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The map label for this gene is ghrA [H]

Identifier: 238028794

GI number: 238028794

Start: 3709844

End: 3710800

Strand: Direct

Name: ghrA [H]

Synonym: bglu_1g32580

Alternate gene names: 238028794

Gene position: 3709844-3710800 (Clockwise)

Preceding gene: 238028792

Following gene: 238028795

Centisome position: 94.97

GC content: 75.13

Gene sequence:

>957_bases
ATGCAGATCCTGCTTCATTACTCCGATGGTGAACTGTCCGACTGGCAACGCGAGACCGCAGCCGCGCTGCCGGGCGCGGT
ACTGCGCGCCTGGCAGCCCGGCGACGACGCGCGCGCCGACTACGCGCTGGTCTGGCAGCCGCCCGCCGCGCTGCTCGCGC
CGCGCGACGGCCTGAAGGCGATCTTCATTCTCGGCGCCGGGGTCGATGCGCTGCTCGCGCTCGAGCGCGAGCGCCCCGGC
ACGCTGCCGGCCGGCGTGCCGCTGGTGCGGCTCGAGGATAGCGGCATGGGCGCGCAGATGGCGGAGTACGTCGTGTACGG
CGTGCTGCGCCACCTGCGGCGCTTCGACGATTACGCGGCGCAGCAGCGCGACCGCCGCTGGGCGCCGCTGCCGGTCGCGC
CGCGCGAGCGCTTCGTGGTGGGCGTGCTGGGCCTCGGCGTGCTCGGCGCACGAGTCGCGCGCGCGCTCGCGGGGCTCGGC
CTCACGGTGCGCGGCTTCAGCCGCAGCGCGAAGGCGCTGGACGGCGTCGCCTGCTCGGCCGGCACGCCGCGCGCGGGCGA
TCCGGCGTTCGACGCGTTCAGCAGCGGCCTGCGGGTGCTCGTGAACCTGCTGCCGGGCACGCCCGACACCGAGGGCGTGC
TGAACGCGCGGCTGTTCGCGCGGCTCGCGCCCGGCGCGCTGCTGGTCAACGTCGCGCGCGGCGCGCACCTGGTCGAGGCG
GACCTGCTCGACGCACTCGCCACCGGACGCCTCGGCGCGGCACTGCTCGACGTGTTGCGCGAGGAGCCGCCGCGCGCCGA
TCATCCGTTCTGGCAGCATCCGCGCATCACGCTCACGCCGCACGTCTCGGCCGAGACCGAACGCGGCGGCGCGATCGCGC
AGATCGCCGCGAAGATCCGCGCGTTCGAGCGCGGCGAGCCCGTGGGCGGGATCGTCGATCTCGCGCGCGGTTATTGA

Upstream 100 bases:

>100_bases
ATTTCGGACTGGCGGCGCCGGATCGCCCGACGCCGTAAAATGGCCGTTTCGGCACGACACGGCCACGCGCCGGCGCCGCC
CTCGCCAGCCCCCGACCACG

Downstream 100 bases:

>100_bases
GGGCGCTCGCGCGGCGCCCGCAACCGCGTCACGCCAGCCAGCCATGCCGGATCACGCAGCCGCCGCGCGGCGCCGGCCCG
GTTGCCCACGACAACCGCAG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MQILLHYSDGELSDWQRETAAALPGAVLRAWQPGDDARADYALVWQPPAALLAPRDGLKAIFILGAGVDALLALERERPG
TLPAGVPLVRLEDSGMGAQMAEYVVYGVLRHLRRFDDYAAQQRDRRWAPLPVAPRERFVVGVLGLGVLGARVARALAGLG
LTVRGFSRSAKALDGVACSAGTPRAGDPAFDAFSSGLRVLVNLLPGTPDTEGVLNARLFARLAPGALLVNVARGAHLVEA
DLLDALATGRLGAALLDVLREEPPRADHPFWQHPRITLTPHVSAETERGGAIAQIAAKIRAFERGEPVGGIVDLARGY

Sequences:

>Translated_318_residues
MQILLHYSDGELSDWQRETAAALPGAVLRAWQPGDDARADYALVWQPPAALLAPRDGLKAIFILGAGVDALLALERERPG
TLPAGVPLVRLEDSGMGAQMAEYVVYGVLRHLRRFDDYAAQQRDRRWAPLPVAPRERFVVGVLGLGVLGARVARALAGLG
LTVRGFSRSAKALDGVACSAGTPRAGDPAFDAFSSGLRVLVNLLPGTPDTEGVLNARLFARLAPGALLVNVARGAHLVEA
DLLDALATGRLGAALLDVLREEPPRADHPFWQHPRITLTPHVSAETERGGAIAQIAAKIRAFERGEPVGGIVDLARGY
>Mature_318_residues
MQILLHYSDGELSDWQRETAAALPGAVLRAWQPGDDARADYALVWQPPAALLAPRDGLKAIFILGAGVDALLALERERPG
TLPAGVPLVRLEDSGMGAQMAEYVVYGVLRHLRRFDDYAAQQRDRRWAPLPVAPRERFVVGVLGLGVLGARVARALAGLG
LTVRGFSRSAKALDGVACSAGTPRAGDPAFDAFSSGLRVLVNLLPGTPDTEGVLNARLFARLAPGALLVNVARGAHLVEA
DLLDALATGRLGAALLDVLREEPPRADHPFWQHPRITLTPHVSAETERGGAIAQIAAKIRAFERGEPVGGIVDLARGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=264, Percent_Identity=28.4090909090909, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI23308577, Length=259, Percent_Identity=27.7992277992278, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI87081824, Length=318, Percent_Identity=48.1132075471698, Blast_Score=290, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17532191, Length=220, Percent_Identity=27.7272727272727, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321253, Length=273, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571528, Length=178, Percent_Identity=29.7752808988764, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921140, Length=170, Percent_Identity=28.8235294117647, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33831; Mature: 33831

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQILLHYSDGELSDWQRETAAALPGAVLRAWQPGDDARADYALVWQPPAALLAPRDGLKA
CEEEEEECCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEEEECCCHHHHCCCCCCEE
IFILGAGVDALLALERERPGTLPAGVPLVRLEDSGMGAQMAEYVVYGVLRHLRRFDDYAA
EEEEECCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
QQRDRRWAPLPVAPRERFVVGVLGLGVLGARVARALAGLGLTVRGFSRSAKALDGVACSA
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHCCEEECC
GTPRAGDPAFDAFSSGLRVLVNLLPGTPDTEGVLNARLFARLAPGALLVNVARGAHLVEA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHEEEHHCCCHHHHH
DLLDALATGRLGAALLDVLREEPPRADHPFWQHPRITLTPHVSAETERGGAIAQIAAKIR
HHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHH
AFERGEPVGGIVDLARGY
HHHCCCCCCHHHHHHCCC
>Mature Secondary Structure
MQILLHYSDGELSDWQRETAAALPGAVLRAWQPGDDARADYALVWQPPAALLAPRDGLKA
CEEEEEECCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEEEECCCHHHHCCCCCCEE
IFILGAGVDALLALERERPGTLPAGVPLVRLEDSGMGAQMAEYVVYGVLRHLRRFDDYAA
EEEEECCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
QQRDRRWAPLPVAPRERFVVGVLGLGVLGARVARALAGLGLTVRGFSRSAKALDGVACSA
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHCCEEECC
GTPRAGDPAFDAFSSGLRVLVNLLPGTPDTEGVLNARLFARLAPGALLVNVARGAHLVEA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHEEEHHCCCHHHHH
DLLDALATGRLGAALLDVLREEPPRADHPFWQHPRITLTPHVSAETERGGAIAQIAAKIR
HHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHH
AFERGEPVGGIVDLARGY
HHHCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA