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The map label for this gene is cusR [H]

Identifier: 238028833

GI number: 238028833

Start: 3755122

End: 3755799

Strand: Reverse

Name: cusR [H]

Synonym: bglu_1g32980

Alternate gene names: 238028833

Gene position: 3755799-3755122 (Counterclockwise)

Preceding gene: 238028835

Following gene: 238028832

Centisome position: 96.14

GC content: 66.96

Gene sequence:

>678_bases
ATGTTTCGTGTCCTTACTATCGAAGACGATGAAATCACCGCGAATGAAATCGTTGGAGAACTGAAAGACCGTGGCTTCGC
CGTGGAATGGGTGGCCAACGGCCGCGACGGCATGGCGCGCGCGCTCAGCGACGAATACGACGTGATCACGCTCGACCGGA
TGCTGCCGGGCGTGGACGGCCTGACCATCGTCACCACCATGCGCAGCATCGGCGTGCGCACGCCGGTGCTGATGCTCAGC
GCGCTCGGCGACGTGGACGAACGCGTGCGCGGGCTGCGCGCCGGCGGCGACGACTACCTGACCAAGCCGTTCGATCCCGA
GGAGATGACGGCGCGCCTCGAGGTGCTGCTGCGGCGCAGCCAGGCCTCGCCCGCGCAGTCGGAAACCACGCTCGAGGTCG
GCCCGCTCGCGCTCGACCTGATCGCGCGCAAGGCCACCCGCGACGGCGCGGAGATCGCGCTGCTGCCCACCGAATACCGC
GTGCTCGAATACATGATGCGCAACGCCGGCCAGACCATCACGCGCACCATGCTGTTCGAGGCGGTGTGGGGCTATCACTT
CGATCCCGGCACCAATCTGATCGACGTCCACATGGGGCGCCTGCGCAGGAAGATCGATCCGCCCGACGCGCCGCCGATGA
TCCGCACCGTGCGCGGCGCCGGCTACATCCTTTCGTGA

Upstream 100 bases:

>100_bases
CGCAGGACGGCCGCTCACCGCCCAGGCCGATATGGCAACATTGCCCTCTTTCCAACACGCATCGCCGGTGCCGCCTCCGC
TCGCGGCCGGCGGGACGACA

Downstream 100 bases:

>100_bases
GCGGCCGATCGTGACTGAACCGGCAAGCCGCGCGTGCGCCGGGCCGCGCTGGTATTCGAGCACGTTCCGGCTGTTCGTCC
TCTACTCGGTGATGTTCTCG

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MFRVLTIEDDEITANEIVGELKDRGFAVEWVANGRDGMARALSDEYDVITLDRMLPGVDGLTIVTTMRSIGVRTPVLMLS
ALGDVDERVRGLRAGGDDYLTKPFDPEEMTARLEVLLRRSQASPAQSETTLEVGPLALDLIARKATRDGAEIALLPTEYR
VLEYMMRNAGQTITRTMLFEAVWGYHFDPGTNLIDVHMGRLRRKIDPPDAPPMIRTVRGAGYILS

Sequences:

>Translated_225_residues
MFRVLTIEDDEITANEIVGELKDRGFAVEWVANGRDGMARALSDEYDVITLDRMLPGVDGLTIVTTMRSIGVRTPVLMLS
ALGDVDERVRGLRAGGDDYLTKPFDPEEMTARLEVLLRRSQASPAQSETTLEVGPLALDLIARKATRDGAEIALLPTEYR
VLEYMMRNAGQTITRTMLFEAVWGYHFDPGTNLIDVHMGRLRRKIDPPDAPPMIRTVRGAGYILS
>Mature_225_residues
MFRVLTIEDDEITANEIVGELKDRGFAVEWVANGRDGMARALSDEYDVITLDRMLPGVDGLTIVTTMRSIGVRTPVLMLS
ALGDVDERVRGLRAGGDDYLTKPFDPEEMTARLEVLLRRSQASPAQSETTLEVGPLALDLIARKATRDGAEIALLPTEYR
VLEYMMRNAGQTITRTMLFEAVWGYHFDPGTNLIDVHMGRLRRKIDPPDAPPMIRTVRGAGYILS

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=42.3423423423423, Blast_Score=181, Evalue=3e-47,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=40.4545454545455, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=41.2556053811659, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=34.8017621145374, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=34.5291479820628, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=33.6244541484716, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.8385650224215, Blast_Score=117, Evalue=4e-28,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=35.6521739130435, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=33.1838565022422, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=32.2869955156951, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=28.82096069869, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=26.5217391304348, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=27.7310924369748, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=31.4814814814815, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25036; Mature: 25036

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRVLTIEDDEITANEIVGELKDRGFAVEWVANGRDGMARALSDEYDVITLDRMLPGVDG
CEEEEEECCCCCCHHHHHHHHHHCCEEEEEEECCCCHHHHHHCCCCCEEEHHHHCCCCCC
LTIVTTMRSIGVRTPVLMLSALGDVDERVRGLRAGGDDYLTKPFDPEEMTARLEVLLRRS
HHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
QASPAQSETTLEVGPLALDLIARKATRDGAEIALLPTEYRVLEYMMRNAGQTITRTMLFE
CCCCCCCCCEEEECHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHH
AVWGYHFDPGTNLIDVHMGRLRRKIDPPDAPPMIRTVRGAGYILS
HHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCCEECC
>Mature Secondary Structure
MFRVLTIEDDEITANEIVGELKDRGFAVEWVANGRDGMARALSDEYDVITLDRMLPGVDG
CEEEEEECCCCCCHHHHHHHHHHCCEEEEEEECCCCHHHHHHCCCCCEEEHHHHCCCCCC
LTIVTTMRSIGVRTPVLMLSALGDVDERVRGLRAGGDDYLTKPFDPEEMTARLEVLLRRS
HHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
QASPAQSETTLEVGPLALDLIARKATRDGAEIALLPTEYRVLEYMMRNAGQTITRTMLFE
CCCCCCCCCEEEECHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHH
AVWGYHFDPGTNLIDVHMGRLRRKIDPPDAPPMIRTVRGAGYILS
HHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]