACCCCGTCGCGCTGGCGATTCCGTGCCATCGC
GTCGTGCAAAAGAGCGGCGCGCTCGCCGGCTATCGCTGGGGTGCCGCGCGCAAGGCGGCGCTGCTCGCGGCCGAGGCGCG
CCATGCGGCCGGCTCGCCGGCCGAGCCGTCGCTCGACGACGCGGCATGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: O6-methylguanine-DNA methyltransferase

Products: NA

Alternate protein names: Regulatory protein of adaptative response; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:
NA

Sequences:

>Translated_362_residues
MQSPRYSTDAARWAALVARDAEADGAFFYAVKTTGVFCRPSCASRMPRRENVAFFETPAAAREAGFRPCKRCQPEREPRE
IEIVRRACAVLDASDRATLAELSAAVHVSPFHLQRLFKRVVGVTPRQYQAARRGAALRDALQGGAAVTRAAVDAGYQSAS
RVYEAVPRELGMAPSDFRRKGAGLRIAYATAPTPLGYVLVGATERGICQIAFGDAIAPLVDALAAAFENAECVAAPERLA
PFLAQIDAYLRGASEQVALPLDISATAFQQRVWEALQKIPYGQTRSYAQIAEAVGSPRAVRAVANACASNPVALAIPCHR
VVQKSGALAGYRWGAARKAALLAAEARHAAGSPAEPSLDDAA
>Mature_362_residues
MQSPRYSTDAARWAALVARDAEADGAFFYAVKTTGVFCRPSCASRMPRRENVAFFETPAAAREAGFRPCKRCQPEREPRE
IEIVRRACAVLDASDRATLAELSAAVHVSPFHLQRLFKRVVGVTPRQYQAARRGAALRDALQGGAAVTRAAVDAGYQSAS
RVYEAVPRELGMAPSDFRRKGAGLRIAYATAPTPLGYVLVGATERGICQIAFGDAIAPLVDALAAAFENAECVAAPERLA
PFLAQIDAYLRGASEQVALPLDISATAFQQRVWEALQKIPYGQTRSYAQIAEAVGSPRAVRAVANACASNPVALAIPCHR
VVQKSGALAGYRWGAARKAALLAAEARHAAGSPAEPSLDDAA

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus. It activates the transcription of alkA, alkB and aidB [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI197304670, Length=172, Percent_Identity=34.8837209302326, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1788542, Length=351, Percent_Identity=45.8689458689459, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1787596, Length=89, Percent_Identity=44.9438202247191, Blast_Score=88, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI115533070, Length=81, Percent_Identity=58.0246913580247, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115533068, Length=81, Percent_Identity=58.0246913580247, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320001, Length=93, Percent_Identity=38.7096774193548, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17137554, Length=88, Percent_Identity=53.4090909090909, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR016221
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR008332
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF01035 DNA_binding_1; PF00165 HTH_AraC; PF02870 Methyltransf_1N [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 38536; Mature: 38536

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS01124 HTH_ARAC_FAMILY_2 ; PS00374 MGMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSPRYSTDAARWAALVARDAEADGAFFYAVKTTGVFCRPSCASRMPRRENVAFFETPAA
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCEEECCHHHHHCCCCCCCEEEECCHH
AREAGFRPCKRCQPEREPREIEIVRRACAVLDASDRATLAELSAAVHVSPFHLQRLFKRV
HHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
VGVTPRQYQAARRGAALRDALQGGAAVTRAAVDAGYQSASRVYEAVPRELGMAPSDFRRK
HCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHC
GAGLRIAYATAPTPLGYVLVGATERGICQIAFGDAIAPLVDALAAAFENAECVAAPERLA
CCCEEEEEECCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHH
PFLAQIDAYLRGASEQVALPLDISATAFQQRVWEALQKIPYGQTRSYAQIAEAVGSPRAV
HHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHH
RAVANACASNPVALAIPCHRVVQKSGALAGYRWGAARKAALLAAEARHAAGSPAEPSLDD
HHHHHHHCCCCEEEEECHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
AA
CC
>Mature Secondary Structure
MQSPRYSTDAARWAALVARDAEADGAFFYAVKTTGVFCRPSCASRMPRRENVAFFETPAA
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCEEECCHHHHHCCCCCCCEEEECCHH
AREAGFRPCKRCQPEREPREIEIVRRACAVLDASDRATLAELSAAVHVSPFHLQRLFKRV
HHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
VGVTPRQYQAARRGAALRDALQGGAAVTRAAVDAGYQSASRVYEAVPRELGMAPSDFRRK
HCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHC
GAGLRIAYATAPTPLGYVLVGATERGICQIAFGDAIAPLVDALAAAFENAECVAAPERLA
CCCEEEEEECCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHH
PFLAQIDAYLRGASEQVALPLDISATAFQQRVWEALQKIPYGQTRSYAQIAEAVGSPRAV
HHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHH
RAVANACASNPVALAIPCHRVVQKSGALAGYRWGAARKAALLAAEARHAAGSPAEPSLDD
HHHHHHHCCCCEEEEECHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2987251; 3887409; 9097040; 9278503; 2982792; 3536913; 3009022; 3529081; 1581309; 8202360; 8500619; 8156986 [H]