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The map label for this gene is mvaB [H]

Identifier: 238028795

GI number: 238028795

Start: 3710945

End: 3711871

Strand: Direct

Name: mvaB [H]

Synonym: bglu_1g32590

Alternate gene names: 238028795

Gene position: 3710945-3711871 (Clockwise)

Preceding gene: 238028794

Following gene: 238028796

Centisome position: 94.99

GC content: 71.63

Gene sequence:

>927_bases
ATGACGTTCCCCGCAGCCGTGACAATCGTTGAAGTCGGGCCGCGCGACGGCCTGCAGAACGAGCCGAGCTTCGTGCCGAC
CGAGGTGAAGATCGCGCTCGTGGACCGGCTTTCGCATGCCGGCTTCGCGAACCTCGAAGTGGCTTCGTTCGTCTCGCCGA
AATGGGTGCCGCAGATGGCCGACGGCGCCGCGGTGATGGCCGGCATCGCGCGCCGCCCCGGCGCGCGCTACTCGGCGCTG
ACGCCGAACCTGAAGGGCCTGGAGAACGCGCTTGGCGCGCGCGCCGACGAGGTGGTGATCTTCGGCGCGGCAAGCGAGGC
GTTCTCGCAGAAGAACATCAACTGCAGCATCGCCGAGAGCATCGCGCGCTTCGAGCCGGTCGCGAAGGCCGCCAAGGAGG
CCGGCGTGCGGCTGCGCGGCAGCGTCTCGTGCGCGCTCGGCTGCCCGTACCAGGGCGAGGTGCCGGTGGCCGCCGTGATC
GACGTGGTCGAGCGCTTCGCCGCGCTCGGCTGCGACGAGATCGACATCGCCGACACGATCGGCGTGGGCACCGCCGCGCA
GACGCGCACGCTGCTGGCCGCCGTCTCGCAGGTGTTCCCGCGCGAGCGGCTGTCGGGCCACTTCCACGACACCTACGGCC
AGGCGCTCGCCAACATCCACGCCGCGCTGCTCGAGGGCATCACGATCTTTCATGCCTCGGTGGCAGGCCTGGGCGGCTGC
CCCTACGCGAAGGGCGCGACCGGCAACGTCGCCACCGAGGACGTGCTGTACCTGATGCAGGGCCTCGGCATCGAGACCGG
CATCGACCTGATCGAGGTGGCCGAGGCCGGCGCTTTCATCTCGCGCGCGATCGGCCGCGAGAACGCCTCGCGCGCCGGCC
GCGCGCTGCTCGCCAAGCGCGGCGACGCGCAGGCCGCCCGCGCCTGA

Upstream 100 bases:

>100_bases
TGCCGGATCACGCAGCCGCCGCGCGGCGCCGGCCCGGTTGCCCACGACAACCGCAGCACCACGCGCCCCTGCGCGCGTCA
CCGAACGATGGAGACTGATC

Downstream 100 bases:

>100_bases
ACCCATTCCGTATTCCCGATTCCCTTGACGCTGACGCCTTCATGACGCCCTCCCCGACTCCGACACCTCCCGAAGCGCTT
CCCGACTCCGCGCGCCGCGT

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTFPAAVTIVEVGPRDGLQNEPSFVPTEVKIALVDRLSHAGFANLEVASFVSPKWVPQMADGAAVMAGIARRPGARYSAL
TPNLKGLENALGARADEVVIFGAASEAFSQKNINCSIAESIARFEPVAKAAKEAGVRLRGSVSCALGCPYQGEVPVAAVI
DVVERFAALGCDEIDIADTIGVGTAAQTRTLLAAVSQVFPRERLSGHFHDTYGQALANIHAALLEGITIFHASVAGLGGC
PYAKGATGNVATEDVLYLMQGLGIETGIDLIEVAEAGAFISRAIGRENASRAGRALLAKRGDAQAARA

Sequences:

>Translated_308_residues
MTFPAAVTIVEVGPRDGLQNEPSFVPTEVKIALVDRLSHAGFANLEVASFVSPKWVPQMADGAAVMAGIARRPGARYSAL
TPNLKGLENALGARADEVVIFGAASEAFSQKNINCSIAESIARFEPVAKAAKEAGVRLRGSVSCALGCPYQGEVPVAAVI
DVVERFAALGCDEIDIADTIGVGTAAQTRTLLAAVSQVFPRERLSGHFHDTYGQALANIHAALLEGITIFHASVAGLGGC
PYAKGATGNVATEDVLYLMQGLGIETGIDLIEVAEAGAFISRAIGRENASRAGRALLAKRGDAQAARA
>Mature_307_residues
TFPAAVTIVEVGPRDGLQNEPSFVPTEVKIALVDRLSHAGFANLEVASFVSPKWVPQMADGAAVMAGIARRPGARYSALT
PNLKGLENALGARADEVVIFGAASEAFSQKNINCSIAESIARFEPVAKAAKEAGVRLRGSVSCALGCPYQGEVPVAAVID
VVERFAALGCDEIDIADTIGVGTAAQTRTLLAAVSQVFPRERLSGHFHDTYGQALANIHAALLEGITIFHASVAGLGGCP
YAKGATGNVATEDVLYLMQGLGIETGIDLIEVAEAGAFISRAIGRENASRAGRALLAKRGDAQAARA

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=294, Percent_Identity=56.4625850340136, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=53.9249146757679, Blast_Score=338, Evalue=2e-93,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=53.9249146757679, Blast_Score=338, Evalue=3e-93,
Organism=Homo sapiens, GI260654708, Length=294, Percent_Identity=39.7959183673469, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17510563, Length=296, Percent_Identity=49.3243243243243, Blast_Score=301, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24582381, Length=289, Percent_Identity=55.0173010380623, Blast_Score=332, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 31911; Mature: 31780

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFPAAVTIVEVGPRDGLQNEPSFVPTEVKIALVDRLSHAGFANLEVASFVSPKWVPQMA
CCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHC
DGAAVMAGIARRPGARYSALTPNLKGLENALGARADEVVIFGAASEAFSQKNINCSIAES
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCHHHHHHCCCCHHHHHH
IARFEPVAKAAKEAGVRLRGSVSCALGCPYQGEVPVAAVIDVVERFAALGCDEIDIADTI
HHHHHHHHHHHHHCCCEEECCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHC
GVGTAAQTRTLLAAVSQVFPRERLSGHFHDTYGQALANIHAALLEGITIFHASVAGLGGC
CCCCHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYAKGATGNVATEDVLYLMQGLGIETGIDLIEVAEAGAFISRAIGRENASRAGRALLAKR
CCCCCCCCCCHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
GDAQAARA
CCCCCCCC
>Mature Secondary Structure 
TFPAAVTIVEVGPRDGLQNEPSFVPTEVKIALVDRLSHAGFANLEVASFVSPKWVPQMA
CCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHC
DGAAVMAGIARRPGARYSALTPNLKGLENALGARADEVVIFGAASEAFSQKNINCSIAES
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCHHHHHHCCCCHHHHHH
IARFEPVAKAAKEAGVRLRGSVSCALGCPYQGEVPVAAVIDVVERFAALGCDEIDIADTI
HHHHHHHHHHHHHCCCEEECCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHC
GVGTAAQTRTLLAAVSQVFPRERLSGHFHDTYGQALANIHAALLEGITIFHASVAGLGGC
CCCCHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYAKGATGNVATEDVLYLMQGLGIETGIDLIEVAEAGAFISRAIGRENASRAGRALLAKR
CCCCCCCCCCHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
GDAQAARA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]