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The map label for this gene is gor [H]

Identifier: 238028835

GI number: 238028835

Start: 3757017

End: 3758378

Strand: Reverse

Name: gor [H]

Synonym: bglu_1g33000

Alternate gene names: 238028835

Gene position: 3758378-3757017 (Counterclockwise)

Preceding gene: 238028836

Following gene: 238028833

Centisome position: 96.21

GC content: 70.93

Gene sequence:

>1362_bases
ATGGAATACGACTATGATCTTTTCGTGATCGGCGCGGGCTCGGGCGGCGTTCGGCTCGCCCGGATTTCGGCCTCGCTCGG
CGCGCGCGTGGGCATCGCCGAGGCGGAGCGCATCGGCGGCACCTGCGTGCTGCGCGGCTGCATCCCGAAGAAGCTGCTGG
TCTACGCCTCGCACTACCGCGGCGAGGTCGAGGACGCGGCCGGCTTCGGCTGGCGCTTCGGCCCCGGCGAGTTCTCCTGG
CCGACGCTGATCGCCGCGAAGGACCGCGAGATCGGCCGGCTCTCCGGCCTCTACGTGAAGCTGCTGACCGACGCCGGCGT
GACGCTTCACGAGGGCCGCGCGACGATCGTCGACGCCCACACGGTCGAGATCGACGCTCAGCGCGTCAGCGCCAGGCACA
TCGGCGTGGCCACCGGCTCATGGCCGACGCTGCCCGAGATTCCCGGCATCGAGCACGCGATCACCTCGCGCGAGGCGCTC
GATCTGCCCGAGCTGCCCGGGCGCGTGGCGGTGGTGGGCGGCGGCTACATCGCGGTGGAGTTCGCCGGCATCTTCAACGG
GCTCGGCTCGCAGGTGGATCTGTTCTATCGCGGCGAGGAGATCCTGCGCCACTTCGACGATGACCTGCGCCGCGTGCTGC
ACGAGGAAATGGTCAAGCGCGGCGTGGCGATCCACACCCACGCCAAGGTGCGCGCGATCGAGCGCGGCACGGACGGTGCG
CTCACGCTCGACGTCAACGGCACGCCGCACGGCCCCTACGACGCCGTGCTCTACGCCACCGGCCGCCATCCGAACACCGC
CGGGCTCGGCCTCGAGAACGTCGGCGTCGAGTGCGAGGCGGGCGGCGCGATCCGCGTGGACGCGTATTCGGCCACCAACG
TGCCCTCGATCCATGCGATCGGCGACGTCACCTCGCGCCCGCAGCTCACCCCGGTGGCCACCCGCGACGGCGCGCTGCTG
GCCGCGAACCTGTTCGGCGGGCGGCGCACCGAGGCCGACCACCGTGCGATCCCGTCGGCCGTGTTCAGCCAGCCCGAACT
CGCCACGGTGGGCCTGGCCGAGCACGAGGCGCGCGCGCAGTACGGCGCGGTGGACATCTACCAGACCTCGTTTCGCGCGC
TCAAGCACACGCTGAGCGGACGCGACGAGAAGATCTTCATGAAGCTGGTGGTGGTGCGCGACTCGCAGCGCGTGGTGGGT
GCGCACATGATCGGGCCGGACGCGGCCGAGACGATCCAGGGCATCGCGATCGCGGTGCGAATGGGCGCGACCAAGGCGCA
GTTCGACGAGACGATCGGCATCCATCCGAGCGCGGCCGAGGAATTCGTCACGCTGCGCACCAAGGCGCCGGACCCGGCCT
GA

Upstream 100 bases:

>100_bases
GCCGGCCGCCGGCCCGCCGGCCGCCGGGCCGGCGCCGCGCATCACGCGCGCCGGCAAAACTTGCTATGGTTCGTCATCGA
CAATCCGGCGGAGCGCAGCG

Downstream 100 bases:

>100_bases
GGCGCGGCCAAGCCGCGGCCGCGCCGATCACGGCGGGCCGCGCGCGTCGCGGCCCGGTTCCCCGGCGCACGGCGGCCGCG
CCGTCACTGCACGCGCGGCG

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MEYDYDLFVIGAGSGGVRLARISASLGARVGIAEAERIGGTCVLRGCIPKKLLVYASHYRGEVEDAAGFGWRFGPGEFSW
PTLIAAKDREIGRLSGLYVKLLTDAGVTLHEGRATIVDAHTVEIDAQRVSARHIGVATGSWPTLPEIPGIEHAITSREAL
DLPELPGRVAVVGGGYIAVEFAGIFNGLGSQVDLFYRGEEILRHFDDDLRRVLHEEMVKRGVAIHTHAKVRAIERGTDGA
LTLDVNGTPHGPYDAVLYATGRHPNTAGLGLENVGVECEAGGAIRVDAYSATNVPSIHAIGDVTSRPQLTPVATRDGALL
AANLFGGRRTEADHRAIPSAVFSQPELATVGLAEHEARAQYGAVDIYQTSFRALKHTLSGRDEKIFMKLVVVRDSQRVVG
AHMIGPDAAETIQGIAIAVRMGATKAQFDETIGIHPSAAEEFVTLRTKAPDPA

Sequences:

>Translated_453_residues
MEYDYDLFVIGAGSGGVRLARISASLGARVGIAEAERIGGTCVLRGCIPKKLLVYASHYRGEVEDAAGFGWRFGPGEFSW
PTLIAAKDREIGRLSGLYVKLLTDAGVTLHEGRATIVDAHTVEIDAQRVSARHIGVATGSWPTLPEIPGIEHAITSREAL
DLPELPGRVAVVGGGYIAVEFAGIFNGLGSQVDLFYRGEEILRHFDDDLRRVLHEEMVKRGVAIHTHAKVRAIERGTDGA
LTLDVNGTPHGPYDAVLYATGRHPNTAGLGLENVGVECEAGGAIRVDAYSATNVPSIHAIGDVTSRPQLTPVATRDGALL
AANLFGGRRTEADHRAIPSAVFSQPELATVGLAEHEARAQYGAVDIYQTSFRALKHTLSGRDEKIFMKLVVVRDSQRVVG
AHMIGPDAAETIQGIAIAVRMGATKAQFDETIGIHPSAAEEFVTLRTKAPDPA
>Mature_453_residues
MEYDYDLFVIGAGSGGVRLARISASLGARVGIAEAERIGGTCVLRGCIPKKLLVYASHYRGEVEDAAGFGWRFGPGEFSW
PTLIAAKDREIGRLSGLYVKLLTDAGVTLHEGRATIVDAHTVEIDAQRVSARHIGVATGSWPTLPEIPGIEHAITSREAL
DLPELPGRVAVVGGGYIAVEFAGIFNGLGSQVDLFYRGEEILRHFDDDLRRVLHEEMVKRGVAIHTHAKVRAIERGTDGA
LTLDVNGTPHGPYDAVLYATGRHPNTAGLGLENVGVECEAGGAIRVDAYSATNVPSIHAIGDVTSRPQLTPVATRDGALL
AANLFGGRRTEADHRAIPSAVFSQPELATVGLAEHEARAQYGAVDIYQTSFRALKHTLSGRDEKIFMKLVVVRDSQRVVG
AHMIGPDAAETIQGIAIAVRMGATKAQFDETIGIHPSAAEEFVTLRTKAPDPA

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=39.5196506550218, Blast_Score=311, Evalue=6e-85,
Organism=Homo sapiens, GI22035672, Length=473, Percent_Identity=37.2093023255814, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI148277065, Length=441, Percent_Identity=36.281179138322, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI33519430, Length=441, Percent_Identity=36.281179138322, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI33519428, Length=441, Percent_Identity=36.281179138322, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI33519426, Length=441, Percent_Identity=36.281179138322, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI148277071, Length=441, Percent_Identity=36.281179138322, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI291045266, Length=475, Percent_Identity=34.9473684210526, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI291045268, Length=473, Percent_Identity=32.9809725158562, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=29.0672451193059, Blast_Score=178, Evalue=1e-44,
Organism=Escherichia coli, GI1789915, Length=428, Percent_Identity=41.8224299065421, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI1786307, Length=468, Percent_Identity=31.1965811965812, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI87082354, Length=452, Percent_Identity=28.0973451327434, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=28.8546255506608, Blast_Score=148, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI71983429, Length=448, Percent_Identity=39.9553571428571, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI71983419, Length=448, Percent_Identity=39.9553571428571, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17557007, Length=468, Percent_Identity=33.7606837606838, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=32.4324324324324, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=31.8872017353579, Blast_Score=195, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=37.9609544468547, Blast_Score=295, Evalue=7e-81,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=29.8507462686567, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321091, Length=474, Percent_Identity=27.8481012658228, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=35.181236673774, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=35.181236673774, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=35.181236673774, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI17737741, Length=484, Percent_Identity=34.504132231405, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=30.2832244008715, Blast_Score=182, Evalue=4e-46,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48338; Mature: 48338

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYDYDLFVIGAGSGGVRLARISASLGARVGIAEAERIGGTCVLRGCIPKKLLVYASHYR
CCCCEEEEEEECCCCCEEEEEEECCCCCEECCCHHHHCCCEEEEECCCCHHHHHHHHHCC
GEVEDAAGFGWRFGPGEFSWPTLIAAKDREIGRLSGLYVKLLTDAGVTLHEGRATIVDAH
CCCCCCCCCCEECCCCCCCCCEEEEECCCCCHHHHCEEEEEEECCCCEEECCCEEEEEEE
TVEIDAQRVSARHIGVATGSWPTLPEIPGIEHAITSREALDLPELPGRVAVVGGGYIAVE
EEEEEHHHHCEEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEEEEECCEEEEE
FAGIFNGLGSQVDLFYRGEEILRHFDDDLRRVLHEEMVKRGVAIHTHAKVRAIERGTDGA
EEHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCCE
LTLDVNGTPHGPYDAVLYATGRHPNTAGLGLENVGVECEAGGAIRVDAYSATNVPSIHAI
EEEEECCCCCCCCCEEEEEECCCCCCCCCCHHHCCEEECCCCEEEEEEECCCCCCCEEEE
GDVTSRPQLTPVATRDGALLAANLFGGRRTEADHRAIPSAVFSQPELATVGLAEHEARAQ
CCCCCCCCCCEEECCCCCEEEEECCCCCCCCCHHHHCCHHHHCCCCEEEEECHHHHHHHH
YGAVDIYQTSFRALKHTLSGRDEKIFMKLVVVRDSQRVVGAHMIGPDAAETIQGIAIAVR
CCEEEEHHHHHHHHHHHHCCCCCEEEEEEEEEECCCEEEEEEECCCCHHHHHCEEEEEEE
MGATKAQFDETIGIHPSAAEEFVTLRTKAPDPA
ECCCHHHHHHHCCCCCCCCHHEEEEEECCCCCC
>Mature Secondary Structure
MEYDYDLFVIGAGSGGVRLARISASLGARVGIAEAERIGGTCVLRGCIPKKLLVYASHYR
CCCCEEEEEEECCCCCEEEEEEECCCCCEECCCHHHHCCCEEEEECCCCHHHHHHHHHCC
GEVEDAAGFGWRFGPGEFSWPTLIAAKDREIGRLSGLYVKLLTDAGVTLHEGRATIVDAH
CCCCCCCCCCEECCCCCCCCCEEEEECCCCCHHHHCEEEEEEECCCCEEECCCEEEEEEE
TVEIDAQRVSARHIGVATGSWPTLPEIPGIEHAITSREALDLPELPGRVAVVGGGYIAVE
EEEEEHHHHCEEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEEEEECCEEEEE
FAGIFNGLGSQVDLFYRGEEILRHFDDDLRRVLHEEMVKRGVAIHTHAKVRAIERGTDGA
EEHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCCE
LTLDVNGTPHGPYDAVLYATGRHPNTAGLGLENVGVECEAGGAIRVDAYSATNVPSIHAI
EEEEECCCCCCCCCEEEEEECCCCCCCCCCHHHCCEEECCCCEEEEEEECCCCCCCEEEE
GDVTSRPQLTPVATRDGALLAANLFGGRRTEADHRAIPSAVFSQPELATVGLAEHEARAQ
CCCCCCCCCCEEECCCCCEEEEECCCCCCCCCHHHHCCHHHHCCCCEEEEECHHHHHHHH
YGAVDIYQTSFRALKHTLSGRDEKIFMKLVVVRDSQRVVGAHMIGPDAAETIQGIAIAVR
CCEEEEHHHHHHHHHHHHCCCCCEEEEEEEEEECCCEEEEEEECCCCHHHHHCEEEEEEE
MGATKAQFDETIGIHPSAAEEFVTLRTKAPDPA
ECCCHHHHHHHCCCCCCCCHHEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]