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The map label for this gene is aceK [H]

Identifier: 238028773

GI number: 238028773

Start: 3676707

End: 3678515

Strand: Direct

Name: aceK [H]

Synonym: bglu_1g32370

Alternate gene names: 238028773

Gene position: 3676707-3678515 (Clockwise)

Preceding gene: 238028771

Following gene: 238028774

Centisome position: 94.12

GC content: 67.0

Gene sequence:

>1809_bases
ATGCACCACTTTCCCAAGCTGCTCTCCTCGCAGATCGGTTTCGACGTCGCCCGGACGATGCTGGACGGGTTCGATCGCCA
TTACCGGGTGTTTCGCGACGCGGCCGTCGAGGCGAAGGCCCGGTTCGAGGCGGCAGACTGGCACGGGCTGCAGCGGCTCG
CGCGCGAGCGCATCACGTCCTACGACGAGCGCGTGCGCGAATGCGTCGAGCAGCTGCAGGACGAATACGACGCCGAGCGC
ATCGACGACGAGGTCTGGCAGCAGATCAAGCTGCACTACATCGGGCTGCTGACCACCCACCTGCAGCCCGAATGCGCGGA
AACCTTCTTCAACTCGGTCTGCTGCAAGATCCTGCACCGCTCGTACTTCAACAACGACTTCATCTTCGTGCGCCCGGCGA
TCTCGACCGACTACCTCGAGAACGCGGCGCCGGCCGCCAGGCCGACCTACCGCGCCTACTATCCGGCGCAGGACGGGCTG
GCGGCCACGCTCGAGCGGATCGTCACGAACTTCCAGCTCGCGCCGCCGTTCGAGGACCTGAGGCGCGACACGGCCTGCCT
GATGCAGGCGATCGACGACGAGTTCGGCCCGTTCAGCGAGGCCTTCAACTTCCAGATCCACGTGCTGTCGTCGCCGTTCT
TCCGCAATCAGGCCGCCTATCTGGTCGGACGCATCGTCAACGGCGAGCGCGTGCTGCCGTTCGCGGTGCCGGTGCGCCAT
GTCGGCGGCGGCAAGCTCGCGCTCGACACGGTGCTGCTGCGGCGCGAGCAGCTGCAGGTGCTGTTCGGCTTCGCGCATTC
GTATTTCCTGGTGGACATGGACGTGCCGTCGGCCTACGTCGCGTTCCTCGGCTCGATCATGCCCGGCAAGCCGAAGGCCG
AGATCTACACCGCGCTGGGGCTGCAGAAGCAGGGCAAGAACCTGTTCTACCGCGACCTGCTGCATCACCTCTCGCATTCG
AGCGACCGCTTCGTGATCGCGCCCGGCATCAAGGGGCTCGTGATGCTGGTGTTCACGCTGCCGTCGTTCCCCTACGTGTT
CAAGGCGATCAAGGACCGCTTCCCGCCGCCGAAGGACACCACGCGCGAGCAGATCATGGAGAAGTACCAGCTCGTCAAGC
GCCACGACCGGCTCGGCCGGATGGCCGACACGCTCGAATACTCGAGCGTGGCGCTGCCGCTCGCGCGCCTCGACGAGGCG
CTGCTGCGCGAGCTGGAGAAGGAAGCGCCGTCGCTGCTCGAATACGACGGCGACAGCGTGGTGATCCGGCACCTGTACAT
CGAGCGGCGCATGACGCCGCTGAACCTCTACCTGCAGCACGGCAGCGACGCCGAGGTCGAGCACGGCGTGCAGGAATACG
GCGATGCGATCAAGGAACTGATCCAGGCGAACATCTTCCCCGGCGACATGCTCTACAAGAACTTCGGGGTGACGCGCCAC
GGCCGCGTGGTGTTCTACGACTACGACGAGATCGAATACCTGACCGACTGCCAGGTGCGCCGCGTGCCGCCGCCGCGCCA
CGAGGACGACGAGCTCGCGAGCGAGCCGTGGTATTCGGTCGGCCCGCGCGACATCTTCCCCGAAACCTACGGGCCGTTCC
TGCTCGGCGATCCGCGCGTGCGCAAGGCGTTCCTGGCCCGGCATCCGGACTTCTTCGATCCGGCGCTCTGGCAGGACAGC
CAGGACCGGCTGCGGCGCGGCGAGCTGCCCGAGTTTTTCCCCTACGCTGCGTCGCTGCGGTTCCGCACGCGCTATCCCGA
GCGCTTCGCCGGCCACGGCGCGGCCCCGGCCGCCCCACGCGCGGCCTGA

Upstream 100 bases:

>100_bases
GGCCGGCCCCGGCCCCGCGCGGCCGGGCGCCAGGGCCGCGGCAACCAGCGCGGGTGACGGTAAAATGGCGGCTCGCCCCA
GCCACGAGCCCGGACGGACC

Downstream 100 bases:

>100_bases
GCACGGCGACGCCCCTTACTCCCTGTCACGGACCCTCGCGATGACCACCAACGCCCACCCGCTCTCCGACCTGTTCGAGA
ACAACGAGACCTGGGTCAAC

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MHHFPKLLSSQIGFDVARTMLDGFDRHYRVFRDAAVEAKARFEAADWHGLQRLARERITSYDERVRECVEQLQDEYDAER
IDDEVWQQIKLHYIGLLTTHLQPECAETFFNSVCCKILHRSYFNNDFIFVRPAISTDYLENAAPAARPTYRAYYPAQDGL
AATLERIVTNFQLAPPFEDLRRDTACLMQAIDDEFGPFSEAFNFQIHVLSSPFFRNQAAYLVGRIVNGERVLPFAVPVRH
VGGGKLALDTVLLRREQLQVLFGFAHSYFLVDMDVPSAYVAFLGSIMPGKPKAEIYTALGLQKQGKNLFYRDLLHHLSHS
SDRFVIAPGIKGLVMLVFTLPSFPYVFKAIKDRFPPPKDTTREQIMEKYQLVKRHDRLGRMADTLEYSSVALPLARLDEA
LLRELEKEAPSLLEYDGDSVVIRHLYIERRMTPLNLYLQHGSDAEVEHGVQEYGDAIKELIQANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCQVRRVPPPRHEDDELASEPWYSVGPRDIFPETYGPFLLGDPRVRKAFLARHPDFFDPALWQDS
QDRLRRGELPEFFPYAASLRFRTRYPERFAGHGAAPAAPRAA

Sequences:

>Translated_602_residues
MHHFPKLLSSQIGFDVARTMLDGFDRHYRVFRDAAVEAKARFEAADWHGLQRLARERITSYDERVRECVEQLQDEYDAER
IDDEVWQQIKLHYIGLLTTHLQPECAETFFNSVCCKILHRSYFNNDFIFVRPAISTDYLENAAPAARPTYRAYYPAQDGL
AATLERIVTNFQLAPPFEDLRRDTACLMQAIDDEFGPFSEAFNFQIHVLSSPFFRNQAAYLVGRIVNGERVLPFAVPVRH
VGGGKLALDTVLLRREQLQVLFGFAHSYFLVDMDVPSAYVAFLGSIMPGKPKAEIYTALGLQKQGKNLFYRDLLHHLSHS
SDRFVIAPGIKGLVMLVFTLPSFPYVFKAIKDRFPPPKDTTREQIMEKYQLVKRHDRLGRMADTLEYSSVALPLARLDEA
LLRELEKEAPSLLEYDGDSVVIRHLYIERRMTPLNLYLQHGSDAEVEHGVQEYGDAIKELIQANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCQVRRVPPPRHEDDELASEPWYSVGPRDIFPETYGPFLLGDPRVRKAFLARHPDFFDPALWQDS
QDRLRRGELPEFFPYAASLRFRTRYPERFAGHGAAPAAPRAA
>Mature_602_residues
MHHFPKLLSSQIGFDVARTMLDGFDRHYRVFRDAAVEAKARFEAADWHGLQRLARERITSYDERVRECVEQLQDEYDAER
IDDEVWQQIKLHYIGLLTTHLQPECAETFFNSVCCKILHRSYFNNDFIFVRPAISTDYLENAAPAARPTYRAYYPAQDGL
AATLERIVTNFQLAPPFEDLRRDTACLMQAIDDEFGPFSEAFNFQIHVLSSPFFRNQAAYLVGRIVNGERVLPFAVPVRH
VGGGKLALDTVLLRREQLQVLFGFAHSYFLVDMDVPSAYVAFLGSIMPGKPKAEIYTALGLQKQGKNLFYRDLLHHLSHS
SDRFVIAPGIKGLVMLVFTLPSFPYVFKAIKDRFPPPKDTTREQIMEKYQLVKRHDRLGRMADTLEYSSVALPLARLDEA
LLRELEKEAPSLLEYDGDSVVIRHLYIERRMTPLNLYLQHGSDAEVEHGVQEYGDAIKELIQANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCQVRRVPPPRHEDDELASEPWYSVGPRDIFPETYGPFLLGDPRVRKAFLARHPDFFDPALWQDS
QDRLRRGELPEFFPYAASLRFRTRYPERFAGHGAAPAAPRAA

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=572, Percent_Identity=41.6083916083916, Blast_Score=456, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 69386; Mature: 69386

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHFPKLLSSQIGFDVARTMLDGFDRHYRVFRDAAVEAKARFEAADWHGLQRLARERITS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
YDERVRECVEQLQDEYDAERIDDEVWQQIKLHYIGLLTTHLQPECAETFFNSVCCKILHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SYFNNDFIFVRPAISTDYLENAAPAARPTYRAYYPAQDGLAATLERIVTNFQLAPPFEDL
HHCCCCEEEEECCCCHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCHHHH
RRDTACLMQAIDDEFGPFSEAFNFQIHVLSSPFFRNQAAYLVGRIVNGERVLPFAVPVRH
HHHHHHHHHHHHHCCCCHHHHCCEEEEEECCCCHHCHHHHHHHEEECCCEEEEEECCHHH
VGGGKLALDTVLLRREQLQVLFGFAHSYFLVDMDVPSAYVAFLGSIMPGKPKAEIYTALG
CCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHC
LQKQGKNLFYRDLLHHLSHSSDRFVIAPGIKGLVMLVFTLPSFPYVFKAIKDRFPPPKDT
CHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
TREQIMEKYQLVKRHDRLGRMADTLEYSSVALPLARLDEALLRELEKEAPSLLEYDGDSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHH
VIRHLYIERRMTPLNLYLQHGSDAEVEHGVQEYGDAIKELIQANIFPGDMLYKNFGVTRH
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCC
GRVVFYDYDEIEYLTDCQVRRVPPPRHEDDELASEPWYSVGPRDIFPETYGPFLLGDPRV
CEEEEEECCHHHHHHCCCEECCCCCCCCCHHHHCCCCCCCCCHHCCCCCCCCCCCCCHHH
RKAFLARHPDFFDPALWQDSQDRLRRGELPEFFPYAASLRFRTRYPERFAGHGAAPAAPR
HHHHHHCCCCCCCHHHCCCCHHHHHCCCCCCHHHHHHHEEHHCCCCHHHCCCCCCCCCCC
AA
CC
>Mature Secondary Structure
MHHFPKLLSSQIGFDVARTMLDGFDRHYRVFRDAAVEAKARFEAADWHGLQRLARERITS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
YDERVRECVEQLQDEYDAERIDDEVWQQIKLHYIGLLTTHLQPECAETFFNSVCCKILHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SYFNNDFIFVRPAISTDYLENAAPAARPTYRAYYPAQDGLAATLERIVTNFQLAPPFEDL
HHCCCCEEEEECCCCHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCHHHH
RRDTACLMQAIDDEFGPFSEAFNFQIHVLSSPFFRNQAAYLVGRIVNGERVLPFAVPVRH
HHHHHHHHHHHHHCCCCHHHHCCEEEEEECCCCHHCHHHHHHHEEECCCEEEEEECCHHH
VGGGKLALDTVLLRREQLQVLFGFAHSYFLVDMDVPSAYVAFLGSIMPGKPKAEIYTALG
CCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHC
LQKQGKNLFYRDLLHHLSHSSDRFVIAPGIKGLVMLVFTLPSFPYVFKAIKDRFPPPKDT
CHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
TREQIMEKYQLVKRHDRLGRMADTLEYSSVALPLARLDEALLRELEKEAPSLLEYDGDSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHH
VIRHLYIERRMTPLNLYLQHGSDAEVEHGVQEYGDAIKELIQANIFPGDMLYKNFGVTRH
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCC
GRVVFYDYDEIEYLTDCQVRRVPPPRHEDDELASEPWYSVGPRDIFPETYGPFLLGDPRV
CEEEEEECCHHHHHHCCCEECCCCCCCCCHHHHCCCCCCCCCHHCCCCCCCCCCCCCHHH
RKAFLARHPDFFDPALWQDSQDRLRRGELPEFFPYAASLRFRTRYPERFAGHGAAPAAPR
HHHHHHCCCCCCCHHHCCCCHHHHHCCCCCCHHHHHHHEEHHCCCCHHHCCCCCCCCCCC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA